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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for PAK5 |
 Gene summary |
| Gene information | Gene symbol | PAK5 | Gene ID | 57144 |
| Gene name | p21 (RAC1) activated kinase 5 | |
| Synonyms | PAK7 | |
| Cytomap | 20p12.2 | |
| Type of gene | protein-coding | |
| Description | serine/threonine-protein kinase PAK 5PAK-5PAK-7p21 (RAC1) activated kinase 7p21 protein (Cdc42/Rac)-activated kinase 7p21(CDKN1A)-activated kinase 7p21-activated kinase 5p21-activated kinase 7p21CDKN1A-activated kinase 7protein kinase PAK5serine | |
| Modification date | 20200313 | |
| UniProtAcc | Q9P286, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for PAK5 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000101349
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for PAK5 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_140322 | chr20 | 9537389:9539617:9542586:9542720:9544369:9544494 | 9542586:9542720 |
| exon_skip_172824 | chr20 | 9562891:9563024:9565893:9566384:9580145:9580930 | 9565893:9566384 |
| exon_skip_18811 | chr20 | 9644125:9644339:9711286:9711435:9818680:9818785 | 9711286:9711435 |
| exon_skip_215956 | chr20 | 9711286:9711435:9818680:9818785:9838762:9838831 | 9818680:9818785 |
| exon_skip_257093 | chr20 | 9537389:9539617:9542586:9542720:9544369:9544488 | 9542586:9542720 |
| exon_skip_260138 | chr20 | 9565893:9566384:9580145:9580930:9644125:9644339 | 9580145:9580930 |
| exon_skip_57280 | chr20 | 9644125:9644339:9711286:9711435:9838762:9838831 | 9711286:9711435 |
| exon_skip_7292 | chr20 | 9580145:9580930:9644125:9644339:9711286:9711435 | 9644125:9644339 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for PAK5 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000353224 | 9644125 | 9644339 | 3UTR-3CDS |
| ENST00000378423 | 9644125 | 9644339 | 3UTR-3CDS |
| ENST00000378429 | 9644125 | 9644339 | 3UTR-3CDS |
| ENST00000353224 | 9711286 | 9711435 | 3UTR-3UTR |
| ENST00000378429 | 9818680 | 9818785 | 3UTR-3UTR |
| ENST00000353224 | 9542586 | 9542720 | In-frame |
| ENST00000378423 | 9542586 | 9542720 | In-frame |
| ENST00000378429 | 9542586 | 9542720 | In-frame |
| ENST00000353224 | 9580145 | 9580930 | In-frame |
| ENST00000378423 | 9580145 | 9580930 | In-frame |
| ENST00000378429 | 9580145 | 9580930 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000378429 | 9818680 | 9818785 | 3UTR-3UTR |
| ENST00000353224 | 9542586 | 9542720 | In-frame |
| ENST00000378423 | 9542586 | 9542720 | In-frame |
| ENST00000378429 | 9542586 | 9542720 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000353224 | 9644125 | 9644339 | 3UTR-3CDS |
| ENST00000378423 | 9644125 | 9644339 | 3UTR-3CDS |
| ENST00000378429 | 9644125 | 9644339 | 3UTR-3CDS |
| ENST00000353224 | 9711286 | 9711435 | 3UTR-3UTR |
| ENST00000378429 | 9711286 | 9711435 | 3UTR-3UTR |
| ENST00000378429 | 9818680 | 9818785 | 3UTR-3UTR |
| ENST00000353224 | 9542586 | 9542720 | In-frame |
| ENST00000378423 | 9542586 | 9542720 | In-frame |
| ENST00000378429 | 9542586 | 9542720 | In-frame |
| ENST00000353224 | 9565893 | 9566384 | In-frame |
| ENST00000378423 | 9565893 | 9566384 | In-frame |
| ENST00000378429 | 9565893 | 9566384 | In-frame |
| ENST00000353224 | 9580145 | 9580930 | In-frame |
| ENST00000378423 | 9580145 | 9580930 | In-frame |
| ENST00000378429 | 9580145 | 9580930 | In-frame |
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Infer the effects of exon skipping event on protein functional features for PAK5 |
p-ENSG00000101349_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in PAK5 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000378429 | 9818680 | 9818785 | hsa-miR-6740-3p | chr20:9818727-9818734 | 8mer-1a | chr20:9818712-9818734 | 151.00 | -18.83 |
| Mayo | ENST00000378429 | 9711286 | 9711435 | hsa-miR-4294 | chr20:9711314-9711321 | 8mer-1a | chr20:9711305-9711322 | 160.00 | -21.61 |
| Mayo | ENST00000378429 | 9818680 | 9818785 | hsa-miR-6861-3p | chr20:9818720-9818727 | 8mer-1a | chr20:9818712-9818734 | 151.00 | -18.83 |
| Mayo | ENST00000378429 | 9711286 | 9711435 | hsa-miR-3185 | chr20:9711372-9711379 | 8mer-1a | chr20:9711361-9711384 | 167.00 | -16.60 |
| Mayo | ENST00000378429 | 9818680 | 9818785 | hsa-miR-519c-5p | chr20:9818767-9818774 | 8mer-1a | chr20:9818749-9818774 | 149.00 | -15.42 |
| Mayo | ENST00000378429 | 9818680 | 9818785 | hsa-miR-519b-5p | chr20:9818767-9818774 | 8mer-1a | chr20:9818749-9818774 | 149.00 | -15.42 |
| Mayo | ENST00000378429 | 9818680 | 9818785 | hsa-miR-523-5p | chr20:9818767-9818774 | 8mer-1a | chr20:9818749-9818774 | 149.00 | -15.42 |
| Mayo | ENST00000378429 | 9818680 | 9818785 | hsa-miR-518f-5p | chr20:9818767-9818774 | 8mer-1a | chr20:9818749-9818774 | 149.00 | -15.42 |
| Mayo | ENST00000378429 | 9818680 | 9818785 | hsa-miR-526a-5p | chr20:9818767-9818774 | 8mer-1a | chr20:9818749-9818774 | 149.00 | -15.42 |
| Mayo | ENST00000378429 | 9818680 | 9818785 | hsa-miR-520c-5p | chr20:9818767-9818774 | 8mer-1a | chr20:9818749-9818774 | 149.00 | -15.42 |
| Mayo | ENST00000378429 | 9818680 | 9818785 | hsa-miR-518e-5p | chr20:9818767-9818774 | 8mer-1a | chr20:9818749-9818774 | 149.00 | -15.42 |
| Mayo | ENST00000378429 | 9818680 | 9818785 | hsa-miR-518d-5p | chr20:9818767-9818774 | 8mer-1a | chr20:9818749-9818774 | 149.00 | -15.42 |
| Mayo | ENST00000378429 | 9818680 | 9818785 | hsa-miR-522-5p | chr20:9818767-9818774 | 8mer-1a | chr20:9818749-9818774 | 149.00 | -15.42 |
| Mayo | ENST00000378429 | 9818680 | 9818785 | hsa-miR-519a-5p | chr20:9818767-9818774 | 8mer-1a | chr20:9818749-9818774 | 149.00 | -15.42 |
| Mayo | ENST00000378429 | 9818680 | 9818785 | hsa-miR-4786-5p | chr20:9818712-9818719 | 8mer-1a | chr20:9818702-9818723 | 162.00 | -21.51 |
| Mayo | ENST00000378429 | 9711286 | 9711435 | hsa-miR-4760-3p | chr20:9711305-9711312 | 8mer-1a | chr20:9711305-9711322 | 160.00 | -21.61 |
| Mayo | ENST00000378429 | 9711286 | 9711435 | hsa-miR-2115-5p | chr20:9711410-9711417 | 8mer-1a | chr20:9711403-9711423 | 158.00 | -19.22 |
| Mayo | ENST00000378429 | 9711286 | 9711435 | hsa-miR-449b-3p | chr20:9711328-9711335 | 8mer-1a | chr20:9711315-9711335 | 155.00 | -18.95 |
