|
Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for DTWD1 |
Gene summary |
Gene information | Gene symbol | DTWD1 | Gene ID | 56986 |
Gene name | DTW domain containing 1 | |
Synonyms | MDS009 | |
Cytomap | 15q21.2 | |
Type of gene | protein-coding | |
Description | DTW domain-containing protein 1x 009 protein | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
Top |
Gene structures and expression levels for DTWD1 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | UP | ENST00000559164.5 | DTWD1-206:protein_coding:DTWD1 | 1.177759e+01 | 8.570573e-01 | 8.014997e-04 | 4.288994e-03 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
Top |
Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for DTWD1 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_112819 | chr15 | 49632171:49632302:49633520:49633612:49634536:49634595 | 49633520:49633612 |
exon_skip_12530 | chr15 | 49625113:49625431:49632171:49632302:49634536:49634595 | 49632171:49632302 |
exon_skip_129555 | chr15 | 49621099:49621122:49623671:49623798:49625113:49625431 | 49623671:49623798 |
exon_skip_152468 | chr15 | 49625113:49625431:49632159:49632302:49634536:49634595 | 49632159:49632302 |
exon_skip_184679 | chr15 | 49625113:49625431:49630956:49631058:49632159:49632177 | 49630956:49631058 |
exon_skip_189483 | chr15 | 49625113:49625431:49631001:49631058:49632159:49632177 | 49631001:49631058 |
exon_skip_253371 | chr15 | 49632171:49632302:49634536:49634794:49643331:49643437 | 49634536:49634794 |
exon_skip_273772 | chr15 | 49621099:49621122:49625113:49625431:49632159:49632177 | 49625113:49625431 |
exon_skip_43815 | chr15 | 49625113:49625431:49632159:49632302:49633520:49633612 | 49632159:49632302 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
Top |
Open reading frame (ORF) annotation in the exon skipping event for DTWD1 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000403028 | 49625113 | 49625431 | 5CDS-5UTR |
ENST00000251250 | 49623671 | 49623798 | 5UTR-5UTR |
ENST00000251250 | 49634536 | 49634794 | Frame-shift |
ENST00000403028 | 49634536 | 49634794 | Frame-shift |
ENST00000558653 | 49634536 | 49634794 | Frame-shift |
ENST00000251250 | 49632159 | 49632302 | In-frame |
ENST00000403028 | 49632159 | 49632302 | In-frame |
ENST00000558653 | 49632159 | 49632302 | In-frame |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000251250 | 49623671 | 49623798 | 5UTR-5UTR |
ENST00000251250 | 49632159 | 49632302 | In-frame |
ENST00000403028 | 49632159 | 49632302 | In-frame |
ENST00000558653 | 49632159 | 49632302 | In-frame |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000403028 | 49625113 | 49625431 | 5CDS-5UTR |
ENST00000251250 | 49623671 | 49623798 | 5UTR-5UTR |
ENST00000251250 | 49634536 | 49634794 | Frame-shift |
