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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for PXK |
 Gene summary |
| Gene information | Gene symbol | PXK | Gene ID | 54899 |
| Gene name | PX domain containing serine/threonine kinase like | |
| Synonyms | MONAKA|SLOB | |
| Cytomap | 3p14.3 | |
| Type of gene | protein-coding | |
| Description | PX domain-containing protein kinase-like proteinPX ser/thr kinase v2PX serine/threonine kinasemodulator of Na,K-ATPase long form | |
| Modification date | 20200313 | |
| UniProtAcc | A0A0C4DG95, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for PXK |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000168297
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
 |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000383715.8 | PXK-203:protein_coding:PXK | 1.953501e+00 | 1.517978e+00 | 1.137185e-03 | 5.759217e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for PXK |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_112319 | chr3 | 58412904:58412963:58420536:58420568:58424752:58424951 | 58420536:58420568 |
| exon_skip_114706 | chr3 | 58365874:58365924:58369431:58369478:58382514:58382605 | 58369431:58369478 |
| exon_skip_119525 | chr3 | 58369431:58369478:58382514:58382700:58390582:58390659 | 58382514:58382700 |
| exon_skip_125107 | chr3 | 58332987:58333090:58369431:58369478:58382514:58382532 | 58369431:58369478 |
| exon_skip_130398 | chr3 | 58410093:58410159:58412904:58412963:58420539:58420735 | 58412904:58412963 |
| exon_skip_143210 | chr3 | 58410090:58410159:58412901:58412963:58424752:58425058 | 58412901:58412963 |
| exon_skip_149517 | chr3 | 58410090:58410159:58412901:58412963:58424752:58424951 | 58412901:58412963 |
| exon_skip_151726 | chr3 | 58391773:58391847:58394998:58395102:58395658:58395759 | 58394998:58395102 |
| exon_skip_158608 | chr3 | 58365874:58365924:58369431:58369478:58382514:58382678 | 58369431:58369478 |
| exon_skip_164846 | chr3 | 58365874:58365924:58369431:58369478:58382514:58382532 | 58369431:58369478 |
| exon_skip_176155 | chr3 | 58399299:58399377:58403862:58403910:58408924:58409001 | 58403862:58403910 |
| exon_skip_178738 | chr3 | 58332987:58333090:58365874:58365924:58369431:58369478 | 58365874:58365924 |
| exon_skip_194721 | chr3 | 58397605:58397722:58399299:58399377:58403862:58403910 | 58399299:58399377 |
| exon_skip_204345 | chr3 | 58410090:58410159:58412904:58412963:58423461:58423494 | 58412904:58412963 |
| exon_skip_21837 | chr3 | 58412904:58412963:58423461:58423494:58424752:58424951 | 58423461:58423494 |
| exon_skip_225405 | chr3 | 58409616:58409618:58410090:58410159:58424752:58425058 | 58410090:58410159 |
| exon_skip_225726 | chr3 | 58410093:58410159:58412901:58412963:58420536:58420568 | 58412901:58412963 |
| exon_skip_229473 | chr3 | 58410090:58410159:58412904:58412963:58420539:58420735 | 58412904:58412963 |
| exon_skip_238659 | chr3 | 58410090:58410159:58412901:58412963:58420536:58420568 | 58412901:58412963 |
| exon_skip_243497 | chr3 | 58410090:58410159:58412904:58412963:58420536:58420568 | 58412904:58412963 |
| exon_skip_247077 | chr3 | 58412904:58412963:58423461:58423494:58424752:58425058 | 58423461:58423494 |
| exon_skip_272127 | chr3 | 58332987:58333090:58382514:58382700:58390582:58390659 | 58382514:58382700 |
| exon_skip_276695 | chr3 | 58332987:58333090:58369431:58369478:58382514:58382605 | 58369431:58369478 |
| exon_skip_38900 | chr3 | 58332987:58333090:58369431:58369478:58382514:58382678 | 58369431:58369478 |
| exon_skip_46335 | chr3 | 58410093:58410159:58412901:58412963:58424752:58425058 | 58412901:58412963 |
| exon_skip_51199 | chr3 | 58412904:58412963:58420536:58420568:58424752:58425058 | 58420536:58420568 |
| exon_skip_84365 | chr3 | 58410093:58410159:58412904:58412963:58420536:58420568 | 58412904:58412963 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_279805 | Mayo_CB | 7.771951e-01 | 8.776119e-01 | -1.004168e-01 | 5.017597e-07 |
| exon_skip_187117 | Mayo_CB | 7.172500e-01 | 8.255556e-01 | -1.083056e-01 | 6.203954e-07 |
| exon_skip_243832 | Mayo_CB | 7.371951e-01 | 8.449231e-01 | -1.077280e-01 | 4.244762e-07 |
| exon_skip_172333 | Mayo_TC | 7.081250e-01 | 8.186957e-01 | -1.105707e-01 | 3.312155e-05 |
| exon_skip_155009 | Mayo_TC | 7.040000e-01 | 8.113043e-01 | -1.073043e-01 | 4.281263e-05 |
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Open reading frame (ORF) annotation in the exon skipping event for PXK |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000356151 | 58382514 | 58382700 | Frame-shift |
| ENST00000356151 | 58399299 | 58399377 | Frame-shift |
| ENST00000356151 | 58365874 | 58365924 | In-frame |
| ENST00000356151 | 58369431 | 58369478 | In-frame |
| ENST00000356151 | 58412901 | 58412963 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000356151 | 58382514 | 58382700 | Frame-shift |
| ENST00000356151 | 58399299 | 58399377 | Frame-shift |
| ENST00000356151 | 58365874 | 58365924 | In-frame |
| ENST00000356151 | 58369431 | 58369478 | In-frame |
| ENST00000356151 | 58412901 | 58412963 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000356151 | 58382514 | 58382700 | Frame-shift |
| ENST00000356151 | 58399299 | 58399377 | Frame-shift |
| ENST00000356151 | 58403862 | 58403910 | Frame-shift |
| ENST00000356151 | 58365874 | 58365924 | In-frame |
| ENST00000356151 | 58369431 | 58369478 | In-frame |
| ENST00000356151 | 58394998 | 58395102 | In-frame |
| ENST00000356151 | 58412901 | 58412963 | In-frame |
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Infer the effects of exon skipping event on protein functional features for PXK |
p-ENSG00000168297_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000356151 | 2054 | 578 | 58365874 | 58365924 | 213 | 262 | 34 | 51 |
| ENST00000356151 | 2054 | 578 | 58369431 | 58369478 | 264 | 310 | 51 | 67 |
| ENST00000356151 | 2054 | 578 | 58412901 | 58412963 | 1576 | 1637 | 489 | 509 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000356151 | 2054 | 578 | 58365874 | 58365924 | 213 | 262 | 34 | 51 |
| ENST00000356151 | 2054 | 578 | 58369431 | 58369478 | 264 | 310 | 51 | 67 |
| ENST00000356151 | 2054 | 578 | 58412901 | 58412963 | 1576 | 1637 | 489 | 509 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000356151 | 2054 | 578 | 58365874 | 58365924 | 213 | 262 | 34 | 51 |
| ENST00000356151 | 2054 | 578 | 58369431 | 58369478 | 264 | 310 | 51 | 67 |
| ENST00000356151 | 2054 | 578 | 58394998 | 58395102 | 726 | 829 | 205 | 240 |
| ENST00000356151 | 2054 | 578 | 58412901 | 58412963 | 1576 | 1637 | 489 | 509 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q7Z7A4 | 34 | 51 | 1 | 226 | Alternative sequence | ID=VSP_051907;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16142408;Dbxref=PMID:16142408 |
| Q7Z7A4 | 34 | 51 | 1 | 137 | Alternative sequence | ID=VSP_051908;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16142408;Dbxref=PMID:16142408 |
| Q7Z7A4 | 34 | 51 | 1 | 83 | Alternative sequence | ID=VSP_051909;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16142408;Dbxref=PMID:16142408 |
| Q7Z7A4 | 34 | 51 | 35 | 67 | Alternative sequence | ID=VSP_051910;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16142408;Dbxref=PMID:16142408 |
| Q7Z7A4 | 34 | 51 | 35 | 51 | Alternative sequence | ID=VSP_051911;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q7Z7A4 | 34 | 51 | 1 | 578 | Chain | ID=PRO_0000086592;Note=PX domain-containing protein kinase-like protein |
| Q7Z7A4 | 34 | 51 | 14 | 126 | Domain | Note=PX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00147 |
| Q7Z7A4 | 34 | 51 | 42 | 42 | Sequence conflict | Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q7Z7A4 | 34 | 51 | 42 | 42 | Sequence conflict | Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q7Z7A4 | 51 | 67 | 1 | 226 | Alternative sequence | ID=VSP_051907;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16142408;Dbxref=PMID:16142408 |
| Q7Z7A4 | 51 | 67 | 1 | 137 | Alternative sequence | ID=VSP_051908;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16142408;Dbxref=PMID:16142408 |
| Q7Z7A4 | 51 | 67 | 1 | 83 | Alternative sequence | ID=VSP_051909;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16142408;Dbxref=PMID:16142408 |
| Q7Z7A4 | 51 | 67 | 35 | 67 | Alternative sequence | ID=VSP_051910;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16142408;Dbxref=PMID:16142408 |
| Q7Z7A4 | 51 | 67 | 35 | 51 | Alternative sequence | ID=VSP_051911;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q7Z7A4 | 51 | 67 | 1 | 578 | Chain | ID=PRO_0000086592;Note=PX domain-containing protein kinase-like protein |
| Q7Z7A4 | 51 | 67 | 14 | 126 | Domain | Note=PX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00147 |
| Q7Z7A4 | 51 | 67 | 54 | 54 | Mutagenesis | Note=No effect on subcellular location. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16142408;Dbxref=PMID:16142408 |
| Q7Z7A4 | 51 | 67 | 56 | 56 | Mutagenesis | Note=Results in redistribution of protein from cytoplasm throughout entire cell. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16142408;Dbxref=PMID:16142408 |
| Q7Z7A4 | 489 | 509 | 1 | 578 | Chain | ID=PRO_0000086592;Note=PX domain-containing protein kinase-like protein |
| Q7Z7A4 | 489 | 509 | 489 | 489 | Sequence conflict | Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q7Z7A4 | 34 | 51 | 1 | 226 | Alternative sequence | ID=VSP_051907;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16142408;Dbxref=PMID:16142408 |
| Q7Z7A4 | 34 | 51 | 1 | 137 | Alternative sequence | ID=VSP_051908;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16142408;Dbxref=PMID:16142408 |
| Q7Z7A4 | 34 | 51 | 1 | 83 | Alternative sequence | ID=VSP_051909;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16142408;Dbxref=PMID:16142408 |
| Q7Z7A4 | 34 | 51 | 35 | 67 | Alternative sequence | ID=VSP_051910;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16142408;Dbxref=PMID:16142408 |
| Q7Z7A4 | 34 | 51 | 35 | 51 | Alternative sequence | ID=VSP_051911;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q7Z7A4 | 34 | 51 | 1 | 578 | Chain | ID=PRO_0000086592;Note=PX domain-containing protein kinase-like protein |
| Q7Z7A4 | 34 | 51 | 14 | 126 | Domain | Note=PX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00147 |
| Q7Z7A4 | 34 | 51 | 42 | 42 | Sequence conflict | Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q7Z7A4 | 34 | 51 | 42 | 42 | Sequence conflict | Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q7Z7A4 | 51 | 67 | 1 | 226 | Alternative sequence | ID=VSP_051907;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16142408;Dbxref=PMID:16142408 |
| Q7Z7A4 | 51 | 67 | 1 | 137 | Alternative sequence | ID=VSP_051908;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16142408;Dbxref=PMID:16142408 |
| Q7Z7A4 | 51 | 67 | 1 | 83 | Alternative sequence | ID=VSP_051909;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16142408;Dbxref=PMID:16142408 |
| Q7Z7A4 | 51 | 67 | 35 | 67 | Alternative sequence | ID=VSP_051910;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16142408;Dbxref=PMID:16142408 |
| Q7Z7A4 | 51 | 67 | 35 | 51 | Alternative sequence | ID=VSP_051911;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q7Z7A4 | 51 | 67 | 1 | 578 | Chain | ID=PRO_0000086592;Note=PX domain-containing protein kinase-like protein |
| Q7Z7A4 | 51 | 67 | 14 | 126 | Domain | Note=PX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00147 |
| Q7Z7A4 | 51 | 67 | 54 | 54 | Mutagenesis | Note=No effect on subcellular location. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16142408;Dbxref=PMID:16142408 |
| Q7Z7A4 | 51 | 67 | 56 | 56 | Mutagenesis | Note=Results in redistribution of protein from cytoplasm throughout entire cell. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16142408;Dbxref=PMID:16142408 |
| Q7Z7A4 | 489 | 509 | 1 | 578 | Chain | ID=PRO_0000086592;Note=PX domain-containing protein kinase-like protein |
| Q7Z7A4 | 489 | 509 | 489 | 489 | Sequence conflict | Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q7Z7A4 | 34 | 51 | 1 | 226 | Alternative sequence | ID=VSP_051907;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16142408;Dbxref=PMID:16142408 |
| Q7Z7A4 | 34 | 51 | 1 | 137 | Alternative sequence | ID=VSP_051908;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16142408;Dbxref=PMID:16142408 |
| Q7Z7A4 | 34 | 51 | 1 | 83 | Alternative sequence | ID=VSP_051909;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16142408;Dbxref=PMID:16142408 |
| Q7Z7A4 | 34 | 51 | 35 | 67 | Alternative sequence | ID=VSP_051910;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16142408;Dbxref=PMID:16142408 |
