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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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3'-UTR located exon skipping events lost miRNA binding sites

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SNVs in the skipped exons with depth of coverage

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AD stage-associated exon skipping events

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Correlation with RNA binding proteins (RBPs)

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Related drugs with this gene

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Related diseases with this gene

Gene summary for STRBP

check button Gene summary
Gene informationGene symbol

STRBP

Gene ID

55342

Gene namespermatid perinuclear RNA binding protein
SynonymsHEL162|ILF3L|SPNR|p74
Cytomap

9q33.3

Type of geneprotein-coding
Descriptionspermatid perinuclear RNA-binding proteinepididymis luminal protein 162epididymis secretory sperm binding protein
Modification date20200313
UniProtAcc

A0A0S2Z5K8,

E9PKQ0,

H0YC91,

H0YD00,

H0YD70,

Q5JPA5,

Q96SI9,

V9HWK4,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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Gene structures and expression levels for STRBP

check buttonSkipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

ENSG00000165209
check button Differentially expressed gene analysis across multiple brain tissues between AD and control.
Tissue typeDEG directionBase mean exp.log2FC(AD/control)P-valueAdj. p-value

check button Differentially expressed isoform analysis across multiple brain tissues between AD and control.
gencode gene structure
Tissue typeDEG directionENSTTranscript info.Base mean exp.log2FC(AD/control)P-valueAdjc. p-value
CBDOWNENST00000530364.1STRBP-210:lncRNA:STRBP4.216670e+01-1.511498e+003.957860e-089.668448e-07
CBUPENST00000492885.1STRBP-208:retained_intron:STRBP1.117938e+008.319405e-016.971143e-032.585836e-02

check button Landscape of isoform expressions across multiple brain tissues between AD and control.
gencode gene structure

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for STRBP

check button Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).
boxplot

check button All exon skipping events in AD cohorts.
Exon skip IDchrExons involved in exon skippingSkipped exon
exon_skip_109773chr9123160977:123161068:123168189:123168258:123169902:123170046123168189:123168258
exon_skip_146897chr9123184132:123184298:123236830:123236966:123268436:123268564123236830:123236966
exon_skip_159916chr9123169902:123170046:123173677:123173834:123179007:123179227123173677:123173834
exon_skip_184474chr9123159096:123159207:123160367:123160462:123160977:123161068123160367:123160462
exon_skip_19524chr9123125220:123125673:123128214:123128258:123132845:123132967123128214:123128258
exon_skip_204529chr9123115929:123116098:123128214:123128258:123132845:123132967123128214:123128258
exon_skip_210797chr9123179007:123179227:123184132:123184298:123236830:123236966123184132:123184298
exon_skip_213387chr9123184132:123184298:123236830:123236966:123268436:123268586123236830:123236966
exon_skip_214736chr9123158332:123158429:123159096:123159207:123160367:123160462123159096:123159207
exon_skip_264351chr9123136381:123136515:123139529:123139687:123146855:123147054123139529:123139687
exon_skip_287182chr9123184132:123184298:123212585:123212708:123213589:123213908123212585:123212708
exon_skip_87470chr9123169902:123170046:123173677:123173842:123179007:123179227123173677:123173842
exon_skip_95132chr9123179007:123179227:123184132:123184298:123268436:123268564123184132:123184298
exon_skip_98729chr9123160367:123160462:123160977:123161068:123169902:123170046123160977:123161068

check button Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.
Exon skipping informationTissue typeAvg(PSIs) in ADAvg(PSIs) in controlDifference (PSI)Adj. p-value


