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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for ZFP64 |
Gene summary |
Gene information | Gene symbol | ZFP64 | Gene ID | 55734 |
Gene name | ZFP64 zinc finger protein | |
Synonyms | ZNF338 | |
Cytomap | 20q13.2 | |
Type of gene | protein-coding | |
Description | zinc finger protein 64zinc finger protein 338zinc finger protein 64 homolog | |
Modification date | 20200327 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ZFP64 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ZFP64 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_271790 | chr20 | 52088392:52088643:52097373:52097435:52098438:52098466 | 52097373:52097435 |
exon_skip_60017 | chr20 | 52164695:52164757:52165864:52166025:52186832:52187065 | 52165864:52166025 |
exon_skip_96797 | chr20 | 52164695:52164757:52165864:52166025:52186832:52186863 | 52165864:52166025 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ZFP64 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000361387 | 52097373 | 52097435 | In-frame |
ENST00000216923 | 52165864 | 52166025 | In-frame |
ENST00000361387 | 52165864 | 52166025 | In-frame |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000216923 | 52165864 | 52166025 | In-frame |
ENST00000361387 | 52165864 | 52166025 | In-frame |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000361387 | 52097373 | 52097435 | In-frame |
ENST00000216923 | 52165864 | 52166025 | In-frame |
ENST00000361387 | 52165864 | 52166025 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ZFP64 |
p-ENSG00000020256_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000361387 | 2562 | 645 | 52165864 | 52166025 | 348 | 508 | 95 | 149 |
ENST00000361387 | 2562 | 645 | 52097373 | 52097435 | 975 | 1036 | 304 | 325 |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000361387 | 2562 | 645 | 52165864 | 52166025 | 348 | 508 | 95 | 149 |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000361387 | 2562 | 645 | 52165864 | 52166025 | 348 | 508 | 95 | 149 |
ENST00000361387 | 2562 | 645 | 52097373 | 52097435 | 975 | 1036 | 304 | 325 |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q9NTW7 | 95 | 149 | 1 | 219 | Alternative sequence | ID=VSP_007285;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
Q9NTW7 | 95 | 149 | 1 | 645 | Chain | ID=PRO_0000047308;Note=Zinc finger protein 64 homolog%2C isoforms 3 and 4 |
Q9NTW7 | 304 | 325 | 236 | 390 | Alternative sequence | ID=VSP_046897;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Q9NTW7 | 304 | 325 | 1 | 645 | Chain | ID=PRO_0000047308;Note=Zinc finger protein 64 homolog%2C isoforms 3 and 4 |
Q9NTW7 | 304 | 325 | 299 | 324 | Zinc finger | Note=C2H2-type 4%3B atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042 |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q9NTW7 | 95 | 149 | 1 | 219 | Alternative sequence | ID=VSP_007285;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
Q9NTW7 | 95 | 149 | 1 | 645 | Chain | ID=PRO_0000047308;Note=Zinc finger protein 64 homolog%2C isoforms 3 and 4 |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q9NTW7 | 95 | 149 | 1 | 219 | Alternative sequence | ID=VSP_007285;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
Q9NTW7 | 95 | 149 | 1 | 645 | Chain | ID=PRO_0000047308;Note=Zinc finger protein 64 homolog%2C isoforms 3 and 4 |
Q9NTW7 | 304 | 325 | 236 | 390 | Alternative sequence | ID=VSP_046897;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Q9NTW7 | 304 | 325 | 1 | 645 | Chain | ID=PRO_0000047308;Note=Zinc finger protein 64 homolog%2C isoforms 3 and 4 |
Q9NTW7 | 304 | 325 | 299 | 324 | Zinc finger | Note=C2H2-type 4%3B atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042 |
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3'-UTR located exon skipping events that lost miRNA binding sites in ZFP64 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for ZFP64 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ZFP64 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZFP64 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ZFP64 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for ZFP64 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZFP64 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |