ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for OXR1

Gene summary

Gene information	Gene symbol	OXR1
	Gene ID	55074
	Gene name	oxidation resistance 1
	Synonyms	CHEGDD\|Nbla00307\|TLDC3
	Cytomap	8q23.1
	Type of gene	protein-coding
	Description	oxidation resistance protein 1TBC/LysM-associated domain containing 3putative protein product of Nbla00307
	Modification date	20200313
	UniProtAcc	C9JY63, E5RFD1, E5RII8, E9PLW2, H0YC07, Q05CY8, Q8N573,
	Context	- 32096020(Lemborexant: First Approval)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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Gene structures and expression levels for OXR1

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000164830

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
DLPFC	DOWN	ENST00000297447.10	OXR1-201:protein_coding:OXR1	6.873603e+01	-8.324732e-01	1.453272e-03	4.298899e-02
PG	DOWN	ENST00000519415.6	OXR1-211:protein_coding:OXR1	2.412200e+02	-1.007556e+00	1.927165e-03	2.323442e-02
CB	UP	ENST00000531443.5	OXR1-215:protein_coding:OXR1	2.902359e+02	3.351747e+00	3.644385e-05	3.147109e-04
CB	UP	ENST00000442977.6	OXR1-205:protein_coding:OXR1	1.395076e+01	1.480033e+00	5.662141e-03	2.180467e-02
TC	UP	ENST00000438229.6	OXR1-204:nonsense_mediated_decay:OXR1	3.757959e+00	1.127171e+00	2.129636e-04	2.942728e-03

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for OXR1

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_10665	chr8	106713823:106713985:106739458:106739583:106740343:106740495	106739458:106739583
exon_skip_109702	chr8	106692728:106692877:106702906:106703090:106706382:106706854	106702906:106703090
exon_skip_126475	chr8	106713823:106713985:106737520:106737600:106739458:106739478	106737520:106737600
exon_skip_147953	chr8	106726107:106726309:106737520:106737600:106739458:106739498	106737520:106737600
exon_skip_173617	chr8	106713823:106713985:106737520:106737600:106739458:106739498	106737520:106737600
exon_skip_177495	chr8	106684246:106684359:106692728:106692877:106702906:106703087	106692728:106692877
exon_skip_18354	chr8	106726107:106726309:106737520:106737600:106739458:106739583	106737520:106737600
exon_skip_193199	chr8	106679210:106679292:106683199:106683306:106684246:106684340	106683199:106683306
exon_skip_197125	chr8	106726107:106726309:106737520:106737600:106739458:106739478	106737520:106737600
exon_skip_2317	chr8	106713854:106713985:106737520:106737600:106739458:106739583	106737520:106737600
exon_skip_255969	chr8	106739458:106739583:106740343:106740495:106742222:106742317	106740343:106740495
exon_skip_257747	chr8	106742222:106742317:106745789:106745862:106750806:106751173	106745789:106745862
exon_skip_258227	chr8	106726185:106726257:106737520:106737600:106739458:106739583	106737520:106737600
exon_skip_267222	chr8	106713854:106713985:106739458:106739583:106740343:106740495	106739458:106739583
exon_skip_295151	chr8	106713823:106713985:106737520:106737600:106739458:106739583	106737520:106737600
exon_skip_41562	chr8	106692728:106692877:106702906:106703090:106706382:106706982	106702906:106703090
exon_skip_71952	chr8	106518943:106519139:106679210:106679292:106683199:106683306	106679210:106679292
exon_skip_78472	chr8	106359476:106359636:106518943:106519139:106679210:106679292	106518943:106519139

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information	Tissue type	Avg(PSIs) in AD	Avg(PSIs) in control	Difference (PSI)	Adj. p-value
exon_skip_295151	Mayo_CB	4.968293e-01	6.919403e-01	-1.951110e-01	3.093795e-08

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Open reading frame (ORF) annotation in the exon skipping event for OXR1

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000442977	106679210	106679292	Frame-shift
ENST00000442977	106702906	106703090	Frame-shift
ENST00000442977	106745789	106745862	Frame-shift
ENST00000442977	106683199	106683306	In-frame
ENST00000442977	106692728	106692877	In-frame
ENST00000442977	106737520	106737600	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000442977	106702906	106703090	Frame-shift
ENST00000442977	106745789	106745862	Frame-shift
ENST00000442977	106692728	106692877	In-frame
ENST00000442977	106737520	106737600	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000442977	106679210	106679292	Frame-shift
ENST00000442977	106702906	106703090	Frame-shift
ENST00000442977	106745789	106745862	Frame-shift
ENST00000442977	106692728	106692877	In-frame
ENST00000442977	106737520	106737600	In-frame
ENST00000442977	106740343	106740495	In-frame

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Infer the effects of exon skipping event on protein functional features for OXR1

p-ENSG00000164830_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000442977	2973	874	106683199	106683306	407	513	102	138
ENST00000442977	2973	874	106692728	106692877	629	777	176	226
ENST00000442977	2973	874	106737520	106737600	2060	2139	653	680

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000442977	2973	874	106692728	106692877	629	777	176	226
ENST00000442977	2973	874	106737520	106737600	2060	2139	653	680

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000442977	2973	874	106692728	106692877	629	777	176	226
ENST00000442977	2973	874	106737520	106737600	2060	2139	653	680
ENST00000442977	2973	874	106740343	106740495	2267	2418	722	773

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q8N573	102	138	1	631	Alternative sequence	ID=VSP_039004;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:12880961;Dbxref=PMID:12880961
Q8N573	102	138	1	511	Alternative sequence	ID=VSP_039005;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q8N573	102	138	23	680	Alternative sequence	ID=VSP_043633;Note=In isoform 7. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|Ref.1;Dbxref=PMID:14702039
Q8N573	102	138	1	874	Chain	ID=PRO_0000231645;Note=Oxidation resistance protein 1
Q8N573	102	138	99	142	Domain	Note=LysM;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01118
Q8N573	102	138	119	119	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q4KMM3
Q8N573	176	226	1	631	Alternative sequence	ID=VSP_039004;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:12880961;Dbxref=PMID:12880961
Q8N573	176	226	1	511	Alternative sequence	ID=VSP_039005;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q8N573	176	226	23	680	Alternative sequence	ID=VSP_043633;Note=In isoform 7. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|Ref.1;Dbxref=PMID:14702039
Q8N573	176	226	1	874	Chain	ID=PRO_0000231645;Note=Oxidation resistance protein 1
Q8N573	176	226	208	275	Domain	Note=GRAM
Q8N573	176	226	201	201	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:16964243,ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:21406692,E
Q8N573	176	226	202	202	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
Q8N573	176	226	204	204	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:18669648;Dbxref=PMID:18669648
Q8N573	653	680	23	680	Alternative sequence	ID=VSP_043633;Note=In isoform 7. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|Ref.1;Dbxref=PMID:14702039
Q8N573	653	680	572	874	Alternative sequence	ID=VSP_039011;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q8N573	653	680	632	653	Alternative sequence	ID=VSP_039012;Note=In isoform 4. KKIEESETIEDSSNQAAAREWE->MSRLWYGKKGRRHQPINHKYTL;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:12880961;Dbxref=PMID:12880961
Q8N573	653	680	654	722	Alternative sequence	ID=VSP_039014;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q8N573	653	680	654	680	Alternative sequence	ID=VSP_039013;Note=In isoform 2 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005;Dbxref=PMID:14702039,PMID:15489334,PMID:17974005
Q8N573	653	680	1	874	Chain	ID=PRO_0000231645;Note=Oxidation resistance protein 1

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q8N573	176	226	1	631	Alternative sequence	ID=VSP_039004;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:12880961;Dbxref=PMID:12880961
Q8N573	176	226	1	511	Alternative sequence	ID=VSP_039005;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q8N573	176	226	23	680	Alternative sequence	ID=VSP_043633;Note=In isoform 7. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|Ref.1;Dbxref=PMID:14702039
Q8N573	176	226	1	874	Chain	ID=PRO_0000231645;Note=Oxidation resistance protein 1
Q8N573	176	226	208	275	Domain	Note=GRAM
Q8N573	176	226	201	201	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:16964243,ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:21406692,E
Q8N573	176	226	202	202	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
Q8N573	176	226	204	204	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:18669648;Dbxref=PMID:18669648
Q8N573	653	680	23	680	Alternative sequence	ID=VSP_043633;Note=In isoform 7. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|Ref.1;Dbxref=PMID:14702039
Q8N573	653	680	572	874	Alternative sequence	ID=VSP_039011;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q8N573	653	680	632	653	Alternative sequence	ID=VSP_039012;Note=In isoform 4. KKIEESETIEDSSNQAAAREWE->MSRLWYGKKGRRHQPINHKYTL;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:12880961;Dbxref=PMID:12880961
Q8N573	653	680	654	722	Alternative sequence	ID=VSP_039014;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q8N573	653	680	654	680	Alternative sequence	ID=VSP_039013;Note=In isoform 2 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005;Dbxref=PMID:14702039,PMID:15489334,PMID:17974005
Q8N573	653	680	1	874	Chain	ID=PRO_0000231645;Note=Oxidation resistance protein 1

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q8N573	176	226	1	631	Alternative sequence	ID=VSP_039004;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:12880961;Dbxref=PMID:12880961
Q8N573	176	226	1	511	Alternative sequence	ID=VSP_039005;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q8N573	176	226	23	680	Alternative sequence	ID=VSP_043633;Note=In isoform 7. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|Ref.1;Dbxref=PMID:14702039
Q8N573	176	226	1	874	Chain	ID=PRO_0000231645;Note=Oxidation resistance protein 1
Q8N573	176	226	208	275	Domain	Note=GRAM
Q8N573	176	226	201	201	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:16964243,ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:21406692,E
Q8N573	176	226	202	202	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
Q8N573	176	226	204	204	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:18669648;Dbxref=PMID:18669648
Q8N573	653	680	23	680	Alternative sequence	ID=VSP_043633;Note=In isoform 7. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|Ref.1;Dbxref=PMID:14702039
Q8N573	653	680	572	874	Alternative sequence	ID=VSP_039011;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q8N573	653	680	632	653	Alternative sequence	ID=VSP_039012;Note=In isoform 4. KKIEESETIEDSSNQAAAREWE->MSRLWYGKKGRRHQPINHKYTL;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:12880961;Dbxref=PMID:12880961
Q8N573	653	680	654	722	Alternative sequence	ID=VSP_039014;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q8N573	653	680	654	680	Alternative sequence	ID=VSP_039013;Note=In isoform 2 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005;Dbxref=PMID:14702039,PMID:15489334,PMID:17974005
Q8N573	653	680	1	874	Chain	ID=PRO_0000231645;Note=Oxidation resistance protein 1
Q8N573	722	773	572	874	Alternative sequence	ID=VSP_039011;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q8N573	722	773	654	722	Alternative sequence	ID=VSP_039014;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q8N573	722	773	1	874	Chain	ID=PRO_0000231645;Note=Oxidation resistance protein 1
Q8N573	722	773	711	847	Domain	Note=TLD
Q8N573	722	773	727	727	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305

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3'-UTR located exon skipping events that lost miRNA binding sites in OXR1

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type

ENST

Exon skip start

Exon skip end

microRNA

Binding site by TargetScan

Binding type by TargetScan

Bdinding site by miRanda

Score of miRanda

Energy by miRanda

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SNVs in the skipped exons for OXR1

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for OXR1

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for OXR1

sQTL information located at the skipped exons.

Tissue type

Exon skip ID

SNP id

Location

P-value

FDR

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Correlation with RNA binding proteins (RBPs) for OXR1

Correlated RBP and related information.

Tissue type	RBP name	Exon skip ID	Correlation coeifficient	P-value
CB	TARDBP	exon_skip_295151	-4.837663e-01	4.105873e-10
CB	RBM6	exon_skip_295151	-5.190929e-01	1.182137e-11
CB	HNRNPA2B1	exon_skip_295151	-4.727613e-01	1.144366e-09
CB	RBM6	exon_skip_18354	-4.341648e-01	6.047254e-08
CB	SRSF9	exon_skip_18354	4.349559e-01	5.686768e-08
CB	HNRNPH2	exon_skip_18354	4.144488e-01	2.662088e-07
FL	ILF2	exon_skip_2317	4.153064e-01	1.729691e-09
FL	HNRNPH2	exon_skip_2317	5.316252e-01	1.514356e-15
HCC	SFPQ	exon_skip_295151	-4.601791e-01	1.163347e-15
HCC	RBM6	exon_skip_295151	-5.497602e-01	6.961569e-23
HCC	HNRNPA2B1	exon_skip_295151	-4.441010e-01	1.419763e-14
HCC	HNRNPF	exon_skip_295151	-5.417396e-01	3.801506e-22
HCC	SFPQ	exon_skip_18354	-4.281618e-01	3.406790e-13
HCC	RBM6	exon_skip_18354	-4.553877e-01	6.391192e-15
HCC	HNRNPA2B1	exon_skip_18354	-4.213884e-01	8.678881e-13
HCC	HNRNPF	exon_skip_18354	-5.040604e-01	2.032888e-18
PCC	RBM6	exon_skip_2317	-4.503947e-01	6.932247e-12
PCC	HNRNPF	exon_skip_2317	-5.497495e-01	5.546316e-18
PCC	SRSF11	exon_skip_267222	4.143617e-01	7.224428e-10
PCC	HNRNPF	exon_skip_267222	5.624890e-01	2.039506e-18
PCC	HNRNPF	exon_skip_18354	-4.486023e-01	1.072794e-10
PG	ILF2	exon_skip_2317	4.101365e-01	9.816513e-09
PG	KHDRBS2	exon_skip_2317	4.903765e-01	2.431753e-12
PG	HNRNPH2	exon_skip_2317	4.832113e-01	5.589875e-12
STG	KHDRBS2	exon_skip_2317	4.500173e-01	1.224806e-05
STG	SRSF9	exon_skip_2317	4.048878e-01	1.002950e-04
STG	HNRNPH2	exon_skip_2317	4.204311e-01	5.026784e-05
TC	RBM6	exon_skip_173617	-4.773852e-01	2.955573e-10
TC	ILF2	exon_skip_173617	4.657560e-01	8.963700e-10
TC	KHDRBS2	exon_skip_173617	7.434631e-01	1.064908e-28
TC	HNRNPH2	exon_skip_173617	6.730722e-01	6.302836e-22
TC	ESRP1	exon_skip_173617	4.995354e-01	3.171876e-11
TC	KHDRBS2	exon_skip_147953	4.396169e-01	8.391741e-09
TC	HNRNPH2	exon_skip_147953	4.226077e-01	3.518230e-08

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RelatedDrugs for OXR1

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for OXR1

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

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Gene summary for OXR1

Gene structures and expression levels for OXR1

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for OXR1

Open reading frame (ORF) annotation in the exon skipping event for OXR1

Infer the effects of exon skipping event on protein functional features for OXR1

3'-UTR located exon skipping events that lost miRNA binding sites in OXR1

SNVs in the skipped exons for OXR1

AD stage-associated exon skippint events for OXR1

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for OXR1

Correlation with RNA binding proteins (RBPs) for OXR1

RelatedDrugs for OXR1

RelatedDiseases for OXR1