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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for PRKCA |
 Gene summary |
| Gene information | Gene symbol | PRKCA | Gene ID | 5578 |
| Gene name | protein kinase C alpha | |
| Synonyms | AAG6|PKC-alpha|PKCA|PKCI+/-|PKCalpha|PRKACA | |
| Cytomap | 17q24.2 | |
| Type of gene | protein-coding | |
| Description | protein kinase C alpha typePKC-Aaging-associated gene 6 | |
| Modification date | 20200327 | |
| UniProtAcc | ||
| Context | - 27165780(Gain-of-function mutations in protein kinase Calpha PKCalpha) may promote synaptic defects in Alzheimer's disease) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| PRKCA | GO:0006468 | protein phosphorylation | 10770950 |
| PRKCA | GO:0035408 | histone H3-T6 phosphorylation | 20228790 |
| PRKCA | GO:0043536 | positive regulation of blood vessel endothelial cell migration | 20011604 |
| PRKCA | GO:0090330 | regulation of platelet aggregation | 12724315 |
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Gene structures and expression levels for PRKCA |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000154229
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for PRKCA |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_122322 | chr17 | 66688302:66688436:66688951:66689047:66732688:66732825 | 66688951:66689047 |
| exon_skip_193159 | chr17 | 66732688:66732825:66735489:66735662:66738764:66738855 | 66735489:66735662 |
| exon_skip_19904 | chr17 | 66496201:66496283:66554519:66554579:66641355:66641466 | 66554519:66554579 |
| exon_skip_202972 | chr17 | 66688951:66689047:66732688:66732825:66735489:66735662 | 66732688:66732825 |
| exon_skip_9311 | chr17 | 66742622:66742760:66773987:66774067:66786867:66786974 | 66773987:66774067 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for PRKCA |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000413366 | 66688951 | 66689047 | Frame-shift |
| ENST00000413366 | 66732688 | 66732825 | In-frame |
| ENST00000413366 | 66735489 | 66735662 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000413366 | 66688951 | 66689047 | Frame-shift |
| ENST00000413366 | 66732688 | 66732825 | In-frame |
| ENST00000413366 | 66735489 | 66735662 | In-frame |
| ENST00000413366 | 66773987 | 66774067 | In-frame |
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Infer the effects of exon skipping event on protein functional features for PRKCA |
p-ENSG00000154229_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000413366 | 8768 | 672 | 66732688 | 66732825 | 946 | 1082 | 306 | 352 |
| ENST00000413366 | 8768 | 672 | 66735489 | 66735662 | 1084 | 1256 | 352 | 410 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000413366 | 8768 | 672 | 66732688 | 66732825 | 946 | 1082 | 306 | 352 |
| ENST00000413366 | 8768 | 672 | 66735489 | 66735662 | 1084 | 1256 | 352 | 410 |
| ENST00000413366 | 8768 | 672 | 66773987 | 66774067 | 1552 | 1631 | 508 | 535 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P17252 | 306 | 352 | 339 | 350 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA4 |
| P17252 | 306 | 352 | 352 | 361 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA4 |
| P17252 | 306 | 352 | 2 | 672 | Chain | ID=PRO_0000055679;Note=Protein kinase C alpha type |
| P17252 | 306 | 352 | 339 | 597 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P17252 | 306 | 352 | 336 | 338 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA4 |
| P17252 | 306 | 352 | 319 | 319 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P05696 |
| P17252 | 306 | 352 | 345 | 353 | Nucleotide binding | Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P17252 | 352 | 410 | 352 | 361 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA4 |
| P17252 | 352 | 410 | 364 | 371 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA4 |
| P17252 | 352 | 410 | 403 | 408 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA4 |
| P17252 | 352 | 410 | 410 | 417 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA4 |
| P17252 | 352 | 410 | 368 | 368 | Binding site | Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P17252 | 352 | 410 | 2 | 672 | Chain | ID=PRO_0000055679;Note=Protein kinase C alpha type |
| P17252 | 352 | 410 | 339 | 597 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P17252 | 352 | 410 | 372 | 377 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA4 |
| P17252 | 352 | 410 | 381 | 392 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA4 |
| P17252 | 352 | 410 | 345 | 353 | Nucleotide binding | Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P17252 | 306 | 352 | 339 | 350 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA4 |
| P17252 | 306 | 352 | 352 | 361 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA4 |
| P17252 | 306 | 352 | 2 | 672 | Chain | ID=PRO_0000055679;Note=Protein kinase C alpha type |
| P17252 | 306 | 352 | 339 | 597 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P17252 | 306 | 352 | 336 | 338 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA4 |
| P17252 | 306 | 352 | 319 | 319 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P05696 |
| P17252 | 306 | 352 | 345 | 353 | Nucleotide binding | Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P17252 | 352 | 410 | 352 | 361 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA4 |
| P17252 | 352 | 410 | 364 | 371 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA4 |
| P17252 | 352 | 410 | 403 | 408 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA4 |
| P17252 | 352 | 410 | 410 | 417 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA4 |
| P17252 | 352 | 410 | 368 | 368 | Binding site | Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P17252 | 352 | 410 | 2 | 672 | Chain | ID=PRO_0000055679;Note=Protein kinase C alpha type |
| P17252 | 352 | 410 | 339 | 597 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P17252 | 352 | 410 | 372 | 377 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA4 |
| P17252 | 352 | 410 | 381 | 392 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA4 |
| P17252 | 352 | 410 | 345 | 353 | Nucleotide binding | Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P17252 | 508 | 535 | 2 | 672 | Chain | ID=PRO_0000055679;Note=Protein kinase C alpha type |
| P17252 | 508 | 535 | 339 | 597 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P17252 | 508 | 535 | 507 | 510 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA4 |
| P17252 | 508 | 535 | 518 | 533 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RA4 |
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3'-UTR located exon skipping events that lost miRNA binding sites in PRKCA |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for PRKCA |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for PRKCA |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PRKCA |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for PRKCA |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for PRKCA |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PRKCA |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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