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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for PSMA3 |
 Gene summary |
| Gene information | Gene symbol | PSMA3 | Gene ID | 5684 |
| Gene name | proteasome 20S subunit alpha 3 | |
| Synonyms | HC8|PSC3 | |
| Cytomap | 14q23.1 | |
| Type of gene | protein-coding | |
| Description | proteasome subunit alpha type-3macropain subunit C8multicatalytic endopeptidase complex subunit C8proteasome (prosome, macropain) subunit, alpha type, 3proteasome component C8proteasome subunit C8proteasome subunit alpha 3proteasome subunit alpha7 | |
| Modification date | 20200327 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for PSMA3 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000100567
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PCC | UP | ENST00000556400.5 | PSMA3-AS1-212:lncRNA:PSMA3 | 6.082749e+00 | 1.290427e+00 | 1.488564e-04 | 7.728495e-03 |
| CB | DOWN | ENST00000553657.5 | PSMA3-AS1-202:lncRNA:PSMA3 | 8.904528e+00 | -1.151962e+00 | 1.358515e-07 | 2.758234e-06 |
| CB | UP | ENST00000556002.5 | PSMA3-AS1-210:lncRNA:PSMA3 | 2.068451e+01 | 1.026316e+00 | 2.481342e-07 | 4.579288e-06 |
| CB | DOWN | ENST00000667365.1 | PSMA3-AS1-216:lncRNA:PSMA3 | 2.735574e+02 | -1.639850e+00 | 4.668118e-06 | 5.527522e-05 |
| CB | DOWN | ENST00000557508.5 | PSMA3-213:protein_coding:PSMA3 | 2.911371e+01 | -1.796502e+00 | 2.067081e-03 | 9.472957e-03 |
| CB | DOWN | ENST00000553677.1 | PSMA3-204:protein_coding:PSMA3 | 9.500286e-01 | -2.878135e+00 | 8.479278e-03 | 3.036356e-02 |
| TC | UP | ENST00000556002.5 | PSMA3-AS1-210:lncRNA:PSMA3 | 1.752056e+01 | 1.005950e+00 | 4.859652e-06 | 1.456371e-04 |
| TC | DOWN | ENST00000557508.5 | PSMA3-213:protein_coding:PSMA3 | 3.350470e+01 | -2.375399e+00 | 1.889151e-05 | 4.283945e-04 |
| TC | DOWN | ENST00000553657.5 | PSMA3-AS1-202:lncRNA:PSMA3 | 5.863273e+00 | -8.920946e-01 | 5.546566e-05 | 1.014174e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for PSMA3 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_101320 | chr14 | 58257925:58257998:58260948:58261020:58263705:58263770 | 58260948:58261020 |
| exon_skip_103830 | chr14 | 58247763:58247832:58252124:58252242:58257745:58257846 | 58252124:58252242 |
| exon_skip_11378 | chr14 | 58247789:58247832:58252119:58252242:58257745:58257824 | 58252119:58252242 |
| exon_skip_129491 | chr14 | 58257925:58257998:58260969:58261020:58263705:58263770 | 58260969:58261020 |
| exon_skip_130458 | chr14 | 58244904:58244941:58247750:58247832:58252119:58252242 | 58247750:58247832 |
| exon_skip_144970 | chr14 | 58244904:58244941:58247750:58247832:58252124:58252242 | 58247750:58247832 |
| exon_skip_151545 | chr14 | 58247763:58247832:58252119:58252242:58257745:58257846 | 58252119:58252242 |
| exon_skip_158921 | chr14 | 58247789:58247832:58252119:58252242:58257745:58257846 | 58252119:58252242 |
| exon_skip_178334 | chr14 | 58244904:58244941:58247750:58247832:58252119:58252241 | 58247750:58247832 |
| exon_skip_254911 | chr14 | 58247789:58247832:58252124:58252242:58257745:58257846 | 58252124:58252242 |
| exon_skip_4165 | chr14 | 58257925:58257998:58260959:58261020:58263705:58263770 | 58260959:58261020 |
| exon_skip_53329 | chr14 | 58247789:58247832:58252124:58252242:58257745:58257824 | 58252124:58252242 |
| exon_skip_67967 | chr14 | 58244904:58244941:58252119:58252242:58257745:58257846 | 58252119:58252242 |
| exon_skip_946 | chr14 | 58244904:58244941:58247750:58247832:58257745:58257846 | 58247750:58247832 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for PSMA3 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000216455 | 58252119 | 58252242 | Frame-shift |
| ENST00000216455 | 58260948 | 58261020 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000216455 | 58252119 | 58252242 | Frame-shift |
| ENST00000216455 | 58260948 | 58261020 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000216455 | 58252119 | 58252242 | Frame-shift |
| ENST00000216455 | 58260948 | 58261020 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for PSMA3 |
p-ENSG00000100567_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in PSMA3 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for PSMA3 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for PSMA3 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PSMA3 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for PSMA3 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| TC | RBM24 | exon_skip_144970 | -4.951642e-01 | 7.682279e-11 |
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RelatedDrugs for PSMA3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PSMA3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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