|
||||||
|
 | |
| |
| |
| Open reading frame (ORF) annotation in the exon skipping event |
| |
| 3'-UTR located exon skipping events lost miRNA binding sites |
| |
| |
| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| |
| |
|
Gene summary for PLS3 |
 Gene summary |
| Gene information | Gene symbol | PLS3 | Gene ID | 5358 |
| Gene name | plastin 3 | |
| Synonyms | BMND18|T-plastin | |
| Cytomap | Xq23 | |
| Type of gene | protein-coding | |
| Description | plastin-3T fimbrinT plastin | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
Gene structures and expression levels for PLS3 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
ENSG00000102024
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
 |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000481823.5 | PLS3-206:nonsense_mediated_decay:PLS3 | 6.606769e+00 | 9.373137e-01 | 1.181029e-02 | 3.981788e-02 |
| TC | UP | ENST00000481823.5 | PLS3-206:nonsense_mediated_decay:PLS3 | 7.328927e+00 | 1.274734e+00 | 1.309678e-04 | 2.004384e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
 |
Top |
Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for PLS3 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
 |
| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_181716 | chrX | 115640408:115640503:115643313:115643508:115645021:115645099 | 115643313:115643508 |
| exon_skip_220142 | chrX | 115610243:115610323:115614153:115614534:115622246:115622409 | 115614153:115614534 |
| exon_skip_250248 | chrX | 115610243:115610323:115610803:115610921:115622246:115622409 | 115610803:115610921 |
| exon_skip_263498 | chrX | 115629198:115629327:115629835:115629967:115634000:115634081 | 115629835:115629967 |
| exon_skip_290673 | chrX | 115636836:115636978:115640110:115640136:115640408:115640503 | 115640110:115640136 |
| exon_skip_292729 | chrX | 115561228:115561260:115610243:115610323:115622246:115622409 | 115610243:115610323 |
| exon_skip_75885 | chrX | 115645021:115645099:115646072:115646186:115646402:115646431 | 115646072:115646186 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
 |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_290673 | ROSMAP_DLPFC | 2.357653e-01 | 3.452336e-01 | -1.094683e-01 | 3.970704e-03 |
| exon_skip_290673 | MSBB_STG | 2.837500e-01 | 4.433333e-01 | -1.595833e-01 | 1.476973e-02 |
| exon_skip_290673 | MSBB_PG | 1.926619e-01 | 3.884906e-01 | -1.958287e-01 | 2.333229e-06 |
Top |
Open reading frame (ORF) annotation in the exon skipping event for PLS3 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000355899 | 115610243 | 115610323 | 5CDS-5UTR |
| ENST00000355899 | 115643313 | 115643508 | Frame-shift |
| ENST00000539310 | 115643313 | 115643508 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000355899 | 115643313 | 115643508 | Frame-shift |
| ENST00000539310 | 115643313 | 115643508 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000355899 | 115610243 | 115610323 | 5CDS-5UTR |
| ENST00000355899 | 115629835 | 115629967 | Frame-shift |
| ENST00000539310 | 115629835 | 115629967 | Frame-shift |
| ENST00000355899 | 115643313 | 115643508 | Frame-shift |
| ENST00000539310 | 115643313 | 115643508 | Frame-shift |
| ENST00000355899 | 115646072 | 115646186 | Frame-shift |
| ENST00000539310 | 115646072 | 115646186 | Frame-shift |
Top |
Infer the effects of exon skipping event on protein functional features for PLS3 |
p-ENSG00000102024_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Top |
3'-UTR located exon skipping events that lost miRNA binding sites in PLS3 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Top |
SNVs in the skipped exons for PLS3 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
AD stage-associated exon skippint events for PLS3 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PLS3 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
Top |
Correlation with RNA binding proteins (RBPs) for PLS3 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | RBM5 | exon_skip_290673 | 4.395886e-01 | 1.632374e-08 |
| CB | SRSF9 | exon_skip_290673 | 6.288791e-01 | 5.325684e-18 |
| FL | SRSF9 | exon_skip_290673 | 4.599566e-01 | 2.172450e-11 |
| PCC | SFPQ | exon_skip_290673 | -4.464715e-01 | 7.863398e-12 |
| STG | SRSF9 | exon_skip_290673 | 4.781987e-01 | 2.453204e-06 |
| TC | SRSF9 | exon_skip_290673 | 4.041077e-01 | 1.162421e-07 |
Top |
RelatedDrugs for PLS3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for PLS3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|