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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TRIM33 |
 Gene summary |
| Gene information | Gene symbol | TRIM33 | Gene ID | 51592 |
| Gene name | tripartite motif containing 33 | |
| Synonyms | ECTO|PTC7|RFG7|TF1G|TIF1G|TIF1GAMMA|TIFGAMMA | |
| Cytomap | 1p13.2 | |
| Type of gene | protein-coding | |
| Description | E3 ubiquitin-protein ligase TRIM33RET-fused gene 7 proteinRING-type E3 ubiquitin transferase TRIM33TIF1-gammaectodermin homologprotein Rfg7transcriptional intermediary factor 1 gamma | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TRIM33 | GO:0016567 | protein ubiquitination | 19135894 |
| TRIM33 | GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway | 19135894 |
| TRIM33 | GO:0030514 | negative regulation of BMP signaling pathway | 19135894 |
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Gene structures and expression levels for TRIM33 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000197323
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TRIM33 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_108141 | chr1 | 114399457:114399609:114401389:114401463:114402760:114402883 | 114401389:114401463 |
| exon_skip_168451 | chr1 | 114463412:114463556:114464270:114464388:114510551:114510691 | 114464270:114464388 |
| exon_skip_233830 | chr1 | 114410184:114410316:114421436:114421636:114424591:114424755 | 114421436:114421636 |
| exon_skip_247258 | chr1 | 114410184:114410316:114420380:114420451:114421436:114421636 | 114420380:114420451 |
| exon_skip_257199 | chr1 | 114463412:114463556:114464270:114464388:114510551:114511160 | 114464270:114464388 |
| exon_skip_26434 | chr1 | 114427748:114427894:114430798:114430912:114433617:114433733 | 114430798:114430912 |
| exon_skip_266354 | chr1 | 114463104:114463236:114463412:114463556:114464270:114464388 | 114463412:114463556 |
| exon_skip_29394 | chr1 | 114397608:114397860:114397940:114397990:114399457:114399609 | 114397940:114397990 |
| exon_skip_94040 | chr1 | 114463412:114463556:114464270:114464388:114510551:114510723 | 114464270:114464388 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TRIM33 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000358465 | 114430798 | 114430912 | Frame-shift |
| ENST00000358465 | 114463412 | 114463556 | Frame-shift |
| ENST00000358465 | 114397940 | 114397990 | In-frame |
| ENST00000358465 | 114401389 | 114401463 | In-frame |
| ENST00000358465 | 114421436 | 114421636 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000358465 | 114430798 | 114430912 | Frame-shift |
| ENST00000358465 | 114463412 | 114463556 | Frame-shift |
| ENST00000358465 | 114397940 | 114397990 | In-frame |
| ENST00000358465 | 114421436 | 114421636 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000358465 | 114430798 | 114430912 | Frame-shift |
| ENST00000358465 | 114463412 | 114463556 | Frame-shift |
| ENST00000358465 | 114397940 | 114397990 | In-frame |
| ENST00000358465 | 114401389 | 114401463 | In-frame |
| ENST00000358465 | 114421436 | 114421636 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TRIM33 |
p-ENSG00000197323_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000358465 | 8356 | 1127 | 114421436 | 114421636 | 1945 | 2144 | 620 | 686 |
| ENST00000358465 | 8356 | 1127 | 114401389 | 114401463 | 2977 | 3050 | 964 | 988 |
| ENST00000358465 | 8356 | 1127 | 114397940 | 114397990 | 3205 | 3254 | 1040 | 1056 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000358465 | 8356 | 1127 | 114421436 | 114421636 | 1945 | 2144 | 620 | 686 |
| ENST00000358465 | 8356 | 1127 | 114397940 | 114397990 | 3205 | 3254 | 1040 | 1056 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000358465 | 8356 | 1127 | 114421436 | 114421636 | 1945 | 2144 | 620 | 686 |
| ENST00000358465 | 8356 | 1127 | 114401389 | 114401463 | 2977 | 3050 | 964 | 988 |
| ENST00000358465 | 8356 | 1127 | 114397940 | 114397990 | 3205 | 3254 | 1040 | 1056 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9UPN9 | 620 | 686 | 1 | 1127 | Chain | ID=PRO_0000056395;Note=E3 ubiquitin-protein ligase TRIM33 |
| Q9UPN9 | 964 | 988 | 1 | 1127 | Chain | ID=PRO_0000056395;Note=E3 ubiquitin-protein ligase TRIM33 |
| Q9UPN9 | 964 | 988 | 974 | 1046 | Domain | Note=Bromo;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00035 |
| Q9UPN9 | 964 | 988 | 960 | 974 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MR8 |
| Q9UPN9 | 964 | 988 | 980 | 982 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MR8 |
