Gene summary |
Gene information | Gene symbol | PYY |
Gene ID | 5697 | Gene name | peptide YY |
Synonyms | PYY-I|PYY1 |
Cytomap | 17q21.31 |
Type of gene | protein-coding |
Description | peptide YYpeptide tyrosine tyrosineprepro-PYY |
Modification date | 20200313 |
UniProtAcc | P10082, |
Context | |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
ENSG00000131096
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
***cutpoints = c(0, 0.0001, 0.001, 0.01, 1), symbols = c("****", "***", "**", "ns")
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
DLPFC | DOWN | 2.060263e+00 | -8.203307e-01 | 1.284891e-06 | 1.064577e-04 |
CB | DOWN | 1.400364e+00 | -9.031865e-01 | 7.131774e-03 | 2.118583e-02 |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
DLPFC | DOWN | ENST00000360085.6 | PYY-201:protein_coding:PYY | 1.574772e+00 | -8.456504e-01 | 1.811474e-05 | 2.149930e-03 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_182000 | chr17 | 43953296:43953483:43953850:43953975:43957938:43958028 | 43953850:43953975 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000360085 | 43953850 | 43953975 | 3UTR-3UTR |
p-ENSG00000131096_img4.png
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Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000360085 | 43953850 | 43953975 | hsa-miR-6880-3p | chr17:43953884-43953891 | 8mer-1a | chr17:43953875-43953895 | 174.00 | -36.75 |
Mayo | ENST00000360085 | 43953850 | 43953975 | hsa-miR-365a-5p | chr17:43953895-43953902 | 8mer-1a | chr17:43953893-43953912 | 163.00 | -25.87 |
Mayo | ENST00000360085 | 43953850 | 43953975 | hsa-miR-365b-5p | chr17:43953895-43953902 | 8mer-1a | chr17:43953893-43953912 | 163.00 | -25.87 |
Mayo | ENST00000360085 | 43953850 | 43953975 | hsa-miR-6803-3p | chr17:43953888-43953895 | 8mer-1a | chr17:43953875-43953895 | 174.00 | -36.75 |
Mayo | ENST00000360085 | 43953850 | 43953975 | hsa-miR-6820-5p | chr17:43953912-43953919 | 8mer-1a | chr17:43953910-43953929 | 154.00 | -24.86 |
Mayo | ENST00000360085 | 43953850 | 43953975 | hsa-miR-4468 | chr17:43953938-43953945 | 8mer-1a | chr17:43953938-43953958 | 162.00 | -21.53 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |