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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for MAPK9 |
 Gene summary |
| Gene information | Gene symbol | MAPK9 | Gene ID | 5601 |
| Gene name | mitogen-activated protein kinase 9 | |
| Synonyms | JNK-55|JNK2|JNK2A|JNK2ALPHA|JNK2B|JNK2BETA|PRKM9|SAPK|SAPK1a|p54a|p54aSAPK | |
| Cytomap | 5q35.3 | |
| Type of gene | protein-coding | |
| Description | mitogen-activated protein kinase 9Jun kinaseMAP kinase 9MAPK 9c-Jun N-terminal kinase 2c-Jun kinase 2stress-activated protein kinase 1astress-activated protein kinase JNK2 | |
| Modification date | 20200327 | |
| UniProtAcc | ||
| Context | - 32019384(Identification of dysregulated genes and pathways of different brain regions in Alzheimer's disease) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| MAPK9 | GO:0007254 | JNK cascade | 8654373 |
| MAPK9 | GO:0018105 | peptidyl-serine phosphorylation | 21856198 |
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Gene structures and expression levels for MAPK9 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000050748
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000397072.7 | MAPK9-205:protein_coding:MAPK9 | 1.487673e+02 | 9.938672e-01 | 2.942568e-05 | 2.623428e-04 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MAPK9 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_112316 | chr5 | 180236396:180236531:180238332:180238403:180239924:180239987 | 180238332:180238403 |
| exon_skip_139927 | chr5 | 180233594:180236531:180238332:180238403:180239924:180239987 | 180238332:180238403 |
| exon_skip_179193 | chr5 | 180247439:180247510:180247663:180247728:180248973:180248982 | 180247663:180247728 |
| exon_skip_188423 | chr5 | 180236333:180236526:180238332:180238403:180239924:180239987 | 180238332:180238403 |
| exon_skip_190927 | chr5 | 180236187:180236526:180238332:180238403:180239924:180239987 | 180238332:180238403 |
| exon_skip_204518 | chr5 | 180269295:180269409:180279796:180280036:180280440:180280581 | 180279796:180280036 |
| exon_skip_214898 | chr5 | 180264781:180264839:180269280:180269409:180280440:180280581 | 180269280:180269409 |
| exon_skip_218853 | chr5 | 180247439:180247510:180247663:180247728:180248973:180249138 | 180247663:180247728 |
| exon_skip_228521 | chr5 | 180236477:180236526:180238332:180238403:180239924:180239987 | 180238332:180238403 |
| exon_skip_231425 | chr5 | 180242728:180242755:180247439:180247510:180248973:180249138 | 180247439:180247510 |
| exon_skip_243851 | chr5 | 180269280:180269409:180279796:180280036:180280440:180280581 | 180279796:180280036 |
| exon_skip_275622 | chr5 | 180280440:180280608:180286975:180287067:180291848:180291967 | 180286975:180287067 |
| exon_skip_275791 | chr5 | 180236277:180236526:180238332:180238403:180239924:180239987 | 180238332:180238403 |
| exon_skip_286457 | chr5 | 180238332:180238403:180239924:180239987:180241031:180241151 | 180239924:180239987 |
| exon_skip_295373 | chr5 | 180269280:180269409:180279796:180280036:180280440:180280572 | 180279796:180280036 |
| exon_skip_295464 | chr5 | 180261684:180261822:180264781:180264839:180269280:180269409 | 180264781:180264839 |
| exon_skip_37785 | chr5 | 180269280:180269409:180280440:180280608:180286975:180287067 | 180280440:180280608 |
| exon_skip_42919 | chr5 | 180236277:180236531:180238332:180238403:180239924:180239987 | 180238332:180238403 |
| exon_skip_47900 | chr5 | 180269280:180269409:180280440:180280608:180291848:180291967 | 180280440:180280608 |
| exon_skip_69992 | chr5 | 180242728:180242755:180247855:180247926:180248973:180249138 | 180247855:180247926 |
| exon_skip_86295 | chr5 | 180238332:180238403:180239924:180239987:180241031:180241155 | 180239924:180239987 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for MAPK9 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000452135 | 180239924 | 180239987 | Frame-shift |
| ENST00000452135 | 180264781 | 180264839 | Frame-shift |
| ENST00000452135 | 180269280 | 180269409 | Frame-shift |
| ENST00000452135 | 180238332 | 180238403 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000452135 | 180239924 | 180239987 | Frame-shift |
| ENST00000452135 | 180238332 | 180238403 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000452135 | 180239924 | 180239987 | Frame-shift |
| ENST00000452135 | 180264781 | 180264839 | Frame-shift |
| ENST00000452135 | 180269280 | 180269409 | Frame-shift |
| ENST00000452135 | 180238332 | 180238403 | In-frame |
| ENST00000452135 | 180247439 | 180247510 | In-frame |
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Infer the effects of exon skipping event on protein functional features for MAPK9 |
p-ENSG00000050748_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000452135 | 4832 | 424 | 180238332 | 180238403 | 1360 | 1430 | 353 | 377 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000452135 | 4832 | 424 | 180238332 | 180238403 | 1360 | 1430 | 353 | 377 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000452135 | 4832 | 424 | 180247439 | 180247510 | 916 | 986 | 205 | 229 |
| ENST00000452135 | 4832 | 424 | 180238332 | 180238403 | 1360 | 1430 | 353 | 377 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P45984 | 353 | 377 | 243 | 424 | Alternative sequence | ID=VSP_041909;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:21110917;Dbxref=PMID:21110917 |
| P45984 | 353 | 377 | 1 | 424 | Chain | ID=PRO_0000186273;Note=Mitogen-activated protein kinase 9 |
| P45984 | 353 | 377 | 349 | 360 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E7O |
| P45984 | 353 | 377 | 366 | 366 | Natural variant | ID=VAR_042263;Note=R->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55736180,PMID:17344846 |
| P45984 | 353 | 377 | 377 | 377 | Sequence conflict | Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P45984 | 353 | 377 | 243 | 424 | Alternative sequence | ID=VSP_041909;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:21110917;Dbxref=PMID:21110917 |
| P45984 | 353 | 377 | 1 | 424 | Chain | ID=PRO_0000186273;Note=Mitogen-activated protein kinase 9 |
| P45984 | 353 | 377 | 349 | 360 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E7O |
| P45984 | 353 | 377 | 366 | 366 | Natural variant | ID=VAR_042263;Note=R->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55736180,PMID:17344846 |
| P45984 | 353 | 377 | 377 | 377 | Sequence conflict | Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P45984 | 205 | 229 | 216 | 230 | Alternative sequence | ID=VSP_004834;Note=In isoform Beta-1 and isoform Beta-2. GELVKGCVIFQGTDH->AEMVLHKVLFPGRDY;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P45984 | 205 | 229 | 1 | 424 | Chain | ID=PRO_0000186273;Note=Mitogen-activated protein kinase 9 |
| P45984 | 205 | 229 | 26 | 321 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P45984 | 205 | 229 | 206 | 220 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E7O |
| P45984 | 353 | 377 | 243 | 424 | Alternative sequence | ID=VSP_041909;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:21110917;Dbxref=PMID:21110917 |
| P45984 | 353 | 377 | 1 | 424 | Chain | ID=PRO_0000186273;Note=Mitogen-activated protein kinase 9 |
| P45984 | 353 | 377 | 349 | 360 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3E7O |
| P45984 | 353 | 377 | 366 | 366 | Natural variant | ID=VAR_042263;Note=R->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55736180,PMID:17344846 |
| P45984 | 353 | 377 | 377 | 377 | Sequence conflict | Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
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3'-UTR located exon skipping events that lost miRNA binding sites in MAPK9 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for MAPK9 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for MAPK9 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAPK9 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for MAPK9 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | TRA2A | exon_skip_42919 | -4.757205e-01 | 3.045573e-10 |
| CB | RBM6 | exon_skip_286457 | -4.941111e-01 | 3.620581e-11 |
| CB | FUBP1 | exon_skip_286457 | -5.194396e-01 | 2.291014e-12 |
| CB | NUP42 | exon_skip_286457 | 4.997742e-01 | 1.991780e-11 |
| DLPFC | TARDBP | exon_skip_243851 | -4.840574e-01 | 1.282059e-17 |
| DLPFC | SRSF2 | exon_skip_243851 | -5.542613e-01 | 1.253935e-23 |
| DLPFC | RBM5 | exon_skip_243851 | -4.184372e-01 | 3.996117e-13 |
| DLPFC | RBM3 | exon_skip_243851 | -4.989956e-01 | 8.767805e-19 |
| DLPFC | PCBP1 | exon_skip_243851 | -5.086160e-01 | 1.451588e-19 |
| DLPFC | ILF2 | exon_skip_243851 | -5.572898e-01 | 6.399598e-24 |
| DLPFC | HNRNPK | exon_skip_243851 | -5.312283e-01 | 1.681348e-21 |
| DLPFC | PCBP4 | exon_skip_243851 | -4.848487e-01 | 1.115871e-17 |
| DLPFC | TRA2A | exon_skip_243851 | -4.881649e-01 | 6.211872e-18 |
| DLPFC | PCBP2 | exon_skip_243851 | -5.251644e-01 | 5.743066e-21 |
| DLPFC | SF1 | exon_skip_243851 | -4.798594e-01 | 2.661897e-17 |
| DLPFC | RBM24 | exon_skip_243851 | -5.194829e-01 | 1.775743e-20 |
| DLPFC | ENOX1 | exon_skip_243851 | -4.412205e-01 | 1.411694e-14 |
| DLPFC | CELF1 | exon_skip_243851 | -4.458015e-01 | 6.989417e-15 |
| DLPFC | EWSR1 | exon_skip_243851 | -5.580358e-01 | 5.416711e-24 |
| DLPFC | HNRNPH2 | exon_skip_243851 | -5.365210e-01 | 5.638463e-22 |
| DLPFC | ESRP1 | exon_skip_243851 | -4.920963e-01 | 3.076383e-18 |
| DLPFC | ZCRB1 | exon_skip_243851 | -4.736940e-01 | 7.644385e-17 |
| DLPFC | NOVA1 | exon_skip_243851 | -4.926871e-01 | 2.765937e-18 |
| FL | RBFOX2 | exon_skip_243851 | -4.332812e-01 | 1.819570e-10 |
| FL | G3BP2 | exon_skip_243851 | -4.166474e-01 | 1.024498e-09 |
| FL | HNRNPH2 | exon_skip_243851 | -4.090828e-01 | 2.180352e-09 |
| HCC | RBM3 | exon_skip_243851 | -4.161157e-01 | 8.991626e-13 |
| HCC | G3BP2 | exon_skip_243851 | -6.540007e-01 | 1.851984e-34 |
| HCC | RBM24 | exon_skip_243851 | -4.446363e-01 | 1.464102e-14 |
| HCC | CELF1 | exon_skip_243851 | -4.452165e-01 | 1.340987e-14 |
| HCC | NOVA1 | exon_skip_243851 | -4.099290e-01 | 2.089299e-12 |
| PCC | PCBP1 | exon_skip_243851 | -4.206582e-01 | 1.862831e-10 |
| PCC | ILF2 | exon_skip_243851 | -5.536513e-01 | 2.404240e-18 |
| PCC | HNRNPK | exon_skip_243851 | -4.492912e-01 | 7.049302e-12 |
| PCC | G3BP2 | exon_skip_243851 | -5.032861e-01 | 5.992692e-15 |
| PCC | HNRNPH2 | exon_skip_243851 | -4.446301e-01 | 1.226826e-11 |
| PCC | NOVA1 | exon_skip_243851 | -4.749656e-01 | 2.852412e-13 |
| PG | TARDBP | exon_skip_243851 | -4.399949e-01 | 4.082397e-11 |
| PG | SRSF2 | exon_skip_243851 | -4.600064e-01 | 3.951653e-12 |
| PG | RBFOX2 | exon_skip_243851 | -5.752997e-01 | 1.846393e-19 |
| PG | MBNL1 | exon_skip_243851 | -4.694017e-01 | 1.251449e-12 |
| PG | ILF2 | exon_skip_243851 | -4.877017e-01 | 1.201976e-13 |
| PG | HNRNPK | exon_skip_243851 | -4.760414e-01 | 5.435061e-13 |
| PG | RC3H1 | exon_skip_243851 | -4.219819e-01 | 2.943610e-10 |
| PG | G3BP2 | exon_skip_243851 | -5.851473e-01 | 3.160210e-20 |
| PG | RBM24 | exon_skip_243851 | -5.424599e-01 | 4.422009e-17 |
| PG | ENOX1 | exon_skip_243851 | -4.140177e-01 | 6.797971e-10 |
| PG | CELF1 | exon_skip_243851 | -4.684002e-01 | 1.416994e-12 |
| PG | EWSR1 | exon_skip_243851 | -4.173123e-01 | 4.821251e-10 |
| PG | HNRNPH2 | exon_skip_243851 | -5.554568e-01 | 5.435397e-18 |
| PG | NOVA1 | exon_skip_243851 | -5.202188e-01 | 1.304040e-15 |
| STG | HNRNPH2 | exon_skip_243851 | -4.061701e-01 | 6.478046e-05 |
| STG | NOVA1 | exon_skip_243851 | -4.799104e-01 | 1.482847e-06 |
| TC | SRSF2 | exon_skip_295373 | -4.439311e-01 | 4.106791e-09 |
| TC | RBFOX2 | exon_skip_295373 | -6.707814e-01 | 2.910739e-22 |
| TC | RBM3 | exon_skip_295373 | -4.020161e-01 | 1.369426e-07 |
| TC | ILF2 | exon_skip_295373 | -4.087064e-01 | 8.075268e-08 |
| TC | G3BP2 | exon_skip_295373 | -6.109591e-01 | 9.566883e-18 |
| TC | RBM24 | exon_skip_295373 | -6.001816e-01 | 4.959920e-17 |
| TC | CELF1 | exon_skip_295373 | -4.258513e-01 | 1.976773e-08 |
| TC | HNRNPH2 | exon_skip_295373 | -6.080790e-01 | 1.494234e-17 |
| TC | ESRP1 | exon_skip_295373 | -5.302324e-01 | 5.563743e-13 |
| TC | NOVA1 | exon_skip_295373 | -5.041290e-01 | 1.074974e-11 |
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RelatedDrugs for MAPK9 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P45984 | approved|investigational | DB12010 | Fostamatinib | small molecule | P45984 |
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RelatedDiseases for MAPK9 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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