ENST00000403028 | 49634536 | 49634794 | Frame-shift |
ENST00000558653 | 49634536 | 49634794 | Frame-shift |
ENST00000251250 | 49632159 | 49632302 | In-frame |
ENST00000403028 | 49632159 | 49632302 | In-frame |
ENST00000558653 | 49632159 | 49632302 | In-frame |
Top |
Infer the effects of exon skipping event on protein functional features for DTWD1 |
p-ENSG00000104047_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000251250 | 13793 | 304 | 49632159 | 49632302 | 473 | 615 | 88 | 136 |
ENST00000403028 | 1601 | 304 | 49632159 | 49632302 | 464 | 606 | 88 | 136 |
ENST00000558653 | 1148 | 304 | 49632159 | 49632302 | 450 | 592 | 88 | 136 |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000251250 | 13793 | 304 | 49632159 | 49632302 | 473 | 615 | 88 | 136 |
ENST00000403028 | 1601 | 304 | 49632159 | 49632302 | 464 | 606 | 88 | 136 |
ENST00000558653 | 1148 | 304 | 49632159 | 49632302 | 450 | 592 | 88 | 136 |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000251250 | 13793 | 304 | 49632159 | 49632302 | 473 | 615 | 88 | 136 |
ENST00000403028 | 1601 | 304 | 49632159 | 49632302 | 464 | 606 | 88 | 136 |
ENST00000558653 | 1148 | 304 | 49632159 | 49632302 | 450 | 592 | 88 | 136 |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q8N5C7 | 88 | 136 | 1 | 88 | Alternative sequence | ID=VSP_028922;Note=In isoform 2. MSLNPPIFLKRSEENSSKFVETKQSQTTSIASEDPLQNLCLASQEVLQKAQQSGRSKCLKCGGSRMFYCYTCYVPVENVPIEQIPLVK->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
Q8N5C7 | 88 | 136 | 1 | 88 | Alternative sequence | ID=VSP_028922;Note=In isoform 2. MSLNPPIFLKRSEENSSKFVETKQSQTTSIASEDPLQNLCLASQEVLQKAQQSGRSKCLKCGGSRMFYCYTCYVPVENVPIEQIPLVK->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
Q8N5C7 | 88 | 136 | 1 | 88 | Alternative sequence | ID=VSP_028922;Note=In isoform 2. MSLNPPIFLKRSEENSSKFVETKQSQTTSIASEDPLQNLCLASQEVLQKAQQSGRSKCLKCGGSRMFYCYTCYVPVENVPIEQIPLVK->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
Q8N5C7 | 88 | 136 | 89 | 304 | Alternative sequence | ID=VSP_028923;Note=In isoform 3. LPLKIDIIKHPNETDGKSTAIHAKLLAPEFVNIYTYPCIPEYEEKDHEVALIFPGPQSISIKDISFHLQKRIQNNVRGKNDDPDKPSFKRKRTEEQEFCDLNDSKCKGTTLKKIIFIDSTWNQTNKIFTDERLQGLLQVELKTRKTCFWRHQKGKPDTFLSTIEAIYYFLVDYHTDILKEKYRGQYDNLLFFYSFMYQLIKNAKCSGDKETGKLTH->FSLY |
Q8N5C7 | 88 | 136 | 89 | 304 | Alternative sequence | ID=VSP_028923;Note=In isoform 3. LPLKIDIIKHPNETDGKSTAIHAKLLAPEFVNIYTYPCIPEYEEKDHEVALIFPGPQSISIKDISFHLQKRIQNNVRGKNDDPDKPSFKRKRTEEQEFCDLNDSKCKGTTLKKIIFIDSTWNQTNKIFTDERLQGLLQVELKTRKTCFWRHQKGKPDTFLSTIEAIYYFLVDYHTDILKEKYRGQYDNLLFFYSFMYQLIKNAKCSGDKETGKLTH->FSLY |
Q8N5C7 | 88 | 136 | 89 | 304 | Alternative sequence | ID=VSP_028923;Note=In isoform 3. LPLKIDIIKHPNETDGKSTAIHAKLLAPEFVNIYTYPCIPEYEEKDHEVALIFPGPQSISIKDISFHLQKRIQNNVRGKNDDPDKPSFKRKRTEEQEFCDLNDSKCKGTTLKKIIFIDSTWNQTNKIFTDERLQGLLQVELKTRKTCFWRHQKGKPDTFLSTIEAIYYFLVDYHTDILKEKYRGQYDNLLFFYSFMYQLIKNAKCSGDKETGKLTH->FSLY |
Q8N5C7 | 88 | 136 | 2 | 304 | Chain | ID=PRO_0000308212;Note=DTW domain-containing protein 1 |
Q8N5C7 | 88 | 136 | 2 | 304 | Chain | ID=PRO_0000308212;Note=DTW domain-containing protein 1 |
Q8N5C7 | 88 | 136 | 2 | 304 | Chain | ID=PRO_0000308212;Note=DTW domain-containing protein 1 |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q8N5C7 | 88 | 136 | 1 | 88 | Alternative sequence | ID=VSP_028922;Note=In isoform 2. MSLNPPIFLKRSEENSSKFVETKQSQTTSIASEDPLQNLCLASQEVLQKAQQSGRSKCLKCGGSRMFYCYTCYVPVENVPIEQIPLVK->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
Q8N5C7 | 88 | 136 | 1 | 88 | Alternative sequence | ID=VSP_028922;Note=In isoform 2. MSLNPPIFLKRSEENSSKFVETKQSQTTSIASEDPLQNLCLASQEVLQKAQQSGRSKCLKCGGSRMFYCYTCYVPVENVPIEQIPLVK->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
Q8N5C7 | 88 | 136 | 1 | 88 | Alternative sequence | ID=VSP_028922;Note=In isoform 2. MSLNPPIFLKRSEENSSKFVETKQSQTTSIASEDPLQNLCLASQEVLQKAQQSGRSKCLKCGGSRMFYCYTCYVPVENVPIEQIPLVK->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
Q8N5C7 | 88 | 136 | 89 | 304 | Alternative sequence | ID=VSP_028923;Note=In isoform 3. LPLKIDIIKHPNETDGKSTAIHAKLLAPEFVNIYTYPCIPEYEEKDHEVALIFPGPQSISIKDISFHLQKRIQNNVRGKNDDPDKPSFKRKRTEEQEFCDLNDSKCKGTTLKKIIFIDSTWNQTNKIFTDERLQGLLQVELKTRKTCFWRHQKGKPDTFLSTIEAIYYFLVDYHTDILKEKYRGQYDNLLFFYSFMYQLIKNAKCSGDKETGKLTH->FSLY |
Q8N5C7 | 88 | 136 | 89 | 304 | Alternative sequence | ID=VSP_028923;Note=In isoform 3. LPLKIDIIKHPNETDGKSTAIHAKLLAPEFVNIYTYPCIPEYEEKDHEVALIFPGPQSISIKDISFHLQKRIQNNVRGKNDDPDKPSFKRKRTEEQEFCDLNDSKCKGTTLKKIIFIDSTWNQTNKIFTDERLQGLLQVELKTRKTCFWRHQKGKPDTFLSTIEAIYYFLVDYHTDILKEKYRGQYDNLLFFYSFMYQLIKNAKCSGDKETGKLTH->FSLY |
Q8N5C7 | 88 | 136 | 89 | 304 | Alternative sequence | ID=VSP_028923;Note=In isoform 3. LPLKIDIIKHPNETDGKSTAIHAKLLAPEFVNIYTYPCIPEYEEKDHEVALIFPGPQSISIKDISFHLQKRIQNNVRGKNDDPDKPSFKRKRTEEQEFCDLNDSKCKGTTLKKIIFIDSTWNQTNKIFTDERLQGLLQVELKTRKTCFWRHQKGKPDTFLSTIEAIYYFLVDYHTDILKEKYRGQYDNLLFFYSFMYQLIKNAKCSGDKETGKLTH->FSLY |
Q8N5C7 | 88 | 136 | 2 | 304 | Chain | ID=PRO_0000308212;Note=DTW domain-containing protein 1 |
Q8N5C7 | 88 | 136 | 2 | 304 | Chain | ID=PRO_0000308212;Note=DTW domain-containing protein 1 |
Q8N5C7 | 88 | 136 | 2 | 304 | Chain | ID=PRO_0000308212;Note=DTW domain-containing protein 1 |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q8N5C7 | 88 | 136 | 1 | 88 | Alternative sequence | ID=VSP_028922;Note=In isoform 2. MSLNPPIFLKRSEENSSKFVETKQSQTTSIASEDPLQNLCLASQEVLQKAQQSGRSKCLKCGGSRMFYCYTCYVPVENVPIEQIPLVK->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
Q8N5C7 | 88 | 136 | 1 | 88 | Alternative sequence | ID=VSP_028922;Note=In isoform 2. MSLNPPIFLKRSEENSSKFVETKQSQTTSIASEDPLQNLCLASQEVLQKAQQSGRSKCLKCGGSRMFYCYTCYVPVENVPIEQIPLVK->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
Q8N5C7 | 88 | 136 | 1 | 88 | Alternative sequence | ID=VSP_028922;Note=In isoform 2. MSLNPPIFLKRSEENSSKFVETKQSQTTSIASEDPLQNLCLASQEVLQKAQQSGRSKCLKCGGSRMFYCYTCYVPVENVPIEQIPLVK->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
Q8N5C7 | 88 | 136 | 89 | 304 | Alternative sequence | ID=VSP_028923;Note=In isoform 3. LPLKIDIIKHPNETDGKSTAIHAKLLAPEFVNIYTYPCIPEYEEKDHEVALIFPGPQSISIKDISFHLQKRIQNNVRGKNDDPDKPSFKRKRTEEQEFCDLNDSKCKGTTLKKIIFIDSTWNQTNKIFTDERLQGLLQVELKTRKTCFWRHQKGKPDTFLSTIEAIYYFLVDYHTDILKEKYRGQYDNLLFFYSFMYQLIKNAKCSGDKETGKLTH->FSLY |
Q8N5C7 | 88 | 136 | 89 | 304 | Alternative sequence | ID=VSP_028923;Note=In isoform 3. LPLKIDIIKHPNETDGKSTAIHAKLLAPEFVNIYTYPCIPEYEEKDHEVALIFPGPQSISIKDISFHLQKRIQNNVRGKNDDPDKPSFKRKRTEEQEFCDLNDSKCKGTTLKKIIFIDSTWNQTNKIFTDERLQGLLQVELKTRKTCFWRHQKGKPDTFLSTIEAIYYFLVDYHTDILKEKYRGQYDNLLFFYSFMYQLIKNAKCSGDKETGKLTH->FSLY |
Q8N5C7 | 88 | 136 | 89 | 304 | Alternative sequence | ID=VSP_028923;Note=In isoform 3. LPLKIDIIKHPNETDGKSTAIHAKLLAPEFVNIYTYPCIPEYEEKDHEVALIFPGPQSISIKDISFHLQKRIQNNVRGKNDDPDKPSFKRKRTEEQEFCDLNDSKCKGTTLKKIIFIDSTWNQTNKIFTDERLQGLLQVELKTRKTCFWRHQKGKPDTFLSTIEAIYYFLVDYHTDILKEKYRGQYDNLLFFYSFMYQLIKNAKCSGDKETGKLTH->FSLY |
Q8N5C7 | 88 | 136 | 2 | 304 | Chain | ID=PRO_0000308212;Note=DTW domain-containing protein 1 |
Q8N5C7 | 88 | 136 | 2 | 304 | Chain | ID=PRO_0000308212;Note=DTW domain-containing protein 1 |
Q8N5C7 | 88 | 136 | 2 | 304 | Chain | ID=PRO_0000308212;Note=DTW domain-containing protein 1 |
Top |
3'-UTR located exon skipping events that lost miRNA binding sites in DTWD1 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Top |
SNVs in the skipped exons for DTWD1 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
AD stage-associated exon skippint events for DTWD1 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DTWD1 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
Top |
Correlation with RNA binding proteins (RBPs) for DTWD1 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | RBM6 | exon_skip_152468 | -4.737408e-01 | 4.787802e-10 |
CB | TRA2A | exon_skip_152468 | -6.177797e-01 | 1.103973e-17 |
CB | KHSRP | exon_skip_152468 | -4.851886e-01 | 1.572814e-10 |
CB | EIF4G2 | exon_skip_152468 | -5.103050e-01 | 1.178123e-11 |
CB | RBM23 | exon_skip_112819 | 4.210118e-01 | 3.278084e-08 |
IFG | EIF4G2 | exon_skip_189483 | -5.255870e-01 | 5.825317e-03 |
IFG | SRSF9 | exon_skip_189483 | -4.755550e-01 | 1.407240e-02 |
TC | RBM3 | exon_skip_29311 | -4.681853e-01 | 8.098378e-10 |
Top |
RelatedDrugs for DTWD1 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for DTWD1 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |