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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for PRKAG2 |
 Gene summary |
| Gene information | Gene symbol | PRKAG2 | Gene ID | 51422 |
| Gene name | protein kinase AMP-activated non-catalytic subunit gamma 2 | |
| Synonyms | AAKG|AAKG2|CMH6|H91620p|WPWS | |
| Cytomap | 7q36.1 | |
| Type of gene | protein-coding | |
| Description | 5'-AMP-activated protein kinase subunit gamma-2AMPK subunit gamma-2epididymis secretory sperm binding proteinprotein kinase, AMP-activated, gamma 2 non-catalytic subunit | |
| Modification date | 20200320 | |
| UniProtAcc | A0A090N8Q6, A0A384MDZ2, A0A494C026, A0A494C068, A0A494C094, | |
| Context | - 32039845(PRKAG2 Gene Expression Is Elevated and its Protein Levels Are Associated with Increased Amyloid-beta Accumulation in the Alzheimer's Disease Brain) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| PRKAG2 | GO:0006469 | negative regulation of protein kinase activity | 17255938 |
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Gene structures and expression levels for PRKAG2 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000106617
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000651188.1 | PRKAG2-221:nonsense_mediated_decay:PRKAG2 | 3.001516e+01 | 1.270792e+00 | 2.275175e-12 | 2.946573e-10 |
| TC | UP | ENST00000492843.6 | PRKAG2-215:protein_coding:PRKAG2 | 5.282873e+01 | 2.014458e+00 | 2.662333e-07 | 1.377802e-05 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for PRKAG2 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_119026 | chr7 | 151565720:151565885:151566573:151566613:151568716:151568842 | 151566573:151566613 |
| exon_skip_120087 | chr7 | 151595345:151595454:151632069:151632138:151675420:151675637 | 151632069:151632138 |
| exon_skip_126551 | chr7 | 151565346:151565383:151565720:151565885:151570171:151570225 | 151565720:151565885 |
| exon_skip_132598 | chr7 | 151565346:151565383:151565720:151566699:151568716:151568842 | 151565720:151566699 |
| exon_skip_149001 | chr7 | 151595345:151595451:151632069:151632138:151675420:151675637 | 151632069:151632138 |
| exon_skip_152140 | chr7 | 151571462:151572709:151574891:151574949:151576371:151576452 | 151574891:151574949 |
| exon_skip_155416 | chr7 | 151565346:151565383:151565720:151565885:151568716:151568842 | 151565720:151565885 |
| exon_skip_168205 | chr7 | 151576371:151576452:151595345:151595454:151675420:151675637 | 151595345:151595454 |
| exon_skip_16932 | chr7 | 151786470:151786541:151790881:151791000:151814416:151814724 | 151790881:151791000 |
| exon_skip_182974 | chr7 | 151576371:151576452:151595345:151595454:151632069:151632138 | 151595345:151595454 |
| exon_skip_189504 | chr7 | 151572664:151572709:151574891:151574949:151576371:151576376 | 151574891:151574949 |
| exon_skip_197586 | chr7 | 151606094:151606183:151632069:151632138:151675420:151675637 | 151632069:151632138 |
| exon_skip_201132 | chr7 | 151595345:151595454:151631638:151631768:151632069:151632177 | 151631638:151631768 |
| exon_skip_224377 | chr7 | 151576371:151576452:151595345:151595451:151675420:151675637 | 151595345:151595451 |
| exon_skip_235705 | chr7 | 151565720:151565885:151566614:151566699:151568716:151568842 | 151566614:151566699 |
| exon_skip_242038 | chr7 | 151576371:151576452:151595345:151595451:151632069:151632138 | 151595345:151595451 |
| exon_skip_244303 | chr7 | 151632133:151632138:151675420:151675637:151781152:151781353 | 151675420:151675637 |
| exon_skip_253820 | chr7 | 151786470:151786541:151790881:151791000:151814416:151814644 | 151790881:151791000 |
| exon_skip_256729 | chr7 | 151565720:151565885:151568716:151568842:151570171:151570225 | 151568716:151568842 |
| exon_skip_60076 | chr7 | 151595345:151595454:151606094:151606183:151632069:151632138 | 151606094:151606183 |
| exon_skip_89941 | chr7 | 151574891:151574949:151576371:151576452:151595345:151595410 | 151576371:151576452 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_149001 | Mayo_CB | 7.017722e-01 | 8.224561e-01 | -1.206840e-01 | 2.025759e-09 |
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Open reading frame (ORF) annotation in the exon skipping event for PRKAG2 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000287878 | 151568716 | 151568842 | Frame-shift |
| ENST00000287878 | 151574891 | 151574949 | Frame-shift |
| ENST00000287878 | 151576371 | 151576452 | Frame-shift |
| ENST00000287878 | 151595345 | 151595454 | Frame-shift |
| ENST00000287878 | 151632069 | 151632138 | Frame-shift |
| ENST00000287878 | 151675420 | 151675637 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000287878 | 151574891 | 151574949 | Frame-shift |
| ENST00000287878 | 151632069 | 151632138 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000287878 | 151565720 | 151565885 | Frame-shift |
| ENST00000287878 | 151568716 | 151568842 | Frame-shift |
| ENST00000287878 | 151574891 | 151574949 | Frame-shift |
| ENST00000287878 | 151595345 | 151595454 | Frame-shift |
| ENST00000287878 | 151632069 | 151632138 | Frame-shift |
| ENST00000287878 | 151675420 | 151675637 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for PRKAG2 |
p-ENSG00000106617_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in PRKAG2 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for PRKAG2 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for PRKAG2 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PRKAG2 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for PRKAG2 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | NUP42 | exon_skip_149001 | 4.117744e-01 | 6.341402e-07 |
| CB | RBM4 | exon_skip_149001 | -4.874906e-01 | 1.755331e-09 |
| CB | NUP42 | exon_skip_120087 | 4.818532e-01 | 7.384579e-10 |
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RelatedDrugs for PRKAG2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PRKAG2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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