| Q7Z7A4 | 34 | 51 | 35 | 51 | Alternative sequence | ID=VSP_051911;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q7Z7A4 | 34 | 51 | 1 | 578 | Chain | ID=PRO_0000086592;Note=PX domain-containing protein kinase-like protein |
| Q7Z7A4 | 34 | 51 | 14 | 126 | Domain | Note=PX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00147 |
| Q7Z7A4 | 34 | 51 | 42 | 42 | Sequence conflict | Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q7Z7A4 | 34 | 51 | 42 | 42 | Sequence conflict | Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q7Z7A4 | 51 | 67 | 1 | 226 | Alternative sequence | ID=VSP_051907;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16142408;Dbxref=PMID:16142408 |
| Q7Z7A4 | 51 | 67 | 1 | 137 | Alternative sequence | ID=VSP_051908;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16142408;Dbxref=PMID:16142408 |
| Q7Z7A4 | 51 | 67 | 1 | 83 | Alternative sequence | ID=VSP_051909;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16142408;Dbxref=PMID:16142408 |
| Q7Z7A4 | 51 | 67 | 35 | 67 | Alternative sequence | ID=VSP_051910;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16142408;Dbxref=PMID:16142408 |
| Q7Z7A4 | 51 | 67 | 35 | 51 | Alternative sequence | ID=VSP_051911;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q7Z7A4 | 51 | 67 | 1 | 578 | Chain | ID=PRO_0000086592;Note=PX domain-containing protein kinase-like protein |
| Q7Z7A4 | 51 | 67 | 14 | 126 | Domain | Note=PX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00147 |
| Q7Z7A4 | 51 | 67 | 54 | 54 | Mutagenesis | Note=No effect on subcellular location. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16142408;Dbxref=PMID:16142408 |
| Q7Z7A4 | 51 | 67 | 56 | 56 | Mutagenesis | Note=Results in redistribution of protein from cytoplasm throughout entire cell. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16142408;Dbxref=PMID:16142408 |
| Q7Z7A4 | 205 | 240 | 1 | 226 | Alternative sequence | ID=VSP_051907;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16142408;Dbxref=PMID:16142408 |
| Q7Z7A4 | 205 | 240 | 1 | 578 | Chain | ID=PRO_0000086592;Note=PX domain-containing protein kinase-like protein |
| Q7Z7A4 | 205 | 240 | 88 | 481 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q7Z7A4 | 489 | 509 | 1 | 578 | Chain | ID=PRO_0000086592;Note=PX domain-containing protein kinase-like protein |
| Q7Z7A4 | 489 | 509 | 489 | 489 | Sequence conflict | Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
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3'-UTR located exon skipping events that lost miRNA binding sites in PXK |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for PXK |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for PXK |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PXK |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| CB | exon_skip_247077 | rs6767498 | chr3:58423399 | 1.153757e-04 | 1.933017e-02 |
| CB | exon_skip_247077 | rs4076852 | chr3:58389559 | 3.119184e-04 | 4.173301e-02 |
| TC | exon_skip_21837 | rs4076852 | chr3:58389559 | 5.342635e-06 | 1.470102e-03 |
| HCC | exon_skip_247077 | rs4075152 | chr3:58399467 | 8.775484e-20 | 1.195263e-16 |
| HCC | exon_skip_247077 | rs12635366 | chr3:58412739 | 8.775484e-20 | 1.195263e-16 |
| HCC | exon_skip_247077 | rs7231 | chr3:58427738 | 2.866107e-19 | 3.624934e-16 |
| HCC | exon_skip_247077 | rs6768547 | chr3:58449242 | 1.138785e-17 | 1.141360e-14 |
| HCC | exon_skip_247077 | rs4390943 | chr3:58390912 | 5.187308e-15 | 3.598179e-12 |
| HCC | exon_skip_247077 | rs11130633 | chr3:58385065 | 2.182191e-08 | 4.984175e-06 |
| HCC | exon_skip_247077 | rs4076852 | chr3:58389559 | 5.248431e-08 | 1.113275e-05 |
| HCC | exon_skip_247077 | rs6772228 | chr3:58390292 | 5.899225e-08 | 1.233031e-05 |
| HCC | exon_skip_247077 | rs7625947 | chr3:58497903 | 4.075683e-05 | 4.226151e-03 |
| HCC | exon_skip_247077 | rs6445973 | chr3:58350868 | 5.958095e-05 | 5.879650e-03 |
| HCC | exon_skip_247077 | rs11714389 | chr3:58461572 | 1.608177e-04 | 1.359052e-02 |
| HCC | exon_skip_247077 | rs11712139 | chr3:58399048 | 1.691565e-04 | 1.417469e-02 |
| HCC | exon_skip_247077 | rs11917591 | chr3:58382722 | 2.502448e-04 | 1.949524e-02 |
| HCC | exon_skip_247077 | rs11130632 | chr3:58383597 | 2.502448e-04 | 1.949524e-02 |
| HCC | exon_skip_247077 | rs11719450 | chr3:58471084 | 2.502448e-04 | 1.949524e-02 |
| HCC | exon_skip_247077 | rs6775710 | chr3:58350474 | 4.806055e-04 | 3.286884e-02 |
| HCC | exon_skip_178738 | rs4390943 | chr3:58390912 | 6.580567e-04 | 4.210102e-02 |
| HCC | exon_skip_178738 | rs4075152 | chr3:58399467 | 7.520789e-04 | 4.675677e-02 |
| HCC | exon_skip_178738 | rs12635366 | chr3:58412739 | 7.520789e-04 | 4.675677e-02 |
| DLPFC | exon_skip_247077 | rs6772228 | chr3:58390292 | 2.989896e-13 | 1.426975e-10 |
| DLPFC | exon_skip_247077 | rs4390943 | chr3:58390912 | 7.668661e-13 | 3.443538e-10 |
| DLPFC | exon_skip_247077 | rs4075152 | chr3:58399467 | 1.917605e-12 | 8.109430e-10 |
| DLPFC | exon_skip_247077 | rs12635366 | chr3:58412739 | 1.917605e-12 | 8.109430e-10 |
| DLPFC | exon_skip_247077 | rs7231 | chr3:58427738 | 4.528929e-12 | 1.836228e-09 |
| DLPFC | exon_skip_247077 | rs6768547 | chr3:58449242 | 7.360661e-12 | 2.879501e-09 |
| DLPFC | exon_skip_247077 | rs11130633 | chr3:58385065 | 4.544341e-06 | 5.622966e-04 |
| DLPFC | exon_skip_247077 | rs4076852 | chr3:58389559 | 7.770673e-06 | 8.976740e-04 |
| DLPFC | exon_skip_247077 | rs7625947 | chr3:58497903 | 8.253699e-04 | 4.778935e-02 |
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Correlation with RNA binding proteins (RBPs) for PXK |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | TRA2A | exon_skip_114706 | -4.329364e-01 | 2.049588e-08 |
| CB | PCBP4 | exon_skip_225726 | 4.745448e-01 | 7.479548e-10 |
| CB | RBM6 | exon_skip_46335 | -4.546951e-01 | 9.180814e-09 |
| CB | PCBP4 | exon_skip_46335 | 4.743210e-01 | 1.673098e-09 |
| CB | DAZAP1 | exon_skip_279805 | -4.307193e-01 | 4.179403e-08 |
| CB | TARDBP | exon_skip_279805 | -4.091475e-01 | 2.209079e-07 |
| CB | ZNF638 | exon_skip_279805 | -6.042903e-01 | 3.363958e-16 |
| CB | RBM6 | exon_skip_279805 | -4.993180e-01 | 9.052800e-11 |
| CB | U2AF2 | exon_skip_279805 | -6.221861e-01 | 2.462918e-17 |
| CB | CNOT4 | exon_skip_279805 | -4.429995e-01 | 1.535926e-08 |
| CB | RBM3 | exon_skip_279805 | 4.984776e-01 | 9.842822e-11 |
| CB | PCBP4 | exon_skip_279805 | 4.984431e-01 | 9.876624e-11 |
| CB | TRA2A | exon_skip_279805 | -6.418069e-01 | 1.147778e-18 |
| CB | FUBP1 | exon_skip_279805 | -4.210306e-01 | 8.956723e-08 |
| CB | HNRNPA2B1 | exon_skip_279805 | -4.559610e-01 | 5.110345e-09 |
| CB | HNRNPDL | exon_skip_279805 | 4.097429e-01 | 2.113123e-07 |
| CB | RBM45 | exon_skip_279805 | 6.841855e-01 | 6.714794e-22 |
| CB | HNRNPC | exon_skip_279805 | -4.172329e-01 | 1.199762e-07 |
| CB | NUP42 | exon_skip_279805 | 5.676435e-01 | 4.391338e-14 |
| CB | PTBP1 | exon_skip_279805 | -5.134258e-01 | 2.147176e-11 |
| CB | RBM6 | exon_skip_187117 | -4.700868e-01 | 3.150462e-09 |
| CB | PCBP4 | exon_skip_187117 | 4.961221e-01 | 2.959565e-10 |
| CB | DAZAP1 | exon_skip_243832 | -4.180815e-01 | 1.371209e-07 |
| CB | ZNF638 | exon_skip_243832 | -5.578896e-01 | 2.125849e-13 |
| CB | RBM6 | exon_skip_243832 | -4.709504e-01 | 1.746056e-09 |
| CB | U2AF2 | exon_skip_243832 | -6.129756e-01 | 1.557159e-16 |
| CB | CNOT4 | exon_skip_243832 | -4.098596e-01 | 2.533991e-07 |
| CB | TIA1 | exon_skip_243832 | 4.509152e-01 | 9.963617e-09 |
| CB | RBM3 | exon_skip_243832 | 5.227623e-01 | 1.106027e-11 |
| CB | PCBP4 | exon_skip_243832 | 5.172091e-01 | 1.983440e-11 |
| CB | TRA2A | exon_skip_243832 | -5.916388e-01 | 3.003157e-15 |
| CB | HNRNPA2B1 | exon_skip_243832 | -4.185640e-01 | 1.321993e-07 |
| CB | HNRNPDL | exon_skip_243832 | 4.353256e-01 | 3.582002e-08 |
| CB | RBM45 | exon_skip_243832 | 7.159228e-01 | 2.178186e-24 |
| CB | NUP42 | exon_skip_243832 | 6.299730e-01 | 1.249699e-17 |
| CB | PTBP1 | exon_skip_243832 | -4.799578e-01 | 7.687925e-10 |
| DLPFC | RBM3 | exon_skip_243832 | 4.332301e-01 | 1.121803e-12 |
| DLPFC | KHDRBS2 | exon_skip_243832 | 4.149661e-01 | 1.171598e-11 |
| DLPFC | RBFOX2 | exon_skip_279805 | 4.526706e-01 | 1.369982e-14 |
| DLPFC | RBM3 | exon_skip_279805 | 4.174388e-01 | 1.987293e-12 |
| DLPFC | KHDRBS2 | exon_skip_279805 | 4.241643e-01 | 8.030682e-13 |
| DLPFC | RBFOX2 | exon_skip_51199 | 7.098621e-01 | 1.478141e-51 |
| HCC | DAZAP1 | exon_skip_279805 | -4.117654e-01 | 1.192129e-11 |
| HCC | RBMS2 | exon_skip_279805 | -4.776107e-01 | 1.191914e-15 |
| HCC | MSI1 | exon_skip_279805 | -5.451437e-01 | 9.381957e-21 |
| HCC | ZNF326 | exon_skip_279805 | -4.093428e-01 | 1.612928e-11 |
| HCC | RBM6 | exon_skip_279805 | -4.442053e-01 | 1.634056e-13 |
| HCC | RBM47 | exon_skip_279805 | -4.205284e-01 | 3.913059e-12 |
| HCC | KHDRBS3 | exon_skip_279805 | -4.016194e-01 | 4.160969e-11 |
| HCC | EIF4G2 | exon_skip_279805 | -4.406473e-01 | 2.675678e-13 |
| HCC | PTBP1 | exon_skip_279805 | -5.304295e-01 | 1.524290e-19 |
| HCC | SRSF4 | exon_skip_279805 | -4.436281e-01 | 1.770834e-13 |
| HCC | HNRNPF | exon_skip_279805 | -4.921501e-01 | 1.177176e-16 |
| HCC | RBMS2 | exon_skip_243832 | -4.213920e-01 | 4.272359e-12 |
| HCC | RBFOX2 | exon_skip_243832 | 4.050949e-01 | 3.272116e-11 |
| HCC | MSI1 | exon_skip_243832 | -5.077676e-01 | 1.168222e-17 |
| HCC | PTBP1 | exon_skip_243832 | -4.781744e-01 | 1.421028e-15 |
| HCC | HNRNPF | exon_skip_243832 | -4.488320e-01 | 1.072535e-13 |
| HCC | RBFOX2 | exon_skip_51199 | 4.701375e-01 | 2.309569e-16 |
| HCC | SFPQ | exon_skip_51199 | -4.755076e-01 | 9.446686e-17 |
| IFG | EIF4G2 | exon_skip_174636 | -4.324844e-01 | 3.929388e-02 |
| IFG | RBFOX2 | exon_skip_51199 | 4.921193e-01 | 1.065790e-02 |
| PCC | RBFOX2 | exon_skip_279805 | 4.795636e-01 | 1.956581e-12 |
| PCC | PTBP1 | exon_skip_279805 | -4.363376e-01 | 2.507322e-10 |
| PCC | RBFOX2 | exon_skip_51199 | 6.404029e-01 | 1.238062e-25 |
| TC | NOVA1 | exon_skip_149517 | 4.312678e-01 | 1.540537e-08 |
| TC | RBMS2 | exon_skip_172333 | -5.072551e-01 | 4.061877e-11 |
| TC | SRSF2 | exon_skip_172333 | 4.065321e-01 | 2.682178e-07 |
| TC | RBFOX2 | exon_skip_172333 | 5.099399e-01 | 3.082817e-11 |
| TC | MSI1 | exon_skip_172333 | -4.642844e-01 | 2.459602e-09 |
| TC | ELAVL4 | exon_skip_172333 | 5.142155e-01 | 1.977134e-11 |
| TC | RBM3 | exon_skip_172333 | 5.065890e-01 | 4.347921e-11 |
| TC | MATR3 | exon_skip_172333 | 4.714204e-01 | 1.293399e-09 |
| TC | KHDRBS2 | exon_skip_172333 | 5.257250e-01 | 5.796768e-12 |
| TC | RBM24 | exon_skip_172333 | 4.103078e-01 | 2.025792e-07 |
| TC | HNRNPA0 | exon_skip_172333 | 4.643906e-01 | 2.436444e-09 |
| TC | RBM45 | exon_skip_172333 | 4.286922e-01 | 4.911770e-08 |
| TC | HNRNPD | exon_skip_172333 | 4.603813e-01 | 3.474168e-09 |
| TC | NUP42 | exon_skip_172333 | 5.062977e-01 | 4.479039e-11 |
| TC | RALYL | exon_skip_172333 | 5.234898e-01 | 7.383108e-12 |
| TC | PTBP1 | exon_skip_172333 | -5.126367e-01 | 2.331225e-11 |
| TC | HNRNPH2 | exon_skip_172333 | 4.649349e-01 | 2.321051e-09 |
| TC | ESRP1 | exon_skip_172333 | 4.514790e-01 | 7.515733e-09 |
| TC | HNRNPF | exon_skip_172333 | -4.023331e-01 | 3.650010e-07 |
| TC | NOVA1 | exon_skip_172333 | 5.868567e-01 | 3.685975e-15 |
| TC | NOVA1 | exon_skip_264222 | 5.314443e-01 | 8.001747e-13 |
| TC | RBMS2 | exon_skip_155009 | -4.831176e-01 | 4.366017e-10 |
| TC | SRSF2 | exon_skip_155009 | 4.114174e-01 | 1.864165e-07 |
| TC | RBFOX2 | exon_skip_155009 | 4.905536e-01 | 2.142321e-10 |
| TC | MSI1 | exon_skip_155009 | -4.553601e-01 | 5.383324e-09 |
| TC | ELAVL4 | exon_skip_155009 | 4.997660e-01 | 8.657221e-11 |
| TC | RBM3 | exon_skip_155009 | 5.107649e-01 | 2.830964e-11 |
| TC | MATR3 | exon_skip_155009 | 4.659258e-01 | 2.124357e-09 |
| TC | KHDRBS2 | exon_skip_155009 | 5.096880e-01 | 3.163972e-11 |
| TC | HNRNPA0 | exon_skip_155009 | 4.585123e-01 | 4.092648e-09 |
| TC | HNRNPDL | exon_skip_155009 | 4.023022e-01 | 3.658245e-07 |
| TC | RBM45 | exon_skip_155009 | 4.277989e-01 | 5.272192e-08 |
| TC | HNRNPD | exon_skip_155009 | 4.640439e-01 | 2.512815e-09 |
| TC | NUP42 | exon_skip_155009 | 4.937066e-01 | 1.575861e-10 |
| TC | RALYL | exon_skip_155009 | 5.020924e-01 | 6.857040e-11 |
| TC | PTBP1 | exon_skip_155009 | -4.828519e-01 | 4.477104e-10 |
| TC | HNRNPH2 | exon_skip_155009 | 4.595720e-01 | 3.730039e-09 |
| TC | ESRP1 | exon_skip_155009 | 4.457073e-01 | 1.225092e-08 |
| TC | NOVA1 | exon_skip_155009 | 5.734786e-01 | 2.104691e-14 |
| TC | RBFOX2 | exon_skip_112319 | 5.394477e-01 | 1.838498e-13 |
| TC | NOVA1 | exon_skip_112319 | 4.750706e-01 | 2.190192e-10 |
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RelatedDrugs for PXK |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PXK |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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