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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for SLC37A1 |
 Gene summary |
| Gene information | Gene symbol | SLC37A1 | Gene ID | 54020 |
| Gene name | solute carrier family 37 member 1 | |
| Synonyms | G3PP | |
| Cytomap | 21q22.3 | |
| Type of gene | protein-coding | |
| Description | glucose-6-phosphate exchanger SLC37A1G-3-P permeaseG-3-P transporterglycerol-3-phosphate permeaseglycerol-3-phosphate transportersolute carrier family 37 (glucose-6-phosphate transporter), member 1solute carrier family 37 (glycerol-3-phosphate trans | |
| Modification date | 20200313 | |
| UniProtAcc | A0A0C4DG69, P57057, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| SLC37A1 | GO:0015760 | glucose-6-phosphate transport | 21949678 |
| SLC37A1 | GO:0035435 | phosphate ion transmembrane transport | 21949678 |
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Gene structures and expression levels for SLC37A1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000160190
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for SLC37A1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_10986 | chr21 | 42525776:42525857:42534698:42534830:42535472:42535550 | 42534698:42534830 |
| exon_skip_135729 | chr21 | 42554062:42554142:42558958:42559089:42562078:42562168 | 42558958:42559089 |
| exon_skip_145306 | chr21 | 42568360:42568438:42574818:42574915:42579736:42579800 | 42574818:42574915 |
| exon_skip_154261 | chr21 | 42513892:42513924:42514631:42514717:42518277:42518510 | 42514631:42514717 |
| exon_skip_185525 | chr21 | 42514631:42514717:42514870:42514935:42518277:42518510 | 42514870:42514935 |
| exon_skip_221193 | chr21 | 42574818:42574915:42579736:42579800:42580345:42581426 | 42579736:42579800 |
| exon_skip_226600 | chr21 | 42542404:42542480:42543436:42543602:42547103:42547140 | 42543436:42543602 |
| exon_skip_264415 | chr21 | 42539512:42539647:42542404:42542480:42543436:42543602 | 42542404:42542480 |
| exon_skip_67882 | chr21 | 42563815:42563877:42564708:42564793:42565827:42565875 | 42564708:42564793 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for SLC37A1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000352133 | 42564708 | 42564793 | Frame-shift |
| ENST00000398341 | 42564708 | 42564793 | Frame-shift |
| ENST00000352133 | 42574818 | 42574915 | Frame-shift |
| ENST00000398341 | 42574818 | 42574915 | Frame-shift |
| ENST00000352133 | 42579736 | 42579800 | Frame-shift |
| ENST00000398341 | 42579736 | 42579800 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000352133 | 42564708 | 42564793 | Frame-shift |
| ENST00000398341 | 42564708 | 42564793 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000352133 | 42534698 | 42534830 | Frame-shift |
| ENST00000398341 | 42534698 | 42534830 | Frame-shift |
| ENST00000352133 | 42542404 | 42542480 | Frame-shift |
| ENST00000398341 | 42542404 | 42542480 | Frame-shift |
| ENST00000352133 | 42543436 | 42543602 | Frame-shift |
| ENST00000398341 | 42543436 | 42543602 | Frame-shift |
| ENST00000352133 | 42564708 | 42564793 | Frame-shift |
| ENST00000398341 | 42564708 | 42564793 | Frame-shift |
| ENST00000352133 | 42574818 | 42574915 | Frame-shift |
| ENST00000398341 | 42574818 | 42574915 | Frame-shift |
| ENST00000352133 | 42579736 | 42579800 | Frame-shift |
| ENST00000398341 | 42579736 | 42579800 | Frame-shift |
| ENST00000352133 | 42558958 | 42559089 | In-frame |
| ENST00000398341 | 42558958 | 42559089 | In-frame |
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Infer the effects of exon skipping event on protein functional features for SLC37A1 |
p-ENSG00000160190_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000352133 | 3681 | 533 | 42558958 | 42559089 | 1833 | 1963 | 283 | 327 |
| ENST00000398341 | 3111 | 533 | 42558958 | 42559089 | 1263 | 1393 | 283 | 327 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P57057 | 283 | 327 | 1 | 533 | Chain | ID=PRO_0000199890;Note=Glucose-6-phosphate exchanger SLC37A1 |
| P57057 | 283 | 327 | 1 | 533 | Chain | ID=PRO_0000199890;Note=Glucose-6-phosphate exchanger SLC37A1 |
| P57057 | 283 | 327 | 303 | 303 | Sequence conflict | Note=H->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P57057 | 283 | 327 | 303 | 303 | Sequence conflict | Note=H->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P57057 | 283 | 327 | 304 | 324 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P57057 | 283 | 327 | 304 | 324 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in SLC37A1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for SLC37A1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for SLC37A1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SLC37A1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for SLC37A1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | RBM4 | exon_skip_221193 | -4.852126e-01 | 1.367719e-10 |
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RelatedDrugs for SLC37A1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC37A1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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