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Open reading frame (ORF) annotation in the exon skipping event for STRBP

check button Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003484031232368301232369663UTR-3UTR
ENST00000348403123173677123173842Frame-shift
ENST00000447404123173677123173842Frame-shift
ENST00000348403123128214123128258In-frame
ENST00000447404123128214123128258In-frame
ENST00000348403123139529123139687In-frame
ENST00000447404123139529123139687In-frame
ENST00000348403123160367123160462In-frame
ENST00000447404123160367123160462In-frame

check button Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003484031231841321231842983UTR-3CDS
ENST000003484031232368301232369663UTR-3UTR
ENST00000348403123173677123173842Frame-shift
ENST00000447404123173677123173842Frame-shift
ENST00000348403123128214123128258In-frame
ENST00000447404123128214123128258In-frame
ENST00000348403123139529123139687In-frame
ENST00000447404123139529123139687In-frame

check button Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003484031232368301232369663UTR-3UTR
ENST00000348403123159096123159207Frame-shift
ENST00000447404123159096123159207Frame-shift
ENST00000348403123160977123161068Frame-shift
ENST00000447404123160977123161068Frame-shift
ENST00000348403123173677123173842Frame-shift
ENST00000447404123173677123173842Frame-shift
ENST00000348403123128214123128258In-frame
ENST00000447404123128214123128258In-frame
ENST00000348403123139529123139687In-frame
ENST00000447404123139529123139687In-frame
ENST00000348403123160367123160462In-frame
ENST00000447404123160367123160462In-frame

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Infer the effects of exon skipping event on protein functional features for STRBP

p-ENSG00000165209_img4.png
boxplot

check button Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST00000348403335467212316036712316046210581152209240
ENST000004474046178672123160367123160462804898209240
ENST00000348403335467212313952912313968717691926446498
ENST00000447404617867212313952912313968715151672446498
ENST00000348403335467212312821412312825823282371632647
ENST00000447404617867212312821412312825820742117632647

check button Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST00000348403335467212313952912313968717691926446498
ENST00000447404617867212313952912313968715151672446498
ENST00000348403335467212312821412312825823282371632647
ENST00000447404617867212312821412312825820742117632647

check button Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST00000348403335467212316036712316046210581152209240
ENST000004474046178672123160367123160462804898209240
ENST00000348403335467212313952912313968717691926446498
ENST00000447404617867212313952912313968715151672446498
ENST00000348403335467212312821412312825823282371632647
ENST00000447404617867212312821412312825820742117632647

check button Lost protein functional features of individual exon skipping events in ROSMAP.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q96SI92092401672ChainID=PRO_0000274917;Note=Spermatid perinuclear RNA-binding protein
Q96SI92092401672ChainID=PRO_0000274917;Note=Spermatid perinuclear RNA-binding protein
Q96SI92092405363DomainNote=DZF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01040
Q96SI92092405363DomainNote=DZF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01040
Q96SI94464981672ChainID=PRO_0000274917;Note=Spermatid perinuclear RNA-binding protein
Q96SI94464981672ChainID=PRO_0000274917;Note=Spermatid perinuclear RNA-binding protein
Q96SI9446498387453DomainNote=DRBM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00266
Q96SI9446498387453DomainNote=DRBM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00266
Q96SI9446498436451HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DMY
Q96SI9446498436451HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DMY
Q96SI96326471672ChainID=PRO_0000274917;Note=Spermatid perinuclear RNA-binding protein
Q96SI96326471672ChainID=PRO_0000274917;Note=Spermatid perinuclear RNA-binding protein

check button Lost protein functional features of individual exon skipping events in MSBB.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q96SI94464981672ChainID=PRO_0000274917;Note=Spermatid perinuclear RNA-binding protein
Q96SI94464981672ChainID=PRO_0000274917;Note=Spermatid perinuclear RNA-binding protein
Q96SI9446498387453DomainNote=DRBM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00266
Q96SI9446498387453DomainNote=DRBM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00266
Q96SI9446498436451HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DMY
Q96SI9446498436451HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DMY
Q96SI96326471672ChainID=PRO_0000274917;Note=Spermatid perinuclear RNA-binding protein
Q96SI96326471672ChainID=PRO_0000274917;Note=Spermatid perinuclear RNA-binding protein

check button Lost protein functional features of individual exon skipping events in Mayo.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q96SI92092401672ChainID=PRO_0000274917;Note=Spermatid perinuclear RNA-binding protein
Q96SI92092401672ChainID=PRO_0000274917;Note=Spermatid perinuclear RNA-binding protein
Q96SI92092405363DomainNote=DZF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01040
Q96SI92092405363DomainNote=DZF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01040
Q96SI94464981672ChainID=PRO_0000274917;Note=Spermatid perinuclear RNA-binding protein
Q96SI94464981672ChainID=PRO_0000274917;Note=Spermatid perinuclear RNA-binding protein
Q96SI9446498387453DomainNote=DRBM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00266
Q96SI9446498387453DomainNote=DRBM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00266
Q96SI9446498436451HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DMY
Q96SI9446498436451HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DMY
Q96SI96326471672ChainID=PRO_0000274917;Note=Spermatid perinuclear RNA-binding protein
Q96SI96326471672ChainID=PRO_0000274917;Note=Spermatid perinuclear RNA-binding protein


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3'-UTR located exon skipping events that lost miRNA binding sites in STRBP

check button 3'-UTR exon skipping evnets lost miRNA binding.
Tissue typeENSTExon skip startExon skip endmicroRNABinding site by TargetScanBinding type by TargetScanBdinding site by miRandaScore of miRandaEnergy by miRanda
MayoENST00000348403123236830123236966hsa-miR-7151-3pchr9:123236872-1232368798mer-1achr9:123236865-123236886196.00-47.06
MayoENST00000348403123236830123236966hsa-miR-4485-5pchr9:123236904-1232369118mer-1achr9:123236895-123236911157.00-26.74
MayoENST00000348403123236830123236966hsa-miR-631chr9:123236940-1232369478mer-1achr9:123236923-123236947156.00-29.07
MayoENST00000348403123236830123236966hsa-miR-4776-3pchr9:123236950-1232369578mer-1achr9:123236942-123236963150.00-21.86
MayoENST00000348403123236830123236966hsa-miR-6814-5pchr9:123236888-1232368958mer-1achr9:123236888-123236909164.00-34.49
MayoENST00000348403123236830123236966hsa-miR-3661chr9:123236940-1232369478mer-1achr9:123236923-123236947156.00-29.07
MayoENST00000348403123236830123236966hsa-miR-1271-3pchr9:123236855-1232368628mer-1achr9:123236849-123236869143.00-27.57
MayoENST00000348403123236830123236966hsa-miR-550a-3-5pchr9:123236855-1232368628mer-1achr9:123236849-123236869143.00-27.57
MayoENST00000348403123236830123236966hsa-miR-550a-5pchr9:123236855-1232368628mer-1achr9:123236849-123236869143.00-27.57
MayoENST00000348403123236830123236966hsa-miR-4659a-5pchr9:123236949-1232369568mer-1achr9:123236942-123236963150.00-21.86
MayoENST00000348403123236830123236966hsa-miR-4659b-5pchr9:123236949-1232369568mer-1achr9:123236942-123236963150.00-21.86
MSBBENST00000348403123236830123236966hsa-miR-7151-3pchr9:123236872-1232368798mer-1achr9:123236865-123236886196.00-47.06
MSBBENST00000348403123236830123236966hsa-miR-4485-5pchr9:123236904-1232369118mer-1achr9:123236895-123236911157.00-26.74
MSBBENST00000348403123236830123236966hsa-miR-631chr9:123236940-1232369478mer-1achr9:123236923-123236947156.00-29.07
MSBBENST00000348403123236830123236966hsa-miR-4776-3pchr9:123236950-1232369578mer-1achr9:123236942-123236963150.00-21.86
MSBBENST00000348403123236830123236966hsa-miR-6814-5pchr9:123236888-1232368958mer-1achr9:123236888-123236909164.00-34.49
MSBBENST00000348403123236830123236966hsa-miR-3661chr9:123236940-1232369478mer-1achr9:123236923-123236947156.00-29.07
