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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for SMOX |
 Gene summary |
| Gene information | Gene symbol | SMOX | Gene ID | 54498 |
| Gene name | spermine oxidase | |
| Synonyms | C20orf16|PAO|PAO-1|PAO1|PAOH|PAOH1|SMO | |
| Cytomap | 20p13 | |
| Type of gene | protein-coding | |
| Description | spermine oxidaseflavin containing amine oxidaseflavin-containing spermine oxidasepolyamine oxidase 1putative cyclin G1 interacting protein | |
| Modification date | 20200313 | |
| UniProtAcc | Q5TE25, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| SMOX | GO:0006598 | polyamine catabolic process | 12477380 |
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Gene structures and expression levels for SMOX |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000088826
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PCC | UP | ENST00000486998.5 | SMOX-209:lncRNA:SMOX | 2.172614e+01 | 1.207220e+00 | 7.713968e-05 | 5.122707e-03 |
| CB | DOWN | ENST00000486998.5 | SMOX-209:lncRNA:SMOX | 4.834865e+01 | -2.493201e+00 | 2.462939e-03 | 1.095283e-02 |
| CB | DOWN | ENST00000457205.1 | SMOX-206:protein_coding:SMOX | 2.442223e+01 | -1.260048e+00 | 2.607041e-03 | 1.148239e-02 |
| TC | DOWN | ENST00000486998.5 | SMOX-209:lncRNA:SMOX | 4.701853e+01 | -3.409151e+00 | 1.506592e-04 | 2.234162e-03 |
| TC | DOWN | ENST00000457205.1 | SMOX-206:protein_coding:SMOX | 3.102826e+01 | -8.673469e-01 | 7.188417e-03 | 4.388274e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for SMOX |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_116467 | chr20 | 4183583:4183654:4186743:4186832:4187270:4187727 | 4186743:4186832 |
| exon_skip_11833 | chr20 | 4183494:4183654:4186743:4186832:4187270:4187746 | 4186743:4186832 |
| exon_skip_202990 | chr20 | 4175030:4175263:4176046:4176163:4177351:4177407 | 4176046:4176163 |
| exon_skip_203247 | chr20 | 4181894:4181976:4182089:4182848:4183494:4183654 | 4182089:4182848 |
| exon_skip_285752 | chr20 | 4183494:4183654:4186743:4186832:4187270:4187727 | 4186743:4186832 |
| exon_skip_289044 | chr20 | 4175030:4175263:4176046:4176163:4177351:4177577 | 4176046:4176163 |
| exon_skip_292745 | chr20 | 4181894:4181976:4182089:4182323:4182483:4182495 | 4182089:4182323 |
| exon_skip_296128 | chr20 | 4183583:4183654:4186743:4186832:4187270:4187341 | 4186743:4186832 |
| exon_skip_33645 | chr20 | 4181894:4181976:4182089:4182323:4182483:4182848 | 4182089:4182323 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for SMOX |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000305958 | 4182089 | 4182848 | Frame-shift |
| ENST00000379460 | 4182089 | 4182848 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000305958 | 4182089 | 4182848 | Frame-shift |
| ENST00000379460 | 4182089 | 4182848 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for SMOX |
p-ENSG00000088826_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in SMOX |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for SMOX |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for SMOX |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SMOX |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for SMOX |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for SMOX |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SMOX |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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