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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ZNF331 |
 Gene summary |
| Gene information | Gene symbol | ZNF331 | Gene ID | 55422 |
| Gene name | zinc finger protein 331 | |
| Synonyms | RITA|ZNF361|ZNF463 | |
| Cytomap | 19q13.42 | |
| Type of gene | protein-coding | |
| Description | zinc finger protein 331C2H2-like zinc finger protein rearranged in thyroid adenomasKRAB zinc finger proteinzinc finger protein 361zinc finger protein 463 | |
| Modification date | 20200313 | |
| UniProtAcc | A0A024R4J5, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ZNF331 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000130844
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000512387.6 | ZNF331-216:protein_coding:ZNF331 | 4.771020e+01 | 1.104426e+00 | 3.032897e-08 | 7.733611e-07 |
| CB | UP | ENST00000511154.5 | ZNF331-213:protein_coding:ZNF331 | 1.337401e+01 | 1.824918e+00 | 5.976027e-08 | 1.373925e-06 |
| CB | UP | ENST00000513999.5 | ZNF331-219:protein_coding:ZNF331 | 6.993216e+00 | 1.522250e+00 | 2.264811e-06 | 3.003876e-05 |
| CB | UP | ENST00000411977.6 | ZNF331-202:protein_coding:ZNF331 | 9.735347e+01 | 8.274659e-01 | 1.603350e-05 | 1.573396e-04 |
| CB | DOWN | ENST00000649780.1 | ZNF331-227:lncRNA:ZNF331 | 2.038571e+00 | -1.582814e+00 | 1.863500e-03 | 8.694637e-03 |
| CB | UP | ENST00000649326.1 | ZNF331-226:protein_coding:ZNF331 | 1.406957e+01 | 1.054708e+00 | 4.186283e-03 | 1.700261e-02 |
| CB | UP | ENST00000647573.1 | ZNF331-221:lncRNA:ZNF331 | 2.143277e+00 | 8.093254e-01 | 8.907012e-03 | 3.162306e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ZNF331 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_114348 | chr19 | 53539216:53539282:53555845:53555908:53563763:53563792 | 53555845:53555908 |
| exon_skip_133166 | chr19 | 53522617:53522684:53539216:53539282:53555845:53555908 | 53539216:53539282 |
| exon_skip_13546 | chr19 | 53522617:53522684:53539216:53539282:53555845:53555852 | 53539216:53539282 |
| exon_skip_170215 | chr19 | 53555845:53555908:53569304:53569385:53571604:53571730 | 53569304:53569385 |
| exon_skip_176923 | chr19 | 53555850:53555908:53569304:53569385:53571604:53571730 | 53569304:53569385 |
| exon_skip_194984 | chr19 | 53569304:53569385:53571604:53571730:53576697:53576701 | 53571604:53571730 |
| exon_skip_195972 | chr19 | 53554601:53554693:53555845:53555903:53569304:53569385 | 53555845:53555903 |
| exon_skip_201618 | chr19 | 53538430:53538491:53539216:53539282:53555845:53555852 | 53539216:53539282 |
| exon_skip_20798 | chr19 | 53522617:53522684:53523264:53523496:53539216:53539282 | 53523264:53523496 |
| exon_skip_225846 | chr19 | 53539221:53539282:53555845:53555908:53569304:53569385 | 53555845:53555908 |
| exon_skip_226555 | chr19 | 53554601:53554693:53555845:53555908:53569304:53569385 | 53555845:53555908 |
| exon_skip_253952 | chr19 | 53539216:53539282:53555845:53555908:53569304:53569385 | 53555845:53555908 |
| exon_skip_274249 | chr19 | 53555850:53555908:53563763:53563792:53569304:53569385 | 53563763:53563792 |
| exon_skip_285357 | chr19 | 53538145:53538296:53539216:53539282:53555845:53555852 | 53539216:53539282 |
| exon_skip_47012 | chr19 | 53522617:53522684:53533124:53533182:53535141:53535234 | 53533124:53533182 |
| exon_skip_86504 | chr19 | 53555845:53555908:53563763:53563792:53569304:53569385 | 53563763:53563792 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ZNF331 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000253144 | 53569304 | 53569385 | 5CDS-5UTR |
| ENST00000411977 | 53569304 | 53569385 | 5CDS-5UTR |
| ENST00000512387 | 53569304 | 53569385 | 5CDS-5UTR |
| ENST00000513999 | 53569304 | 53569385 | 5CDS-5UTR |
| ENST00000253144 | 53539216 | 53539282 | 5UTR-5UTR |
| ENST00000411977 | 53539216 | 53539282 | 5UTR-5UTR |
| ENST00000253144 | 53555845 | 53555908 | 5UTR-5UTR |
| ENST00000411977 | 53555845 | 53555908 | 5UTR-5UTR |
| ENST00000513999 | 53555845 | 53555908 | 5UTR-5UTR |
| ENST00000511593 | 53563763 | 53563792 | 5UTR-5UTR |
| ENST00000253144 | 53571604 | 53571730 | Frame-shift |
| ENST00000411977 | 53571604 | 53571730 | Frame-shift |
| ENST00000449416 | 53571604 | 53571730 | Frame-shift |
| ENST00000511154 | 53571604 | 53571730 | Frame-shift |
| ENST00000511593 | 53571604 | 53571730 | Frame-shift |
| ENST00000512387 | 53571604 | 53571730 | Frame-shift |
| ENST00000513999 | 53571604 | 53571730 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000253144 | 53555845 | 53555908 | 5UTR-5UTR |
| ENST00000411977 | 53555845 | 53555908 | 5UTR-5UTR |
| ENST00000512387 | 53555845 | 53555908 | 5UTR-5UTR |
| ENST00000513999 | 53555845 | 53555908 | 5UTR-5UTR |
| ENST00000511593 | 53563763 | 53563792 | 5UTR-5UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000253144 | 53569304 | 53569385 | 5CDS-5UTR |
| ENST00000411977 | 53569304 | 53569385 | 5CDS-5UTR |
| ENST00000512387 | 53569304 | 53569385 | 5CDS-5UTR |
| ENST00000513999 | 53569304 | 53569385 | 5CDS-5UTR |
| ENST00000253144 | 53539216 | 53539282 | 5UTR-5UTR |
| ENST00000253144 | 53555845 | 53555908 | 5UTR-5UTR |
| ENST00000411977 | 53555845 | 53555908 | 5UTR-5UTR |
| ENST00000513999 | 53555845 | 53555908 | 5UTR-5UTR |
| ENST00000511593 | 53563763 | 53563792 | 5UTR-5UTR |
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Infer the effects of exon skipping event on protein functional features for ZNF331 |
p-ENSG00000130844_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in ZNF331 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for ZNF331 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ZNF331 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZNF331 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ZNF331 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for ZNF331 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF331 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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