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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for PPARG |
 Gene summary |
| Gene information | Gene symbol | PPARG | Gene ID | 5468 |
| Gene name | peroxisome proliferator activated receptor gamma | |
| Synonyms | CIMT1|GLM1|NR1C3|PPARG1|PPARG2|PPARgamma | |
| Cytomap | 3p25.2 | |
| Type of gene | protein-coding | |
| Description | peroxisome proliferator-activated receptor gammaPPAR-gammanuclear receptor subfamily 1 group C member 3peroxisome proliferator-activated nuclear receptor gamma variant 1 | |
| Modification date | 20200329 | |
| UniProtAcc | A0A0S2Z4K5, A0A3P3ZKM0, A0A494C012, A0A494C0D9, A0A494C0T3, A0A494C1F9, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| PPARG | GO:0000122 | negative regulation of transcription by RNA polymerase II | 12700342 |
| PPARG | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 18293083 |
| PPARG | GO:0007165 | signal transduction | 9568716 |
| PPARG | GO:0010742 | macrophage derived foam cell differentiation | 26504087 |
| PPARG | GO:0010745 | negative regulation of macrophage derived foam cell differentiation | 19114110 |
| PPARG | GO:0010871 | negative regulation of receptor biosynthetic process | 12700342 |
| PPARG | GO:0010887 | negative regulation of cholesterol storage | 19114110 |
| PPARG | GO:0010891 | negative regulation of sequestering of triglyceride | 12700342 |
| PPARG | GO:0016525 | negative regulation of angiogenesis | 28566713 |
| PPARG | GO:0030224 | monocyte differentiation | 9568716 |
| PPARG | GO:0032526 | response to retinoic acid | 16239304 |
| PPARG | GO:0042953 | lipoprotein transport | 9568716 |
| PPARG | GO:0043537 | negative regulation of blood vessel endothelial cell migration | 28566713 |
| PPARG | GO:0045713 | low-density lipoprotein particle receptor biosynthetic process | 9568716 |
| PPARG | GO:0045944 | positive regulation of transcription by RNA polymerase II | 9568715|12700342|16239304|17611579 |
| PPARG | GO:0048469 | cell maturation | 9568716 |
| PPARG | GO:0048662 | negative regulation of smooth muscle cell proliferation | 20622039 |
| PPARG | GO:0051091 | positive regulation of DNA-binding transcription factor activity | 18293083 |
| PPARG | GO:0061614 | pri-miRNA transcription by RNA polymerase II | 28566713 |
| PPARG | GO:0071404 | cellular response to low-density lipoprotein particle stimulus | 9568716 |
| PPARG | GO:1904706 | negative regulation of vascular smooth muscle cell proliferation | 28522568 |
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Gene structures and expression levels for PPARG |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000132170
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for PPARG |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_143629 | chr3 | 12392614:12392752:12399348:12399490:12405882:12406081 | 12399348:12399490 |
| exon_skip_149465 | chr3 | 12287884:12288020:12312380:12312453:12379704:12379902 | 12312380:12312453 |
| exon_skip_159016 | chr3 | 12405882:12406081:12416704:12417154:12433898:12433903 | 12416704:12417154 |
| exon_skip_174851 | chr3 | 12392614:12392752:12405882:12406081:12416704:12417102 | 12405882:12406081 |
| exon_skip_289980 | chr3 | 12287884:12288020:12312380:12312453:12379704:12379931 | 12312380:12312453 |
| exon_skip_48405 | chr3 | 12405882:12406081:12416704:12417154:12433898:12433915 | 12416704:12417154 |
| exon_skip_71136 | chr3 | 12287850:12288020:12312380:12312453:12379704:12379931 | 12312380:12312453 |
| exon_skip_86546 | chr3 | 12312380:12312453:12379704:12379931:12381322:12381491 | 12379704:12379931 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for PPARG |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000287820 | 12416704 | 12417154 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000287820 | 12416704 | 12417154 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000287820 | 12405882 | 12406081 | Frame-shift |
| ENST00000287820 | 12416704 | 12417154 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for PPARG |
p-ENSG00000132170_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in PPARG |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for PPARG |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for PPARG |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PPARG |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for PPARG |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for PPARG |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P37231 | approved | DB00244 | Mesalazine | small molecule | P37231 |
| P37231 | approved|investigational | DB00313 | Valproic Acid | small molecule | P37231 |
| P37231 | approved|investigational | DB00328 | Indometacin | small molecule | P37231 |
| P37231 | approved|investigational | DB00412 | Rosiglitazone | small molecule | P37231 |
| P37231 | approved | DB00573 | Fenoprofen | small molecule | P37231 |
| P37231 | approved|investigational | DB00731 | Nateglinide | small molecule | P37231 |
| P37231 | approved | DB00795 | Sulfasalazine | small molecule | P37231 |
| P37231 | approved|investigational | DB00912 | Repaglinide | small molecule | P37231 |
| P37231 | approved|investigational | DB00966 | Telmisartan | small molecule | P37231 |
| P37231 | approved|investigational | DB01014 | Balsalazide | small molecule | P37231 |
| P37231 | approved | DB01039 | Fenofibrate | small molecule | P37231 |
| P37231 | approved | DB01050 | Ibuprofen | small molecule | P37231 |
| P37231 | approved|investigational | DB01067 | Glipizide | small molecule | P37231 |
| P37231 | approved|investigational | DB01118 | Amiodarone | small molecule | P37231 |
| P37231 | approved|investigational | DB01132 | Pioglitazone | small molecule | P37231 |
| P37231 | approved|investigational | DB01393 | Bezafibrate | small molecule | P37231 |
| P37231 | approved | DB02266 | Flufenamic Acid | small molecule | P37231 |
| P37231 | approved|investigational | DB08604 | Triclosan | small molecule | P37231 |
| P37231 | approved|investigational | DB09061 | Cannabidiol | small molecule | P37231 |
| P37231 | approved|investigational | DB09213 | Dexibuprofen | small molecule | P37231 |
| P37231 | approved | DB13873 | Fenofibric acid | small molecule | P37231 |
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RelatedDiseases for PPARG |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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