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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for PCBP4 |
 Gene summary |
| Gene information | Gene symbol | PCBP4 | Gene ID | 57060 |
| Gene name | poly(rC) binding protein 4 | |
| Synonyms | CBP|LIP4|MCG10 | |
| Cytomap | 3p21.2 | |
| Type of gene | protein-coding | |
| Description | poly(rC)-binding protein 4LYST-interacting proteinRNA binding protein MCG10alpha-CP4 | |
| Modification date | 20200320 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| PCBP4 | GO:0043488 | regulation of mRNA stability | 20817677 |
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Gene structures and expression levels for PCBP4 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000090097
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000322099.11 | PCBP4-201:protein_coding:PCBP4 | 3.645909e+03 | -9.469028e-01 | 1.334428e-15 | 7.340056e-13 |
| TC | DOWN | ENST00000322099.11 | PCBP4-201:protein_coding:PCBP4 | 1.050205e+03 | -9.318721e-01 | 5.878427e-11 | 1.234523e-08 |
| TC | DOWN | ENST00000497390.5 | PCBP4-216:retained_intron:PCBP4 | 1.281742e+02 | -9.517827e-01 | 4.281480e-06 | 1.316368e-04 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for PCBP4 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_119775 | chr3 | 51960301:51960320:51960526:51960642:51960866:51960898 | 51960526:51960642 |
| exon_skip_155058 | chr3 | 51959367:51959411:51959577:51959651:51959895:51959915 | 51959577:51959651 |
| exon_skip_181850 | chr3 | 51959577:51959651:51959895:51960023:51960189:51960320 | 51959895:51960023 |
| exon_skip_186126 | chr3 | 51960301:51960320:51960526:51960637:51960866:51960898 | 51960526:51960637 |
| exon_skip_212534 | chr3 | 51959367:51959411:51959577:51959651:51960189:51960279 | 51959577:51959651 |
| exon_skip_250266 | chr3 | 51959603:51959651:51959895:51960023:51960189:51960320 | 51959895:51960023 |
| exon_skip_252214 | chr3 | 51959367:51959411:51959577:51959651:51960189:51960320 | 51959577:51959651 |
| exon_skip_264407 | chr3 | 51959229:51959292:51959367:51959411:51959577:51959651 | 51959367:51959411 |
| exon_skip_293113 | chr3 | 51961160:51961304:51961941:51962088:51967326:51967445 | 51961941:51962088 |
| exon_skip_3517 | chr3 | 51960557:51960642:51960866:51960898:51961010:51961033 | 51960866:51960898 |
| exon_skip_51333 | chr3 | 51961160:51961304:51962810:51962892:51967326:51967434 | 51962810:51962892 |
| exon_skip_56573 | chr3 | 51959603:51959651:51959895:51960023:51960189:51960279 | 51959895:51960023 |
| exon_skip_86037 | chr3 | 51961160:51961304:51961941:51962088:51962810:51962892 | 51961941:51962088 |
| exon_skip_93100 | chr3 | 51960301:51960320:51960526:51960898:51961010:51961033 | 51960526:51960898 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_248287 | Mayo_CB | 7.460256e-01 | 8.781429e-01 | -1.321172e-01 | 1.606896e-06 |
| exon_skip_12465 | Mayo_CB | 3.930488e-01 | 4.976623e-01 | -1.046136e-01 | 1.644204e-06 |
| exon_skip_51333 | Mayo_CB | 4.009756e-01 | 5.100000e-01 | -1.090244e-01 | 5.278818e-06 |
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Open reading frame (ORF) annotation in the exon skipping event for PCBP4 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000461554 | 51961941 | 51962088 | 3UTR-3UTR |
| ENST00000322099 | 51959577 | 51959651 | In-frame |
| ENST00000355852 | 51959577 | 51959651 | In-frame |
| ENST00000461554 | 51959577 | 51959651 | In-frame |
| ENST00000322099 | 51959895 | 51960023 | In-frame |
| ENST00000355852 | 51959895 | 51960023 | In-frame |
| ENST00000461554 | 51959895 | 51960023 | In-frame |
| ENST00000322099 | 51960526 | 51960642 | In-frame |
| ENST00000355852 | 51960526 | 51960642 | In-frame |
| ENST00000461554 | 51960526 | 51960642 | In-frame |
| ENST00000322099 | 51960866 | 51960898 | In-frame |
| ENST00000355852 | 51960866 | 51960898 | In-frame |
| ENST00000461554 | 51960866 | 51960898 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000461554 | 51961941 | 51962088 | 3UTR-3UTR |
| ENST00000322099 | 51959895 | 51960023 | In-frame |
| ENST00000355852 | 51959895 | 51960023 | In-frame |
| ENST00000461554 | 51959895 | 51960023 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000461554 | 51961941 | 51962088 | 3UTR-3UTR |
| ENST00000322099 | 51959367 | 51959411 | In-frame |
| ENST00000355852 | 51959367 | 51959411 | In-frame |
| ENST00000461554 | 51959367 | 51959411 | In-frame |
| ENST00000322099 | 51959577 | 51959651 | In-frame |
| ENST00000355852 | 51959577 | 51959651 | In-frame |
| ENST00000461554 | 51959577 | 51959651 | In-frame |
| ENST00000322099 | 51959895 | 51960023 | In-frame |
| ENST00000355852 | 51959895 | 51960023 | In-frame |
| ENST00000461554 | 51959895 | 51960023 | In-frame |
| ENST00000322099 | 51960526 | 51960642 | In-frame |
| ENST00000355852 | 51960526 | 51960642 | In-frame |
| ENST00000461554 | 51960526 | 51960642 | In-frame |
| ENST00000322099 | 51960866 | 51960898 | In-frame |
| ENST00000355852 | 51960866 | 51960898 | In-frame |
| ENST00000461554 | 51960866 | 51960898 | In-frame |
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Infer the effects of exon skipping event on protein functional features for PCBP4 |
p-ENSG00000090097_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000322099 | 1981 | 403 | 51960866 | 51960898 | 253 | 284 | 35 | 45 |
| ENST00000355852 | 2032 | 403 | 51960866 | 51960898 | 302 | 333 | 35 | 45 |
| ENST00000461554 | 2164 | 403 | 51960866 | 51960898 | 438 | 469 | 35 | 45 |
| ENST00000322099 | 1981 | 403 | 51960526 | 51960642 | 286 | 401 | 46 | 84 |
| ENST00000355852 | 2032 | 403 | 51960526 | 51960642 | 335 | 450 | 46 | 84 |
| ENST00000461554 | 2164 | 403 | 51960526 | 51960642 | 471 | 586 | 46 | 84 |
| ENST00000322099 | 1981 | 403 | 51959895 | 51960023 | 535 | 662 | 129 | 171 |
| ENST00000355852 | 2032 | 403 | 51959895 | 51960023 | 584 | 711 | 129 | 171 |
| ENST00000461554 | 2164 | 403 | 51959895 | 51960023 | 720 | 847 | 129 | 171 |
| ENST00000322099 | 1981 | 403 | 51959577 | 51959651 | 664 | 737 | 172 | 196 |
| ENST00000355852 | 2032 | 403 | 51959577 | 51959651 | 713 | 786 | 172 | 196 |
| ENST00000461554 | 2164 | 403 | 51959577 | 51959651 | 849 | 922 | 172 | 196 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000322099 | 1981 | 403 | 51959895 | 51960023 | 535 | 662 | 129 | 171 |
| ENST00000355852 | 2032 | 403 | 51959895 | 51960023 | 584 | 711 | 129 | 171 |
| ENST00000461554 | 2164 | 403 | 51959895 | 51960023 | 720 | 847 | 129 | 171 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000322099 | 1981 | 403 | 51960866 | 51960898 | 253 | 284 | 35 | 45 |
| ENST00000355852 | 2032 | 403 | 51960866 | 51960898 | 302 | 333 | 35 | 45 |
| ENST00000461554 | 2164 | 403 | 51960866 | 51960898 | 438 | 469 | 35 | 45 |
| ENST00000322099 | 1981 | 403 | 51960526 | 51960642 | 286 | 401 | 46 | 84 |
| ENST00000355852 | 2032 | 403 | 51960526 | 51960642 | 335 | 450 | 46 | 84 |
| ENST00000461554 | 2164 | 403 | 51960526 | 51960642 | 471 | 586 | 46 | 84 |
| ENST00000322099 | 1981 | 403 | 51959895 | 51960023 | 535 | 662 | 129 | 171 |
| ENST00000355852 | 2032 | 403 | 51959895 | 51960023 | 584 | 711 | 129 | 171 |
| ENST00000461554 | 2164 | 403 | 51959895 | 51960023 | 720 | 847 | 129 | 171 |
| ENST00000322099 | 1981 | 403 | 51959577 | 51959651 | 664 | 737 | 172 | 196 |
| ENST00000355852 | 2032 | 403 | 51959577 | 51959651 | 713 | 786 | 172 | 196 |
| ENST00000461554 | 2164 | 403 | 51959577 | 51959651 | 849 | 922 | 172 | 196 |
| ENST00000322099 | 1981 | 403 | 51959367 | 51959411 | 739 | 782 | 197 | 211 |
| ENST00000355852 | 2032 | 403 | 51959367 | 51959411 | 788 | 831 | 197 | 211 |
| ENST00000461554 | 2164 | 403 | 51959367 | 51959411 | 924 | 967 | 197 | 211 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P57723 | 35 | 45 | 1 | 403 | Chain | ID=PRO_0000050094;Note=Poly(rC)-binding protein 4 |
| P57723 | 35 | 45 | 1 | 403 | Chain | ID=PRO_0000050094;Note=Poly(rC)-binding protein 4 |
| P57723 | 35 | 45 | 1 | 403 | Chain | ID=PRO_0000050094;Note=Poly(rC)-binding protein 4 |
| P57723 | 35 | 45 | 17 | 67 | Domain | Note=KH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117 |
| P57723 | 35 | 45 | 17 | 67 | Domain | Note=KH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117 |
| P57723 | 35 | 45 | 17 | 67 | Domain | Note=KH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117 |
| P57723 | 46 | 84 | 1 | 403 | Chain | ID=PRO_0000050094;Note=Poly(rC)-binding protein 4 |
| P57723 | 46 | 84 | 1 | 403 | Chain | ID=PRO_0000050094;Note=Poly(rC)-binding protein 4 |
| P57723 | 46 | 84 | 1 | 403 | Chain | ID=PRO_0000050094;Note=Poly(rC)-binding protein 4 |
| P57723 | 46 | 84 | 17 | 67 | Domain | Note=KH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117 |
| P57723 | 46 | 84 | 17 | 67 | Domain | Note=KH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117 |
| P57723 | 46 | 84 | 17 | 67 | Domain | Note=KH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117 |
| P57723 | 129 | 171 | 130 | 172 | Alternative sequence | ID=VSP_010016;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| P57723 | 129 | 171 | 130 | 172 | Alternative sequence | ID=VSP_010016;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| P57723 | 129 | 171 | 130 | 172 | Alternative sequence | ID=VSP_010016;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| P57723 | 129 | 171 | 1 | 403 | Chain | ID=PRO_0000050094;Note=Poly(rC)-binding protein 4 |
| P57723 | 129 | 171 | 1 | 403 | Chain | ID=PRO_0000050094;Note=Poly(rC)-binding protein 4 |
| P57723 | 129 | 171 | 1 | 403 | Chain | ID=PRO_0000050094;Note=Poly(rC)-binding protein 4 |
| P57723 | 129 | 171 | 101 | 154 | Domain | Note=KH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117 |
| P57723 | 129 | 171 | 101 | 154 | Domain | Note=KH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117 |
| P57723 | 129 | 171 | 101 | 154 | Domain | Note=KH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117 |
| P57723 | 172 | 196 | 130 | 172 | Alternative sequence | ID=VSP_010016;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| P57723 | 172 | 196 | 130 | 172 | Alternative sequence | ID=VSP_010016;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| P57723 | 172 | 196 | 130 | 172 | Alternative sequence | ID=VSP_010016;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| P57723 | 172 | 196 | 1 | 403 | Chain | ID=PRO_0000050094;Note=Poly(rC)-binding protein 4 |
| P57723 | 172 | 196 | 1 | 403 | Chain | ID=PRO_0000050094;Note=Poly(rC)-binding protein 4 |
| P57723 | 172 | 196 | 1 | 403 | Chain | ID=PRO_0000050094;Note=Poly(rC)-binding protein 4 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P57723 | 129 | 171 | 130 | 172 | Alternative sequence | ID=VSP_010016;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| P57723 | 129 | 171 | 130 | 172 | Alternative sequence | ID=VSP_010016;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| P57723 | 129 | 171 | 130 | 172 | Alternative sequence | ID=VSP_010016;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| P57723 | 129 | 171 | 1 | 403 | Chain | ID=PRO_0000050094;Note=Poly(rC)-binding protein 4 |
| P57723 | 129 | 171 | 1 | 403 | Chain | ID=PRO_0000050094;Note=Poly(rC)-binding protein 4 |
| P57723 | 129 | 171 | 1 | 403 | Chain | ID=PRO_0000050094;Note=Poly(rC)-binding protein 4 |
| P57723 | 129 | 171 | 101 | 154 | Domain | Note=KH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117 |
| P57723 | 129 | 171 | 101 | 154 | Domain | Note=KH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117 |
| P57723 | 129 | 171 | 101 | 154 | Domain | Note=KH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P57723 | 35 | 45 | 1 | 403 | Chain | ID=PRO_0000050094;Note=Poly(rC)-binding protein 4 |
| P57723 | 35 | 45 | 1 | 403 | Chain | ID=PRO_0000050094;Note=Poly(rC)-binding protein 4 |
| P57723 | 35 | 45 | 1 | 403 | Chain | ID=PRO_0000050094;Note=Poly(rC)-binding protein 4 |
| P57723 | 35 | 45 | 17 | 67 | Domain | Note=KH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117 |
| P57723 | 35 | 45 | 17 | 67 | Domain | Note=KH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117 |
| P57723 | 35 | 45 | 17 | 67 | Domain | Note=KH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117 |
| P57723 | 46 | 84 | 1 | 403 | Chain | ID=PRO_0000050094;Note=Poly(rC)-binding protein 4 |
| P57723 | 46 | 84 | 1 | 403 | Chain | ID=PRO_0000050094;Note=Poly(rC)-binding protein 4 |
| P57723 | 46 | 84 | 1 | 403 | Chain | ID=PRO_0000050094;Note=Poly(rC)-binding protein 4 |
| P57723 | 46 | 84 | 17 | 67 | Domain | Note=KH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117 |
| P57723 | 46 | 84 | 17 | 67 | Domain | Note=KH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117 |
| P57723 | 46 | 84 | 17 | 67 | Domain | Note=KH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117 |
| P57723 | 129 | 171 | 130 | 172 | Alternative sequence | ID=VSP_010016;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| P57723 | 129 | 171 | 130 | 172 | Alternative sequence | ID=VSP_010016;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| P57723 | 129 | 171 | 130 | 172 | Alternative sequence | ID=VSP_010016;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| P57723 | 129 | 171 | 1 | 403 | Chain | ID=PRO_0000050094;Note=Poly(rC)-binding protein 4 |
| P57723 | 129 | 171 | 1 | 403 | Chain | ID=PRO_0000050094;Note=Poly(rC)-binding protein 4 |
| P57723 | 129 | 171 | 1 | 403 | Chain | ID=PRO_0000050094;Note=Poly(rC)-binding protein 4 |
| P57723 | 129 | 171 | 101 | 154 | Domain | Note=KH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117 |
| P57723 | 129 | 171 | 101 | 154 | Domain | Note=KH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117 |
| P57723 | 129 | 171 | 101 | 154 | Domain | Note=KH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117 |
| P57723 | 172 | 196 | 130 | 172 | Alternative sequence | ID=VSP_010016;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| P57723 | 172 | 196 | 130 | 172 | Alternative sequence | ID=VSP_010016;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| P57723 | 172 | 196 | 130 | 172 | Alternative sequence | ID=VSP_010016;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| P57723 | 172 | 196 | 1 | 403 | Chain | ID=PRO_0000050094;Note=Poly(rC)-binding protein 4 |
| P57723 | 172 | 196 | 1 | 403 | Chain | ID=PRO_0000050094;Note=Poly(rC)-binding protein 4 |
| P57723 | 172 | 196 | 1 | 403 | Chain | ID=PRO_0000050094;Note=Poly(rC)-binding protein 4 |
| P57723 | 197 | 211 | 1 | 403 | Chain | ID=PRO_0000050094;Note=Poly(rC)-binding protein 4 |
| P57723 | 197 | 211 | 1 | 403 | Chain | ID=PRO_0000050094;Note=Poly(rC)-binding protein 4 |
| P57723 | 197 | 211 | 1 | 403 | Chain | ID=PRO_0000050094;Note=Poly(rC)-binding protein 4 |
| P57723 | 197 | 211 | 198 | 198 | Natural variant | ID=VAR_049681;Note=G->S;Dbxref=dbSNP:rs323872 |
