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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for PIM1 |
 Gene summary |
| Gene information | Gene symbol | PIM1 | Gene ID | 5292 |
| Gene name | Pim-1 proto-oncogene, serine/threonine kinase | |
| Synonyms | PIM | |
| Cytomap | 6p21.2 | |
| Type of gene | protein-coding | |
| Description | serine/threonine-protein kinase pim-1Oncogene PIM1pim-1 kinase 44 kDa isoformpim-1 oncogene (proviral integration site 1)proto-oncogene serine/threonine-protein kinase pim-1 | |
| Modification date | 20200313 | |
| UniProtAcc | A0A024RD25, P11309, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| PIM1 | GO:0006468 | protein phosphorylation | 1825810|16266891|18056989 |
| PIM1 | GO:0043066 | negative regulation of apoptotic process | 16186805 |
| PIM1 | GO:0043433 | negative regulation of DNA-binding transcription factor activity | 18593906 |
| PIM1 | GO:0046777 | protein autophosphorylation | 16266891 |
| PIM1 | GO:0060045 | positive regulation of cardiac muscle cell proliferation | 21474815 |
| PIM1 | GO:1905062 | positive regulation of cardioblast proliferation | 21474815 |
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Gene structures and expression levels for PIM1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000137193
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for PIM1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_89345 | chr6 | 37170773:37170879:37170981:37171031:37171125:37171491 | 37170981:37171031 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for PIM1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000373509 | 37170981 | 37171031 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000373509 | 37170981 | 37171031 | In-frame |
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Infer the effects of exon skipping event on protein functional features for PIM1 |
p-ENSG00000137193_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000373509 | 2667 | 313 | 37170981 | 37171031 | 564 | 613 | 63 | 80 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000373509 | 2667 | 313 | 37170981 | 37171031 | 564 | 613 | 63 | 80 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P11309 | 63 | 80 | 63 | 70 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A99 |
| P11309 | 63 | 80 | 77 | 79 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A99 |
| P11309 | 63 | 80 | 67 | 67 | Binding site | Note=ATP |
| P11309 | 63 | 80 | 1 | 313 | Chain | ID=PRO_0000043349;Note=Serine/threonine-protein kinase pim-1 |
| P11309 | 63 | 80 | 38 | 290 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P11309 | 63 | 80 | 71 | 73 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A99 |
| P11309 | 63 | 80 | 68 | 68 | Mutagenesis | Note=Increased kinase activity. H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15808862;Dbxref=PMID:15808862 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P11309 | 63 | 80 | 63 | 70 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A99 |
| P11309 | 63 | 80 | 77 | 79 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A99 |
| P11309 | 63 | 80 | 67 | 67 | Binding site | Note=ATP |
| P11309 | 63 | 80 | 1 | 313 | Chain | ID=PRO_0000043349;Note=Serine/threonine-protein kinase pim-1 |
| P11309 | 63 | 80 | 38 | 290 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P11309 | 63 | 80 | 71 | 73 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A99 |
| P11309 | 63 | 80 | 68 | 68 | Mutagenesis | Note=Increased kinase activity. H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15808862;Dbxref=PMID:15808862 |
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3'-UTR located exon skipping events that lost miRNA binding sites in PIM1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for PIM1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for PIM1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PIM1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for PIM1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for PIM1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P11309 | approved|investigational | DB12010 | Fostamatinib | small molecule | P11309 |
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RelatedDiseases for PIM1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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