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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for FBXW7 |
 Gene summary |
| Gene information | Gene symbol | FBXW7 | Gene ID | 55294 |
| Gene name | F-box and WD repeat domain containing 7 | |
| Synonyms | AGO|CDC4|FBW6|FBW7|FBX30|FBXO30|FBXW6|SEL-10|SEL10|hAgo|hCdc4 | |
| Cytomap | 4q31.3 | |
| Type of gene | protein-coding | |
| Description | F-box/WD repeat-containing protein 7F-box and WD repeat domain containing 7, E3 ubiquitin protein ligaseF-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)F-box protein FBW7F-box protein FBX30F-box protein SEL-10archipelagohomolog of | |
| Modification date | 20200327 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| FBXW7 | GO:0016567 | protein ubiquitination | 12354302|15103331 |
| FBXW7 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 15103331|17434132 |
| FBXW7 | GO:0031398 | positive regulation of protein ubiquitination | 12628165 |
| FBXW7 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity | 20208556 |
| FBXW7 | GO:0050821 | protein stabilization | 20208556 |
| FBXW7 | GO:0051443 | positive regulation of ubiquitin-protein transferase activity | 12628165 |
| FBXW7 | GO:1901800 | positive regulation of proteasomal protein catabolic process | 23858059 |
| FBXW7 | GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway | 23858059 |
| FBXW7 | GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process | 20208556 |
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Gene structures and expression levels for FBXW7 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000109670
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| DLPFC | UP | ENST00000296555.11 | FBXW7-202:protein_coding:FBXW7 | 5.256048e+01 | 2.055151e+00 | 2.713126e-04 | 1.392370e-02 |
| PG | DOWN | ENST00000603821.1 | FBXW7-205:retained_intron:FBXW7 | 2.118176e+02 | -1.019325e+00 | 2.933503e-10 | 1.562259e-07 |
| PG | DOWN | ENST00000604822.1 | FBXW7-210:retained_intron:FBXW7 | 6.506810e+01 | -8.982089e-01 | 1.071379e-09 | 4.345720e-07 |
| PG | DOWN | ENST00000605147.1 | FBXW7-AS1-201:lncRNA:FBXW7 | 1.309186e+01 | -8.682258e-01 | 4.430321e-07 | 4.773751e-05 |
| PG | DOWN | ENST00000647183.1 | FBXW7-216:lncRNA:FBXW7 | 2.655802e+01 | -1.115090e+00 | 2.400721e-04 | 5.208176e-03 |
| CB | DOWN | ENST00000296555.11 | FBXW7-202:protein_coding:FBXW7 | 1.922687e+02 | -5.586876e+00 | 7.421686e-09 | 2.343032e-07 |
| CB | UP | ENST00000604822.1 | FBXW7-210:retained_intron:FBXW7 | 1.250347e+00 | 9.949449e-01 | 8.696457e-04 | 4.590251e-03 |
| TC | DOWN | ENST00000647183.1 | FBXW7-216:lncRNA:FBXW7 | 7.873171e+00 | -1.566971e+00 | 2.374666e-04 | 3.202132e-03 |
| TC | DOWN | ENST00000296555.11 | FBXW7-202:protein_coding:FBXW7 | 5.254924e+01 | -2.480237e+00 | 2.022774e-03 | 1.693310e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for FBXW7 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_205843 | chr4 | 152329672:152329785:152330732:152330868:152332596:152332719 | 152330732:152330868 |
| exon_skip_224007 | chr4 | 152346930:152347071:152350042:152350124:152411303:152411872 | 152350042:152350124 |
| exon_skip_283883 | chr4 | 152412480:152412529:152451660:152451776:152534941:152535033 | 152451660:152451776 |
| exon_skip_291524 | chr4 | 152412480:152412529:152534941:152535033:152535127:152535241 | 152534941:152535033 |
| exon_skip_57721 | chr4 | 152346930:152347071:152350042:152350124:152352470:152352696 | 152350042:152350124 |
| exon_skip_86450 | chr4 | 152411593:152411872:152412480:152412529:152535127:152535241 | 152412480:152412529 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for FBXW7 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000281708 | 152534941 | 152535033 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000281708 | 152534941 | 152535033 | 3UTR-3UTR |
| ENST00000281708 | 152330732 | 152330868 | Frame-shift |
| ENST00000603548 | 152330732 | 152330868 | Frame-shift |
| ENST00000603841 | 152330732 | 152330868 | Frame-shift |
| ENST00000281708 | 152350042 | 152350124 | Frame-shift |
| ENST00000603548 | 152350042 | 152350124 | Frame-shift |
| ENST00000603841 | 152350042 | 152350124 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for FBXW7 |
p-ENSG00000109670_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in FBXW7 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000281708 | 152534941 | 152535033 | hsa-miR-1307-3p | chr4:152534962-152534969 | 8mer-1a | chr4:152534948-152534969 | 155.00 | -24.36 |
| ROSMAP | ENST00000281708 | 152534941 | 152535033 | hsa-miR-1307-3p | chr4:152534962-152534969 | 8mer-1a | chr4:152534948-152534969 | 155.00 | -24.36 |
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SNVs in the skipped exons for FBXW7 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for FBXW7 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FBXW7 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for FBXW7 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for FBXW7 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FBXW7 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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