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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for MAP2K2 |
 Gene summary |
| Gene information | Gene symbol | MAP2K2 | Gene ID | 5605 |
| Gene name | mitogen-activated protein kinase kinase 2 | |
| Synonyms | CFC4|MAPKK2|MEK2|MKK2|PRKMK2 | |
| Cytomap | 19p13.3 | |
| Type of gene | protein-coding | |
| Description | dual specificity mitogen-activated protein kinase kinase 2ERK activator kinase 2MAP kinase kinase 2MAPK/ERK kinase 2mitogen-activated protein kinase kinase 2, p45 | |
| Modification date | 20200327 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| MAP2K2 | GO:0036289 | peptidyl-serine autophosphorylation | 8388392 |
| MAP2K2 | GO:0071902 | positive regulation of protein serine/threonine kinase activity | 8388392 |
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Gene structures and expression levels for MAP2K2 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000126934
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000597263.5 | MAP2K2-206:lncRNA:MAP2K2 | 9.284771e+01 | -8.800046e-01 | 3.080496e-05 | 2.727192e-04 |
| CB | DOWN | ENST00000599021.1 | MAP2K2-207:protein_coding:MAP2K2 | 1.569191e+01 | -1.351697e+00 | 7.147652e-04 | 3.896411e-03 |
| TC | DOWN | ENST00000597263.5 | MAP2K2-206:lncRNA:MAP2K2 | 9.436139e+01 | -9.423888e-01 | 8.333085e-06 | 2.238589e-04 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MAP2K2 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_100561 | chr19 | 4102388:4102453:4103412:4103484:4110509:4110655 | 4103412:4103484 |
| exon_skip_140945 | chr19 | 4097279:4097343:4099201:4099414:4101019:4101047 | 4099201:4099414 |
| exon_skip_164278 | chr19 | 4110612:4110655:4117419:4117629:4123784:4123815 | 4117419:4117629 |
| exon_skip_17428 | chr19 | 4097288:4097343:4099201:4099414:4101019:4101047 | 4099201:4099414 |
| exon_skip_176246 | chr19 | 4090597:4090708:4094453:4095449:4097279:4097343 | 4094453:4095449 |
| exon_skip_178143 | chr19 | 4110509:4110655:4117419:4117629:4123784:4123815 | 4117419:4117629 |
| exon_skip_207886 | chr19 | 4095388:4095449:4097279:4097343:4101019:4101047 | 4097279:4097343 |
| exon_skip_211130 | chr19 | 4095388:4095449:4097279:4097343:4099201:4099414 | 4097279:4097343 |
| exon_skip_211533 | chr19 | 4090597:4090708:4094453:4094498:4095388:4095449 | 4094453:4094498 |
| exon_skip_235760 | chr19 | 4095396:4095449:4097279:4097343:4101019:4101047 | 4097279:4097343 |
| exon_skip_273766 | chr19 | 4094453:4094498:4095388:4095449:4097279:4097343 | 4095388:4095449 |
| exon_skip_280955 | chr19 | 4102376:4102453:4103412:4103484:4110509:4110655 | 4103412:4103484 |
| exon_skip_283436 | chr19 | 4102376:4102453:4103412:4103484:4110509:4110573 | 4103412:4103484 |
| exon_skip_289168 | chr19 | 4097279:4097343:4099201:4099414:4101019:4101041 | 4099201:4099414 |
| exon_skip_71232 | chr19 | 4102376:4102453:4110509:4110655:4117419:4117629 | 4110509:4110655 |
| exon_skip_99449 | chr19 | 4095410:4095449:4097279:4097343:4101019:4101047 | 4097279:4097343 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for MAP2K2 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000262948 | 4094453 | 4094498 | Frame-shift |
| ENST00000262948 | 4095388 | 4095449 | Frame-shift |
| ENST00000262948 | 4099201 | 4099414 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000262948 | 4097279 | 4097343 | Frame-shift |
| ENST00000262948 | 4099201 | 4099414 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000262948 | 4094453 | 4094498 | Frame-shift |
| ENST00000262948 | 4097279 | 4097343 | Frame-shift |
| ENST00000262948 | 4099201 | 4099414 | Frame-shift |
| ENST00000262948 | 4110509 | 4110655 | In-frame |
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Infer the effects of exon skipping event on protein functional features for MAP2K2 |
p-ENSG00000126934_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000262948 | 1751 | 400 | 4110509 | 4110655 | 558 | 703 | 101 | 149 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P36507 | 101 | 149 | 97 | 103 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S9I |
| P36507 | 101 | 149 | 133 | 148 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S9I |
| P36507 | 101 | 149 | 101 | 101 | Binding site | Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P36507 | 101 | 149 | 1 | 400 | Chain | ID=PRO_0000086372;Note=Dual specificity mitogen-activated protein kinase kinase 2 |
| P36507 | 101 | 149 | 72 | 369 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P36507 | 101 | 149 | 110 | 119 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S9I |
| P36507 | 101 | 149 | 120 | 122 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S9I |
| P36507 | 101 | 149 | 128 | 128 | Natural variant | ID=VAR_069782;Note=In CFC4%3B results in increased kinase activity. P->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20358587;Dbxref=dbSNP:rs267607230,PMID:20358587 |
| P36507 | 101 | 149 | 134 | 134 | Natural variant | ID=VAR_069783;Note=In CFC4. Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18042262;Dbxref=dbSNP:rs121434499,PMID:18042262 |
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3'-UTR located exon skipping events that lost miRNA binding sites in MAP2K2 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for MAP2K2 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for MAP2K2 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAP2K2 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for MAP2K2 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | RBM6 | exon_skip_140945 | -4.996644e-01 | 2.015196e-11 |
| CB | SAMD4A | exon_skip_140945 | -5.050541e-01 | 1.129639e-11 |
| CB | CNOT4 | exon_skip_140945 | -4.908675e-01 | 5.073395e-11 |
| CB | PCBP1 | exon_skip_140945 | -4.352210e-01 | 9.866897e-09 |
| CB | PCBP4 | exon_skip_140945 | 5.652209e-01 | 8.389165e-15 |
| CB | TRA2A | exon_skip_140945 | -5.749285e-01 | 2.278018e-15 |
| CB | RBM45 | exon_skip_140945 | 7.156134e-01 | 3.018921e-26 |
| CB | RBM4B | exon_skip_140945 | -5.935464e-01 | 1.651778e-16 |
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RelatedDrugs for MAP2K2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P36507 | approved | DB06616 | Bosutinib | small molecule | P36507 |
| P36507 | approved | DB08911 | Trametinib | small molecule | P36507 |
| P36507 | approved|investigational | DB11967 | Binimetinib | small molecule | P36507 |
| P36507 | approved|investigational | DB12010 | Fostamatinib | small molecule | P36507 |
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RelatedDiseases for MAP2K2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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