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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for PPP3CC |
 Gene summary |
| Gene information | Gene symbol | PPP3CC | Gene ID | 5533 |
| Gene name | protein phosphatase 3 catalytic subunit gamma | |
| Synonyms | CALNA3|CNA3|PP2Bgamma | |
| Cytomap | 8p21.3 | |
| Type of gene | protein-coding | |
| Description | serine/threonine-protein phosphatase 2B catalytic subunit gamma isoformCAM-PRP catalytic subunitcalcineurin, testis-specific catalytic subunitcalmodulin-dependent calcineurin A subunit gamma isoformprotein phosphatase 2B, catalytic subunit, gamma isof | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| PPP3CC | GO:0006470 | protein dephosphorylation | 19154138 |
| PPP3CC | GO:0033173 | calcineurin-NFAT signaling cascade | 19154138 |
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Gene structures and expression levels for PPP3CC |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000120910
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | UP | ENST00000289963.12 | PPP3CC-202:protein_coding:PPP3CC | 4.967329e+01 | 8.330101e-01 | 1.234581e-03 | 1.701237e-02 |
| CB | UP | ENST00000522034.5 | PPP3CC-207:protein_coding:PPP3CC | 2.310338e+00 | 9.989793e-01 | 2.528105e-03 | 1.119483e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for PPP3CC |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_104897 | chr8 | 22528506:22528577:22531302:22531328:22532225:22532306 | 22531302:22531328 |
| exon_skip_109489 | chr8 | 22528512:22528577:22531302:22531328:22532225:22532306 | 22531302:22531328 |
| exon_skip_149551 | chr8 | 22527392:22527517:22528506:22528577:22532225:22532306 | 22528506:22528577 |
| exon_skip_288581 | chr8 | 22498001:22498112:22511086:22511231:22513293:22513432 | 22511086:22511231 |
| exon_skip_43398 | chr8 | 22522655:22522749:22527392:22527517:22528506:22528577 | 22527392:22527517 |
| exon_skip_94967 | chr8 | 22532921:22533018:22539469:22539498:22540615:22541056 | 22539469:22539498 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_94967 | Mayo_CB | 6.781707e-01 | 7.811688e-01 | -1.029981e-01 | 7.282226e-06 |
| exon_skip_211180 | Mayo_TC | 2.776923e-01 | 3.843243e-01 | -1.066320e-01 | 1.452761e-03 |
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Open reading frame (ORF) annotation in the exon skipping event for PPP3CC |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000240139 | 22511086 | 22511231 | Frame-shift |
| ENST00000240139 | 22528506 | 22528577 | In-frame |
| ENST00000240139 | 22539469 | 22539498 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000240139 | 22511086 | 22511231 | Frame-shift |
| ENST00000240139 | 22528506 | 22528577 | In-frame |
| ENST00000240139 | 22539469 | 22539498 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000240139 | 22511086 | 22511231 | Frame-shift |
| ENST00000240139 | 22527392 | 22527517 | In-frame |
| ENST00000240139 | 22528506 | 22528577 | In-frame |
| ENST00000240139 | 22539469 | 22539498 | In-frame |
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Infer the effects of exon skipping event on protein functional features for PPP3CC |
p-ENSG00000120910_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000240139 | 2206 | 512 | 22528506 | 22528577 | 1398 | 1468 | 357 | 380 |
| ENST00000240139 | 2206 | 512 | 22539469 | 22539498 | 1650 | 1678 | 441 | 450 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000240139 | 2206 | 512 | 22528506 | 22528577 | 1398 | 1468 | 357 | 380 |
| ENST00000240139 | 2206 | 512 | 22539469 | 22539498 | 1650 | 1678 | 441 | 450 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000240139 | 2206 | 512 | 22527392 | 22527517 | 1272 | 1396 | 315 | 356 |
| ENST00000240139 | 2206 | 512 | 22528506 | 22528577 | 1398 | 1468 | 357 | 380 |
| ENST00000240139 | 2206 | 512 | 22539469 | 22539498 | 1650 | 1678 | 441 | 450 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P48454 | 357 | 380 | 380 | 380 | Alternative sequence | ID=VSP_045211;Note=In isoform 3. E->EDHYIPSYQK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P48454 | 357 | 380 | 1 | 512 | Chain | ID=PRO_0000058828;Note=Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform |
| P48454 | 357 | 380 | 344 | 366 | Region | Note=Calcineurin B binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P16298 |
| P48454 | 441 | 450 | 442 | 451 | Alternative sequence | ID=VSP_037946;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1339277,ECO:0000303|Ref.2;Dbxref=PMID:1339277 |
| P48454 | 441 | 450 | 1 | 512 | Chain | ID=PRO_0000058828;Note=Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P48454 | 357 | 380 | 380 | 380 | Alternative sequence | ID=VSP_045211;Note=In isoform 3. E->EDHYIPSYQK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P48454 | 357 | 380 | 1 | 512 | Chain | ID=PRO_0000058828;Note=Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform |
| P48454 | 357 | 380 | 344 | 366 | Region | Note=Calcineurin B binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P16298 |
| P48454 | 441 | 450 | 442 | 451 | Alternative sequence | ID=VSP_037946;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1339277,ECO:0000303|Ref.2;Dbxref=PMID:1339277 |
| P48454 | 441 | 450 | 1 | 512 | Chain | ID=PRO_0000058828;Note=Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P48454 | 315 | 356 | 1 | 512 | Chain | ID=PRO_0000058828;Note=Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform |
| P48454 | 315 | 356 | 52 | 343 | Region | Note=Catalytic;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P48454 | 315 | 356 | 344 | 366 | Region | Note=Calcineurin B binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P16298 |
| P48454 | 357 | 380 | 380 | 380 | Alternative sequence | ID=VSP_045211;Note=In isoform 3. E->EDHYIPSYQK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P48454 | 357 | 380 | 1 | 512 | Chain | ID=PRO_0000058828;Note=Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform |
| P48454 | 357 | 380 | 344 | 366 | Region | Note=Calcineurin B binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P16298 |
| P48454 | 441 | 450 | 442 | 451 | Alternative sequence | ID=VSP_037946;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1339277,ECO:0000303|Ref.2;Dbxref=PMID:1339277 |
| P48454 | 441 | 450 | 1 | 512 | Chain | ID=PRO_0000058828;Note=Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform |
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3'-UTR located exon skipping events that lost miRNA binding sites in PPP3CC |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for PPP3CC |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for PPP3CC |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PPP3CC |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for PPP3CC |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | RBM4B | exon_skip_211180 | -4.599251e-01 | 1.067950e-09 |
| HCC | SFPQ | exon_skip_94967 | -4.535660e-01 | 6.673585e-15 |
| HCC | RBM4B | exon_skip_94967 | -4.904532e-01 | 1.665076e-17 |
| PCC | ILF2 | exon_skip_219221 | -4.188993e-01 | 2.748250e-10 |
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RelatedDrugs for PPP3CC |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PPP3CC |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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