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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ADAM22 |
 Gene summary |
| Gene information | Gene symbol | ADAM22 | Gene ID | 53616 |
| Gene name | ADAM metallopeptidase domain 22 | |
| Synonyms | ADAM 22|EIEE61|MDC2 | |
| Cytomap | 7q21.12 | |
| Type of gene | protein-coding | |
| Description | disintegrin and metalloproteinase domain-containing protein 22a disintegrin and metalloproteinase domain 22metalloproteinase-disintegrin ADAM22-3metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ADAM22 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000008277
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ADAM22 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_112294 | chr7 | 88114584:88114647:88116745:88116814:88125589:88125659 | 88116745:88116814 |
| exon_skip_115460 | chr7 | 88125589:88125659:88128602:88128676:88130388:88130439 | 88128602:88128676 |
| exon_skip_118061 | chr7 | 88182005:88182024:88193116:88193239:88196471:88196491 | 88193116:88193239 |
| exon_skip_123970 | chr7 | 88182005:88182024:88184292:88184402:88186615:88186701 | 88184292:88184402 |
| exon_skip_146157 | chr7 | 88168137:88168227:88171544:88171561:88178935:88179042 | 88171544:88171561 |
| exon_skip_14977 | chr7 | 88184292:88184402:88186615:88186701:88193116:88193239 | 88186615:88186701 |
| exon_skip_157589 | chr7 | 88131269:88131435:88132867:88132951:88134329:88134419 | 88132867:88132951 |
| exon_skip_165125 | chr7 | 88186615:88186701:88193116:88193239:88196471:88196491 | 88193116:88193239 |
| exon_skip_16905 | chr7 | 87935029:87935186:87964634:87964684:87978336:87978412 | 87964634:87964684 |
| exon_skip_185104 | chr7 | 87935029:87935186:87978336:87978412:88075626:88075692 | 87978336:87978412 |
| exon_skip_190149 | chr7 | 88130388:88130459:88131269:88131435:88132867:88132951 | 88131269:88131435 |
| exon_skip_19543 | chr7 | 88181505:88181605:88181958:88182024:88193116:88193239 | 88181958:88182024 |
| exon_skip_228563 | chr7 | 88151257:88151320:88153221:88153326:88155887:88156006 | 88153221:88153326 |
| exon_skip_291160 | chr7 | 88182005:88182024:88186615:88186701:88193116:88193239 | 88186615:88186701 |
| exon_skip_294423 | chr7 | 88168137:88168227:88171544:88171561:88181505:88181605 | 88171544:88171561 |
| exon_skip_5127 | chr7 | 88171544:88171561:88178935:88179042:88181505:88181605 | 88178935:88179042 |
| exon_skip_52912 | chr7 | 88135980:88136031:88143026:88143125:88145125:88145196 | 88143026:88143125 |
| exon_skip_61892 | chr7 | 88132867:88132951:88134329:88134419:88135980:88136031 | 88134329:88134419 |
| exon_skip_98125 | chr7 | 88171544:88171561:88178935:88179129:88181505:88181605 | 88178935:88179129 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_5127 | Mayo_TC | 2.193671e-01 | 3.693651e-01 | -1.499980e-01 | 5.939621e-06 |
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Open reading frame (ORF) annotation in the exon skipping event for ADAM22 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000265727 | 87978336 | 87978412 | Frame-shift |
| ENST00000265727 | 88116745 | 88116814 | Frame-shift |
| ENST00000265727 | 88134329 | 88134419 | Frame-shift |
| ENST00000265727 | 88143026 | 88143125 | Frame-shift |
| ENST00000265727 | 88153221 | 88153326 | Frame-shift |
| ENST00000265727 | 88193116 | 88193239 | Frame-shift |
| ENST00000265727 | 88128602 | 88128676 | In-frame |
| ENST00000265727 | 88171544 | 88171561 | In-frame |
| ENST00000265727 | 88178935 | 88179042 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000265727 | 87978336 | 87978412 | Frame-shift |
| ENST00000265727 | 88116745 | 88116814 | Frame-shift |
| ENST00000265727 | 88132867 | 88132951 | Frame-shift |
| ENST00000265727 | 88134329 | 88134419 | Frame-shift |
| ENST00000265727 | 88153221 | 88153326 | Frame-shift |
| ENST00000265727 | 88193116 | 88193239 | Frame-shift |
| ENST00000265727 | 88128602 | 88128676 | In-frame |
| ENST00000265727 | 88171544 | 88171561 | In-frame |
| ENST00000265727 | 88178935 | 88179042 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000265727 | 88116745 | 88116814 | Frame-shift |
| ENST00000265727 | 88131269 | 88131435 | Frame-shift |
| ENST00000265727 | 88132867 | 88132951 | Frame-shift |
| ENST00000265727 | 88134329 | 88134419 | Frame-shift |
| ENST00000265727 | 88153221 | 88153326 | Frame-shift |
| ENST00000265727 | 88181958 | 88182024 | Frame-shift |
| ENST00000265727 | 88193116 | 88193239 | Frame-shift |
| ENST00000265727 | 88128602 | 88128676 | In-frame |
| ENST00000265727 | 88171544 | 88171561 | In-frame |
| ENST00000265727 | 88178935 | 88179042 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ADAM22 |
p-ENSG00000008277_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000265727 | 2908 | 906 | 88128602 | 88128676 | 759 | 832 | 226 | 251 |
| ENST00000265727 | 2908 | 906 | 88178935 | 88179042 | 2381 | 2487 | 767 | 802 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000265727 | 2908 | 906 | 88128602 | 88128676 | 759 | 832 | 226 | 251 |
| ENST00000265727 | 2908 | 906 | 88178935 | 88179042 | 2381 | 2487 | 767 | 802 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000265727 | 2908 | 906 | 88128602 | 88128676 | 759 | 832 | 226 | 251 |
| ENST00000265727 | 2908 | 906 | 88178935 | 88179042 | 2381 | 2487 | 767 | 802 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9P0K1 | 226 | 251 | 235 | 237 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G5C |
| Q9P0K1 | 226 | 251 | 239 | 247 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G5C |
| Q9P0K1 | 226 | 251 | 223 | 906 | Chain | ID=PRO_0000029113;Note=Disintegrin and metalloproteinase domain-containing protein 22 |
| Q9P0K1 | 226 | 251 | 239 | 438 | Domain | Note=Peptidase M12B;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00276 |
| Q9P0K1 | 226 | 251 | 249 | 253 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G5C |
| Q9P0K1 | 226 | 251 | 223 | 736 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9P0K1 | 767 | 802 | 768 | 803 | Alternative sequence | ID=VSP_005482;Note=In isoform 2%2C isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11050470,ECO:0000303|PubMed:9693107,ECO:0000303|Ref.3;Dbxref=PMID:11050470,PMID:9693107 |
| Q9P0K1 | 767 | 802 | 223 | 906 | Chain | ID=PRO_0000029113;Note=Disintegrin and metalloproteinase domain-containing protein 22 |
| Q9P0K1 | 767 | 802 | 758 | 906 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9P0K1 | 226 | 251 | 235 | 237 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G5C |
| Q9P0K1 | 226 | 251 | 239 | 247 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G5C |
| Q9P0K1 | 226 | 251 | 223 | 906 | Chain | ID=PRO_0000029113;Note=Disintegrin and metalloproteinase domain-containing protein 22 |
| Q9P0K1 | 226 | 251 | 239 | 438 | Domain | Note=Peptidase M12B;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00276 |
| Q9P0K1 | 226 | 251 | 249 | 253 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G5C |
| Q9P0K1 | 226 | 251 | 223 | 736 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9P0K1 | 767 | 802 | 768 | 803 | Alternative sequence | ID=VSP_005482;Note=In isoform 2%2C isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11050470,ECO:0000303|PubMed:9693107,ECO:0000303|Ref.3;Dbxref=PMID:11050470,PMID:9693107 |
| Q9P0K1 | 767 | 802 | 223 | 906 | Chain | ID=PRO_0000029113;Note=Disintegrin and metalloproteinase domain-containing protein 22 |
| Q9P0K1 | 767 | 802 | 758 | 906 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9P0K1 | 226 | 251 | 235 | 237 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G5C |
| Q9P0K1 | 226 | 251 | 239 | 247 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G5C |
| Q9P0K1 | 226 | 251 | 223 | 906 | Chain | ID=PRO_0000029113;Note=Disintegrin and metalloproteinase domain-containing protein 22 |
| Q9P0K1 | 226 | 251 | 239 | 438 | Domain | Note=Peptidase M12B;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00276 |
| Q9P0K1 | 226 | 251 | 249 | 253 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3G5C |
| Q9P0K1 | 226 | 251 | 223 | 736 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9P0K1 | 767 | 802 | 768 | 803 | Alternative sequence | ID=VSP_005482;Note=In isoform 2%2C isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11050470,ECO:0000303|PubMed:9693107,ECO:0000303|Ref.3;Dbxref=PMID:11050470,PMID:9693107 |
| Q9P0K1 | 767 | 802 | 223 | 906 | Chain | ID=PRO_0000029113;Note=Disintegrin and metalloproteinase domain-containing protein 22 |
| Q9P0K1 | 767 | 802 | 758 | 906 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in ADAM22 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for ADAM22 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ADAM22 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| ADstage | MSBB | IFG | exon_skip_185299 | -4.106019e-01 | 2.997779e-02 | chr7 | + | 87935029 | 87935186 | 87971294 | 87971375 | 87978336 | 87978412 |
| ADstage | MSBB | IFG | exon_skip_112294 | -3.974559e-01 | 3.622315e-02 | chr7 | + | 88114584 | 88114647 | 88116745 | 88116814 | 88125589 | 88125659 |
| CDR | MSBB | IFG | exon_skip_112294 | -3.937460e-01 | 3.816247e-02 | chr7 | + | 88114584 | 88114647 | 88116745 | 88116814 | 88125589 | 88125659 |
| CDR | MSBB | IFG | exon_skip_185299 | -3.775406e-01 | 4.762825e-02 | chr7 | + | 87935029 | 87935186 | 87971294 | 87971375 | 87978336 | 87978412 |
| CDR | MSBB | IFG | exon_skip_291160 | 3.760713e-01 | 4.857088e-02 | chr7 | + | 88182005 | 88182024 | 88186615 | 88186701 | 88193116 | 88193239 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ADAM22 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ADAM22 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | RBM6 | exon_skip_112294 | -5.334912e-01 | 2.926205e-12 |
| CB | PTBP1 | exon_skip_112294 | -5.394462e-01 | 1.504068e-12 |
| CB | DAZAP1 | exon_skip_115460 | -4.992449e-01 | 2.198551e-10 |
| CB | TARDBP | exon_skip_115460 | -5.435112e-01 | 2.312843e-12 |
| CB | PABPN1 | exon_skip_115460 | -4.586269e-01 | 8.393440e-09 |
| CB | ELAVL1 | exon_skip_115460 | -4.579906e-01 | 8.853419e-09 |
| CB | TRA2A | exon_skip_115460 | -6.432837e-01 | 4.575738e-18 |
| CB | FUBP1 | exon_skip_115460 | -5.067027e-01 | 1.067888e-10 |
| CB | KHSRP | exon_skip_115460 | -4.544689e-01 | 1.187173e-08 |
| CB | TIA1 | exon_skip_5127 | 4.072709e-01 | 2.104905e-07 |
| CB | TRA2A | exon_skip_5127 | -4.785483e-01 | 5.136752e-10 |
| CB | NUP42 | exon_skip_5127 | 5.935021e-01 | 9.686651e-16 |
| CB | PABPC4 | exon_skip_5127 | 4.176663e-01 | 9.520693e-08 |
| CB | TARDBP | exon_skip_291160 | -4.375582e-01 | 1.552429e-08 |
| HCC | FUBP3 | exon_skip_291160 | 5.019314e-01 | 6.198085e-18 |
| IFG | TIA1 | exon_skip_5127 | -4.440719e-01 | 2.031596e-02 |
| IFG | TRA2A | exon_skip_5127 | -4.661072e-01 | 1.426535e-02 |
| IFG | SNRPA | exon_skip_5127 | -4.489367e-01 | 1.882598e-02 |
| IFG | ENOX1 | exon_skip_5127 | -4.037675e-01 | 3.674129e-02 |
| IFG | KHSRP | exon_skip_5127 | -4.462142e-01 | 1.964836e-02 |
| IFG | PABPC4 | exon_skip_5127 | -4.636588e-01 | 1.485332e-02 |
| IFG | IGF2BP2 | exon_skip_291160 | 5.735922e-01 | 1.417399e-03 |
| IFG | KHDRBS3 | exon_skip_291160 | -5.001395e-01 | 6.723106e-03 |
| IFG | RBM23 | exon_skip_118061 | 5.107628e-01 | 5.480159e-03 |
| PCC | PTBP1 | exon_skip_5127 | -4.615734e-01 | 9.823794e-12 |
| PCC | ELAVL4 | exon_skip_98125 | 4.493200e-01 | 4.975441e-11 |
| STG | NOVA1 | exon_skip_5127 | 4.225945e-01 | 1.161053e-04 |
| TC | ILF2 | exon_skip_5127 | 5.677343e-01 | 1.735274e-13 |
| TC | KHDRBS2 | exon_skip_5127 | 7.737994e-01 | 1.497344e-29 |
| TC | KHDRBS3 | exon_skip_5127 | 6.832005e-01 | 7.491103e-21 |
| TC | ENOX1 | exon_skip_5127 | 4.366872e-01 | 5.541395e-08 |
| TC | HNRNPA0 | exon_skip_5127 | 7.126750e-01 | 2.604257e-23 |
| TC | PUM1 | exon_skip_5127 | 6.504037e-01 | 1.958087e-18 |
| TC | NUP42 | exon_skip_5127 | 6.639034e-01 | 2.156007e-19 |
| TC | RALYL | exon_skip_5127 | 7.428640e-01 | 3.585858e-26 |
| TC | PTBP1 | exon_skip_5127 | -4.902549e-01 | 5.908052e-10 |
| TC | PTBP3 | exon_skip_5127 | 5.041108e-01 | 1.597827e-10 |
| TC | CPEB1 | exon_skip_5127 | 6.452907e-01 | 4.387566e-18 |
| TC | ESRP1 | exon_skip_5127 | 6.563008e-01 | 7.573356e-19 |
| TC | NOVA1 | exon_skip_5127 | 7.473522e-01 | 1.244244e-26 |
| TC | SRSF2 | exon_skip_98125 | 4.676339e-01 | 4.424293e-09 |
| TC | HNRNPD | exon_skip_98125 | 4.630517e-01 | 6.536617e-09 |
| TC | CPEB1 | exon_skip_98125 | 4.548019e-01 | 1.301117e-08 |
| TC | NOVA1 | exon_skip_98125 | 4.815267e-01 | 1.307325e-09 |
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RelatedDrugs for ADAM22 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ADAM22 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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