| Mayo | ENST00000378429 | 9818680 | 9818785 | hsa-miR-1206 | chr20:9818777-9818784 | 8mer-1a | chr20:9818764-9818784 | 146.00 | -15.30 |
| Mayo | ENST00000378429 | 9818680 | 9818785 | hsa-miR-4329 | chr20:9818714-9818721 | 8mer-1a | chr20:9818702-9818723 | 162.00 | -21.51 |
| MSBB | ENST00000378429 | 9818680 | 9818785 | hsa-miR-6740-3p | chr20:9818727-9818734 | 8mer-1a | chr20:9818712-9818734 | 151.00 | -18.83 |
| MSBB | ENST00000378429 | 9818680 | 9818785 | hsa-miR-6861-3p | chr20:9818720-9818727 | 8mer-1a | chr20:9818712-9818734 | 151.00 | -18.83 |
| MSBB | ENST00000378429 | 9818680 | 9818785 | hsa-miR-519c-5p | chr20:9818767-9818774 | 8mer-1a | chr20:9818749-9818774 | 149.00 | -15.42 |
| MSBB | ENST00000378429 | 9818680 | 9818785 | hsa-miR-519b-5p | chr20:9818767-9818774 | 8mer-1a | chr20:9818749-9818774 | 149.00 | -15.42 |
| MSBB | ENST00000378429 | 9818680 | 9818785 | hsa-miR-523-5p | chr20:9818767-9818774 | 8mer-1a | chr20:9818749-9818774 | 149.00 | -15.42 |
| MSBB | ENST00000378429 | 9818680 | 9818785 | hsa-miR-518f-5p | chr20:9818767-9818774 | 8mer-1a | chr20:9818749-9818774 | 149.00 | -15.42 |
| MSBB | ENST00000378429 | 9818680 | 9818785 | hsa-miR-526a-5p | chr20:9818767-9818774 | 8mer-1a | chr20:9818749-9818774 | 149.00 | -15.42 |
| MSBB | ENST00000378429 | 9818680 | 9818785 | hsa-miR-520c-5p | chr20:9818767-9818774 | 8mer-1a | chr20:9818749-9818774 | 149.00 | -15.42 |
| MSBB | ENST00000378429 | 9818680 | 9818785 | hsa-miR-518e-5p | chr20:9818767-9818774 | 8mer-1a | chr20:9818749-9818774 | 149.00 | -15.42 |
| MSBB | ENST00000378429 | 9818680 | 9818785 | hsa-miR-518d-5p | chr20:9818767-9818774 | 8mer-1a | chr20:9818749-9818774 | 149.00 | -15.42 |
| MSBB | ENST00000378429 | 9818680 | 9818785 | hsa-miR-522-5p | chr20:9818767-9818774 | 8mer-1a | chr20:9818749-9818774 | 149.00 | -15.42 |
| MSBB | ENST00000378429 | 9818680 | 9818785 | hsa-miR-519a-5p | chr20:9818767-9818774 | 8mer-1a | chr20:9818749-9818774 | 149.00 | -15.42 |
| MSBB | ENST00000378429 | 9818680 | 9818785 | hsa-miR-4786-5p | chr20:9818712-9818719 | 8mer-1a | chr20:9818702-9818723 | 162.00 | -21.51 |
| MSBB | ENST00000378429 | 9818680 | 9818785 | hsa-miR-1206 | chr20:9818777-9818784 | 8mer-1a | chr20:9818764-9818784 | 146.00 | -15.30 |
| MSBB | ENST00000378429 | 9818680 | 9818785 | hsa-miR-4329 | chr20:9818714-9818721 | 8mer-1a | chr20:9818702-9818723 | 162.00 | -21.51 |
| ROSMAP | ENST00000378429 | 9818680 | 9818785 | hsa-miR-6740-3p | chr20:9818727-9818734 | 8mer-1a | chr20:9818712-9818734 | 151.00 | -18.83 |
| ROSMAP | ENST00000353224 | 9711286 | 9711435 | hsa-miR-4294 | chr20:9711314-9711321 | 8mer-1a | chr20:9711305-9711322 | 160.00 | -21.61 |
| ROSMAP | ENST00000378429 | 9818680 | 9818785 | hsa-miR-6861-3p | chr20:9818720-9818727 | 8mer-1a | chr20:9818712-9818734 | 151.00 | -18.83 |
| ROSMAP | ENST00000353224 | 9711286 | 9711435 | hsa-miR-3185 | chr20:9711372-9711379 | 8mer-1a | chr20:9711361-9711384 | 167.00 | -16.60 |