| Q9UPN9 | 964 | 988 | 964 | 965 | Site | Note=Breakpoint for translocation to form TRIM33-RET oncogene |
| Q9UPN9 | 1040 | 1056 | 1041 | 1057 | Alternative sequence | ID=VSP_005774;Note=In isoform Beta. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10439047,ECO:0000303|PubMed:11331580;Dbxref=PMID:10439047,PMID:11331580 |
| Q9UPN9 | 1040 | 1056 | 1 | 1127 | Chain | ID=PRO_0000056395;Note=E3 ubiquitin-protein ligase TRIM33 |
| Q9UPN9 | 1040 | 1056 | 1043 | 1043 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
| Q9UPN9 | 1040 | 1056 | 974 | 1046 | Domain | Note=Bromo;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00035 |
| Q9UPN9 | 1040 | 1056 | 1051 | 1051 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9UPN9 | 620 | 686 | 1 | 1127 | Chain | ID=PRO_0000056395;Note=E3 ubiquitin-protein ligase TRIM33 |
| Q9UPN9 | 1040 | 1056 | 1041 | 1057 | Alternative sequence | ID=VSP_005774;Note=In isoform Beta. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10439047,ECO:0000303|PubMed:11331580;Dbxref=PMID:10439047,PMID:11331580 |
| Q9UPN9 | 1040 | 1056 | 1 | 1127 | Chain | ID=PRO_0000056395;Note=E3 ubiquitin-protein ligase TRIM33 |
| Q9UPN9 | 1040 | 1056 | 1043 | 1043 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
| Q9UPN9 | 1040 | 1056 | 974 | 1046 | Domain | Note=Bromo;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00035 |
| Q9UPN9 | 1040 | 1056 | 1051 | 1051 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9UPN9 | 620 | 686 | 1 | 1127 | Chain | ID=PRO_0000056395;Note=E3 ubiquitin-protein ligase TRIM33 |
| Q9UPN9 | 964 | 988 | 1 | 1127 | Chain | ID=PRO_0000056395;Note=E3 ubiquitin-protein ligase TRIM33 |
| Q9UPN9 | 964 | 988 | 974 | 1046 | Domain | Note=Bromo;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00035 |
| Q9UPN9 | 964 | 988 | 960 | 974 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MR8 |
| Q9UPN9 | 964 | 988 | 980 | 982 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MR8 |
| Q9UPN9 | 964 | 988 | 964 | 965 | Site | Note=Breakpoint for translocation to form TRIM33-RET oncogene |
| Q9UPN9 | 1040 | 1056 | 1041 | 1057 | Alternative sequence | ID=VSP_005774;Note=In isoform Beta. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10439047,ECO:0000303|PubMed:11331580;Dbxref=PMID:10439047,PMID:11331580 |
| Q9UPN9 | 1040 | 1056 | 1 | 1127 | Chain | ID=PRO_0000056395;Note=E3 ubiquitin-protein ligase TRIM33 |
| Q9UPN9 | 1040 | 1056 | 1043 | 1043 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
| Q9UPN9 | 1040 | 1056 | 974 | 1046 | Domain | Note=Bromo;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00035 |
| Q9UPN9 | 1040 | 1056 | 1051 | 1051 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
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3'-UTR located exon skipping events that lost miRNA binding sites in TRIM33 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for TRIM33 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TRIM33 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TRIM33 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TRIM33 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | RBM45 | exon_skip_29394 | 5.562020e-01 | 2.712644e-14 |
| CB | ZNF638 | exon_skip_247258 | -4.712353e-01 | 1.526475e-08 |
| CB | RBM3 | exon_skip_247258 | 5.333379e-01 | 6.448118e-11 |
| CB | TRA2A | exon_skip_247258 | -4.243840e-01 | 4.856087e-07 |
| CB | DAZAP1 | exon_skip_26434 | -4.577814e-01 | 1.650041e-08 |
| CB | RBM3 | exon_skip_26434 | 4.123501e-01 | 5.023958e-07 |
| CB | TRA2A | exon_skip_26434 | -5.978730e-01 | 9.769003e-15 |
| CB | RBM45 | exon_skip_26434 | 6.801419e-01 | 4.558463e-20 |
| CB | NUP42 | exon_skip_26434 | 5.356158e-01 | 1.296871e-11 |
| IFG | RBM3 | exon_skip_247258 | 5.935157e-01 | 1.392714e-03 |
| PCC | RBM3 | exon_skip_247258 | 5.586393e-01 | 5.507326e-17 |
| PG | ELAVL4 | exon_skip_29394 | 4.016127e-01 | 1.018531e-08 |
| STG | SRSF11 | exon_skip_29394 | 4.202987e-01 | 5.057172e-05 |
| TC | ELAVL4 | exon_skip_29394 | 4.094011e-01 | 9.232726e-08 |
| TC | HNRNPD | exon_skip_29394 | 4.377980e-01 | 8.801053e-09 |
| TC | RALYL | exon_skip_29394 | 4.199144e-01 | 3.965861e-08 |
| TC | RBM3 | exon_skip_247258 | 4.833843e-01 | 4.970622e-09 |
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RelatedDrugs for TRIM33 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRIM33 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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