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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TRIT1 |
 Gene summary |
| Gene information | Gene symbol | TRIT1 | Gene ID | 54802 |
| Gene name | tRNA isopentenyltransferase 1 | |
| Synonyms | COXPD35|GRO1|IPPT|IPT|IPTase|MOD5|hGRO1 | |
| Cytomap | 1p34.2 | |
| Type of gene | protein-coding | |
| Description | tRNA dimethylallyltransferaseIPP transferaseisopentenyl-diphosphate:tRNA isopentenyltransferasetRNA dimethylallyltransferase, mitochondrialtRNA isopentenylpyrophosphate transferase | |
| Modification date | 20200313 | |
| UniProtAcc | A0A3B3ITK2, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for TRIT1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000043514
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000541099.5 | TRIT1-215:protein_coding:TRIT1 | 5.398997e+00 | 1.368132e+00 | 1.375358e-03 | 6.750122e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TRIT1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_100863 | chr1 | 39844531:39844640:39847220:39847297:39847548:39847660 | 39847220:39847297 |
| exon_skip_165224 | chr1 | 39844531:39844640:39847548:39847660:39847986:39848091 | 39847548:39847660 |
| exon_skip_176485 | chr1 | 39844196:39844218:39844531:39844640:39847220:39847297 | 39844531:39844640 |
| exon_skip_176492 | chr1 | 39847986:39848097:39850123:39850261:39853970:39854068 | 39850123:39850261 |
| exon_skip_207458 | chr1 | 39844531:39844640:39847220:39847297:39847986:39848091 | 39847220:39847297 |
| exon_skip_225842 | chr1 | 39847986:39848097:39850119:39850261:39853970:39854068 | 39850119:39850261 |
| exon_skip_271652 | chr1 | 39844531:39844640:39847220:39847297:39847548:39847656 | 39847220:39847297 |
| exon_skip_281440 | chr1 | 39847281:39847297:39847548:39847660:39847986:39848091 | 39847548:39847660 |
| exon_skip_284839 | chr1 | 39850123:39850261:39852731:39852876:39853970:39854066 | 39852731:39852876 |
| exon_skip_291552 | chr1 | 39850123:39850261:39852731:39852876:39853970:39854068 | 39852731:39852876 |
| exon_skip_70004 | chr1 | 39847220:39847297:39847548:39847660:39847986:39848097 | 39847548:39847660 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TRIT1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000316891 | 39847548 | 39847660 | Frame-shift |
| ENST00000316891 | 39852731 | 39852876 | Frame-shift |
| ENST00000316891 | 39847220 | 39847297 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000316891 | 39847548 | 39847660 | Frame-shift |
| ENST00000316891 | 39852731 | 39852876 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000316891 | 39844531 | 39844640 | Frame-shift |
| ENST00000316891 | 39847548 | 39847660 | Frame-shift |
| ENST00000316891 | 39852731 | 39852876 | Frame-shift |
| ENST00000316891 | 39847220 | 39847297 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TRIT1 |
p-ENSG00000043514_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000316891 | 2129 | 467 | 39847220 | 39847297 | 944 | 1020 | 309 | 335 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000316891 | 2129 | 467 | 39847220 | 39847297 | 944 | 1020 | 309 | 335 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9H3H1 | 309 | 335 | 6 | 309 | Alternative sequence | ID=VSP_053747;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15870694;Dbxref=PMID:15870694 |
| Q9H3H1 | 309 | 335 | 311 | 336 | Alternative sequence | ID=VSP_010721;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11560893;Dbxref=PMID:11560893 |
| Q9H3H1 | 309 | 335 | 48 | 467 | Chain | ID=PRO_0000019023;Note=tRNA dimethylallyltransferase |
| Q9H3H1 | 309 | 335 | 8 | 467 | Natural variant | ID=VAR_080745;Note=In COXPD35. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28185376;Dbxref=PMID:28185376 |
| Q9H3H1 | 309 | 335 | 323 | 323 | Natural variant | ID=VAR_080748;Note=In COXPD35%3B reduced tRNA dimethylallyltransferase activity. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24901367;Dbxref=PMID:24901367 |
| Q9H3H1 | 309 | 335 | 313 | 331 | Region | Note=Interaction with substrate tRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q9H3H1 | 309 | 335 | 323 | 330 | Region | Note=Interaction with substrate tRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9H3H1 | 309 | 335 | 6 | 309 | Alternative sequence | ID=VSP_053747;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15870694;Dbxref=PMID:15870694 |
| Q9H3H1 | 309 | 335 | 311 | 336 | Alternative sequence | ID=VSP_010721;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11560893;Dbxref=PMID:11560893 |
| Q9H3H1 | 309 | 335 | 48 | 467 | Chain | ID=PRO_0000019023;Note=tRNA dimethylallyltransferase |
| Q9H3H1 | 309 | 335 | 8 | 467 | Natural variant | ID=VAR_080745;Note=In COXPD35. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28185376;Dbxref=PMID:28185376 |
| Q9H3H1 | 309 | 335 | 323 | 323 | Natural variant | ID=VAR_080748;Note=In COXPD35%3B reduced tRNA dimethylallyltransferase activity. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24901367;Dbxref=PMID:24901367 |
| Q9H3H1 | 309 | 335 | 313 | 331 | Region | Note=Interaction with substrate tRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q9H3H1 | 309 | 335 | 323 | 330 | Region | Note=Interaction with substrate tRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
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3'-UTR located exon skipping events that lost miRNA binding sites in TRIT1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for TRIT1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TRIT1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TRIT1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TRIT1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | RBM4 | exon_skip_265732 | -4.070926e-01 | 6.330398e-06 |
| CB | RBM45 | exon_skip_284839 | 4.160775e-01 | 6.329307e-07 |
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RelatedDrugs for TRIT1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRIT1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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