| ROSMAP | ENST00000378429 | 9818680 | 9818785 | hsa-miR-519c-5p | chr20:9818767-9818774 | 8mer-1a | chr20:9818749-9818774 | 149.00 | -15.42 |
| ROSMAP | ENST00000378429 | 9818680 | 9818785 | hsa-miR-519b-5p | chr20:9818767-9818774 | 8mer-1a | chr20:9818749-9818774 | 149.00 | -15.42 |
| ROSMAP | ENST00000378429 | 9818680 | 9818785 | hsa-miR-523-5p | chr20:9818767-9818774 | 8mer-1a | chr20:9818749-9818774 | 149.00 | -15.42 |
| ROSMAP | ENST00000378429 | 9818680 | 9818785 | hsa-miR-518f-5p | chr20:9818767-9818774 | 8mer-1a | chr20:9818749-9818774 | 149.00 | -15.42 |
| ROSMAP | ENST00000378429 | 9818680 | 9818785 | hsa-miR-526a-5p | chr20:9818767-9818774 | 8mer-1a | chr20:9818749-9818774 | 149.00 | -15.42 |
| ROSMAP | ENST00000378429 | 9818680 | 9818785 | hsa-miR-520c-5p | chr20:9818767-9818774 | 8mer-1a | chr20:9818749-9818774 | 149.00 | -15.42 |
| ROSMAP | ENST00000378429 | 9818680 | 9818785 | hsa-miR-518e-5p | chr20:9818767-9818774 | 8mer-1a | chr20:9818749-9818774 | 149.00 | -15.42 |
| ROSMAP | ENST00000378429 | 9818680 | 9818785 | hsa-miR-518d-5p | chr20:9818767-9818774 | 8mer-1a | chr20:9818749-9818774 | 149.00 | -15.42 |
| ROSMAP | ENST00000378429 | 9818680 | 9818785 | hsa-miR-522-5p | chr20:9818767-9818774 | 8mer-1a | chr20:9818749-9818774 | 149.00 | -15.42 |
| ROSMAP | ENST00000378429 | 9818680 | 9818785 | hsa-miR-519a-5p | chr20:9818767-9818774 | 8mer-1a | chr20:9818749-9818774 | 149.00 | -15.42 |
| ROSMAP | ENST00000378429 | 9818680 | 9818785 | hsa-miR-4786-5p | chr20:9818712-9818719 | 8mer-1a | chr20:9818702-9818723 | 162.00 | -21.51 |
| ROSMAP | ENST00000353224 | 9711286 | 9711435 | hsa-miR-4760-3p | chr20:9711305-9711312 | 8mer-1a | chr20:9711305-9711322 | 160.00 | -21.61 |
| ROSMAP | ENST00000353224 | 9711286 | 9711435 | hsa-miR-2115-5p | chr20:9711410-9711417 | 8mer-1a | chr20:9711403-9711423 | 158.00 | -19.22 |
| ROSMAP | ENST00000353224 | 9711286 | 9711435 | hsa-miR-449b-3p | chr20:9711328-9711335 | 8mer-1a | chr20:9711315-9711335 | 155.00 | -18.95 |
| ROSMAP | ENST00000378429 | 9818680 | 9818785 | hsa-miR-1206 | chr20:9818777-9818784 | 8mer-1a | chr20:9818764-9818784 | 146.00 | -15.30 |
| ROSMAP | ENST00000378429 | 9818680 | 9818785 | hsa-miR-4329 | chr20:9818714-9818721 | 8mer-1a | chr20:9818702-9818723 | 162.00 | -21.51 |
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SNVs in the skipped exons for PAK5 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for PAK5 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PAK5 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for PAK5 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | HNRNPDL | exon_skip_215956 | 4.142073e-01 | 3.629535e-07 |
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RelatedDrugs for PAK5 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Q9P286 | approved|investigational | DB12010 | Fostamatinib | small molecule | Q9P286 |
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RelatedDiseases for PAK5 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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