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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for NBDY |
 Gene summary |
| Gene information | Gene symbol | NBDY | Gene ID | 550643 |
| Gene name | negative regulator of P-body association | |
| Synonyms | LINC01420|NoBody | |
| Cytomap | Xp11.21 | |
| Type of gene | protein-coding | |
| Description | negative regulator of P-body associationP-body dissociating proteinlong intergenic non-protein coding RNA 1420non-annotated P-body dissociating polypeptideprotein NoBody | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| NBDY | GO:0000956 | nuclear-transcribed mRNA catabolic process | 27918561 |
| NBDY | GO:0010607 | negative regulation of cytoplasmic mRNA processing body assembly | 27918561 |
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Gene structures and expression levels for NBDY |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000204272
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for NBDY |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_164715 | chrX | 56729354:56729589:56732063:56732199:56817320:56817376 | 56732063:56732199 |
| exon_skip_29901 | chrX | 56732063:56732199:56811020:56811179:56817320:56817376 | 56811020:56811179 |
| exon_skip_84949 | chrX | 56729354:56729589:56732063:56732199:56817320:56817626 | 56732063:56732199 |
| exon_skip_98254 | chrX | 56732071:56732199:56811020:56811179:56817320:56817376 | 56811020:56811179 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for NBDY |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000374922 | 56732063 | 56732199 | 3UTR-3UTR |
| ENST00000637096 | 56811020 | 56811179 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000374922 | 56732063 | 56732199 | 3UTR-3UTR |
| ENST00000637096 | 56811020 | 56811179 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000374922 | 56732063 | 56732199 | 3UTR-3UTR |
| ENST00000637096 | 56811020 | 56811179 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for NBDY |
p-ENSG00000204272_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in NBDY |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000637096 | 56811020 | 56811179 | hsa-miR-3085-3p | chrX:56811157-56811164 | 8mer-1a | chrX:56811142-56811164 | 150.00 | -20.95 |
| Mayo | ENST00000637096 | 56811020 | 56811179 | hsa-miR-6503-5p | chrX:56811086-56811093 | 8mer-1a | chrX:56811075-56811095 | 151.00 | -27.41 |
| Mayo | ENST00000637096 | 56811020 | 56811179 | hsa-miR-6861-3p | chrX:56811039-56811046 | 8mer-1a | chrX:56811036-56811058 | 156.00 | -23.95 |
| Mayo | ENST00000637096 | 56811020 | 56811179 | hsa-miR-6504-5p | chrX:56811157-56811164 | 8mer-1a | chrX:56811142-56811164 | 150.00 | -20.95 |
| Mayo | ENST00000374922 | 56732063 | 56732199 | hsa-miR-4733-3p | chrX:56732119-56732126 | 8mer-1a | chrX:56732105-56732126 | 154.00 | -17.15 |
| Mayo | ENST00000637096 | 56811020 | 56811179 | hsa-miR-4736 | chrX:56811144-56811151 | 8mer-1a | chrX:56811142-56811163 | 158.00 | -25.42 |
| Mayo | ENST00000637096 | 56811020 | 56811179 | hsa-miR-3064-5p | chrX:56811157-56811164 | 8mer-1a | chrX:56811142-56811164 | 150.00 | -20.95 |
| Mayo | ENST00000637096 | 56811020 | 56811179 | hsa-miR-4527 | chrX:56811086-56811093 | 8mer-1a | chrX:56811075-56811095 | 151.00 | -27.41 |
| Mayo | ENST00000637096 | 56811020 | 56811179 | hsa-miR-520a-5p | chrX:56811118-56811125 | 8mer-1a | chrX:56811105-56811125 | 168.00 | -21.89 |
| Mayo | ENST00000637096 | 56811020 | 56811179 | hsa-miR-525-5p | chrX:56811118-56811125 | 8mer-1a | chrX:56811105-56811125 | 168.00 | -21.89 |
| Mayo | ENST00000374922 | 56732063 | 56732199 | hsa-miR-5000-3p | chrX:56732169-56732176 | 8mer-1a | chrX:56732154-56732176 | 158.00 | -21.14 |
| Mayo | ENST00000374922 | 56732063 | 56732199 | hsa-miR-4436a | chrX:56732169-56732176 | 8mer-1a | chrX:56732154-56732176 | 158.00 | -21.14 |
| Mayo | ENST00000637096 | 56811020 | 56811179 | hsa-miR-6817-3p | chrX:56811135-56811142 | 8mer-1a | chrX:56811130-56811151 | 155.00 | -24.18 |
| Mayo | ENST00000637096 | 56811020 | 56811179 | hsa-miR-6131 | chrX:56811089-56811096 | 8mer-1a | chrX:56811075-56811098 | 142.00 | -28.73 |
| Mayo | ENST00000374922 | 56732063 | 56732199 | hsa-miR-5692a | chrX:56732138-56732145 | 8mer-1a | chrX:56732138-56732158 | 152.00 | -16.24 |
| Mayo | ENST00000637096 | 56811020 | 56811179 | hsa-miR-6895-3p | chrX:56811137-56811144 | 8mer-1a | chrX:56811130-56811151 | 155.00 | -24.18 |
| Mayo | ENST00000637096 | 56811020 | 56811179 | hsa-miR-1184 | chrX:56811083-56811090 | 8mer-1a | chrX:56811075-56811095 | 151.00 | -27.41 |
| MSBB | ENST00000637096 | 56811020 | 56811179 | hsa-miR-3085-3p | chrX:56811157-56811164 | 8mer-1a | chrX:56811142-56811164 | 150.00 | -20.95 |
| MSBB | ENST00000637096 | 56811020 | 56811179 | hsa-miR-6503-5p | chrX:56811086-56811093 | 8mer-1a | chrX:56811075-56811095 | 151.00 | -27.41 |
| MSBB | ENST00000637096 | 56811020 | 56811179 | hsa-miR-6861-3p | chrX:56811039-56811046 | 8mer-1a | chrX:56811036-56811058 | 156.00 | -23.95 |
| MSBB | ENST00000637096 | 56811020 | 56811179 | hsa-miR-6504-5p | chrX:56811157-56811164 | 8mer-1a | chrX:56811142-56811164 | 150.00 | -20.95 |
| MSBB | ENST00000374922 | 56732063 | 56732199 | hsa-miR-4733-3p | chrX:56732119-56732126 | 8mer-1a | chrX:56732105-56732126 | 154.00 | -17.15 |
| MSBB | ENST00000637096 | 56811020 | 56811179 | hsa-miR-4736 | chrX:56811144-56811151 | 8mer-1a | chrX:56811142-56811163 | 158.00 | -25.42 |
| MSBB | ENST00000637096 | 56811020 | 56811179 | hsa-miR-3064-5p | chrX:56811157-56811164 | 8mer-1a | chrX:56811142-56811164 | 150.00 | -20.95 |
| MSBB | ENST00000637096 | 56811020 | 56811179 | hsa-miR-4527 | chrX:56811086-56811093 | 8mer-1a | chrX:56811075-56811095 | 151.00 | -27.41 |
| MSBB | ENST00000637096 | 56811020 | 56811179 | hsa-miR-520a-5p | chrX:56811118-56811125 | 8mer-1a | chrX:56811105-56811125 | 168.00 | -21.89 |
| MSBB | ENST00000637096 | 56811020 | 56811179 | hsa-miR-525-5p | chrX:56811118-56811125 | 8mer-1a | chrX:56811105-56811125 | 168.00 | -21.89 |
| MSBB | ENST00000374922 | 56732063 | 56732199 | hsa-miR-5000-3p | chrX:56732169-56732176 | 8mer-1a | chrX:56732154-56732176 | 158.00 | -21.14 |
| MSBB | ENST00000374922 | 56732063 | 56732199 | hsa-miR-4436a | chrX:56732169-56732176 | 8mer-1a | chrX:56732154-56732176 | 158.00 | -21.14 |
| MSBB | ENST00000637096 | 56811020 | 56811179 | hsa-miR-6817-3p | chrX:56811135-56811142 | 8mer-1a | chrX:56811130-56811151 | 155.00 | -24.18 |
| MSBB | ENST00000637096 | 56811020 | 56811179 | hsa-miR-6131 | chrX:56811089-56811096 | 8mer-1a | chrX:56811075-56811098 | 142.00 | -28.73 |
| MSBB | ENST00000374922 | 56732063 | 56732199 | hsa-miR-5692a | chrX:56732138-56732145 | 8mer-1a | chrX:56732138-56732158 | 152.00 | -16.24 |
| MSBB | ENST00000637096 | 56811020 | 56811179 | hsa-miR-6895-3p | chrX:56811137-56811144 | 8mer-1a | chrX:56811130-56811151 | 155.00 | -24.18 |
| MSBB | ENST00000637096 | 56811020 | 56811179 | hsa-miR-1184 | chrX:56811083-56811090 | 8mer-1a | chrX:56811075-56811095 | 151.00 | -27.41 |
| ROSMAP | ENST00000637096 | 56811020 | 56811179 | hsa-miR-3085-3p | chrX:56811157-56811164 | 8mer-1a | chrX:56811142-56811164 | 150.00 | -20.95 |
| ROSMAP | ENST00000637096 | 56811020 | 56811179 | hsa-miR-6503-5p | chrX:56811086-56811093 | 8mer-1a | chrX:56811075-56811095 | 151.00 | -27.41 |
| ROSMAP | ENST00000637096 | 56811020 | 56811179 | hsa-miR-6861-3p | chrX:56811039-56811046 | 8mer-1a | chrX:56811036-56811058 | 156.00 | -23.95 |
| ROSMAP | ENST00000637096 | 56811020 | 56811179 | hsa-miR-6504-5p | chrX:56811157-56811164 | 8mer-1a | chrX:56811142-56811164 | 150.00 | -20.95 |
| ROSMAP | ENST00000374922 | 56732063 | 56732199 | hsa-miR-4733-3p | chrX:56732119-56732126 | 8mer-1a | chrX:56732105-56732126 | 154.00 | -17.15 |
| ROSMAP | ENST00000637096 | 56811020 | 56811179 | hsa-miR-4736 | chrX:56811144-56811151 | 8mer-1a | chrX:56811142-56811163 | 158.00 | -25.42 |
| ROSMAP | ENST00000637096 | 56811020 | 56811179 | hsa-miR-3064-5p | chrX:56811157-56811164 | 8mer-1a | chrX:56811142-56811164 | 150.00 | -20.95 |
| ROSMAP | ENST00000637096 | 56811020 | 56811179 | hsa-miR-4527 | chrX:56811086-56811093 | 8mer-1a | chrX:56811075-56811095 | 151.00 | -27.41 |
| ROSMAP | ENST00000637096 | 56811020 | 56811179 | hsa-miR-520a-5p | chrX:56811118-56811125 | 8mer-1a | chrX:56811105-56811125 | 168.00 | -21.89 |
| ROSMAP | ENST00000637096 | 56811020 | 56811179 | hsa-miR-525-5p | chrX:56811118-56811125 | 8mer-1a | chrX:56811105-56811125 | 168.00 | -21.89 |
| ROSMAP | ENST00000374922 | 56732063 | 56732199 | hsa-miR-5000-3p | chrX:56732169-56732176 | 8mer-1a | chrX:56732154-56732176 | 158.00 | -21.14 |
| ROSMAP | ENST00000374922 | 56732063 | 56732199 | hsa-miR-4436a | chrX:56732169-56732176 | 8mer-1a | chrX:56732154-56732176 | 158.00 | -21.14 |
| ROSMAP | ENST00000637096 | 56811020 | 56811179 | hsa-miR-6817-3p | chrX:56811135-56811142 | 8mer-1a | chrX:56811130-56811151 | 155.00 | -24.18 |
| ROSMAP | ENST00000637096 | 56811020 | 56811179 | hsa-miR-6131 | chrX:56811089-56811096 | 8mer-1a | chrX:56811075-56811098 | 142.00 | -28.73 |
| ROSMAP | ENST00000374922 | 56732063 | 56732199 | hsa-miR-5692a | chrX:56732138-56732145 | 8mer-1a | chrX:56732138-56732158 | 152.00 | -16.24 |
| ROSMAP | ENST00000637096 | 56811020 | 56811179 | hsa-miR-6895-3p | chrX:56811137-56811144 | 8mer-1a | chrX:56811130-56811151 | 155.00 | -24.18 |
| ROSMAP | ENST00000637096 | 56811020 | 56811179 | hsa-miR-1184 | chrX:56811083-56811090 | 8mer-1a | chrX:56811075-56811095 | 151.00 | -27.41 |
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SNVs in the skipped exons for NBDY |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for NBDY |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NBDY |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for NBDY |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for NBDY |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NBDY |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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