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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for QRICH1 |
Gene summary |
Gene information | Gene symbol | QRICH1 | Gene ID | 54870 |
Gene name | glutamine rich 1 | |
Synonyms | AB-DIP|VERBRAS | |
Cytomap | 3p21.31 | |
Type of gene | protein-coding | |
Description | glutamine-rich protein 1 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for QRICH1 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for QRICH1 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_103279 | chr3 | 49033120:49033228:49044390:49044504:49046425:49046458 | 49044390:49044504 |
exon_skip_152706 | chr3 | 49076873:49077038:49092397:49092456:49093255:49093611 | 49092397:49092456 |
exon_skip_210568 | chr3 | 49076873:49077038:49092397:49092456:49093912:49094051 | 49092397:49092456 |
exon_skip_232121 | chr3 | 49030375:49030644:49032183:49032273:49032622:49032773 | 49032183:49032273 |
exon_skip_34152 | chr3 | 49047069:49047246:49056862:49057890:49076709:49077038 | 49056862:49057890 |
exon_skip_60202 | chr3 | 49076873:49077038:49092397:49092456:49093912:49093929 | 49092397:49092456 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for QRICH1 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000357496 | 49092397 | 49092456 | 3UTR-3UTR |
ENST00000424300 | 49092397 | 49092456 | 3UTR-3UTR |
ENST00000357496 | 49044390 | 49044504 | Frame-shift |
ENST00000395443 | 49044390 | 49044504 | Frame-shift |
ENST00000424300 | 49044390 | 49044504 | Frame-shift |
ENST00000357496 | 49056862 | 49057890 | In-frame |
ENST00000395443 | 49056862 | 49057890 | In-frame |
ENST00000424300 | 49056862 | 49057890 | In-frame |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000357496 | 49092397 | 49092456 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000357496 | 49092397 | 49092456 | 3UTR-3UTR |
ENST00000424300 | 49092397 | 49092456 | 3UTR-3UTR |
ENST00000357496 | 49032183 | 49032273 | Frame-shift |
ENST00000395443 | 49032183 | 49032273 | Frame-shift |
ENST00000424300 | 49032183 | 49032273 | Frame-shift |
ENST00000357496 | 49044390 | 49044504 | Frame-shift |
ENST00000395443 | 49044390 | 49044504 | Frame-shift |
ENST00000424300 | 49044390 | 49044504 | Frame-shift |
ENST00000357496 | 49056862 | 49057890 | In-frame |
ENST00000395443 | 49056862 | 49057890 | In-frame |
ENST00000424300 | 49056862 | 49057890 | In-frame |
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Infer the effects of exon skipping event on protein functional features for QRICH1 |
p-ENSG00000198218_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000357496 | 3100 | 776 | 49056862 | 49057890 | 542 | 1569 | 103 | 445 |
ENST00000395443 | 3566 | 776 | 49056862 | 49057890 | 783 | 1810 | 103 | 445 |
ENST00000424300 | 3026 | 776 | 49056862 | 49057890 | 748 | 1775 | 103 | 445 |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000357496 | 3100 | 776 | 49056862 | 49057890 | 542 | 1569 | 103 | 445 |
ENST00000395443 | 3566 | 776 | 49056862 | 49057890 | 783 | 1810 | 103 | 445 |
ENST00000424300 | 3026 | 776 | 49056862 | 49057890 | 748 | 1775 | 103 | 445 |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q2TAL8 | 103 | 445 | 1 | 776 | Chain | ID=PRO_0000269853;Note=Glutamine-rich protein 1 |
Q2TAL8 | 103 | 445 | 1 | 776 | Chain | ID=PRO_0000269853;Note=Glutamine-rich protein 1 |
Q2TAL8 | 103 | 445 | 1 | 776 | Chain | ID=PRO_0000269853;Note=Glutamine-rich protein 1 |
Q2TAL8 | 103 | 445 | 85 | 462 | Compositional bias | Note=Gln-rich |
Q2TAL8 | 103 | 445 | 85 | 462 | Compositional bias | Note=Gln-rich |
Q2TAL8 | 103 | 445 | 85 | 462 | Compositional bias | Note=Gln-rich |
Q2TAL8 | 103 | 445 | 353 | 353 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
Q2TAL8 | 103 | 445 | 353 | 353 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
Q2TAL8 | 103 | 445 | 353 | 353 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
Q2TAL8 | 103 | 445 | 358 | 358 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
Q2TAL8 | 103 | 445 | 358 | 358 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
Q2TAL8 | 103 | 445 | 358 | 358 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
Q2TAL8 | 103 | 445 | 345 | 345 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332 |
Q2TAL8 | 103 | 445 | 345 | 345 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332 |
Q2TAL8 | 103 | 445 | 345 | 345 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332 |
Q2TAL8 | 103 | 445 | 251 | 251 | Sequence conflict | Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Q2TAL8 | 103 | 445 | 251 | 251 | Sequence conflict | Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Q2TAL8 | 103 | 445 | 251 | 251 | Sequence conflict | Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q2TAL8 | 103 | 445 | 1 | 776 | Chain | ID=PRO_0000269853;Note=Glutamine-rich protein 1 |
Q2TAL8 | 103 | 445 | 1 | 776 | Chain | ID=PRO_0000269853;Note=Glutamine-rich protein 1 |
Q2TAL8 | 103 | 445 | 1 | 776 | Chain | ID=PRO_0000269853;Note=Glutamine-rich protein 1 |
Q2TAL8 | 103 | 445 | 85 | 462 | Compositional bias | Note=Gln-rich |
Q2TAL8 | 103 | 445 | 85 | 462 | Compositional bias | Note=Gln-rich |
Q2TAL8 | 103 | 445 | 85 | 462 | Compositional bias | Note=Gln-rich |
Q2TAL8 | 103 | 445 | 353 | 353 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
Q2TAL8 | 103 | 445 | 353 | 353 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
Q2TAL8 | 103 | 445 | 353 | 353 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
Q2TAL8 | 103 | 445 | 358 | 358 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
Q2TAL8 | 103 | 445 | 358 | 358 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
Q2TAL8 | 103 | 445 | 358 | 358 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
Q2TAL8 | 103 | 445 | 345 | 345 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332 |
Q2TAL8 | 103 | 445 | 345 | 345 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332 |
Q2TAL8 | 103 | 445 | 345 | 345 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332 |
Q2TAL8 | 103 | 445 | 251 | 251 | Sequence conflict | Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Q2TAL8 | 103 | 445 | 251 | 251 | Sequence conflict | Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Q2TAL8 | 103 | 445 | 251 | 251 | Sequence conflict | Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
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3'-UTR located exon skipping events that lost miRNA binding sites in QRICH1 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000424300 | 49092397 | 49092456 | hsa-miR-4511 | chr3:49092435-49092442 | 8mer-1a | chr3:49092429-49092449 | 147.00 | -12.82 |
Mayo | ENST00000424300 | 49092397 | 49092456 | hsa-miR-5000-3p | chr3:49092428-49092435 | 8mer-1a | chr3:49092415-49092435 | 168.00 | -25.58 |
Mayo | ENST00000424300 | 49092397 | 49092456 | hsa-miR-4436a | chr3:49092428-49092435 | 8mer-1a | chr3:49092415-49092435 | 168.00 | -25.58 |
MSBB | ENST00000357496 | 49092397 | 49092456 | hsa-miR-4511 | chr3:49092435-49092442 | 8mer-1a | chr3:49092429-49092449 | 147.00 | -12.82 |
MSBB | ENST00000357496 | 49092397 | 49092456 | hsa-miR-5000-3p | chr3:49092428-49092435 | 8mer-1a | chr3:49092415-49092435 | 168.00 | -25.58 |
MSBB | ENST00000357496 | 49092397 | 49092456 | hsa-miR-4436a | chr3:49092428-49092435 | 8mer-1a | chr3:49092415-49092435 | 168.00 | -25.58 |
ROSMAP | ENST00000424300 | 49092397 | 49092456 | hsa-miR-4511 | chr3:49092435-49092442 | 8mer-1a | chr3:49092429-49092449 | 147.00 | -12.82 |
ROSMAP | ENST00000424300 | 49092397 | 49092456 | hsa-miR-5000-3p | chr3:49092428-49092435 | 8mer-1a | chr3:49092415-49092435 | 168.00 | -25.58 |
ROSMAP | ENST00000424300 | 49092397 | 49092456 | hsa-miR-4436a | chr3:49092428-49092435 | 8mer-1a | chr3:49092415-49092435 | 168.00 | -25.58 |
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SNVs in the skipped exons for QRICH1 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for QRICH1 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for QRICH1 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for QRICH1 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | ZNF638 | exon_skip_103279 | -4.553479e-01 | 1.634255e-09 |
CB | TRA2A | exon_skip_103279 | -4.497897e-01 | 2.716802e-09 |
CB | NUP42 | exon_skip_103279 | 4.102530e-01 | 7.847542e-08 |
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RelatedDrugs for QRICH1 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for QRICH1 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |