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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for NCAPG2 |
 Gene summary |
| Gene information | Gene symbol | NCAPG2 | Gene ID | 54892 |
| Gene name | non-SMC condensin II complex subunit G2 | |
| Synonyms | 3KS|CAP-G2|CAPG2|LUZP5|MTB|hCAP-G2 | |
| Cytomap | 7q36.3 | |
| Type of gene | protein-coding | |
| Description | condensin-2 complex subunit G2chromosome-associated protein G2leucine zipper protein 5more than blood homolog | |
| Modification date | 20200320 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for NCAPG2 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000146918
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for NCAPG2 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_125841 | chr7 | 158658338:158658408:158662194:158662367:158664184:158664291 | 158662194:158662367 |
| exon_skip_128624 | chr7 | 158689819:158689953:158690568:158690722:158692842:158692956 | 158690568:158690722 |
| exon_skip_210581 | chr7 | 158701822:158701938:158703650:158703702:158704724:158704798 | 158703650:158703702 |
| exon_skip_21961 | chr7 | 158655118:158655258:158655339:158655455:158656260:158656433 | 158655339:158655455 |
| exon_skip_219861 | chr7 | 158658338:158658408:158662194:158662367:158664184:158664296 | 158662194:158662367 |
| exon_skip_236801 | chr7 | 158646460:158646563:158650832:158650972:158652293:158652480 | 158650832:158650972 |
| exon_skip_25967 | chr7 | 158646460:158646563:158650832:158650972:158652293:158652409 | 158650832:158650972 |
| exon_skip_285794 | chr7 | 158646460:158646563:158652293:158652480:158654595:158654694 | 158652293:158652480 |
| exon_skip_29357 | chr7 | 158683300:158683386:158686172:158686241:158687348:158687442 | 158686172:158686241 |
| exon_skip_997 | chr7 | 158664528:158664750:158668396:158668492:158671514:158671666 | 158668396:158668492 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for NCAPG2 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000409423 | 158703650 | 158703702 | 3UTR-3UTR |
| ENST00000356309 | 158690568 | 158690722 | Frame-shift |
| ENST00000409423 | 158690568 | 158690722 | Frame-shift |
| ENST00000356309 | 158650832 | 158650972 | In-frame |
| ENST00000409423 | 158650832 | 158650972 | In-frame |
| ENST00000356309 | 158655339 | 158655455 | In-frame |
| ENST00000409423 | 158655339 | 158655455 | In-frame |
| ENST00000356309 | 158662194 | 158662367 | In-frame |
| ENST00000409423 | 158662194 | 158662367 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000409423 | 158703650 | 158703702 | 3UTR-3UTR |
| ENST00000356309 | 158690568 | 158690722 | Frame-shift |
| ENST00000409423 | 158690568 | 158690722 | Frame-shift |
| ENST00000356309 | 158655339 | 158655455 | In-frame |
| ENST00000409423 | 158655339 | 158655455 | In-frame |
| ENST00000356309 | 158662194 | 158662367 | In-frame |
| ENST00000409423 | 158662194 | 158662367 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000409423 | 158703650 | 158703702 | 3UTR-3UTR |
| ENST00000356309 | 158686172 | 158686241 | Frame-shift |
| ENST00000409423 | 158686172 | 158686241 | Frame-shift |
| ENST00000356309 | 158690568 | 158690722 | Frame-shift |
| ENST00000409423 | 158690568 | 158690722 | Frame-shift |
| ENST00000356309 | 158650832 | 158650972 | In-frame |
| ENST00000409423 | 158650832 | 158650972 | In-frame |
| ENST00000356309 | 158655339 | 158655455 | In-frame |
| ENST00000409423 | 158655339 | 158655455 | In-frame |
| ENST00000356309 | 158662194 | 158662367 | In-frame |
| ENST00000409423 | 158662194 | 158662367 | In-frame |
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Infer the effects of exon skipping event on protein functional features for NCAPG2 |
p-ENSG00000146918_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000356309 | 3947 | 1143 | 158662194 | 158662367 | 1961 | 2133 | 605 | 662 |
| ENST00000409423 | 3974 | 1143 | 158662194 | 158662367 | 1989 | 2161 | 605 | 662 |
| ENST00000356309 | 3947 | 1143 | 158655339 | 158655455 | 2534 | 2649 | 796 | 834 |
| ENST00000409423 | 3974 | 1143 | 158655339 | 158655455 | 2562 | 2677 | 796 | 834 |
| ENST00000356309 | 3947 | 1143 | 158650832 | 158650972 | 3080 | 3219 | 978 | 1024 |
| ENST00000409423 | 3974 | 1143 | 158650832 | 158650972 | 3108 | 3247 | 978 | 1024 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000356309 | 3947 | 1143 | 158662194 | 158662367 | 1961 | 2133 | 605 | 662 |
| ENST00000409423 | 3974 | 1143 | 158662194 | 158662367 | 1989 | 2161 | 605 | 662 |
| ENST00000356309 | 3947 | 1143 | 158655339 | 158655455 | 2534 | 2649 | 796 | 834 |
| ENST00000409423 | 3974 | 1143 | 158655339 | 158655455 | 2562 | 2677 | 796 | 834 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000356309 | 3947 | 1143 | 158662194 | 158662367 | 1961 | 2133 | 605 | 662 |
| ENST00000409423 | 3974 | 1143 | 158662194 | 158662367 | 1989 | 2161 | 605 | 662 |
| ENST00000356309 | 3947 | 1143 | 158655339 | 158655455 | 2534 | 2649 | 796 | 834 |
| ENST00000409423 | 3974 | 1143 | 158655339 | 158655455 | 2562 | 2677 | 796 | 834 |
| ENST00000356309 | 3947 | 1143 | 158650832 | 158650972 | 3080 | 3219 | 978 | 1024 |
| ENST00000409423 | 3974 | 1143 | 158650832 | 158650972 | 3108 | 3247 | 978 | 1024 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q86XI2 | 605 | 662 | 1 | 1143 | Chain | ID=PRO_0000255942;Note=Condensin-2 complex subunit G2 |
| Q86XI2 | 605 | 662 | 1 | 1143 | Chain | ID=PRO_0000255942;Note=Condensin-2 complex subunit G2 |
| Q86XI2 | 796 | 834 | 1 | 1143 | Chain | ID=PRO_0000255942;Note=Condensin-2 complex subunit G2 |
| Q86XI2 | 796 | 834 | 1 | 1143 | Chain | ID=PRO_0000255942;Note=Condensin-2 complex subunit G2 |
| Q86XI2 | 796 | 834 | 805 | 805 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163 |
| Q86XI2 | 796 | 834 | 805 | 805 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163 |
| Q86XI2 | 978 | 1024 | 1 | 1143 | Chain | ID=PRO_0000255942;Note=Condensin-2 complex subunit G2 |
| Q86XI2 | 978 | 1024 | 1 | 1143 | Chain | ID=PRO_0000255942;Note=Condensin-2 complex subunit G2 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q86XI2 | 605 | 662 | 1 | 1143 | Chain | ID=PRO_0000255942;Note=Condensin-2 complex subunit G2 |
| Q86XI2 | 605 | 662 | 1 | 1143 | Chain | ID=PRO_0000255942;Note=Condensin-2 complex subunit G2 |
| Q86XI2 | 796 | 834 | 1 | 1143 | Chain | ID=PRO_0000255942;Note=Condensin-2 complex subunit G2 |
| Q86XI2 | 796 | 834 | 1 | 1143 | Chain | ID=PRO_0000255942;Note=Condensin-2 complex subunit G2 |
| Q86XI2 | 796 | 834 | 805 | 805 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163 |
| Q86XI2 | 796 | 834 | 805 | 805 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q86XI2 | 605 | 662 | 1 | 1143 | Chain | ID=PRO_0000255942;Note=Condensin-2 complex subunit G2 |
| Q86XI2 | 605 | 662 | 1 | 1143 | Chain | ID=PRO_0000255942;Note=Condensin-2 complex subunit G2 |
| Q86XI2 | 796 | 834 | 1 | 1143 | Chain | ID=PRO_0000255942;Note=Condensin-2 complex subunit G2 |
| Q86XI2 | 796 | 834 | 1 | 1143 | Chain | ID=PRO_0000255942;Note=Condensin-2 complex subunit G2 |
| Q86XI2 | 796 | 834 | 805 | 805 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163 |
| Q86XI2 | 796 | 834 | 805 | 805 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163 |
| Q86XI2 | 978 | 1024 | 1 | 1143 | Chain | ID=PRO_0000255942;Note=Condensin-2 complex subunit G2 |
| Q86XI2 | 978 | 1024 | 1 | 1143 | Chain | ID=PRO_0000255942;Note=Condensin-2 complex subunit G2 |
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3'-UTR located exon skipping events that lost miRNA binding sites in NCAPG2 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000409423 | 158703650 | 158703702 | hsa-miR-1914-5p | chr7:158703686-158703693 | 8mer-1a | chr7:158703676-158703696 | 161.00 | -24.33 |
| MSBB | ENST00000409423 | 158703650 | 158703702 | hsa-miR-1914-5p | chr7:158703686-158703693 | 8mer-1a | chr7:158703676-158703696 | 161.00 | -24.33 |
| ROSMAP | ENST00000409423 | 158703650 | 158703702 | hsa-miR-1914-5p | chr7:158703686-158703693 | 8mer-1a | chr7:158703676-158703696 | 161.00 | -24.33 |
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SNVs in the skipped exons for NCAPG2 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for NCAPG2 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NCAPG2 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for NCAPG2 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for NCAPG2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NCAPG2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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