MSBBENST00000348403123236830123236966hsa-miR-1271-3pchr9:123236855-1232368628mer-1achr9:123236849-123236869143.00-27.57
MSBBENST00000348403123236830123236966hsa-miR-550a-3-5pchr9:123236855-1232368628mer-1achr9:123236849-123236869143.00-27.57
MSBBENST00000348403123236830123236966hsa-miR-550a-5pchr9:123236855-1232368628mer-1achr9:123236849-123236869143.00-27.57
MSBBENST00000348403123236830123236966hsa-miR-4659a-5pchr9:123236949-1232369568mer-1achr9:123236942-123236963150.00-21.86
MSBBENST00000348403123236830123236966hsa-miR-4659b-5pchr9:123236949-1232369568mer-1achr9:123236942-123236963150.00-21.86
ROSMAPENST00000348403123236830123236966hsa-miR-7151-3pchr9:123236872-1232368798mer-1achr9:123236865-123236886196.00-47.06
ROSMAPENST00000348403123236830123236966hsa-miR-4485-5pchr9:123236904-1232369118mer-1achr9:123236895-123236911157.00-26.74
ROSMAPENST00000348403123236830123236966hsa-miR-631chr9:123236940-1232369478mer-1achr9:123236923-123236947156.00-29.07
ROSMAPENST00000348403123236830123236966hsa-miR-4776-3pchr9:123236950-1232369578mer-1achr9:123236942-123236963150.00-21.86
ROSMAPENST00000348403123236830123236966hsa-miR-6814-5pchr9:123236888-1232368958mer-1achr9:123236888-123236909164.00-34.49
ROSMAPENST00000348403123236830123236966hsa-miR-3661chr9:123236940-1232369478mer-1achr9:123236923-123236947156.00-29.07
ROSMAPENST00000348403123236830123236966hsa-miR-1271-3pchr9:123236855-1232368628mer-1achr9:123236849-123236869143.00-27.57
ROSMAPENST00000348403123236830123236966hsa-miR-550a-3-5pchr9:123236855-1232368628mer-1achr9:123236849-123236869143.00-27.57
ROSMAPENST00000348403123236830123236966hsa-miR-550a-5pchr9:123236855-1232368628mer-1achr9:123236849-123236869143.00-27.57
ROSMAPENST00000348403123236830123236966hsa-miR-4659a-5pchr9:123236949-1232369568mer-1achr9:123236942-123236963150.00-21.86
ROSMAPENST00000348403123236830123236966hsa-miR-4659b-5pchr9:123236949-1232369568mer-1achr9:123236942-123236963150.00-21.86

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SNVs in the skipped exons for STRBP

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Depth of Coverage in the skipped exon of the mutated samples.

check button - Sashimi plot in the skipped exon of the mutated samples.

check button - Non-synonymous mutations located in the skipped exons.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange

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AD stage-associated exon skippint events for STRBP

check button Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).
AD stage infoCohortTissueSE idCoefficient P-valueChromosomeStrandE1 startE1 endSkipped startSkipped endE2 startE2 end

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for STRBP

check button sQTL information located at the skipped exons.
Tissue typeExon skip IDSNP idLocationP-valueFDR

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Correlation with RNA binding proteins (RBPs) for STRBP

check button Correlated RBP and related information.
Tissue typeRBP nameExon skip IDCorrelation coeifficientP-value
CBTARDBPexon_skip_264351-4.703950e-016.578034e-10
CBRBM6exon_skip_264351-4.494141e-014.468212e-09
CBFUBP1exon_skip_264351-4.618451e-011.458691e-09

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RelatedDrugs for STRBP

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
UniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STRBP

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource