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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for TMEM100 |
Gene summary |
Gene information | Gene symbol | TMEM100 | Gene ID | 55273 |
Gene name | transmembrane protein 100 | |
Synonyms | - | |
Cytomap | 17q22 | |
Type of gene | protein-coding | |
Description | transmembrane protein 100 | |
Modification date | 20200313 | |
UniProtAcc | A0A0A0MTR3, Q9NV29, | |
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
TMEM100 | GO:0030509 | BMP signaling pathway | 22783020 |
TMEM100 | GO:0071773 | cellular response to BMP stimulus | 22783020 |
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Gene structures and expression levels for TMEM100 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TMEM100 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_54140 | chr17 | 55722619:55722729:55727801:55727982:55731671:55731884 | 55727801:55727982 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TMEM100 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000575734 | 55727801 | 55727982 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000575734 | 55727801 | 55727982 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for TMEM100 |
p-ENSG00000166292_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in TMEM100 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000575734 | 55727801 | 55727982 | hsa-miR-12136 | chr17:55727969-55727976 | 8mer-1a | chr17:55727959-55727976 | 143.00 | -5.70 |
Mayo | ENST00000575734 | 55727801 | 55727982 | hsa-miR-7856-5p | chr17:55727838-55727845 | 8mer-1a | chr17:55727836-55727857 | 155.00 | -20.78 |
Mayo | ENST00000575734 | 55727801 | 55727982 | hsa-miR-765 | chr17:55727879-55727886 | 8mer-1a | chr17:55727868-55727889 | 161.00 | -26.92 |
Mayo | ENST00000575734 | 55727801 | 55727982 | hsa-miR-4753-5p | chr17:55727835-55727842 | 8mer-1a | chr17:55727831-55727855 | 145.00 | -25.80 |
Mayo | ENST00000575734 | 55727801 | 55727982 | hsa-miR-11181-3p | chr17:55727879-55727886 | 8mer-1a | chr17:55727868-55727889 | 161.00 | -26.92 |
Mayo | ENST00000575734 | 55727801 | 55727982 | hsa-miR-4268 | chr17:55727939-55727946 | 8mer-1a | chr17:55727926-55727946 | 156.00 | -21.23 |
Mayo | ENST00000575734 | 55727801 | 55727982 | hsa-miR-548g-3p | chr17:55727900-55727907 | 8mer-1a | chr17:55727894-55727915 | 152.00 | -15.97 |
Mayo | ENST00000575734 | 55727801 | 55727982 | hsa-miR-891b | chr17:55727921-55727928 | 8mer-1a | chr17:55727907-55727930 | 151.00 | -23.80 |
ROSMAP | ENST00000575734 | 55727801 | 55727982 | hsa-miR-12136 | chr17:55727969-55727976 | 8mer-1a | chr17:55727959-55727976 | 143.00 | -5.70 |
ROSMAP | ENST00000575734 | 55727801 | 55727982 | hsa-miR-7856-5p | chr17:55727838-55727845 | 8mer-1a | chr17:55727836-55727857 | 155.00 | -20.78 |
ROSMAP | ENST00000575734 | 55727801 | 55727982 | hsa-miR-765 | chr17:55727879-55727886 | 8mer-1a | chr17:55727868-55727889 | 161.00 | -26.92 |
ROSMAP | ENST00000575734 | 55727801 | 55727982 | hsa-miR-4753-5p | chr17:55727835-55727842 | 8mer-1a | chr17:55727831-55727855 | 145.00 | -25.80 |
ROSMAP | ENST00000575734 | 55727801 | 55727982 | hsa-miR-11181-3p | chr17:55727879-55727886 | 8mer-1a | chr17:55727868-55727889 | 161.00 | -26.92 |
ROSMAP | ENST00000575734 | 55727801 | 55727982 | hsa-miR-4268 | chr17:55727939-55727946 | 8mer-1a | chr17:55727926-55727946 | 156.00 | -21.23 |
ROSMAP | ENST00000575734 | 55727801 | 55727982 | hsa-miR-548g-3p | chr17:55727900-55727907 | 8mer-1a | chr17:55727894-55727915 | 152.00 | -15.97 |
ROSMAP | ENST00000575734 | 55727801 | 55727982 | hsa-miR-891b | chr17:55727921-55727928 | 8mer-1a | chr17:55727907-55727930 | 151.00 | -23.80 |
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SNVs in the skipped exons for TMEM100 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TMEM100 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TMEM100 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TMEM100 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for TMEM100 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMEM100 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |