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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TRPM7 |
 Gene summary |
| Gene information | Gene symbol | TRPM7 | Gene ID | 54822 |
| Gene name | transient receptor potential cation channel subfamily M member 7 | |
| Synonyms | ALSPDC|CHAK|CHAK1|LTRPC7|LTrpC-7|TRP-PLIK | |
| Cytomap | 15q21.2 | |
| Type of gene | protein-coding | |
| Description | transient receptor potential cation channel subfamily M member 7LTRPC ion channel family member 7channel-kinase 1long transient receptor potential channel 7transient receptor potential-phospholipase C-interacting kinase | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context | - 28870815(Activation of Transient Receptor Potential Melastatin 7 (TRPM7) Channel Increases Basal Autophagy and Reduces Amyloid β-peptide) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for TRPM7 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000092439
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | UP | ENST00000645282.1 | TRPM7-209:retained_intron:TRPM7 | 7.658169e+00 | 8.696543e-01 | 1.277503e-03 | 1.739172e-02 |
| CB | UP | ENST00000558444.5 | TRPM7-201:lncRNA:TRPM7 | 1.525794e+01 | 1.112747e+00 | 8.170103e-10 | 3.691981e-08 |
| CB | UP | ENST00000560955.5 | TRPM7-206:protein_coding:TRPM7 | 1.061825e+03 | 9.073577e-01 | 1.294050e-04 | 9.220772e-04 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TRPM7 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_103953 | chr15 | 50586392:50586488:50589592:50589656:50591911:50592038 | 50589592:50589656 |
| exon_skip_131931 | chr15 | 50604866:50605144:50607200:50607328:50609581:50609724 | 50607200:50607328 |
| exon_skip_158455 | chr15 | 50580874:50580908:50583089:50583156:50586392:50586488 | 50583089:50583156 |
| exon_skip_184544 | chr15 | 50594429:50594613:50596255:50596381:50599122:50599296 | 50596255:50596381 |
| exon_skip_210844 | chr15 | 50613707:50613841:50614123:50614263:50619745:50619798 | 50614123:50614263 |
| exon_skip_234123 | chr15 | 50611093:50611321:50612549:50612829:50613707:50613841 | 50612549:50612829 |
| exon_skip_235494 | chr15 | 50583089:50583159:50586392:50586488:50589592:50589655 | 50586392:50586488 |
| exon_skip_236473 | chr15 | 50624166:50624300:50628149:50628249:50631417:50631489 | 50628149:50628249 |
| exon_skip_24548 | chr15 | 50578639:50578664:50580874:50580908:50583089:50583156 | 50580874:50580908 |
| exon_skip_253658 | chr15 | 50632869:50632992:50634382:50634556:50637422:50637593 | 50634382:50634556 |
| exon_skip_253792 | chr15 | 50583089:50583156:50586392:50586488:50589592:50589656 | 50586392:50586488 |
| exon_skip_256371 | chr15 | 50637422:50637593:50639424:50639548:50643340:50643553 | 50639424:50639548 |
| exon_skip_284543 | chr15 | 50657781:50657819:50662967:50663046:50686531:50686771 | 50662967:50663046 |
| exon_skip_289308 | chr15 | 50575869:50575919:50578639:50578664:50580874:50580908 | 50578639:50578664 |
| exon_skip_32271 | chr15 | 50580874:50580908:50583089:50583156:50586392:50586487 | 50583089:50583156 |
| exon_skip_4827 | chr15 | 50634382:50634556:50637422:50637593:50639424:50639548 | 50637422:50637593 |
| exon_skip_51742 | chr15 | 50575869:50575919:50578559:50578664:50580874:50580908 | 50578559:50578664 |
| exon_skip_64482 | chr15 | 50580874:50580908:50583089:50583159:50586392:50586488 | 50583089:50583159 |
| exon_skip_64713 | chr15 | 50583089:50583159:50586392:50586488:50589592:50589656 | 50586392:50586488 |
| exon_skip_86113 | chr15 | 50594429:50594613:50596255:50596381:50599122:50599246 | 50596255:50596381 |
| exon_skip_9427 | chr15 | 50580874:50580908:50583089:50583159:50586392:50586487 | 50583089:50583159 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_138761 | Mayo_CB | 1.800000e-01 | 3.864407e-02 | 1.413559e-01 | 3.542607e-02 |
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Open reading frame (ORF) annotation in the exon skipping event for TRPM7 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000646667 | 50578639 | 50578664 | Frame-shift |
| ENST00000646667 | 50583089 | 50583159 | Frame-shift |
| ENST00000646667 | 50586392 | 50586488 | Frame-shift |
| ENST00000646667 | 50596255 | 50596381 | Frame-shift |
| ENST00000646667 | 50628149 | 50628249 | Frame-shift |
| ENST00000646667 | 50634382 | 50634556 | Frame-shift |
| ENST00000646667 | 50639424 | 50639548 | Frame-shift |
| ENST00000646667 | 50607200 | 50607328 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000646667 | 50578639 | 50578664 | Frame-shift |
| ENST00000646667 | 50583089 | 50583159 | Frame-shift |
| ENST00000646667 | 50586392 | 50586488 | Frame-shift |
| ENST00000646667 | 50589592 | 50589656 | Frame-shift |
| ENST00000646667 | 50596255 | 50596381 | Frame-shift |
| ENST00000646667 | 50628149 | 50628249 | Frame-shift |
| ENST00000646667 | 50634382 | 50634556 | Frame-shift |
| ENST00000646667 | 50639424 | 50639548 | Frame-shift |
| ENST00000646667 | 50662967 | 50663046 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000646667 | 50578639 | 50578664 | Frame-shift |
| ENST00000646667 | 50580874 | 50580908 | Frame-shift |
| ENST00000646667 | 50583089 | 50583159 | Frame-shift |
| ENST00000646667 | 50586392 | 50586488 | Frame-shift |
| ENST00000646667 | 50589592 | 50589656 | Frame-shift |
| ENST00000646667 | 50596255 | 50596381 | Frame-shift |
| ENST00000646667 | 50612549 | 50612829 | Frame-shift |
| ENST00000646667 | 50628149 | 50628249 | Frame-shift |
| ENST00000646667 | 50634382 | 50634556 | Frame-shift |
| ENST00000646667 | 50637422 | 50637593 | Frame-shift |
| ENST00000646667 | 50639424 | 50639548 | Frame-shift |
| ENST00000646667 | 50662967 | 50663046 | Frame-shift |
| ENST00000646667 | 50607200 | 50607328 | In-frame |
| ENST00000646667 | 50614123 | 50614263 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TRPM7 |
p-ENSG00000092439_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000646667 | 10399 | 1865 | 50607200 | 50607328 | 2845 | 2972 | 860 | 902 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000646667 | 10399 | 1865 | 50614123 | 50614263 | 1759 | 1898 | 498 | 544 |
| ENST00000646667 | 10399 | 1865 | 50607200 | 50607328 | 2845 | 2972 | 860 | 902 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q96QT4 | 860 | 902 | 1 | 1865 | Chain | ID=PRO_0000215331;Note=Transient receptor potential cation channel subfamily M member 7 |
| Q96QT4 | 860 | 902 | 877 | 918 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q96QT4 | 860 | 902 | 856 | 876 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q96QT4 | 498 | 544 | 1 | 1865 | Chain | ID=PRO_0000215331;Note=Transient receptor potential cation channel subfamily M member 7 |
| Q96QT4 | 498 | 544 | 1 | 755 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q96QT4 | 860 | 902 | 1 | 1865 | Chain | ID=PRO_0000215331;Note=Transient receptor potential cation channel subfamily M member 7 |
| Q96QT4 | 860 | 902 | 877 | 918 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q96QT4 | 860 | 902 | 856 | 876 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in TRPM7 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for TRPM7 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TRPM7 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TRPM7 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TRPM7 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | TRA2A | exon_skip_289308 | -5.423559e-01 | 6.349864e-13 |
| CB | TRA2A | exon_skip_158455 | -5.125641e-01 | 4.378915e-11 |
| CB | NUP42 | exon_skip_158455 | 5.257874e-01 | 1.114514e-11 |
| CB | TRA2A | exon_skip_64482 | -5.023854e-01 | 4.262156e-11 |
| CB | NUP42 | exon_skip_64482 | 4.839155e-01 | 2.686919e-10 |
| CB | PCBP4 | exon_skip_253792 | 5.212734e-01 | 2.104530e-11 |
| CB | TRA2A | exon_skip_253792 | -4.151385e-01 | 2.295496e-07 |
| CB | RBM45 | exon_skip_253792 | 6.131858e-01 | 3.096196e-16 |
| CB | NUP42 | exon_skip_253792 | 4.624783e-01 | 5.357268e-09 |
| CB | TARDBP | exon_skip_235494 | -4.129276e-01 | 1.663916e-07 |
| CB | CNOT4 | exon_skip_235494 | -4.339540e-01 | 3.223044e-08 |
| CB | PCBP4 | exon_skip_235494 | 4.450471e-01 | 1.294757e-08 |
| CB | TRA2A | exon_skip_235494 | -4.513743e-01 | 7.583231e-09 |
| CB | RBM45 | exon_skip_235494 | 5.740253e-01 | 1.963078e-14 |
| CB | NUP42 | exon_skip_235494 | 4.377604e-01 | 2.365674e-08 |
| CB | FUBP1 | exon_skip_236473 | -4.306602e-01 | 3.146665e-07 |
| CB | SRSF4 | exon_skip_236473 | -4.270308e-01 | 4.048401e-07 |
| CB | CNOT4 | exon_skip_256371 | -4.008725e-01 | 1.323528e-06 |
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RelatedDrugs for TRPM7 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRPM7 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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