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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for FMN2 |
 Gene summary |
| Gene information | Gene symbol | FMN2 | Gene ID | 56776 |
| Gene name | formin 2 | |
| Synonyms | - | |
| Cytomap | 1q43 | |
| Type of gene | protein-coding | |
| Description | formin-2 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| FMN2 | GO:0006974 | cellular response to DNA damage stimulus | 26287480 |
| FMN2 | GO:0070649 | formin-nucleated actin cable assembly | 26287480 |
| FMN2 | GO:2000781 | positive regulation of double-strand break repair | 26287480 |
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Gene structures and expression levels for FMN2 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000155816
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for FMN2 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_171359 | chr1 | 240355816:240355908:240392511:240392562:240438061:240438210 | 240392511:240392562 |
| exon_skip_181300 | chr1 | 240294822:240294883:240329076:240329167:240329339:240329392 | 240329076:240329167 |
| exon_skip_19188 | chr1 | 240177921:240178068:240180169:240180180:240188207:240188262 | 240180169:240180180 |
| exon_skip_194977 | chr1 | 240177921:240178068:240180169:240180180:240188207:240188216 | 240180169:240180180 |
| exon_skip_203283 | chr1 | 240438061:240438210:240472372:240472453:240474128:240474267 | 240472372:240472453 |
| exon_skip_215451 | chr1 | 240188207:240188262:240206799:240208732:240211091:240211235 | 240206799:240208732 |
| exon_skip_268156 | chr1 | 240211093:240211235:240257945:240258032:240294822:240294883 | 240257945:240258032 |
| exon_skip_38222 | chr1 | 240211091:240211235:240257945:240258032:240294822:240294883 | 240257945:240258032 |
| exon_skip_48005 | chr1 | 240330603:240330749:240333887:240333946:240334109:240334118 | 240333887:240333946 |
| exon_skip_53226 | chr1 | 240188228:240188262:240206799:240208732:240211091:240211235 | 240206799:240208732 |
| exon_skip_67849 | chr1 | 240177921:240178068:240188207:240188262:240206799:240206992 | 240188207:240188262 |
| exon_skip_7952 | chr1 | 240177921:240178068:240188207:240188262:240206799:240207187 | 240188207:240188262 |
| exon_skip_91806 | chr1 | 240257945:240258032:240294822:240294883:240329076:240329167 | 240294822:240294883 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_19188 | MSBB_PG | 4.561194e-01 | 6.067273e-01 | -1.506079e-01 | 6.986436e-04 |
| exon_skip_194977 | Mayo_TC | 2.359756e-01 | 3.523684e-01 | -1.163928e-01 | 1.609565e-04 |
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Open reading frame (ORF) annotation in the exon skipping event for FMN2 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000319653 | 240188207 | 240188262 | Frame-shift |
| ENST00000319653 | 240206799 | 240208732 | Frame-shift |
| ENST00000319653 | 240257945 | 240258032 | Frame-shift |
| ENST00000319653 | 240294822 | 240294883 | Frame-shift |
| ENST00000319653 | 240392511 | 240392562 | Frame-shift |
| ENST00000319653 | 240472372 | 240472453 | Frame-shift |
| ENST00000319653 | 240333887 | 240333946 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000319653 | 240206799 | 240208732 | Frame-shift |
| ENST00000319653 | 240294822 | 240294883 | Frame-shift |
| ENST00000319653 | 240392511 | 240392562 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000319653 | 240188207 | 240188262 | Frame-shift |
| ENST00000319653 | 240206799 | 240208732 | Frame-shift |
| ENST00000319653 | 240257945 | 240258032 | Frame-shift |
| ENST00000319653 | 240294822 | 240294883 | Frame-shift |
| ENST00000319653 | 240329076 | 240329167 | Frame-shift |
| ENST00000319653 | 240392511 | 240392562 | Frame-shift |
| ENST00000319653 | 240333887 | 240333946 | In-frame |
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Infer the effects of exon skipping event on protein functional features for FMN2 |
p-ENSG00000155816_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000319653 | 6451 | 1722 | 240333887 | 240333946 | 4816 | 4874 | 1528 | 1548 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000319653 | 6451 | 1722 | 240333887 | 240333946 | 4816 | 4874 | 1528 | 1548 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9NZ56 | 1528 | 1548 | 1 | 1722 | Chain | ID=PRO_0000194888;Note=Formin-2 |
| Q9NZ56 | 1528 | 1548 | 1283 | 1698 | Domain | Note=FH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00774 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9NZ56 | 1528 | 1548 | 1 | 1722 | Chain | ID=PRO_0000194888;Note=Formin-2 |
| Q9NZ56 | 1528 | 1548 | 1283 | 1698 | Domain | Note=FH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00774 |
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3'-UTR located exon skipping events that lost miRNA binding sites in FMN2 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for FMN2 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for FMN2 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FMN2 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for FMN2 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | G3BP2 | exon_skip_19188 | 5.051134e-01 | 1.122406e-11 |
| CB | SRSF9 | exon_skip_19188 | 5.082567e-01 | 7.970219e-12 |
| DLPFC | G3BP2 | exon_skip_19188 | 5.752870e-01 | 9.605642e-28 |
| FL | G3BP2 | exon_skip_19188 | 6.290426e-01 | 9.084791e-23 |
| FL | SRSF9 | exon_skip_19188 | 4.791338e-01 | 1.579362e-12 |
| HCC | RBM5 | exon_skip_19188 | -5.604081e-01 | 8.230720e-24 |
| IFG | G3BP2 | exon_skip_19188 | 4.039498e-01 | 3.301916e-02 |
| PCC | G3BP2 | exon_skip_19188 | 6.776888e-01 | 1.379052e-29 |
| PG | G3BP2 | exon_skip_19188 | 6.550964e-01 | 1.516496e-24 |
| STG | G3BP2 | exon_skip_19188 | 5.401571e-01 | 4.675824e-08 |
| TC | G3BP2 | exon_skip_194977 | 6.609620e-01 | 3.376482e-21 |
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RelatedDrugs for FMN2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FMN2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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