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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for PRKACB |
 Gene summary |
| Gene information | Gene symbol | PRKACB | Gene ID | 5567 |
| Gene name | protein kinase cAMP-activated catalytic subunit beta | |
| Synonyms | PKA C-beta|PKACB | |
| Cytomap | 1p31.1 | |
| Type of gene | protein-coding | |
| Description | cAMP-dependent protein kinase catalytic subunit betacAMP-dependent protein kinase catalytic beta subunit isoform 4abprotein kinase A catalytic subunit betaprotein kinase, cAMP-dependent, beta catalytic subunitprotein kinase, cAMP-dependent, catalytic, | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| PRKACB | GO:0006468 | protein phosphorylation | 12420224|21880142 |
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Gene structures and expression levels for PRKACB |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000142875
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| DLPFC | DOWN | ENST00000614872.4 | PRKACB-219:protein_coding:PRKACB | 9.601953e+02 | -8.980093e-01 | 8.812132e-04 | 3.097062e-02 |
| CB | UP | ENST00000413538.5 | PRKACB-209:protein_coding:PRKACB | 3.111739e+01 | 1.896589e+00 | 5.186005e-14 | 1.374797e-11 |
| CB | UP | ENST00000417530.5 | PRKACB-210:protein_coding:PRKACB | 4.049831e+01 | 1.846858e+00 | 6.472466e-12 | 6.848504e-10 |
| CB | DOWN | ENST00000394839.6 | PRKACB-208:protein_coding:PRKACB | 1.211037e+03 | -1.165842e+00 | 2.703832e-07 | 4.927136e-06 |
| CB | UP | ENST00000432111.5 | PRKACB-211:protein_coding:PRKACB | 2.572310e+01 | 1.322226e+00 | 3.513106e-07 | 6.160923e-06 |
| CB | UP | ENST00000370684.5 | PRKACB-203:protein_coding:PRKACB | 9.336859e+01 | 1.193963e+00 | 9.056436e-07 | 1.377591e-05 |
| CB | DOWN | ENST00000370688.7 | PRKACB-205:protein_coding:PRKACB | 5.360781e+01 | -9.115503e-01 | 2.214313e-05 | 2.062684e-04 |
| CB | UP | ENST00000610703.4 | PRKACB-218:protein_coding:PRKACB | 5.492687e+03 | 8.109354e-01 | 4.695921e-05 | 3.899258e-04 |
| CB | UP | ENST00000450730.5 | PRKACB-214:protein_coding:PRKACB | 2.249437e+02 | 8.860266e-01 | 1.790207e-03 | 8.408500e-03 |
| TC | DOWN | ENST00000394839.6 | PRKACB-208:protein_coding:PRKACB | 9.156165e+02 | -1.112136e+00 | 3.022515e-05 | 6.203597e-04 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for PRKACB |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_133545 | chr1 | 84173329:84173352:84175033:84175056:84179177:84179238 | 84175033:84175056 |
| exon_skip_146847 | chr1 | 84164966:84165013:84175033:84175056:84179177:84179238 | 84175033:84175056 |
| exon_skip_156863 | chr1 | 84175033:84175056:84175799:84175807:84179177:84179238 | 84175799:84175807 |
| exon_skip_21819 | chr1 | 84202683:84202805:84214153:84214317:84235180:84235309 | 84214153:84214317 |
| exon_skip_230289 | chr1 | 84197729:84197824:84202683:84202805:84214153:84214317 | 84202683:84202805 |
| exon_skip_240216 | chr1 | 84164394:84164422:84175033:84175056:84179177:84179238 | 84175033:84175056 |
| exon_skip_24413 | chr1 | 84164966:84165013:84173329:84173352:84175033:84175056 | 84173329:84173352 |
| exon_skip_270419 | chr1 | 84202765:84202805:84214153:84214317:84235180:84235309 | 84214153:84214317 |
| exon_skip_43007 | chr1 | 84164394:84164422:84173329:84173352:84175033:84175056 | 84173329:84173352 |
| exon_skip_9690 | chr1 | 84182200:84182328:84184037:84184135:84185100:84185182 | 84184037:84184135 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_258415 | ROSMAP_PCC | 5.995000e-01 | 7.050000e-01 | -1.055000e-01 | 3.825723e-03 |
| exon_skip_156863 | MSBB_STG | 3.185246e-01 | 4.237500e-01 | -1.052254e-01 | 2.935508e-02 |
| exon_skip_258415 | MSBB_PG | 4.126126e-01 | 6.410000e-01 | -2.283874e-01 | 2.984106e-02 |
| exon_skip_96370 | MSBB_PG | 7.618033e-01 | 8.953846e-01 | -1.335813e-01 | 9.268637e-03 |
| exon_skip_43007 | Mayo_CB | 5.346154e-01 | 6.893220e-01 | -1.547066e-01 | 5.957526e-08 |
| exon_skip_258415 | Mayo_CB | 3.723750e-01 | 5.003125e-01 | -1.279375e-01 | 1.173662e-05 |
| exon_skip_24413 | Mayo_CB | 6.918750e-01 | 8.241667e-01 | -1.322917e-01 | 5.267553e-08 |
| exon_skip_96370 | Mayo_CB | 6.687500e-01 | 8.026667e-01 | -1.339167e-01 | 6.588327e-07 |
| exon_skip_258415 | Mayo_TC | 2.239024e-01 | 3.288889e-01 | -1.049864e-01 | 9.951879e-03 |
| exon_skip_156863 | Mayo_TC | 3.574359e-01 | 4.800000e-01 | -1.225641e-01 | 2.597629e-05 |
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Open reading frame (ORF) annotation in the exon skipping event for PRKACB |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000370689 | 84184037 | 84184135 | In-frame |
| ENST00000370689 | 84202683 | 84202805 | In-frame |
| ENST00000370689 | 84214153 | 84214317 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000370689 | 84184037 | 84184135 | In-frame |
| ENST00000370689 | 84214153 | 84214317 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000370689 | 84184037 | 84184135 | In-frame |
| ENST00000370689 | 84202683 | 84202805 | In-frame |
| ENST00000370689 | 84214153 | 84214317 | In-frame |
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Infer the effects of exon skipping event on protein functional features for PRKACB |
p-ENSG00000142875_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000370689 | 4530 | 351 | 84184037 | 84184135 | 503 | 600 | 79 | 112 |
| ENST00000370689 | 4530 | 351 | 84202683 | 84202805 | 908 | 1029 | 214 | 255 |
| ENST00000370689 | 4530 | 351 | 84214153 | 84214317 | 1031 | 1194 | 255 | 310 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000370689 | 4530 | 351 | 84184037 | 84184135 | 503 | 600 | 79 | 112 |
| ENST00000370689 | 4530 | 351 | 84214153 | 84214317 | 1031 | 1194 | 255 | 310 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000370689 | 4530 | 351 | 84184037 | 84184135 | 503 | 600 | 79 | 112 |
| ENST00000370689 | 4530 | 351 | 84202683 | 84202805 | 908 | 1029 | 214 | 255 |
| ENST00000370689 | 4530 | 351 | 84214153 | 84214317 | 1031 | 1194 | 255 | 310 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P22694 | 79 | 112 | 79 | 111 | Alternative sequence | ID=VSP_046238;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P22694 | 79 | 112 | 2 | 351 | Chain | ID=PRO_0000086060;Note=cAMP-dependent protein kinase catalytic subunit beta |
| P22694 | 79 | 112 | 44 | 298 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P22694 | 79 | 112 | 106 | 106 | Natural variant | ID=VAR_040594;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs36117118,PMID:17344846 |
| P22694 | 79 | 112 | 80 | 80 | Sequence conflict | Note=V->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P22694 | 214 | 255 | 2 | 351 | Chain | ID=PRO_0000086060;Note=cAMP-dependent protein kinase catalytic subunit beta |
| P22694 | 214 | 255 | 44 | 298 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P22694 | 214 | 255 | 233 | 233 | Sequence conflict | Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P22694 | 255 | 310 | 256 | 257 | Alternative sequence | ID=VSP_036556;Note=In isoform 8. VR->NF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| P22694 | 255 | 310 | 258 | 351 | Alternative sequence | ID=VSP_036557;Note=In isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| P22694 | 255 | 310 | 2 | 351 | Chain | ID=PRO_0000086060;Note=cAMP-dependent protein kinase catalytic subunit beta |
| P22694 | 255 | 310 | 44 | 298 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P22694 | 255 | 310 | 299 | 351 | Domain | Note=AGC-kinase C-terminal |
| P22694 | 255 | 310 | 261 | 261 | Sequence conflict | Note=H->N;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P22694 | 79 | 112 | 79 | 111 | Alternative sequence | ID=VSP_046238;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P22694 | 79 | 112 | 2 | 351 | Chain | ID=PRO_0000086060;Note=cAMP-dependent protein kinase catalytic subunit beta |
| P22694 | 79 | 112 | 44 | 298 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P22694 | 79 | 112 | 106 | 106 | Natural variant | ID=VAR_040594;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs36117118,PMID:17344846 |
| P22694 | 79 | 112 | 80 | 80 | Sequence conflict | Note=V->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P22694 | 255 | 310 | 256 | 257 | Alternative sequence | ID=VSP_036556;Note=In isoform 8. VR->NF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| P22694 | 255 | 310 | 258 | 351 | Alternative sequence | ID=VSP_036557;Note=In isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| P22694 | 255 | 310 | 2 | 351 | Chain | ID=PRO_0000086060;Note=cAMP-dependent protein kinase catalytic subunit beta |
| P22694 | 255 | 310 | 44 | 298 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P22694 | 255 | 310 | 299 | 351 | Domain | Note=AGC-kinase C-terminal |
| P22694 | 255 | 310 | 261 | 261 | Sequence conflict | Note=H->N;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P22694 | 79 | 112 | 79 | 111 | Alternative sequence | ID=VSP_046238;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P22694 | 79 | 112 | 2 | 351 | Chain | ID=PRO_0000086060;Note=cAMP-dependent protein kinase catalytic subunit beta |
| P22694 | 79 | 112 | 44 | 298 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P22694 | 79 | 112 | 106 | 106 | Natural variant | ID=VAR_040594;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs36117118,PMID:17344846 |
| P22694 | 79 | 112 | 80 | 80 | Sequence conflict | Note=V->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P22694 | 214 | 255 | 2 | 351 | Chain | ID=PRO_0000086060;Note=cAMP-dependent protein kinase catalytic subunit beta |
| P22694 | 214 | 255 | 44 | 298 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P22694 | 214 | 255 | 233 | 233 | Sequence conflict | Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P22694 | 255 | 310 | 256 | 257 | Alternative sequence | ID=VSP_036556;Note=In isoform 8. VR->NF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| P22694 | 255 | 310 | 258 | 351 | Alternative sequence | ID=VSP_036557;Note=In isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| P22694 | 255 | 310 | 2 | 351 | Chain | ID=PRO_0000086060;Note=cAMP-dependent protein kinase catalytic subunit beta |
| P22694 | 255 | 310 | 44 | 298 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P22694 | 255 | 310 | 299 | 351 | Domain | Note=AGC-kinase C-terminal |
| P22694 | 255 | 310 | 261 | 261 | Sequence conflict | Note=H->N;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
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3'-UTR located exon skipping events that lost miRNA binding sites in PRKACB |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for PRKACB |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for PRKACB |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PRKACB |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| PCC | exon_skip_24413 | rs645868 | chr1:84269644 | 1.074958e-06 | 3.637598e-04 |
| PCC | exon_skip_24413 | rs316686 | chr1:84270027 | 1.261465e-06 | 4.222691e-04 |
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Correlation with RNA binding proteins (RBPs) for PRKACB |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | TARDBP | exon_skip_43007 | -5.268241e-01 | 3.768676e-11 |
| CB | TARDBP | exon_skip_24413 | -4.669879e-01 | 6.021419e-09 |
| HCC | TARDBP | exon_skip_96370 | -4.154657e-01 | 1.313563e-12 |
| HCC | RBM47 | exon_skip_96370 | -4.494355e-01 | 9.935383e-15 |
| HCC | RBM47 | exon_skip_214118 | -4.140002e-01 | 1.602229e-12 |
| IFG | TARDBP | exon_skip_240216 | -4.300784e-01 | 2.514753e-02 |
| IFG | RC3H1 | exon_skip_240216 | -5.095527e-01 | 6.629960e-03 |
| IFG | CELF1 | exon_skip_240216 | -4.135721e-01 | 3.200424e-02 |
| IFG | TARDBP | exon_skip_146847 | -5.217967e-01 | 1.526042e-02 |
| PCC | MSI1 | exon_skip_41331 | -4.107419e-01 | 1.530852e-09 |
| PCC | RBM47 | exon_skip_258415 | -4.434578e-01 | 3.081016e-11 |
| PCC | RBM47 | exon_skip_96370 | -4.402284e-01 | 4.955393e-11 |
| PG | RBM47 | exon_skip_258415 | -5.396557e-01 | 1.504398e-13 |
| PG | RBM47 | exon_skip_96370 | -4.890850e-01 | 7.509504e-12 |
| STG | HNRNPK | exon_skip_258415 | 4.160972e-01 | 9.141849e-05 |
| TC | MBNL1 | exon_skip_258415 | 4.178395e-01 | 6.978305e-08 |
| TC | HNRNPK | exon_skip_258415 | 4.403953e-01 | 1.094023e-08 |
| TC | CELF1 | exon_skip_258415 | 5.282132e-01 | 1.919309e-12 |
| TC | NOVA1 | exon_skip_258415 | 6.664279e-01 | 3.992832e-21 |
| TC | NOVA1 | exon_skip_24413 | 4.344910e-01 | 1.399499e-07 |
| TC | MBNL1 | exon_skip_96370 | 4.490384e-01 | 4.114142e-09 |
| TC | HNRNPK | exon_skip_96370 | 4.077713e-01 | 1.266842e-07 |
| TC | CELF1 | exon_skip_96370 | 5.708122e-01 | 7.257965e-15 |
| TC | NOVA1 | exon_skip_96370 | 6.145188e-01 | 1.432295e-17 |
| TC | MBNL1 | exon_skip_146847 | 4.521799e-01 | 1.274754e-08 |
| TC | CELF1 | exon_skip_146847 | 5.074058e-01 | 8.559564e-11 |
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RelatedDrugs for PRKACB |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P22694 | approved|investigational | DB12010 | Fostamatinib | small molecule | P22694 |
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RelatedDiseases for PRKACB |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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