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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for PLAC8 |
Gene summary |
Gene information | Gene symbol | PLAC8 | Gene ID | 51316 |
Gene name | placenta associated 8 | |
Synonyms | C15|DGIC|PNAS-144|onzin | |
Cytomap | 4q21.22 | |
Type of gene | protein-coding | |
Description | placenta-specific gene 8 proteindown-regulated in gastrointestinal cancer proteinplacenta specific 8 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for PLAC8 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for PLAC8 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_12931 | chr4 | 83094678:83094791:83104896:83105020:83114666:83114715 | 83104896:83105020 |
exon_skip_156627 | chr4 | 83117884:83117971:83134535:83134634:83136959:83137075 | 83134535:83134634 |
exon_skip_191442 | chr4 | 83094678:83094791:83104896:83105020:83114666:83114736 | 83104896:83105020 |
exon_skip_239690 | chr4 | 83104896:83105020:83107804:83107950:83114666:83114715 | 83107804:83107950 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for PLAC8 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000426923 | 83107804 | 83107950 | 3UTR-3CDS |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000426923 | 83107804 | 83107950 | 3UTR-3CDS |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000426923 | 83107804 | 83107950 | 3UTR-3CDS |
ENST00000505406 | 83134535 | 83134634 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for PLAC8 |
p-ENSG00000145287_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in PLAC8 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000505406 | 83134535 | 83134634 | hsa-miR-346 | chr4:83134599-83134606 | 8mer-1a | chr4:83134588-83134607 | 168.00 | -30.50 |
Mayo | ENST00000505406 | 83134535 | 83134634 | hsa-miR-3182 | chr4:83134607-83134614 | 8mer-1a | chr4:83134597-83134618 | 154.00 | -14.25 |
Mayo | ENST00000505406 | 83134535 | 83134634 | hsa-miR-632 | chr4:83134600-83134607 | 8mer-1a | chr4:83134588-83134607 | 168.00 | -30.50 |
Mayo | ENST00000505406 | 83134535 | 83134634 | hsa-miR-4316 | chr4:83134555-83134562 | 8mer-1a | chr4:83134552-83134575 | 149.00 | -15.98 |
Mayo | ENST00000505406 | 83134535 | 83134634 | hsa-miR-3188 | chr4:83134553-83134560 | 8mer-1a | chr4:83134539-83134560 | 150.00 | -22.02 |
Mayo | ENST00000505406 | 83134535 | 83134634 | hsa-miR-6817-5p | chr4:83134566-83134573 | 8mer-1a | chr4:83134552-83134575 | 149.00 | -15.98 |
Mayo | ENST00000505406 | 83134535 | 83134634 | hsa-miR-4288 | chr4:83134600-83134607 | 8mer-1a | chr4:83134588-83134607 | 168.00 | -30.50 |
Mayo | ENST00000505406 | 83134535 | 83134634 | hsa-miR-4769-3p | chr4:83134566-83134573 | 8mer-1a | chr4:83134552-83134575 | 149.00 | -15.98 |
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SNVs in the skipped exons for PLAC8 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for PLAC8 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PLAC8 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for PLAC8 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for PLAC8 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PLAC8 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |