ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for MAPK1

Gene summary

Gene information	Gene symbol	MAPK1
	Gene ID	5594
	Gene name	mitogen-activated protein kinase 1
	Synonyms	ERK\|ERK-2\|ERK2\|ERT1\|MAPK2\|P42MAPK\|PRKM1\|PRKM2\|p38\|p40\|p41\|p41mapk\|p42-MAPK
	Cytomap	22q11.22
	Type of gene	protein-coding
	Description	mitogen-activated protein kinase 1MAP kinase 1MAP kinase 2MAP kinase isoform p42MAPK 2extracellular signal-regulated kinase 2mitogen-activated protein kinase 2protein tyrosine kinase ERK2
	Modification date	20200327
	UniProtAcc	P28482, Q1HBJ4, Q499G7,
	Context	- 31204500(MicroRNA-101a Regulates Autophagy Phenomenon via the MAPK Pathway to Modulate Alzheimer's-Associated Pathogenesis)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
MAPK1	GO:0006468	protein phosphorylation	23184662
MAPK1	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	16314496
MAPK1	GO:0018105	peptidyl-serine phosphorylation	15850461
MAPK1	GO:0034198	cellular response to amino acid starvation	11096076
MAPK1	GO:0038127	ERBB signaling pathway	15133037
MAPK1	GO:0051403	stress-activated MAPK cascade	11096076
MAPK1	GO:0070371	ERK1 and ERK2 cascade	16314496
MAPK1	GO:0070849	response to epidermal growth factor	18794356

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Gene structures and expression levels for MAPK1

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000100030

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
CB	UP	ENST00000398822.7	MAPK1-202:protein_coding:MAPK1	3.101333e+02	1.009229e+00	1.067615e-05	1.113358e-04
CB	UP	ENST00000491588.1	MAPK1-203:lncRNA:MAPK1	1.119740e+02	8.933713e-01	1.115100e-04	8.113753e-04

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MAPK1

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_163237	chr22	21772873:21772982:21788257:21788388:21788694:21788808	21788257:21788388
exon_skip_218873	chr22	21763984:21764240:21769195:21769320:21772873:21772982	21769195:21769320
exon_skip_226256	chr22	21769204:21769320:21772873:21772982:21788257:21788388	21772873:21772982
exon_skip_229677	chr22	21788694:21788808:21799012:21799128:21805850:21806039	21799012:21799128
exon_skip_231990	chr22	21788694:21788808:21799012:21799128:21805850:21805965	21799012:21799128
exon_skip_255557	chr22	21772873:21772982:21788694:21788808:21799012:21799128	21788694:21788808

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information

Tissue type

Avg(PSIs) in AD

Avg(PSIs) in control

Difference (PSI)

Adj. p-value

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Open reading frame (ORF) annotation in the exon skipping event for MAPK1

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000215832	21772873	21772982	Frame-shift
ENST00000398822	21772873	21772982	Frame-shift
ENST00000215832	21788257	21788388	In-frame
ENST00000398822	21788257	21788388	In-frame
ENST00000215832	21799012	21799128	In-frame
ENST00000398822	21799012	21799128	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000215832	21799012	21799128	In-frame
ENST00000398822	21799012	21799128	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000215832	21769195	21769320	5CDS-5UTR
ENST00000215832	21799012	21799128	In-frame
ENST00000398822	21799012	21799128	In-frame

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Infer the effects of exon skipping event on protein functional features for MAPK1

p-ENSG00000100030_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000215832	11039	360	21799012	21799128	682	797	164	202
ENST00000398822	1504	360	21799012	21799128	733	848	164	202
ENST00000215832	11039	360	21788257	21788388	914	1044	241	285
ENST00000398822	1504	360	21788257	21788388	965	1095	241	285

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000215832	11039	360	21799012	21799128	682	797	164	202
ENST00000398822	1504	360	21799012	21799128	733	848	164	202

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000215832	11039	360	21799012	21799128	682	797	164	202
ENST00000398822	1504	360	21799012	21799128	733	848	164	202

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P28482	164	202	163	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	164	202	163	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	164	202	201	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5K4I
P28482	164	202	201	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5K4I
P28482	164	202	166	166	Binding site	Note=Inhibitor;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:16139248,ECO:0000269\|PubMed:16242327,ECO:0000269\|PubMed:17194451,ECO:0000269\|PubMed:17300186,ECO:0000269\|PubMed:19827834,ECO:0
P28482	164	202	166	166	Binding site	Note=Inhibitor;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:16139248,ECO:0000269\|PubMed:16242327,ECO:0000269\|PubMed:17194451,ECO:0000269\|PubMed:17300186,ECO:0000269\|PubMed:19827834,ECO:0
P28482	164	202	167	167	Binding site	Note=Inhibitor;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:16139248,ECO:0000269\|PubMed:16242327,ECO:0000269\|PubMed:17194451,ECO:0000269\|PubMed:17300186,ECO:0000269\|PubMed:19827834,ECO:0
P28482	164	202	167	167	Binding site	Note=Inhibitor;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:16139248,ECO:0000269\|PubMed:16242327,ECO:0000269\|PubMed:17194451,ECO:0000269\|PubMed:17300186,ECO:0000269\|PubMed:19827834,ECO:0
P28482	164	202	2	360	Chain	ID=PRO_0000186247;Note=Mitogen-activated protein kinase 1
P28482	164	202	2	360	Chain	ID=PRO_0000186247;Note=Mitogen-activated protein kinase 1
P28482	164	202	25	313	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P28482	164	202	25	313	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P28482	164	202	168	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3I5Z
P28482	164	202	168	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3I5Z
P28482	164	202	176	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	164	202	176	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	164	202	191	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	164	202	191	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	164	202	196	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	164	202	196	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	164	202	185	185	Modified residue	Note=Phosphothreonine%3B by MAP2K1 and MAP2K2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:
P28482	164	202	185	185	Modified residue	Note=Phosphothreonine%3B by MAP2K1 and MAP2K2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:
P28482	164	202	187	187	Modified residue	Note=Phosphotyrosine%3B by MAP2K1 and MAP2K2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,ECO
P28482	164	202	187	187	Modified residue	Note=Phosphotyrosine%3B by MAP2K1 and MAP2K2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,ECO
P28482	164	202	190	190	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19060905;Dbxref=PMID:19060905
P28482	164	202	190	190	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19060905;Dbxref=PMID:19060905
P28482	164	202	185	187	Motif	Note=TXY;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18760948;Dbxref=PMID:18760948
P28482	164	202	185	187	Motif	Note=TXY;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18760948;Dbxref=PMID:18760948
P28482	164	202	176	179	Mutagenesis	Note=Inhibits homodimerization and interaction with TPR. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18794356;Dbxref=PMID:18794356
P28482	164	202	176	179	Mutagenesis	Note=Inhibits homodimerization and interaction with TPR. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18794356;Dbxref=PMID:18794356
P28482	164	202	185	185	Mutagenesis	Note=Inhibits interaction with TPR%3B when associated with A-187. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18794356;Dbxref=PMID:18794356
P28482	164	202	185	185	Mutagenesis	Note=Inhibits interaction with TPR%3B when associated with A-187. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18794356;Dbxref=PMID:18794356
P28482	164	202	187	187	Mutagenesis	Note=Inhibits interaction with TPR%3B when associated with A-185. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18794356;Dbxref=PMID:18794356
P28482	164	202	187	187	Mutagenesis	Note=Inhibits interaction with TPR%3B when associated with A-185. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18794356;Dbxref=PMID:18794356
P28482	164	202	181	185	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2Y9Q
P28482	164	202	181	185	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2Y9Q
P28482	241	285	242	285	Alternative sequence	ID=VSP_047815;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.3
P28482	241	285	242	285	Alternative sequence	ID=VSP_047815;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.3
P28482	241	285	280	282	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5NHO
P28482	241	285	280	282	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5NHO
P28482	241	285	2	360	Chain	ID=PRO_0000186247;Note=Mitogen-activated protein kinase 1
P28482	241	285	2	360	Chain	ID=PRO_0000186247;Note=Mitogen-activated protein kinase 1
P28482	241	285	259	277	DNA binding	.
P28482	241	285	259	277	DNA binding	.
P28482	241	285	25	313	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P28482	241	285	25	313	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P28482	241	285	235	244	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	241	285	235	244	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	241	285	249	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	241	285	249	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	241	285	258	265	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	241	285	258	265	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	241	285	275	278	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	241	285	275	278	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	241	285	284	293	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	241	285	284	293	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	241	285	246	246	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18760948;Dbxref=PMID:18760948
P28482	241	285	246	246	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18760948;Dbxref=PMID:18760948
P28482	241	285	248	248	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18760948;Dbxref=PMID:18760948
P28482	241	285	248	248	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18760948;Dbxref=PMID:18760948
P28482	241	285	284	284	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:19369195;Dbxref=PMID:19369195
P28482	241	285	284	284	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:19369195;Dbxref=PMID:19369195

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P28482	164	202	163	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	164	202	163	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	164	202	201	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5K4I
P28482	164	202	201	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5K4I
P28482	164	202	166	166	Binding site	Note=Inhibitor;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:16139248,ECO:0000269\|PubMed:16242327,ECO:0000269\|PubMed:17194451,ECO:0000269\|PubMed:17300186,ECO:0000269\|PubMed:19827834,ECO:0
P28482	164	202	166	166	Binding site	Note=Inhibitor;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:16139248,ECO:0000269\|PubMed:16242327,ECO:0000269\|PubMed:17194451,ECO:0000269\|PubMed:17300186,ECO:0000269\|PubMed:19827834,ECO:0
P28482	164	202	167	167	Binding site	Note=Inhibitor;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:16139248,ECO:0000269\|PubMed:16242327,ECO:0000269\|PubMed:17194451,ECO:0000269\|PubMed:17300186,ECO:0000269\|PubMed:19827834,ECO:0
P28482	164	202	167	167	Binding site	Note=Inhibitor;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:16139248,ECO:0000269\|PubMed:16242327,ECO:0000269\|PubMed:17194451,ECO:0000269\|PubMed:17300186,ECO:0000269\|PubMed:19827834,ECO:0
P28482	164	202	2	360	Chain	ID=PRO_0000186247;Note=Mitogen-activated protein kinase 1
P28482	164	202	2	360	Chain	ID=PRO_0000186247;Note=Mitogen-activated protein kinase 1
P28482	164	202	25	313	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P28482	164	202	25	313	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P28482	164	202	168	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3I5Z
P28482	164	202	168	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3I5Z
P28482	164	202	176	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	164	202	176	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	164	202	191	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	164	202	191	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	164	202	196	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	164	202	196	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	164	202	185	185	Modified residue	Note=Phosphothreonine%3B by MAP2K1 and MAP2K2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:
P28482	164	202	185	185	Modified residue	Note=Phosphothreonine%3B by MAP2K1 and MAP2K2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:
P28482	164	202	187	187	Modified residue	Note=Phosphotyrosine%3B by MAP2K1 and MAP2K2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,ECO
P28482	164	202	187	187	Modified residue	Note=Phosphotyrosine%3B by MAP2K1 and MAP2K2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,ECO
P28482	164	202	190	190	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19060905;Dbxref=PMID:19060905
P28482	164	202	190	190	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19060905;Dbxref=PMID:19060905
P28482	164	202	185	187	Motif	Note=TXY;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18760948;Dbxref=PMID:18760948
P28482	164	202	185	187	Motif	Note=TXY;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18760948;Dbxref=PMID:18760948
P28482	164	202	176	179	Mutagenesis	Note=Inhibits homodimerization and interaction with TPR. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18794356;Dbxref=PMID:18794356
P28482	164	202	176	179	Mutagenesis	Note=Inhibits homodimerization and interaction with TPR. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18794356;Dbxref=PMID:18794356
P28482	164	202	185	185	Mutagenesis	Note=Inhibits interaction with TPR%3B when associated with A-187. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18794356;Dbxref=PMID:18794356
P28482	164	202	185	185	Mutagenesis	Note=Inhibits interaction with TPR%3B when associated with A-187. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18794356;Dbxref=PMID:18794356
P28482	164	202	187	187	Mutagenesis	Note=Inhibits interaction with TPR%3B when associated with A-185. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18794356;Dbxref=PMID:18794356
P28482	164	202	187	187	Mutagenesis	Note=Inhibits interaction with TPR%3B when associated with A-185. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18794356;Dbxref=PMID:18794356
P28482	164	202	181	185	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2Y9Q
P28482	164	202	181	185	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2Y9Q

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P28482	164	202	163	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	164	202	163	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	164	202	201	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5K4I
P28482	164	202	201	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5K4I
P28482	164	202	166	166	Binding site	Note=Inhibitor;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:16139248,ECO:0000269\|PubMed:16242327,ECO:0000269\|PubMed:17194451,ECO:0000269\|PubMed:17300186,ECO:0000269\|PubMed:19827834,ECO:0
P28482	164	202	166	166	Binding site	Note=Inhibitor;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:16139248,ECO:0000269\|PubMed:16242327,ECO:0000269\|PubMed:17194451,ECO:0000269\|PubMed:17300186,ECO:0000269\|PubMed:19827834,ECO:0
P28482	164	202	167	167	Binding site	Note=Inhibitor;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:16139248,ECO:0000269\|PubMed:16242327,ECO:0000269\|PubMed:17194451,ECO:0000269\|PubMed:17300186,ECO:0000269\|PubMed:19827834,ECO:0
P28482	164	202	167	167	Binding site	Note=Inhibitor;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:16139248,ECO:0000269\|PubMed:16242327,ECO:0000269\|PubMed:17194451,ECO:0000269\|PubMed:17300186,ECO:0000269\|PubMed:19827834,ECO:0
P28482	164	202	2	360	Chain	ID=PRO_0000186247;Note=Mitogen-activated protein kinase 1
P28482	164	202	2	360	Chain	ID=PRO_0000186247;Note=Mitogen-activated protein kinase 1
P28482	164	202	25	313	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P28482	164	202	25	313	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P28482	164	202	168	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3I5Z
P28482	164	202	168	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3I5Z
P28482	164	202	176	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	164	202	176	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	164	202	191	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	164	202	191	193	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	164	202	196	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	164	202	196	200	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4ZZN
P28482	164	202	185	185	Modified residue	Note=Phosphothreonine%3B by MAP2K1 and MAP2K2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:
P28482	164	202	185	185	Modified residue	Note=Phosphothreonine%3B by MAP2K1 and MAP2K2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:
P28482	164	202	187	187	Modified residue	Note=Phosphotyrosine%3B by MAP2K1 and MAP2K2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,ECO
P28482	164	202	187	187	Modified residue	Note=Phosphotyrosine%3B by MAP2K1 and MAP2K2;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,ECO
P28482	164	202	190	190	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19060905;Dbxref=PMID:19060905
P28482	164	202	190	190	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19060905;Dbxref=PMID:19060905
P28482	164	202	185	187	Motif	Note=TXY;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18760948;Dbxref=PMID:18760948
P28482	164	202	185	187	Motif	Note=TXY;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18760948;Dbxref=PMID:18760948
P28482	164	202	176	179	Mutagenesis	Note=Inhibits homodimerization and interaction with TPR. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18794356;Dbxref=PMID:18794356
P28482	164	202	176	179	Mutagenesis	Note=Inhibits homodimerization and interaction with TPR. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18794356;Dbxref=PMID:18794356
P28482	164	202	185	185	Mutagenesis	Note=Inhibits interaction with TPR%3B when associated with A-187. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18794356;Dbxref=PMID:18794356
P28482	164	202	185	185	Mutagenesis	Note=Inhibits interaction with TPR%3B when associated with A-187. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18794356;Dbxref=PMID:18794356
P28482	164	202	187	187	Mutagenesis	Note=Inhibits interaction with TPR%3B when associated with A-185. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18794356;Dbxref=PMID:18794356
P28482	164	202	187	187	Mutagenesis	Note=Inhibits interaction with TPR%3B when associated with A-185. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18794356;Dbxref=PMID:18794356
P28482	164	202	181	185	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2Y9Q
P28482	164	202	181	185	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2Y9Q

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3'-UTR located exon skipping events that lost miRNA binding sites in MAPK1

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type

ENST

Exon skip start

Exon skip end

microRNA

Binding site by TargetScan

Binding type by TargetScan

Bdinding site by miRanda

Score of miRanda

Energy by miRanda

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SNVs in the skipped exons for MAPK1

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for MAPK1

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAPK1

sQTL information located at the skipped exons.

Tissue type

Exon skip ID

SNP id

Location

P-value

FDR

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Correlation with RNA binding proteins (RBPs) for MAPK1

Correlated RBP and related information.

Tissue type

RBP name

Exon skip ID

Correlation coeifficient

P-value

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RelatedDrugs for MAPK1

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
P28482	approved\|investigational	DB01064	Isoprenaline	small molecule	P28482
P28482	approved\|investigational	DB01169	Arsenic trioxide	small molecule	P28482

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RelatedDiseases for MAPK1

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

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Gene summary for MAPK1

Gene structures and expression levels for MAPK1

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MAPK1

Open reading frame (ORF) annotation in the exon skipping event for MAPK1

Infer the effects of exon skipping event on protein functional features for MAPK1

3'-UTR located exon skipping events that lost miRNA binding sites in MAPK1

SNVs in the skipped exons for MAPK1

AD stage-associated exon skippint events for MAPK1

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAPK1

Correlation with RNA binding proteins (RBPs) for MAPK1

RelatedDrugs for MAPK1

RelatedDiseases for MAPK1