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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for ZNF83 |
Gene summary |
Gene information | Gene symbol | ZNF83 | Gene ID | 55769 |
Gene name | zinc finger protein 83 | |
Synonyms | HPF1|ZNF816B | |
Cytomap | 19q13.41 | |
Type of gene | protein-coding | |
Description | zinc finger protein 83zinc finger protein 816Bzinc finger protein HPF1 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ZNF83 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | DOWN | ENST00000301096.7 | ZNF83-201:protein_coding:ZNF83 | 1.693297e+03 | -1.339515e+00 | 9.120834e-11 | 5.862241e-09 |
TC | DOWN | ENST00000301096.7 | ZNF83-201:protein_coding:ZNF83 | 3.294479e+02 | -1.083376e+00 | 1.146162e-03 | 1.098916e-02 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ZNF83 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_128132 | chr19 | 52614689:52614797:52618936:52619062:52635066:52635153 | 52618936:52619062 |
exon_skip_130780 | chr19 | 52635066:52635153:52655561:52655687:52660762:52660843 | 52655561:52655687 |
exon_skip_133107 | chr19 | 52616718:52616815:52618628:52618765:52618936:52619062 | 52618628:52618765 |
exon_skip_136733 | chr19 | 52616718:52616841:52617246:52617335:52618936:52619062 | 52617246:52617335 |
exon_skip_156430 | chr19 | 52614690:52614797:52618936:52619062:52635066:52635153 | 52618936:52619062 |
exon_skip_207257 | chr19 | 52616718:52616841:52618936:52619062:52635066:52635153 | 52618936:52619062 |
exon_skip_224833 | chr19 | 52614690:52614797:52616718:52616875:52618936:52619062 | 52616718:52616875 |
exon_skip_44432 | chr19 | 52660762:52660843:52674182:52674253:52690443:52690474 | 52674182:52674253 |
exon_skip_63322 | chr19 | 52655561:52655687:52660762:52660843:52690443:52690474 | 52660762:52660843 |
exon_skip_66636 | chr19 | 52660762:52660843:52674182:52674253:52690443:52690486 | 52674182:52674253 |
exon_skip_94572 | chr19 | 52614690:52614797:52616718:52616841:52618936:52619062 | 52616718:52616841 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ZNF83 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000536937 | 52618936 | 52619062 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000536937 | 52618936 | 52619062 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000536937 | 52618936 | 52619062 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for ZNF83 |
p-ENSG00000167766_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in ZNF83 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000536937 | 52618936 | 52619062 | hsa-miR-3116 | chr19:52619001-52619008 | 8mer-1a | chr19:52618998-52619020 | 154.00 | -25.42 |
Mayo | ENST00000536937 | 52618936 | 52619062 | hsa-miR-3664-3p | chr19:52619019-52619026 | 8mer-1a | chr19:52619012-52619032 | 159.00 | -16.23 |
Mayo | ENST00000536937 | 52618936 | 52619062 | hsa-miR-12128 | chr19:52619043-52619050 | 8mer-1a | chr19:52619023-52619050 | 161.00 | -25.26 |
Mayo | ENST00000536937 | 52618936 | 52619062 | hsa-miR-5093 | chr19:52619007-52619014 | 8mer-1a | chr19:52618998-52619020 | 154.00 | -25.42 |
Mayo | ENST00000536937 | 52618936 | 52619062 | hsa-miR-4531 | chr19:52618959-52618966 | 8mer-1a | chr19:52618948-52618967 | 154.00 | -12.99 |
Mayo | ENST00000536937 | 52618936 | 52619062 | hsa-miR-1284 | chr19:52618978-52618985 | 8mer-1a | chr19:52618967-52618994 | 158.00 | -25.10 |
Mayo | ENST00000536937 | 52618936 | 52619062 | hsa-miR-6847-5p | chr19:52618987-52618994 | 8mer-1a | chr19:52618985-52619007 | 170.00 | -26.13 |
MSBB | ENST00000536937 | 52618936 | 52619062 | hsa-miR-3116 | chr19:52619001-52619008 | 8mer-1a | chr19:52618998-52619020 | 154.00 | -25.42 |
MSBB | ENST00000536937 | 52618936 | 52619062 | hsa-miR-3664-3p | chr19:52619019-52619026 | 8mer-1a | chr19:52619012-52619032 | 159.00 | -16.23 |
MSBB | ENST00000536937 | 52618936 | 52619062 | hsa-miR-12128 | chr19:52619043-52619050 | 8mer-1a | chr19:52619023-52619050 | 161.00 | -25.26 |
MSBB | ENST00000536937 | 52618936 | 52619062 | hsa-miR-5093 | chr19:52619007-52619014 | 8mer-1a | chr19:52618998-52619020 | 154.00 | -25.42 |
MSBB | ENST00000536937 | 52618936 | 52619062 | hsa-miR-4531 | chr19:52618959-52618966 | 8mer-1a | chr19:52618948-52618967 | 154.00 | -12.99 |
MSBB | ENST00000536937 | 52618936 | 52619062 | hsa-miR-1284 | chr19:52618978-52618985 | 8mer-1a | chr19:52618967-52618994 | 158.00 | -25.10 |
MSBB | ENST00000536937 | 52618936 | 52619062 | hsa-miR-6847-5p | chr19:52618987-52618994 | 8mer-1a | chr19:52618985-52619007 | 170.00 | -26.13 |
ROSMAP | ENST00000536937 | 52618936 | 52619062 | hsa-miR-3116 | chr19:52619001-52619008 | 8mer-1a | chr19:52618998-52619020 | 154.00 | -25.42 |
ROSMAP | ENST00000536937 | 52618936 | 52619062 | hsa-miR-3664-3p | chr19:52619019-52619026 | 8mer-1a | chr19:52619012-52619032 | 159.00 | -16.23 |
ROSMAP | ENST00000536937 | 52618936 | 52619062 | hsa-miR-12128 | chr19:52619043-52619050 | 8mer-1a | chr19:52619023-52619050 | 161.00 | -25.26 |
ROSMAP | ENST00000536937 | 52618936 | 52619062 | hsa-miR-5093 | chr19:52619007-52619014 | 8mer-1a | chr19:52618998-52619020 | 154.00 | -25.42 |
ROSMAP | ENST00000536937 | 52618936 | 52619062 | hsa-miR-4531 | chr19:52618959-52618966 | 8mer-1a | chr19:52618948-52618967 | 154.00 | -12.99 |
ROSMAP | ENST00000536937 | 52618936 | 52619062 | hsa-miR-1284 | chr19:52618978-52618985 | 8mer-1a | chr19:52618967-52618994 | 158.00 | -25.10 |
ROSMAP | ENST00000536937 | 52618936 | 52619062 | hsa-miR-6847-5p | chr19:52618987-52618994 | 8mer-1a | chr19:52618985-52619007 | 170.00 | -26.13 |
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SNVs in the skipped exons for ZNF83 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ZNF83 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZNF83 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
CB | exon_skip_130780 | rs475188 | chr19:52646714 | 4.962899e-10 | 4.344370e-07 |
CB | exon_skip_130780 | rs12974023 | chr19:52660609 | 2.539229e-09 | 1.908408e-06 |
CB | exon_skip_130780 | rs10401904 | chr19:52617306 | 4.522611e-07 | 1.808873e-04 |
CB | exon_skip_130780 | rs7256113 | chr19:52679298 | 3.246509e-05 | 6.865252e-03 |
CB | exon_skip_130780 | rs6509658 | chr19:52634690 | 3.775278e-04 | 4.848155e-02 |
TC | exon_skip_130780 | rs12974023 | chr19:52660609 | 5.074505e-08 | 2.410317e-05 |
TC | exon_skip_130780 | rs475188 | chr19:52646714 | 2.578218e-07 | 1.004568e-04 |
TC | exon_skip_130780 | rs10401904 | chr19:52617306 | 2.527078e-05 | 5.334782e-03 |
HCC | exon_skip_156430 | rs329953 | chr19:52641567 | 2.529854e-06 | 3.780942e-04 |
HCC | exon_skip_156430 | rs329955 | chr19:52640829 | 9.557754e-06 | 1.201875e-03 |
HCC | exon_skip_156430 | rs8107738 | chr19:52668118 | 1.119870e-05 | 1.386190e-03 |
HCC | exon_skip_156430 | rs6509658 | chr19:52634690 | 2.405219e-05 | 2.700345e-03 |
HCC | exon_skip_156430 | rs329941 | chr19:52653691 | 7.621212e-04 | 4.719477e-02 |
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Correlation with RNA binding proteins (RBPs) for ZNF83 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for ZNF83 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF83 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |