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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for PPARA |
 Gene summary |
| Gene information | Gene symbol | PPARA | Gene ID | 5465 |
| Gene name | peroxisome proliferator activated receptor alpha | |
| Synonyms | NR1C1|PPAR|PPARalpha|hPPAR | |
| Cytomap | 22q13.31 | |
| Type of gene | protein-coding | |
| Description | peroxisome proliferator-activated receptor alphaPPAR-alphanuclear receptor subfamily 1 group C member 1peroxisome proliferative activated receptor, alphaperoxisome proliferator-activated nuclear receptor alpha variant 3 | |
| Modification date | 20200329 | |
| UniProtAcc | ||
| Context | - 26118928(HMG-CoA Reductase Inhibitors Bind to PPARalpha to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| PPARA | GO:0000122 | negative regulation of transcription by RNA polymerase II | 9748239|12700342 |
| PPARA | GO:0010565 | regulation of cellular ketone metabolic process | 19955185 |
| PPARA | GO:0010745 | negative regulation of macrophage derived foam cell differentiation | 19114110 |
| PPARA | GO:0010871 | negative regulation of receptor biosynthetic process | 12700342 |
| PPARA | GO:0010887 | negative regulation of cholesterol storage | 19114110 |
| PPARA | GO:0010891 | negative regulation of sequestering of triglyceride | 12700342 |
| PPARA | GO:0019217 | regulation of fatty acid metabolic process | 19955185 |
| PPARA | GO:0045820 | negative regulation of glycolytic process | 19955185 |
| PPARA | GO:0045893 | positive regulation of transcription, DNA-templated | 12955147 |
| PPARA | GO:0045944 | positive regulation of transcription by RNA polymerase II | 9748239|19955185|20837115 |
| PPARA | GO:0050728 | negative regulation of inflammatory response | 21636785 |
| PPARA | GO:1902894 | negative regulation of pri-miRNA transcription by RNA polymerase II | 21636785 |
| PPARA | GO:1903038 | negative regulation of leukocyte cell-cell adhesion | 21636785 |
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Gene structures and expression levels for PPARA |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000186951
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | UP | ENST00000262735.9 | PPARA-201:protein_coding:PPARA | 3.771893e+02 | 9.285000e-01 | 1.121434e-04 | 2.987945e-03 |
| PG | UP | ENST00000481567.5 | PPARA-208:lncRNA:PPARA | 1.139662e+00 | 9.650340e-01 | 1.424756e-03 | 1.879503e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for PPARA |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_198049 | chr22 | 46176766:46176836:46188723:46188822:46198345:46198410 | 46188723:46188822 |
| exon_skip_246412 | chr22 | 46218263:46218401:46219812:46220014:46231792:46232239 | 46219812:46220014 |
| exon_skip_33278 | chr22 | 46151888:46151970:46176753:46176836:46198342:46198591 | 46176753:46176836 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for PPARA |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000407236 | 46176753 | 46176836 | 5UTR-5UTR |
| ENST00000262735 | 46219812 | 46220014 | Frame-shift |
| ENST00000402126 | 46219812 | 46220014 | Frame-shift |
| ENST00000407236 | 46219812 | 46220014 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000407236 | 46176753 | 46176836 | 5UTR-5UTR |
| ENST00000262735 | 46219812 | 46220014 | Frame-shift |
| ENST00000402126 | 46219812 | 46220014 | Frame-shift |
| ENST00000407236 | 46219812 | 46220014 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000407236 | 46176753 | 46176836 | 5UTR-5UTR |
| ENST00000262735 | 46219812 | 46220014 | Frame-shift |
| ENST00000402126 | 46219812 | 46220014 | Frame-shift |
| ENST00000407236 | 46219812 | 46220014 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for PPARA |
p-ENSG00000186951_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in PPARA |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for PPARA |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for PPARA |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PPARA |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for PPARA |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for PPARA |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Q07869 | approved|investigational | DB00313 | Valproic Acid | small molecule | Q07869 |
| Q07869 | approved|investigational | DB00328 | Indometacin | small molecule | Q07869 |
| Q07869 | approved|investigational | DB00412 | Rosiglitazone | small molecule | Q07869 |
| Q07869 | approved | DB00573 | Fenoprofen | small molecule | Q07869 |
| Q07869 | approved|investigational | DB00636 | Clofibrate | small molecule | Q07869 |
| Q07869 | approved | DB01039 | Fenofibrate | small molecule | Q07869 |
| Q07869 | approved | DB01050 | Ibuprofen | small molecule | Q07869 |
| Q07869 | approved|investigational | DB01132 | Pioglitazone | small molecule | Q07869 |
| Q07869 | approved | DB01241 | Gemfibrozil | small molecule | Q07869 |
| Q07869 | approved|investigational | DB01393 | Bezafibrate | small molecule | Q07869 |
| Q07869 | approved|investigational|nutraceutical | DB01708 | Prasterone | small molecule | Q07869 |
| Q07869 | approved | DB02266 | Flufenamic Acid | small molecule | Q07869 |
| Q07869 | approved|investigational | DB09064 | Ciprofibrate | small molecule | Q07869 |
| Q07869 | approved|investigational | DB09213 | Dexibuprofen | small molecule | Q07869 |
| Q07869 | approved | DB13873 | Fenofibric acid | small molecule | Q07869 |
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RelatedDiseases for PPARA |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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