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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for ATP5PF |
Gene summary |
Gene information | Gene symbol | ATP5PF | Gene ID | 522 |
Gene name | ATP synthase peripheral stalk subunit F6 | |
Synonyms | ATP5|ATP5A|ATP5J|ATPM|CF6|F6 | |
Cytomap | 21q21.3 | |
Type of gene | protein-coding | |
Description | ATP synthase-coupling factor 6, mitochondrialATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6ATP synthase, H+ transporting, mitochondrial Fo complex subunit F6ATPase subunit F6coupling factor 6mitochondrial ATP synthase, coupling f | |
Modification date | 20200313 | |
UniProtAcc | A8MUH2, P18859, | |
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
ATP5PF | GO:0042776 | mitochondrial ATP synthesis coupled proton transport | 12110673 |
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Gene structures and expression levels for ATP5PF |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | DOWN | ENST00000457143.6 | ATP5PF-207:protein_coding:ATP5PF | 4.685443e+01 | -8.050191e-01 | 1.608893e-11 | 1.437821e-09 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ATP5PF |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_190411 | chr21 | 25729725:25729801:25734333:25734375:25734853:25734904 | 25734333:25734375 |
exon_skip_215039 | chr21 | 25725226:25725350:25729631:25729801:25734989:25735027 | 25729631:25729801 |
exon_skip_283886 | chr21 | 25729772:25729801:25734333:25734375:25734853:25734904 | 25734333:25734375 |
exon_skip_295746 | chr21 | 25725226:25725350:25729631:25729801:25734939:25735033 | 25729631:25729801 |
exon_skip_30081 | chr21 | 25725226:25725350:25729631:25729801:25734853:25734904 | 25729631:25729801 |
exon_skip_93425 | chr21 | 25725226:25725350:25729631:25729801:25734333:25734375 | 25729631:25729801 |
exon_skip_96239 | chr21 | 25729631:25729801:25734333:25734375:25734853:25734904 | 25734333:25734375 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ATP5PF |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000284971 | 25729631 | 25729801 | 3UTR-3CDS |
ENST00000400094 | 25734333 | 25734375 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000400094 | 25734333 | 25734375 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000284971 | 25729631 | 25729801 | 3UTR-3CDS |
ENST00000400093 | 25729631 | 25729801 | 3UTR-3CDS |
ENST00000400094 | 25729631 | 25729801 | 3UTR-3CDS |
ENST00000400094 | 25734333 | 25734375 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for ATP5PF |
p-ENSG00000154723_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in ATP5PF |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for ATP5PF |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ATP5PF |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
ADstage | MSBB | IFG | exon_skip_96239 | -5.277028e-01 | 3.902229e-03 | chr21 | - | 25729631 | 25729801 | 25734333 | 25734375 | 25734853 | 25734904 |
CDR | MSBB | IFG | exon_skip_96239 | -3.890475e-01 | 4.073683e-02 | chr21 | - | 25729631 | 25729801 | 25734333 | 25734375 | 25734853 | 25734904 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ATP5PF |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ATP5PF |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for ATP5PF |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ATP5PF |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |