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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for PAG1 |
Gene summary |
Gene information | Gene symbol | PAG1 | Gene ID | 55824 |
Gene name | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | |
Synonyms | CBP|PAG | |
Cytomap | 8q21.13 | |
Type of gene | protein-coding | |
Description | phosphoprotein associated with glycosphingolipid-enriched microdomains 1Csk-binding proteinphosphoprotein associated with glycosphingolipid microdomains 1transmembrane adapter protein PAGtransmembrane adaptor protein PAGtransmembrane phosphoprotein C | |
Modification date | 20200313 | |
UniProtAcc | Q9NWQ8, | |
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
PAG1 | GO:0035556 | intracellular signal transduction | 10790433 |
PAG1 | GO:0050863 | regulation of T cell activation | 10790433 |
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Gene structures and expression levels for PAG1 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | UP | ENST00000523463.1 | PAG1-204:lncRNA:PAG1 | 4.597568e+01 | 8.163747e-01 | 1.509355e-05 | 1.494740e-04 |
CB | UP | ENST00000522811.1 | PAG1-203:retained_intron:PAG1 | 1.287139e+00 | 9.720684e-01 | 1.324118e-04 | 9.400362e-04 |
TC | UP | ENST00000519409.1 | SPAG1-203:lncRNA:SPAG1 | 2.293632e+00 | 9.738486e-01 | 5.056230e-04 | 5.803210e-03 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for PAG1 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_26297 | chr8 | 80993103:80993307:81029996:81030089:81070112:81070170 | 81029996:81030089 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for PAG1 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000220597 | 81029996 | 81030089 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000220597 | 81029996 | 81030089 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for PAG1 |
p-ENSG00000076641_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in PAG1 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000220597 | 81029996 | 81030089 | hsa-miR-6505-5p | chr8:81030023-81030030 | 8mer-1a | chr8:81030010-81030032 | 149.00 | -21.80 |
Mayo | ENST00000220597 | 81029996 | 81030089 | hsa-miR-6511b-3p | chr8:81030062-81030069 | 8mer-1a | chr8:81030048-81030070 | 156.00 | -20.97 |
Mayo | ENST00000220597 | 81029996 | 81030089 | hsa-miR-6511a-3p | chr8:81030062-81030069 | 8mer-1a | chr8:81030048-81030070 | 156.00 | -20.97 |
Mayo | ENST00000220597 | 81029996 | 81030089 | hsa-miR-3654 | chr8:81030012-81030019 | 8mer-1a | chr8:81030001-81030019 | 156.00 | -17.53 |
ROSMAP | ENST00000220597 | 81029996 | 81030089 | hsa-miR-6505-5p | chr8:81030023-81030030 | 8mer-1a | chr8:81030010-81030032 | 149.00 | -21.80 |
ROSMAP | ENST00000220597 | 81029996 | 81030089 | hsa-miR-6511b-3p | chr8:81030062-81030069 | 8mer-1a | chr8:81030048-81030070 | 156.00 | -20.97 |
ROSMAP | ENST00000220597 | 81029996 | 81030089 | hsa-miR-6511a-3p | chr8:81030062-81030069 | 8mer-1a | chr8:81030048-81030070 | 156.00 | -20.97 |
ROSMAP | ENST00000220597 | 81029996 | 81030089 | hsa-miR-3654 | chr8:81030012-81030019 | 8mer-1a | chr8:81030001-81030019 | 156.00 | -17.53 |
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SNVs in the skipped exons for PAG1 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for PAG1 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PAG1 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for PAG1 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | NUP42 | exon_skip_199791 | 4.169522e-01 | 2.982279e-07 |
CB | PTBP1 | exon_skip_199791 | -4.776987e-01 | 2.399446e-09 |
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RelatedDrugs for PAG1 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PAG1 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |