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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for SDK2 |
 Gene summary |
| Gene information | Gene symbol | SDK2 | Gene ID | 54549 |
| Gene name | sidekick cell adhesion molecule 2 | |
| Synonyms | - | |
| Cytomap | 17q25.1 | |
| Type of gene | protein-coding | |
| Description | protein sidekick-2sidekick homolog 2 | |
| Modification date | 20200313 | |
| UniProtAcc | H7C2P2, Q58EX2, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for SDK2 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000069188
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for SDK2 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_20433 | chr17 | 73379448:73379549:73380894:73380950:73383876:73384011 | 73380894:73380950 |
| exon_skip_208021 | chr17 | 73361684:73361845:73365258:73365395:73368407:73368593 | 73365258:73365395 |
| exon_skip_53822 | chr17 | 73437739:73437822:73437964:73438154:73440812:73440923 | 73437964:73438154 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for SDK2 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000392650 | 73437964 | 73438154 | Frame-shift |
| ENST00000392650 | 73365258 | 73365395 | In-frame |
| ENST00000392650 | 73380894 | 73380950 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000392650 | 73380894 | 73380950 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000392650 | 73437964 | 73438154 | Frame-shift |
| ENST00000392650 | 73365258 | 73365395 | In-frame |
| ENST00000392650 | 73380894 | 73380950 | In-frame |
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Infer the effects of exon skipping event on protein functional features for SDK2 |
p-ENSG00000069188_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000392650 | 10740 | 2172 | 73380894 | 73380950 | 4707 | 4762 | 1568 | 1587 |
| ENST00000392650 | 10740 | 2172 | 73365258 | 73365395 | 5169 | 5305 | 1722 | 1768 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000392650 | 10740 | 2172 | 73380894 | 73380950 | 4707 | 4762 | 1568 | 1587 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000392650 | 10740 | 2172 | 73380894 | 73380950 | 4707 | 4762 | 1568 | 1587 |
| ENST00000392650 | 10740 | 2172 | 73365258 | 73365395 | 5169 | 5305 | 1722 | 1768 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q58EX2 | 1568 | 1587 | 1569 | 1588 | Alternative sequence | ID=VSP_017522;Note=In isoform 3. SMYSMRNLSRPSLTQYELDN->Y;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q58EX2 | 1568 | 1587 | 21 | 2172 | Chain | ID=PRO_0000226978;Note=Protein sidekick-2 |
| Q58EX2 | 1568 | 1587 | 1504 | 1621 | Domain | Note=Fibronectin type-III 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316 |
| Q58EX2 | 1568 | 1587 | 21 | 1932 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q58EX2 | 1722 | 1768 | 21 | 2172 | Chain | ID=PRO_0000226978;Note=Protein sidekick-2 |
| Q58EX2 | 1722 | 1768 | 1626 | 1722 | Domain | Note=Fibronectin type-III 11;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316 |
| Q58EX2 | 1722 | 1768 | 1726 | 1821 | Domain | Note=Fibronectin type-III 12;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316 |
| Q58EX2 | 1722 | 1768 | 21 | 1932 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q58EX2 | 1568 | 1587 | 1569 | 1588 | Alternative sequence | ID=VSP_017522;Note=In isoform 3. SMYSMRNLSRPSLTQYELDN->Y;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q58EX2 | 1568 | 1587 | 21 | 2172 | Chain | ID=PRO_0000226978;Note=Protein sidekick-2 |
| Q58EX2 | 1568 | 1587 | 1504 | 1621 | Domain | Note=Fibronectin type-III 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316 |
| Q58EX2 | 1568 | 1587 | 21 | 1932 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q58EX2 | 1568 | 1587 | 1569 | 1588 | Alternative sequence | ID=VSP_017522;Note=In isoform 3. SMYSMRNLSRPSLTQYELDN->Y;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q58EX2 | 1568 | 1587 | 21 | 2172 | Chain | ID=PRO_0000226978;Note=Protein sidekick-2 |
| Q58EX2 | 1568 | 1587 | 1504 | 1621 | Domain | Note=Fibronectin type-III 10;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316 |
| Q58EX2 | 1568 | 1587 | 21 | 1932 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q58EX2 | 1722 | 1768 | 21 | 2172 | Chain | ID=PRO_0000226978;Note=Protein sidekick-2 |
| Q58EX2 | 1722 | 1768 | 1626 | 1722 | Domain | Note=Fibronectin type-III 11;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316 |
| Q58EX2 | 1722 | 1768 | 1726 | 1821 | Domain | Note=Fibronectin type-III 12;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316 |
| Q58EX2 | 1722 | 1768 | 21 | 1932 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in SDK2 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for SDK2 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for SDK2 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SDK2 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for SDK2 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for SDK2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SDK2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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