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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for PHB |
 Gene summary |
| Gene information | Gene symbol | PHB | Gene ID | 5245 |
| Gene name | prohibitin | |
| Synonyms | HEL-215|HEL-S-54e|PHB1 | |
| Cytomap | 17q21.33 | |
| Type of gene | protein-coding | |
| Description | prohibitinepididymis luminal protein 215epididymis secretory sperm binding protein Li 54e | |
| Modification date | 20200329 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| PHB | GO:0000122 | negative regulation of transcription by RNA polymerase II | 16964284 |
| PHB | GO:0006355 | regulation of transcription, DNA-templated | 14500729 |
| PHB | GO:0010944 | negative regulation of transcription by competitive promoter binding | 18487222 |
| PHB | GO:0016575 | histone deacetylation | 12466959 |
| PHB | GO:0045892 | negative regulation of transcription, DNA-templated | 12065415|12566959 |
| PHB | GO:0045893 | positive regulation of transcription, DNA-templated | 14500729 |
| PHB | GO:0045917 | positive regulation of complement activation | 17070910 |
| PHB | GO:0050847 | progesterone receptor signaling pathway | 16964284 |
| PHB | GO:0060766 | negative regulation of androgen receptor signaling pathway | 16964284 |
| PHB | GO:0071354 | cellular response to interleukin-6 | 17324931 |
| PHB | GO:2000323 | negative regulation of glucocorticoid receptor signaling pathway | 16964284 |
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Gene structures and expression levels for PHB |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000167085
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for PHB |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_125569 | chr17 | 49413177:49413291:49414242:49414333:49414835:49414858 | 49414242:49414333 |
| exon_skip_130057 | chr17 | 49406761:49406854:49409042:49409158:49409331:49409473 | 49409042:49409158 |
| exon_skip_231690 | chr17 | 49411678:49411839:49413177:49413291:49414835:49414858 | 49413177:49413291 |
| exon_skip_231708 | chr17 | 49409449:49409473:49411678:49411839:49413177:49413253 | 49411678:49411839 |
| exon_skip_253782 | chr17 | 49405187:49405204:49406759:49406854:49409042:49409158 | 49406759:49406854 |
| exon_skip_89202 | chr17 | 49411678:49411839:49413177:49413291:49414835:49414877 | 49413177:49413291 |
| exon_skip_93259 | chr17 | 49409331:49409473:49411678:49411839:49413177:49413253 | 49411678:49411839 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for PHB |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000300408 | 49413177 | 49413291 | 3UTR-3CDS |
| ENST00000614445 | 49414242 | 49414333 | 3UTR-3UTR |
| ENST00000300408 | 49406759 | 49406854 | In-frame |
| ENST00000614445 | 49406759 | 49406854 | In-frame |
| ENST00000617874 | 49406759 | 49406854 | In-frame |
| ENST00000300408 | 49409042 | 49409158 | In-frame |
| ENST00000614445 | 49409042 | 49409158 | In-frame |
| ENST00000617874 | 49409042 | 49409158 | In-frame |
| ENST00000300408 | 49411678 | 49411839 | In-frame |
| ENST00000614445 | 49411678 | 49411839 | In-frame |
| ENST00000617874 | 49411678 | 49411839 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000614445 | 49414242 | 49414333 | 3UTR-3UTR |
| ENST00000300408 | 49411678 | 49411839 | In-frame |
| ENST00000614445 | 49411678 | 49411839 | In-frame |
| ENST00000617874 | 49411678 | 49411839 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000300408 | 49413177 | 49413291 | 3UTR-3CDS |
| ENST00000614445 | 49414242 | 49414333 | 3UTR-3UTR |
| ENST00000300408 | 49411678 | 49411839 | In-frame |
| ENST00000614445 | 49411678 | 49411839 | In-frame |
| ENST00000617874 | 49411678 | 49411839 | In-frame |
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Infer the effects of exon skipping event on protein functional features for PHB |
p-ENSG00000167085_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000300408 | 1849 | 272 | 49411678 | 49411839 | 162 | 322 | 29 | 83 |
| ENST00000614445 | 1969 | 272 | 49411678 | 49411839 | 279 | 439 | 29 | 83 |
| ENST00000617874 | 1925 | 272 | 49411678 | 49411839 | 235 | 395 | 29 | 83 |
| ENST00000300408 | 1849 | 272 | 49409042 | 49409158 | 467 | 582 | 131 | 169 |
| ENST00000614445 | 1969 | 272 | 49409042 | 49409158 | 584 | 699 | 131 | 169 |
| ENST00000617874 | 1925 | 272 | 49409042 | 49409158 | 540 | 655 | 131 | 169 |
| ENST00000300408 | 1849 | 272 | 49406759 | 49406854 | 584 | 678 | 170 | 201 |
| ENST00000614445 | 1969 | 272 | 49406759 | 49406854 | 701 | 795 | 170 | 201 |
| ENST00000617874 | 1925 | 272 | 49406759 | 49406854 | 657 | 751 | 170 | 201 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000300408 | 1849 | 272 | 49411678 | 49411839 | 162 | 322 | 29 | 83 |
| ENST00000614445 | 1969 | 272 | 49411678 | 49411839 | 279 | 439 | 29 | 83 |
| ENST00000617874 | 1925 | 272 | 49411678 | 49411839 | 235 | 395 | 29 | 83 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000300408 | 1849 | 272 | 49411678 | 49411839 | 162 | 322 | 29 | 83 |
| ENST00000614445 | 1969 | 272 | 49411678 | 49411839 | 279 | 439 | 29 | 83 |
| ENST00000617874 | 1925 | 272 | 49411678 | 49411839 | 235 | 395 | 29 | 83 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P35232 | 29 | 83 | 2 | 272 | Chain | ID=PRO_0000213878;Note=Prohibitin |
| P35232 | 29 | 83 | 2 | 272 | Chain | ID=PRO_0000213878;Note=Prohibitin |
| P35232 | 29 | 83 | 2 | 272 | Chain | ID=PRO_0000213878;Note=Prohibitin |
| P35232 | 131 | 169 | 140 | 256 | Alternative sequence | ID=VSP_054922;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P35232 | 131 | 169 | 140 | 256 | Alternative sequence | ID=VSP_054922;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P35232 | 131 | 169 | 140 | 256 | Alternative sequence | ID=VSP_054922;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P35232 | 131 | 169 | 2 | 272 | Chain | ID=PRO_0000213878;Note=Prohibitin |
| P35232 | 131 | 169 | 2 | 272 | Chain | ID=PRO_0000213878;Note=Prohibitin |
| P35232 | 131 | 169 | 2 | 272 | Chain | ID=PRO_0000213878;Note=Prohibitin |
| P35232 | 170 | 201 | 140 | 256 | Alternative sequence | ID=VSP_054922;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P35232 | 170 | 201 | 140 | 256 | Alternative sequence | ID=VSP_054922;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P35232 | 170 | 201 | 140 | 256 | Alternative sequence | ID=VSP_054922;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P35232 | 170 | 201 | 2 | 272 | Chain | ID=PRO_0000213878;Note=Prohibitin |
| P35232 | 170 | 201 | 2 | 272 | Chain | ID=PRO_0000213878;Note=Prohibitin |
| P35232 | 170 | 201 | 2 | 272 | Chain | ID=PRO_0000213878;Note=Prohibitin |
| P35232 | 170 | 201 | 177 | 211 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P35232 | 170 | 201 | 177 | 211 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P35232 | 170 | 201 | 177 | 211 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P35232 | 170 | 201 | 186 | 186 | Modified residue | Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P67778 |
| P35232 | 170 | 201 | 186 | 186 | Modified residue | Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P67778 |
| P35232 | 170 | 201 | 186 | 186 | Modified residue | Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P67778 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P35232 | 29 | 83 | 2 | 272 | Chain | ID=PRO_0000213878;Note=Prohibitin |
| P35232 | 29 | 83 | 2 | 272 | Chain | ID=PRO_0000213878;Note=Prohibitin |
| P35232 | 29 | 83 | 2 | 272 | Chain | ID=PRO_0000213878;Note=Prohibitin |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P35232 | 29 | 83 | 2 | 272 | Chain | ID=PRO_0000213878;Note=Prohibitin |
| P35232 | 29 | 83 | 2 | 272 | Chain | ID=PRO_0000213878;Note=Prohibitin |
| P35232 | 29 | 83 | 2 | 272 | Chain | ID=PRO_0000213878;Note=Prohibitin |
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3'-UTR located exon skipping events that lost miRNA binding sites in PHB |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000614445 | 49414242 | 49414333 | hsa-miR-655-3p | chr17:49414270-49414277 | 8mer-1a | chr17:49414262-49414282 | 163.00 | -13.72 |
| Mayo | ENST00000614445 | 49414242 | 49414333 | hsa-miR-4267 | chr17:49414304-49414311 | 8mer-1a | chr17:49414290-49414313 | 166.00 | -20.87 |
| Mayo | ENST00000614445 | 49414242 | 49414333 | hsa-miR-2115-5p | chr17:49414295-49414302 | 8mer-1a | chr17:49414290-49414313 | 166.00 | -20.87 |
| Mayo | ENST00000614445 | 49414242 | 49414333 | hsa-miR-874-5p | chr17:49414320-49414327 | 8mer-1a | chr17:49414305-49414327 | 142.00 | -22.06 |
| Mayo | ENST00000614445 | 49414242 | 49414333 | hsa-miR-374c-5p | chr17:49414270-49414277 | 8mer-1a | chr17:49414262-49414282 | 163.00 | -13.72 |
| MSBB | ENST00000614445 | 49414242 | 49414333 | hsa-miR-655-3p | chr17:49414270-49414277 | 8mer-1a | chr17:49414262-49414282 | 163.00 | -13.72 |
| MSBB | ENST00000614445 | 49414242 | 49414333 | hsa-miR-4267 | chr17:49414304-49414311 | 8mer-1a | chr17:49414290-49414313 | 166.00 | -20.87 |
| MSBB | ENST00000614445 | 49414242 | 49414333 | hsa-miR-2115-5p | chr17:49414295-49414302 | 8mer-1a | chr17:49414290-49414313 | 166.00 | -20.87 |
| MSBB | ENST00000614445 | 49414242 | 49414333 | hsa-miR-874-5p | chr17:49414320-49414327 | 8mer-1a | chr17:49414305-49414327 | 142.00 | -22.06 |
| MSBB | ENST00000614445 | 49414242 | 49414333 | hsa-miR-374c-5p | chr17:49414270-49414277 | 8mer-1a | chr17:49414262-49414282 | 163.00 | -13.72 |
| ROSMAP | ENST00000614445 | 49414242 | 49414333 | hsa-miR-655-3p | chr17:49414270-49414277 | 8mer-1a | chr17:49414262-49414282 | 163.00 | -13.72 |
| ROSMAP | ENST00000614445 | 49414242 | 49414333 | hsa-miR-4267 | chr17:49414304-49414311 | 8mer-1a | chr17:49414290-49414313 | 166.00 | -20.87 |
| ROSMAP | ENST00000614445 | 49414242 | 49414333 | hsa-miR-2115-5p | chr17:49414295-49414302 | 8mer-1a | chr17:49414290-49414313 | 166.00 | -20.87 |
| ROSMAP | ENST00000614445 | 49414242 | 49414333 | hsa-miR-874-5p | chr17:49414320-49414327 | 8mer-1a | chr17:49414305-49414327 | 142.00 | -22.06 |
| ROSMAP | ENST00000614445 | 49414242 | 49414333 | hsa-miR-374c-5p | chr17:49414270-49414277 | 8mer-1a | chr17:49414262-49414282 | 163.00 | -13.72 |
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SNVs in the skipped exons for PHB |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for PHB |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PHB |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for PHB |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for PHB |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PHB |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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