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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for PLAGL1 |
Gene summary |
Gene information | Gene symbol | PLAGL1 | Gene ID | 5325 |
Gene name | PLAG1 like zinc finger 1 | |
Synonyms | LOT1|ZAC|ZAC1 | |
Cytomap | 6q24.2 | |
Type of gene | protein-coding | |
Description | zinc finger protein PLAGL1PLAG-like 1lost on transformation 1pleiomorphic adenoma gene-like 1tumor suppressor ZAC | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
PLAGL1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 9671765|15888726 |
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Gene structures and expression levels for PLAGL1 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
PG | UP | ENST00000367572.3 | PLAGL1-204:protein_coding:PLAGL1 | 2.030188e+00 | 2.915556e+00 | 4.014789e-04 | 7.542108e-03 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for PLAGL1 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_1109 | chr6 | 143964787:143964818:143966158:143966212:143968907:143968978 | 143966158:143966212 |
exon_skip_128488 | chr6 | 143964787:143964818:143965850:143966198:143968907:143968978 | 143965850:143966198 |
exon_skip_131960 | chr6 | 143964787:143964818:143966158:143966198:143968907:143968950 | 143966158:143966198 |
exon_skip_136814 | chr6 | 143948344:143948460:143960469:143960556:143964787:143964818 | 143960469:143960556 |
exon_skip_145179 | chr6 | 143964787:143964818:143965180:143965303:143966158:143966198 | 143965180:143965303 |
exon_skip_15370 | chr6 | 143964787:143964818:143965180:143965303:143966158:143966285 | 143965180:143965303 |
exon_skip_165808 | chr6 | 143964787:143964818:143965108:143965313:143966158:143966198 | 143965108:143965313 |
exon_skip_167757 | chr6 | 143964787:143964818:143966158:143966285:143968907:143968950 | 143966158:143966285 |
exon_skip_186236 | chr6 | 143960469:143960542:143964787:143964818:143966158:143966198 | 143964787:143964818 |
exon_skip_190901 | chr6 | 143964787:143964818:143966158:143966230:143968907:143968978 | 143966158:143966230 |
exon_skip_208310 | chr6 | 143968907:143968978:143985135:143985174:144064451:144064598 | 143985135:143985174 |
exon_skip_238299 | chr6 | 143964787:143964818:143966158:143966230:143968907:143968950 | 143966158:143966230 |
exon_skip_242928 | chr6 | 143964787:143964818:143966158:143966212:143968907:143968950 | 143966158:143966212 |
exon_skip_246012 | chr6 | 143942624:143942663:143947985:143948460:143960473:143960556 | 143947985:143948460 |
exon_skip_246528 | chr6 | 143948344:143948460:143960473:143960556:143964787:143964818 | 143960473:143960556 |
exon_skip_246835 | chr6 | 143942624:143942663:143960469:143960556:143964787:143964818 | 143960469:143960556 |
exon_skip_27496 | chr6 | 143942624:143942663:143960469:143960542:143964787:143964818 | 143960469:143960542 |
exon_skip_282657 | chr6 | 143964787:143964818:143966158:143966285:143968907:143968978 | 143966158:143966285 |
exon_skip_39589 | chr6 | 143948344:143948460:143960469:143960542:143964787:143964818 | 143960469:143960542 |
exon_skip_4329 | chr6 | 143942436:143942663:143947985:143948460:143960469:143960542 | 143947985:143948460 |
exon_skip_68561 | chr6 | 143964787:143964818:143966158:143966198:143968907:143968978 | 143966158:143966198 |
exon_skip_68593 | chr6 | 143942624:143942663:143947985:143948460:143960469:143960542 | 143947985:143948460 |
exon_skip_99427 | chr6 | 143940302:143942663:143960469:143960542:143964787:143968838 | 143960469:143960542 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for PLAGL1 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000354765 | 143947985 | 143948460 | 3UTR-3CDS |
ENST00000360537 | 143947985 | 143948460 | 3UTR-3CDS |
ENST00000367571 | 143947985 | 143948460 | 3UTR-3CDS |
ENST00000444202 | 143947985 | 143948460 | 3UTR-3CDS |
ENST00000625622 | 143947985 | 143948460 | 3UTR-3CDS |
ENST00000360537 | 143960469 | 143960542 | 3UTR-3UTR |
ENST00000625622 | 143960469 | 143960542 | 3UTR-3UTR |
ENST00000354765 | 143965180 | 143965303 | 3UTR-3UTR |
ENST00000625622 | 143965850 | 143966198 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000354765 | 143947985 | 143948460 | 3UTR-3CDS |
ENST00000360537 | 143947985 | 143948460 | 3UTR-3CDS |
ENST00000367571 | 143947985 | 143948460 | 3UTR-3CDS |
ENST00000444202 | 143947985 | 143948460 | 3UTR-3CDS |
ENST00000625622 | 143947985 | 143948460 | 3UTR-3CDS |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000354765 | 143947985 | 143948460 | 3UTR-3CDS |
ENST00000360537 | 143947985 | 143948460 | 3UTR-3CDS |
ENST00000367571 | 143947985 | 143948460 | 3UTR-3CDS |
ENST00000444202 | 143947985 | 143948460 | 3UTR-3CDS |
ENST00000625622 | 143947985 | 143948460 | 3UTR-3CDS |
ENST00000360537 | 143960469 | 143960542 | 3UTR-3UTR |
ENST00000625622 | 143960469 | 143960542 | 3UTR-3UTR |
ENST00000354765 | 143965180 | 143965303 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for PLAGL1 |
p-ENSG00000118495_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in PLAGL1 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000354765 | 143965180 | 143965303 | hsa-miR-3157-5p | chr6:143965262-143965269 | 8mer-1a | chr6:143965243-143965269 | 153.00 | -19.84 |
Mayo | ENST00000625622 | 143960469 | 143960542 | hsa-miR-6752-3p | chr6:143960499-143960506 | 8mer-1a | chr6:143960497-143960520 | 149.00 | -26.27 |
Mayo | ENST00000354765 | 143965180 | 143965303 | hsa-miR-4691-3p | chr6:143965261-143965268 | 8mer-1a | chr6:143965246-143965268 | 169.00 | -28.42 |
Mayo | ENST00000354765 | 143965180 | 143965303 | hsa-miR-1261 | chr6:143965233-143965240 | 8mer-1a | chr6:143965222-143965240 | 142.00 | -12.65 |
Mayo | ENST00000625622 | 143960469 | 143960542 | hsa-miR-7106-5p | chr6:143960512-143960519 | 8mer-1a | chr6:143960501-143960520 | 156.00 | -28.01 |
Mayo | ENST00000354765 | 143965180 | 143965303 | hsa-miR-493-3p | chr6:143965277-143965284 | 8mer-1a | chr6:143965260-143965284 | 151.00 | -21.02 |
Mayo | ENST00000354765 | 143965180 | 143965303 | hsa-miR-6863 | chr6:143965197-143965204 | 8mer-1a | chr6:143965197-143965218 | 161.00 | -27.95 |
Mayo | ENST00000625622 | 143960469 | 143960542 | hsa-miR-4314 | chr6:143960515-143960522 | 8mer-1a | chr6:143960509-143960532 | 146.00 | -15.29 |
Mayo | ENST00000625622 | 143960469 | 143960542 | hsa-miR-4746-5p | chr6:143960503-143960510 | 8mer-1a | chr6:143960501-143960520 | 156.00 | -28.01 |
Mayo | ENST00000625622 | 143960469 | 143960542 | hsa-miR-3192-5p | chr6:143960514-143960521 | 8mer-1a | chr6:143960499-143960521 | 145.00 | -22.68 |
ROSMAP | ENST00000625622 | 143965850 | 143966198 | hsa-miR-5087 | chr6:143965984-143965991 | 8mer-1a | chr6:143965978-143965999 | 145.00 | -11.88 |
ROSMAP | ENST00000625622 | 143965850 | 143966198 | hsa-miR-4480 | chr6:143965883-143965890 | 8mer-1a | chr6:143965877-143965900 | 147.00 | -21.97 |
ROSMAP | ENST00000354765 | 143965180 | 143965303 | hsa-miR-3157-5p | chr6:143965262-143965269 | 8mer-1a | chr6:143965243-143965269 | 153.00 | -19.84 |
ROSMAP | ENST00000625622 | 143965850 | 143966198 | hsa-miR-8070 | chr6:143966098-143966105 | 8mer-1a | chr6:143966098-143966119 | 160.00 | -24.64 |
ROSMAP | ENST00000625622 | 143965850 | 143966198 | hsa-miR-612 | chr6:143965874-143965881 | 8mer-1a | chr6:143965858-143965881 | 163.00 | -32.47 |
ROSMAP | ENST00000625622 | 143965850 | 143966198 | hsa-miR-6860 | chr6:143965874-143965881 | 8mer-1a | chr6:143965858-143965881 | 163.00 | -32.47 |