| P57723 | 197 | 211 | 198 | 198 | Natural variant | ID=VAR_049681;Note=G->S;Dbxref=dbSNP:rs323872 |
| P57723 | 197 | 211 | 198 | 198 | Natural variant | ID=VAR_049681;Note=G->S;Dbxref=dbSNP:rs323872 |
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3'-UTR located exon skipping events that lost miRNA binding sites in PCBP4 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000461554 | 51961941 | 51962088 | hsa-miR-6073 | chr3:51961963-51961970 | 8mer-1a | chr3:51961952-51961970 | 160.00 | -18.82 |
| Mayo | ENST00000461554 | 51961941 | 51962088 | hsa-miR-4758-3p | chr3:51962013-51962020 | 8mer-1a | chr3:51961999-51962020 | 167.00 | -33.60 |
| Mayo | ENST00000461554 | 51961941 | 51962088 | hsa-miR-5197-3p | chr3:51962066-51962073 | 8mer-1a | chr3:51962047-51962073 | 150.00 | -16.14 |
| Mayo | ENST00000461554 | 51961941 | 51962088 | hsa-miR-20b-3p | chr3:51961965-51961972 | 8mer-1a | chr3:51961964-51961981 | 145.00 | -24.06 |
| MSBB | ENST00000461554 | 51961941 | 51962088 | hsa-miR-6073 | chr3:51961963-51961970 | 8mer-1a | chr3:51961952-51961970 | 160.00 | -18.82 |
| MSBB | ENST00000461554 | 51961941 | 51962088 | hsa-miR-4758-3p | chr3:51962013-51962020 | 8mer-1a | chr3:51961999-51962020 | 167.00 | -33.60 |
| MSBB | ENST00000461554 | 51961941 | 51962088 | hsa-miR-5197-3p | chr3:51962066-51962073 | 8mer-1a | chr3:51962047-51962073 | 150.00 | -16.14 |
| MSBB | ENST00000461554 | 51961941 | 51962088 | hsa-miR-20b-3p | chr3:51961965-51961972 | 8mer-1a | chr3:51961964-51961981 | 145.00 | -24.06 |
| ROSMAP | ENST00000461554 | 51961941 | 51962088 | hsa-miR-6073 | chr3:51961963-51961970 | 8mer-1a | chr3:51961952-51961970 | 160.00 | -18.82 |
| ROSMAP | ENST00000461554 | 51961941 | 51962088 | hsa-miR-4758-3p | chr3:51962013-51962020 | 8mer-1a | chr3:51961999-51962020 | 167.00 | -33.60 |
| ROSMAP | ENST00000461554 | 51961941 | 51962088 | hsa-miR-5197-3p | chr3:51962066-51962073 | 8mer-1a | chr3:51962047-51962073 | 150.00 | -16.14 |
| ROSMAP | ENST00000461554 | 51961941 | 51962088 | hsa-miR-20b-3p | chr3:51961965-51961972 | 8mer-1a | chr3:51961964-51961981 | 145.00 | -24.06 |
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SNVs in the skipped exons for PCBP4 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for PCBP4 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PCBP4 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for PCBP4 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | PCBP4 | exon_skip_212534 | 4.016215e-01 | 2.437766e-07 |
| CB | PCBP1 | exon_skip_248287 | -4.523382e-01 | 7.855298e-09 |
| CB | PCBP4 | exon_skip_248287 | 5.216599e-01 | 1.057001e-11 |
| CB | TARDBP | exon_skip_12465 | -4.105852e-01 | 7.642296e-08 |
| CB | PCBP1 | exon_skip_12465 | -5.713774e-01 | 3.688257e-15 |
| CB | PCBP4 | exon_skip_12465 | 4.535803e-01 | 1.922863e-09 |
| CB | HNRNPAB | exon_skip_12465 | -5.898996e-01 | 2.798626e-16 |
| CB | EIF4G2 | exon_skip_12465 | -4.932635e-01 | 3.955596e-11 |
| CB | HNRNPAB | exon_skip_51333 | -5.903018e-01 | 2.641365e-16 |
| DLPFC | SRSF2 | exon_skip_12465 | 4.324423e-01 | 1.317334e-16 |
| DLPFC | SFPQ | exon_skip_12465 | 4.215720e-01 | 8.840860e-16 |
| DLPFC | RBM5 | exon_skip_12465 | 4.082896e-01 | 8.261037e-15 |
| DLPFC | NUP42 | exon_skip_12465 | 4.113054e-01 | 5.016781e-15 |
| DLPFC | SRSF5 | exon_skip_12465 | 4.651901e-01 | 2.766484e-19 |
| DLPFC | SRSF5 | exon_skip_51333 | 4.347073e-01 | 7.898151e-17 |
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RelatedDrugs for PCBP4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PCBP4 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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