ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for MAP2K1

Gene summary

Gene information	Gene symbol	MAP2K1
	Gene ID	5604
	Gene name	mitogen-activated protein kinase kinase 1
	Synonyms	CFC3\|MAPKK1\|MEK1\|MKK1\|PRKMK1
	Cytomap	15q22.31
	Type of gene	protein-coding
	Description	dual specificity mitogen-activated protein kinase kinase 1ERK activator kinase 1MAPK/ERK kinase 1MAPKK 1MEK 1protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
	Modification date	20200327
	UniProtAcc	A4QPA9, B4DFY5, H3BRW9, Q02750,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
MAP2K1	GO:0000187	activation of MAPK activity	10644344
MAP2K1	GO:0006468	protein phosphorylation	28166211
MAP2K1	GO:0008285	negative regulation of cell proliferation	9765203
MAP2K1	GO:0071902	positive regulation of protein serine/threonine kinase activity	8388392

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Gene structures and expression levels for MAP2K1

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000169032

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
CB	UP	ENST00000425818.2	MAP2K1-202:retained_intron:MAP2K1	2.532813e+01	1.413867e+00	6.636706e-07	1.058299e-05
TC	DOWN	ENST00000425818.2	MAP2K1-202:retained_intron:MAP2K1	6.013531e+00	-8.258072e-01	3.178775e-03	2.383406e-02

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MAP2K1

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_162941	chr15	66435027:66435237:66436746:66436892:66443280:66443357	66436746:66436892
exon_skip_184525	chr15	66484994:66485191:66487228:66487292:66489215:66489276	66487228:66487292
exon_skip_206153	chr15	66484990:66485191:66487228:66487292:66489215:66489276	66487228:66487292
exon_skip_206613	chr15	66487228:66487292:66489215:66489276:66489718:66489763	66489215:66489276
exon_skip_220589	chr15	66453454:66453543:66481755:66481879:66484990:66485191	66481755:66481879
exon_skip_231303	chr15	66386837:66387427:66435027:66435237:66436746:66436892	66435027:66435237
exon_skip_27214	chr15	66436746:66436892:66443280:66443357:66444656:66444707	66443280:66443357
exon_skip_28377	chr15	66489215:66489276:66489718:66489763:66490502:66491343	66489718:66489763
exon_skip_293377	chr15	66481755:66481879:66484990:66485191:66487228:66487292	66484990:66485191
exon_skip_69	chr15	66444656:66444707:66481755:66481879:66484990:66485191	66481755:66481879

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information

Tissue type

Avg(PSIs) in AD

Avg(PSIs) in control

Difference (PSI)

Adj. p-value

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Open reading frame (ORF) annotation in the exon skipping event for MAP2K1

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000307102	66484990	66485191	Frame-shift
ENST00000307102	66487228	66487292	Frame-shift
ENST00000307102	66489718	66489763	Frame-shift
ENST00000307102	66436746	66436892	In-frame
ENST00000307102	66443280	66443357	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000307102	66436746	66436892	In-frame
ENST00000307102	66443280	66443357	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000307102	66481755	66481879	Frame-shift
ENST00000307102	66484990	66485191	Frame-shift
ENST00000307102	66487228	66487292	Frame-shift
ENST00000307102	66489215	66489276	Frame-shift
ENST00000307102	66489718	66489763	Frame-shift
ENST00000307102	66436746	66436892	In-frame
ENST00000307102	66443280	66443357	In-frame

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Infer the effects of exon skipping event on protein functional features for MAP2K1

p-ENSG00000169032_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000307102	3427	393	66436746	66436892	824	969	97	146
ENST00000307102	3427	393	66443280	66443357	971	1047	146	172

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000307102	3427	393	66436746	66436892	824	969	97	146
ENST00000307102	3427	393	66443280	66443357	971	1047	146	172

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000307102	3427	393	66436746	66436892	824	969	97	146
ENST00000307102	3427	393	66443280	66443357	971	1047	146	172

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q02750	97	146	93	100	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3EQC
Q02750	97	146	129	135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3EQC
Q02750	97	146	138	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3EQC
Q02750	97	146	97	97	Binding site	Note=ATP;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159,ECO:0000269\|PubMed:15543157,ECO:0000269\|PubMed:17880056,ECO:0000269\|PubMed:18951019,ECO:0000269\|PubMed
Q02750	97	146	97	97	Binding site	Note=Inhibitor;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:15543157,ECO:0000269\|PubMed:17880056,ECO:0000269\|PubMed:18951019,ECO:0000269\|PubMed:19019675,ECO:00002
Q02750	97	146	1	393	Chain	ID=PRO_0000086365;Note=Dual specificity mitogen-activated protein kinase kinase 1
Q02750	97	146	68	361	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q02750	97	146	105	115	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3EQC
Q02750	97	146	116	120	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3EQC
Q02750	97	146	97	97	Mutagenesis	Note=Inactivation. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:8131746;Dbxref=PMID:8131746
Q02750	97	146	128	128	Natural variant	ID=VAR_069780;Note=In CFC3. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18042262;Dbxref=dbSNP:rs730880508,PMID:18042262
Q02750	97	146	130	130	Natural variant	ID=VAR_035094;Note=In CFC3. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16439621;Dbxref=dbSNP:rs121908595,PMID:16439621
Q02750	97	146	143	146	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159,ECO:0000269\|PubMed:15543157,ECO:0000269\|PubMed:17880056,ECO:0000269\|PubMed:18951019,ECO:0000269\|PubMed
Q02750	97	146	144	146	Region	Note=Inhibitor binding
Q02750	146	172	147	172	Alternative sequence	ID=VSP_040500;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:1281467;Dbxref=PMID:1281467
Q02750	146	172	1	393	Chain	ID=PRO_0000086365;Note=Dual specificity mitogen-activated protein kinase kinase 1
Q02750	146	172	68	361	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q02750	146	172	151	158	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3EQC
Q02750	146	172	163	184	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3EQC
Q02750	146	172	150	150	Mutagenesis	Note=No loss of activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:8131746;Dbxref=PMID:8131746
Q02750	146	172	143	146	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159,ECO:0000269\|PubMed:15543157,ECO:0000269\|PubMed:17880056,ECO:0000269\|PubMed:18951019,ECO:0000269\|PubMed
Q02750	146	172	150	153	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159,ECO:0000269\|PubMed:15543157,ECO:0000269\|PubMed:17880056,ECO:0000269\|PubMed:18951019,ECO:0000269\|PubMed
Q02750	146	172	144	146	Region	Note=Inhibitor binding

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q02750	97	146	93	100	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3EQC
Q02750	97	146	129	135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3EQC
Q02750	97	146	138	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3EQC
Q02750	97	146	97	97	Binding site	Note=ATP;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159,ECO:0000269\|PubMed:15543157,ECO:0000269\|PubMed:17880056,ECO:0000269\|PubMed:18951019,ECO:0000269\|PubMed
Q02750	97	146	97	97	Binding site	Note=Inhibitor;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:15543157,ECO:0000269\|PubMed:17880056,ECO:0000269\|PubMed:18951019,ECO:0000269\|PubMed:19019675,ECO:00002
Q02750	97	146	1	393	Chain	ID=PRO_0000086365;Note=Dual specificity mitogen-activated protein kinase kinase 1
Q02750	97	146	68	361	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q02750	97	146	105	115	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3EQC
Q02750	97	146	116	120	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3EQC
Q02750	97	146	97	97	Mutagenesis	Note=Inactivation. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:8131746;Dbxref=PMID:8131746
Q02750	97	146	128	128	Natural variant	ID=VAR_069780;Note=In CFC3. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18042262;Dbxref=dbSNP:rs730880508,PMID:18042262
Q02750	97	146	130	130	Natural variant	ID=VAR_035094;Note=In CFC3. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16439621;Dbxref=dbSNP:rs121908595,PMID:16439621
Q02750	97	146	143	146	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159,ECO:0000269\|PubMed:15543157,ECO:0000269\|PubMed:17880056,ECO:0000269\|PubMed:18951019,ECO:0000269\|PubMed
Q02750	97	146	144	146	Region	Note=Inhibitor binding
Q02750	146	172	147	172	Alternative sequence	ID=VSP_040500;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:1281467;Dbxref=PMID:1281467
Q02750	146	172	1	393	Chain	ID=PRO_0000086365;Note=Dual specificity mitogen-activated protein kinase kinase 1
Q02750	146	172	68	361	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q02750	146	172	151	158	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3EQC
Q02750	146	172	163	184	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3EQC
Q02750	146	172	150	150	Mutagenesis	Note=No loss of activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:8131746;Dbxref=PMID:8131746
Q02750	146	172	143	146	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159,ECO:0000269\|PubMed:15543157,ECO:0000269\|PubMed:17880056,ECO:0000269\|PubMed:18951019,ECO:0000269\|PubMed
Q02750	146	172	150	153	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159,ECO:0000269\|PubMed:15543157,ECO:0000269\|PubMed:17880056,ECO:0000269\|PubMed:18951019,ECO:0000269\|PubMed
Q02750	146	172	144	146	Region	Note=Inhibitor binding

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q02750	97	146	93	100	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3EQC
Q02750	97	146	129	135	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3EQC
Q02750	97	146	138	143	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3EQC
Q02750	97	146	97	97	Binding site	Note=ATP;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159,ECO:0000269\|PubMed:15543157,ECO:0000269\|PubMed:17880056,ECO:0000269\|PubMed:18951019,ECO:0000269\|PubMed
Q02750	97	146	97	97	Binding site	Note=Inhibitor;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:15543157,ECO:0000269\|PubMed:17880056,ECO:0000269\|PubMed:18951019,ECO:0000269\|PubMed:19019675,ECO:00002
Q02750	97	146	1	393	Chain	ID=PRO_0000086365;Note=Dual specificity mitogen-activated protein kinase kinase 1
Q02750	97	146	68	361	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q02750	97	146	105	115	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3EQC
Q02750	97	146	116	120	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3EQC
Q02750	97	146	97	97	Mutagenesis	Note=Inactivation. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:8131746;Dbxref=PMID:8131746
Q02750	97	146	128	128	Natural variant	ID=VAR_069780;Note=In CFC3. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18042262;Dbxref=dbSNP:rs730880508,PMID:18042262
Q02750	97	146	130	130	Natural variant	ID=VAR_035094;Note=In CFC3. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16439621;Dbxref=dbSNP:rs121908595,PMID:16439621
Q02750	97	146	143	146	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159,ECO:0000269\|PubMed:15543157,ECO:0000269\|PubMed:17880056,ECO:0000269\|PubMed:18951019,ECO:0000269\|PubMed
Q02750	97	146	144	146	Region	Note=Inhibitor binding
Q02750	146	172	147	172	Alternative sequence	ID=VSP_040500;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:1281467;Dbxref=PMID:1281467
Q02750	146	172	1	393	Chain	ID=PRO_0000086365;Note=Dual specificity mitogen-activated protein kinase kinase 1
Q02750	146	172	68	361	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q02750	146	172	151	158	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3EQC
Q02750	146	172	163	184	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3EQC
Q02750	146	172	150	150	Mutagenesis	Note=No loss of activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:8131746;Dbxref=PMID:8131746
Q02750	146	172	143	146	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159,ECO:0000269\|PubMed:15543157,ECO:0000269\|PubMed:17880056,ECO:0000269\|PubMed:18951019,ECO:0000269\|PubMed
Q02750	146	172	150	153	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159,ECO:0000269\|PubMed:15543157,ECO:0000269\|PubMed:17880056,ECO:0000269\|PubMed:18951019,ECO:0000269\|PubMed
Q02750	146	172	144	146	Region	Note=Inhibitor binding

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3'-UTR located exon skipping events that lost miRNA binding sites in MAP2K1

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type

ENST

Exon skip start

Exon skip end

microRNA

Binding site by TargetScan

Binding type by TargetScan

Bdinding site by miRanda

Score of miRanda

Energy by miRanda

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SNVs in the skipped exons for MAP2K1

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for MAP2K1

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAP2K1

sQTL information located at the skipped exons.

Tissue type

Exon skip ID

SNP id

Location

P-value

FDR

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Correlation with RNA binding proteins (RBPs) for MAP2K1

Correlated RBP and related information.

Tissue type	RBP name	Exon skip ID	Correlation coeifficient	P-value
CB	TRA2A	exon_skip_27214	-4.495836e-01	2.767994e-09

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RelatedDrugs for MAP2K1

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Q02750	approved\|investigational	DB05239	Cobimetinib	small molecule	Q02750
Q02750	approved	DB06616	Bosutinib	small molecule	Q02750
Q02750	approved	DB08911	Trametinib	small molecule	Q02750

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RelatedDiseases for MAP2K1

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

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Gene summary for MAP2K1

Gene structures and expression levels for MAP2K1

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MAP2K1

Open reading frame (ORF) annotation in the exon skipping event for MAP2K1

Infer the effects of exon skipping event on protein functional features for MAP2K1

3'-UTR located exon skipping events that lost miRNA binding sites in MAP2K1

SNVs in the skipped exons for MAP2K1

AD stage-associated exon skippint events for MAP2K1

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAP2K1

Correlation with RNA binding proteins (RBPs) for MAP2K1

RelatedDrugs for MAP2K1

RelatedDiseases for MAP2K1