ROSMAP | ENST00000625622 | 143960469 | 143960542 | hsa-miR-6752-3p | chr6:143960499-143960506 | 8mer-1a | chr6:143960497-143960520 | 149.00 | -26.27 |
ROSMAP | ENST00000625622 | 143965850 | 143966198 | hsa-miR-6752-3p | chr6:143965887-143965894 | 8mer-1a | chr6:143965884-143965905 | 170.00 | -31.48 |
ROSMAP | ENST00000354765 | 143965180 | 143965303 | hsa-miR-4691-3p | chr6:143965261-143965268 | 8mer-1a | chr6:143965246-143965268 | 169.00 | -28.42 |
ROSMAP | ENST00000354765 | 143965180 | 143965303 | hsa-miR-1261 | chr6:143965233-143965240 | 8mer-1a | chr6:143965222-143965240 | 142.00 | -12.65 |
ROSMAP | ENST00000625622 | 143965850 | 143966198 | hsa-miR-100-3p | chr6:143965992-143965999 | 8mer-1a | chr6:143965988-143966006 | 156.00 | -19.76 |
ROSMAP | ENST00000625622 | 143965850 | 143966198 | hsa-miR-1251-5p | chr6:143965919-143965926 | 8mer-1a | chr6:143965906-143965926 | 144.00 | -14.79 |
ROSMAP | ENST00000625622 | 143960469 | 143960542 | hsa-miR-7106-5p | chr6:143960512-143960519 | 8mer-1a | chr6:143960501-143960520 | 156.00 | -28.01 |
ROSMAP | ENST00000625622 | 143965850 | 143966198 | hsa-miR-5586-3p | chr6:143965940-143965947 | 8mer-1a | chr6:143965937-143965959 | 159.00 | -21.47 |
ROSMAP | ENST00000354765 | 143965180 | 143965303 | hsa-miR-493-3p | chr6:143965277-143965284 | 8mer-1a | chr6:143965260-143965284 | 151.00 | -21.02 |
ROSMAP | ENST00000625622 | 143965850 | 143966198 | hsa-miR-136-5p | chr6:143965926-143965933 | 8mer-1a | chr6:143965911-143965933 | 146.00 | -11.26 |
ROSMAP | ENST00000625622 | 143965850 | 143966198 | hsa-miR-3179 | chr6:143966086-143966093 | 8mer-1a | chr6:143966072-143966093 | 151.00 | -14.26 |
ROSMAP | ENST00000354765 | 143965180 | 143965303 | hsa-miR-6863 | chr6:143965197-143965204 | 8mer-1a | chr6:143965197-143965218 | 161.00 | -27.95 |
ROSMAP | ENST00000625622 | 143965850 | 143966198 | hsa-miR-5189-5p | chr6:143965874-143965881 | 8mer-1a | chr6:143965858-143965881 | 163.00 | -32.47 |
ROSMAP | ENST00000625622 | 143960469 | 143960542 | hsa-miR-4314 | chr6:143960515-143960522 | 8mer-1a | chr6:143960509-143960532 | 146.00 | -15.29 |
ROSMAP | ENST00000625622 | 143965850 | 143966198 | hsa-miR-3187-5p | chr6:143965874-143965881 | 8mer-1a | chr6:143965858-143965881 | 163.00 | -32.47 |
ROSMAP | ENST00000625622 | 143960469 | 143960542 | hsa-miR-4746-5p | chr6:143960503-143960510 | 8mer-1a | chr6:143960501-143960520 | 156.00 | -28.01 |
ROSMAP | ENST00000625622 | 143965850 | 143966198 | hsa-miR-520b-5p | chr6:143966018-143966025 | 8mer-1a | chr6:143966005-143966026 | 155.00 | -21.65 |
ROSMAP | ENST00000625622 | 143965850 | 143966198 | hsa-miR-519a-2-5p | chr6:143966018-143966025 | 8mer-1a | chr6:143966005-143966026 | 155.00 | -21.65 |
ROSMAP | ENST00000625622 | 143965850 | 143966198 | hsa-miR-1285-3p | chr6:143965874-143965881 | 8mer-1a | chr6:143965858-143965881 | 163.00 | -32.47 |
ROSMAP | ENST00000625622 | 143960469 | 143960542 | hsa-miR-3192-5p | chr6:143960514-143960521 | 8mer-1a | chr6:143960499-143960521 | 145.00 | -22.68 |
ROSMAP | ENST00000625622 | 143965850 | 143966198 | hsa-miR-10522-5p | chr6:143966167-143966174 | 8mer-1a | chr6:143966154-143966174 | 145.00 | -16.70 |
ROSMAP | ENST00000625622 | 143965850 | 143966198 | hsa-miR-4666b | chr6:143966131-143966138 | 8mer-1a | chr6:143966118-143966138 | 153.00 | -12.92 |
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SNVs in the skipped exons for PLAGL1 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for PLAGL1 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PLAGL1 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for PLAGL1 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for PLAGL1 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PLAGL1 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |