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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for KANSL3 |
 Gene summary |
| Gene information | Gene symbol | KANSL3 | Gene ID | 55683 |
| Gene name | KAT8 regulatory NSL complex subunit 3 | |
| Synonyms | KIAA1310|NSL3|Rcd1 | |
| Cytomap | 2q11.2 | |
| Type of gene | protein-coding | |
| Description | KAT8 regulatory NSL complex subunit 3NSL complex protein NSL3non-specific lethal 3 homologserum inhibited-related proteintestis development protein PRTD | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| KANSL3 | GO:0043981 | histone H4-K5 acetylation | 20018852 |
| KANSL3 | GO:0043982 | histone H4-K8 acetylation | 20018852 |
| KANSL3 | GO:0043984 | histone H4-K16 acetylation | 20018852 |
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Gene structures and expression levels for KANSL3 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000114982
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000447759.5 | KANSL3-208:nonsense_mediated_decay:KANSL3 | 3.980789e+02 | -1.079807e+00 | 5.087023e-09 | 1.705320e-07 |
| CB | DOWN | ENST00000487070.5 | KANSL3-217:lncRNA:KANSL3 | 2.050902e+02 | -1.173950e+00 | 2.219498e-06 | 2.953491e-05 |
| TC | UP | ENST00000475820.1 | KANSL3-213:lncRNA:KANSL3 | 8.403819e-01 | 1.605538e+00 | 1.243806e-04 | 1.925210e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for KANSL3 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_12328 | chr2 | 96605320:96605511:96606970:96607047:96608508:96608664 | 96606970:96607047 |
| exon_skip_12335 | chr2 | 96631312:96631482:96636921:96637185:96638283:96638312 | 96636921:96637185 |
| exon_skip_12401 | chr2 | 96619359:96619544:96619672:96619762:96631312:96631462 | 96619672:96619762 |
| exon_skip_125975 | chr2 | 96602753:96602862:96604250:96604380:96604779:96604857 | 96604250:96604380 |
| exon_skip_152070 | chr2 | 96613488:96613619:96619359:96619544:96631312:96631482 | 96619359:96619544 |
| exon_skip_156906 | chr2 | 96601643:96601776:96602116:96602338:96602753:96602862 | 96602116:96602338 |
| exon_skip_203582 | chr2 | 96615492:96615544:96619359:96619544:96631312:96631482 | 96619359:96619544 |
| exon_skip_211777 | chr2 | 96593176:96595631:96598081:96598160:96601643:96601776 | 96598081:96598160 |
| exon_skip_224160 | chr2 | 96595586:96595631:96598081:96598160:96601643:96601776 | 96598081:96598160 |
| exon_skip_23680 | chr2 | 96602116:96602338:96602753:96602862:96604250:96604380 | 96602753:96602862 |
| exon_skip_249771 | chr2 | 96631312:96631482:96634149:96634178:96636921:96637185 | 96634149:96634178 |
| exon_skip_260164 | chr2 | 96619672:96619762:96631312:96631543:96636921:96636990 | 96631312:96631543 |
| exon_skip_277731 | chr2 | 96595586:96595631:96598081:96598160:96601643:96601768 | 96598081:96598160 |
| exon_skip_27824 | chr2 | 96619672:96619762:96631312:96631482:96636921:96637185 | 96631312:96631482 |
| exon_skip_280703 | chr2 | 96619359:96619544:96619672:96619762:96631312:96631482 | 96619672:96619762 |
| exon_skip_34205 | chr2 | 96619359:96619544:96631312:96631482:96636921:96637185 | 96631312:96631482 |
| exon_skip_38430 | chr2 | 96619672:96619762:96631312:96631482:96636921:96636990 | 96631312:96631482 |
| exon_skip_46099 | chr2 | 96605320:96605511:96606970:96607047:96608508:96608582 | 96606970:96607047 |
| exon_skip_49300 | chr2 | 96601643:96601776:96602753:96602862:96604250:96604380 | 96602753:96602862 |
| exon_skip_52945 | chr2 | 96613526:96613619:96615492:96615544:96619359:96619544 | 96615492:96615544 |
| exon_skip_59305 | chr2 | 96605320:96605511:96606970:96607047:96608508:96608580 | 96606970:96607047 |
| exon_skip_71960 | chr2 | 96619672:96619762:96631312:96631543:96636921:96637185 | 96631312:96631543 |
| exon_skip_78469 | chr2 | 96613526:96613619:96619359:96619544:96631312:96631482 | 96619359:96619544 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_12328 | Mayo_TC | 5.679268e-01 | 7.228571e-01 | -1.549303e-01 | 1.824927e-06 |
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Open reading frame (ORF) annotation in the exon skipping event for KANSL3 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for KANSL3 |
p-ENSG00000114982_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in KANSL3 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for KANSL3 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for KANSL3 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| CDR | MSBB | IFG | exon_skip_280703 | 3.935335e-01 | 3.827604e-02 | chr2 | - | 96619359 | 96619544 | 96619672 | 96619762 | 96631312 | 96631482 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for KANSL3 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for KANSL3 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | RBM6 | exon_skip_49300 | -4.072920e-01 | 2.535569e-07 |
| CB | PCBP1 | exon_skip_49300 | -4.313695e-01 | 3.967577e-08 |
| CB | PCBP4 | exon_skip_49300 | 4.091466e-01 | 2.209225e-07 |
| CB | PCBP1 | exon_skip_23680 | -4.169423e-01 | 7.491345e-08 |
| CB | RBM3 | exon_skip_59305 | 4.088557e-01 | 1.059412e-07 |
| CB | NUP42 | exon_skip_59305 | 5.973160e-01 | 1.487795e-16 |
| CB | RALYL | exon_skip_59305 | 5.628965e-01 | 1.677820e-14 |
| DLPFC | KHDRBS2 | exon_skip_12328 | 5.889254e-01 | 1.082378e-26 |
| HCC | RBM6 | exon_skip_46099 | -4.870988e-01 | 1.299203e-17 |
| HCC | FUBP1 | exon_skip_46099 | -4.235959e-01 | 2.865801e-13 |
| HCC | PTBP1 | exon_skip_46099 | -5.805853e-01 | 6.549630e-26 |
| HCC | SRSF4 | exon_skip_46099 | -4.634955e-01 | 6.829660e-16 |
| IFG | RBM6 | exon_skip_156906 | -4.817051e-01 | 1.095457e-02 |
| IFG | ESRP2 | exon_skip_156906 | -5.354090e-01 | 4.002703e-03 |
| IFG | IGF2BP3 | exon_skip_12328 | -4.718794e-01 | 1.494106e-02 |
| IFG | RBM23 | exon_skip_12328 | -4.121174e-01 | 3.643419e-02 |
| IFG | SAMD4A | exon_skip_280703 | 6.138557e-01 | 5.121191e-04 |
| IFG | RBM5 | exon_skip_280703 | 4.706539e-01 | 1.148181e-02 |
| PCC | RBM6 | exon_skip_12328 | -4.390144e-01 | 2.120356e-11 |
| PCC | RBM3 | exon_skip_12328 | 4.195136e-01 | 1.911040e-10 |
| PCC | PTBP1 | exon_skip_12328 | -6.134836e-01 | 2.612714e-23 |
| PCC | SAMD4A | exon_skip_280703 | 5.185403e-01 | 1.666860e-15 |
| TC | RBM3 | exon_skip_12328 | 5.412840e-01 | 1.751846e-13 |
| TC | KHDRBS2 | exon_skip_12328 | 4.978205e-01 | 2.450839e-11 |
| TC | NUP42 | exon_skip_12328 | 5.359326e-01 | 3.345641e-13 |
| TC | RALYL | exon_skip_12328 | 5.282785e-01 | 8.276813e-13 |
| TC | PTBP1 | exon_skip_12328 | -4.720260e-01 | 3.362948e-10 |
| TC | SRSF5 | exon_skip_12328 | 4.894517e-01 | 5.871841e-11 |
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RelatedDrugs for KANSL3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KANSL3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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