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![]() | Open reading frame (ORF) annotation in the exon skipping event |
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![]() | 3'-UTR located exon skipping events lost miRNA binding sites |
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![]() | Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ATG16L1 |
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Gene information | Gene symbol | ATG16L1 | Gene ID | 55054 |
Gene name | autophagy related 16 like 1 | |
Synonyms | APG16L|ATG16A|ATG16L|IBD10|WDR30 | |
Cytomap | 2q37.1 | |
Type of gene | protein-coding | |
Description | autophagy-related protein 16-1APG16L betaATG16 autophagy related 16-like 1WD repeat domain 30 | |
Modification date | 20200320 | |
UniProtAcc | A0A024R494, | |
Context |
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Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ATG16L1 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
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Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | DOWN | ENST00000373525.9 | ATG16L1-202:protein_coding:ATG16L1 | 7.225513e+01 | -2.996176e+00 | 1.378218e-10 | 8.258286e-09 |
CB | DOWN | ENST00000347464.9 | ATG16L1-201:protein_coding:ATG16L1 | 8.667125e+01 | -9.259799e-01 | 2.642026e-05 | 2.397841e-04 |
TC | DOWN | ENST00000373525.9 | ATG16L1-202:protein_coding:ATG16L1 | 3.145599e+01 | -1.992139e+00 | 1.581387e-03 | 1.400972e-02 |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ATG16L1 |
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Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_15684 | chr2 | 233263996:233264065:233264892:233265143:233270002:233270067 | 233264892:233265143 |
exon_skip_219078 | chr2 | 233273721:233273777:233273991:233274041:233274676:233274738 | 233273991:233274041 |
exon_skip_220904 | chr2 | 233251714:233251942:233256102:233256195:233270002:233270067 | 233256102:233256195 |
exon_skip_248930 | chr2 | 233263130:233263235:233263992:233264065:233264892:233264920 | 233263992:233264065 |
exon_skip_293127 | chr2 | 233251714:233251942:233256102:233256195:233263130:233263235 | 233256102:233256195 |
exon_skip_30218 | chr2 | 233272966:233273052:233273721:233273777:233274676:233274738 | 233273721:233273777 |
exon_skip_58225 | chr2 | 233277568:233277673:233281105:233281175:233282682:233282753 | 233281105:233281175 |
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Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
exon_skip_30218 | Mayo_TC | 6.344156e-01 | 7.681356e-01 | -1.337200e-01 | 7.963349e-07 |
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Open reading frame (ORF) annotation in the exon skipping event for ATG16L1 |
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ENST | Start of skipped exon | End of skipped exon | ORF |
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ENST | Start of skipped exon | End of skipped exon | ORF |
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ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for ATG16L1 |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in ATG16L1 |
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Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for ATG16L1 |
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Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ATG16L1 |
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AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ATG16L1 |
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Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ATG16L1 |
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Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | RALYL | exon_skip_30218 | 4.291478e-01 | 2.293694e-07 |
HCC | MSI1 | exon_skip_30218 | -4.869596e-01 | 7.124060e-16 |
HCC | HNRNPF | exon_skip_30218 | -4.357035e-01 | 1.114054e-12 |
TC | MSI1 | exon_skip_30218 | -4.841348e-01 | 2.351673e-09 |
TC | RALYL | exon_skip_30218 | 4.481775e-01 | 4.465291e-08 |
TC | HNRNPF | exon_skip_30218 | -4.259378e-01 | 2.343326e-07 |
TC | NOVA1 | exon_skip_219078 | 5.290554e-01 | 3.739394e-10 |
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RelatedDrugs for ATG16L1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ATG16L1 |
![]() (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |