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![]() | Open reading frame (ORF) annotation in the exon skipping event |
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![]() | 3'-UTR located exon skipping events lost miRNA binding sites |
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![]() | Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for MFSD6 |
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Gene information | Gene symbol | MFSD6 | Gene ID | 54842 |
Gene name | major facilitator superfamily domain containing 6 | |
Synonyms | MMR2|hMMR2 | |
Cytomap | 2q32.2 | |
Type of gene | protein-coding | |
Description | major facilitator superfamily domain-containing protein 6macrophage MHC class I receptor 2 homologmacrophage MHC receptor 2 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
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Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for MFSD6 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
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Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MFSD6 |
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Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_12137 | chr2 | 190415296:190415413:190433327:190433392:190435977:190436156 | 190433327:190433392 |
exon_skip_239878 | chr2 | 190415292:190415413:190433327:190433392:190435977:190436156 | 190433327:190433392 |
exon_skip_242070 | chr2 | 190408355:190408503:190415292:190415413:190435977:190436156 | 190415292:190415413 |
exon_skip_265630 | chr2 | 190497649:190497719:190499832:190499856:190500015:190500276 | 190499832:190499856 |
exon_skip_92457 | chr2 | 190408431:190408503:190415292:190415413:190435977:190436156 | 190415292:190415413 |
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Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
exon_skip_265630 | MSBB_PG | 6.134921e-01 | 7.550980e-01 | -1.416060e-01 | 4.028163e-03 |
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Open reading frame (ORF) annotation in the exon skipping event for MFSD6 |
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ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000392328 | 190415292 | 190415413 | 5UTR-5UTR |
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ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000392328 | 190415292 | 190415413 | 5UTR-5UTR |
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ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000392328 | 190415292 | 190415413 | 5UTR-5UTR |
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Infer the effects of exon skipping event on protein functional features for MFSD6 |
p-ENSG00000151690_img4.png![]() |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in MFSD6 |
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Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for MFSD6 |
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Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for MFSD6 |
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AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MFSD6 |
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Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for MFSD6 |
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Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | SRSF2 | exon_skip_265630 | 4.745878e-01 | 5.032125e-10 |
CB | NUP42 | exon_skip_265630 | 4.291263e-01 | 2.808134e-08 |
CB | SRSF9 | exon_skip_265630 | 4.865897e-01 | 1.571486e-10 |
HCC | DAZAP1 | exon_skip_265630 | -5.448336e-01 | 5.774670e-22 |
HCC | RBM5 | exon_skip_265630 | -5.637838e-01 | 1.018927e-23 |
HCC | EIF4G2 | exon_skip_265630 | -5.129460e-01 | 2.972155e-19 |
IFG | SRSF9 | exon_skip_192088 | 4.784175e-01 | 1.342515e-02 |
IFG | EIF4G2 | exon_skip_265630 | 4.270064e-01 | 2.343632e-02 |
IFG | SRSF9 | exon_skip_265630 | 4.130138e-01 | 2.893271e-02 |
TC | SRSF2 | exon_skip_265630 | 4.003650e-01 | 1.704543e-07 |
TC | NUP42 | exon_skip_265630 | 6.761939e-01 | 1.370472e-22 |
TC | EIF4G2 | exon_skip_265630 | 4.601123e-01 | 1.049382e-09 |
TC | SRSF9 | exon_skip_265630 | 4.434096e-01 | 4.815063e-09 |
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RelatedDrugs for MFSD6 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MFSD6 |
![]() (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |