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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for CDK18 |
 Gene summary |
| Gene information | Gene symbol | CDK18 | Gene ID | 5129 |
| Gene name | cyclin dependent kinase 18 | |
| Synonyms | PCTAIRE|PCTAIRE3|PCTK3 | |
| Cytomap | 1q32.1 | |
| Type of gene | protein-coding | |
| Description | cyclin-dependent kinase 18PCTAIRE protein kinase 3PCTAIRE-motif protein kinase 3cell division protein kinase 18serine/threonine-protein kinase PCTAIRE-3 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context | - 32247043(The Galphaq/phospholipase Cbeta signaling system represses tau aggregation) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for CDK18 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000117266
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| STG | UP | ENST00000489617.5 | CDK18-211:retained_intron:CDK18 | 1.785706e+02 | 8.018998e-01 | 1.419598e-04 | 1.362831e-02 |
| PG | UP | ENST00000504162.1 | CDK18-212:retained_intron:CDK18 | 3.119769e+00 | 8.446238e-01 | 1.845223e-03 | 2.250742e-02 |
| CB | DOWN | ENST00000507240.1 | CDK18-219:lncRNA:CDK18 | 1.182825e+00 | -1.477554e+00 | 2.444123e-04 | 1.578096e-03 |
| TC | DOWN | ENST00000515494.5 | CDK18-222:nonsense_mediated_decay:CDK18 | 3.466222e+02 | -8.133094e-01 | 7.014646e-08 | 4.547157e-06 |
| TC | DOWN | ENST00000507240.1 | CDK18-219:lncRNA:CDK18 | 5.469267e+00 | -8.127400e-01 | 1.571709e-04 | 2.309560e-03 |
| TC | UP | ENST00000462976.1 | CDK18-206:nonsense_mediated_decay:CDK18 | 1.667073e+01 | 1.074039e+00 | 5.501675e-04 | 6.198104e-03 |
| TC | DOWN | ENST00000443813.6 | CDK18-204:protein_coding:CDK18 | 4.609883e+00 | -1.001787e+00 | 6.273285e-03 | 3.964933e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CDK18 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_166040 | chr1 | 205504749:205504796:205523147:205523625:205524232:205524329 | 205523147:205523625 |
| exon_skip_186895 | chr1 | 205504802:205504878:205523147:205523297:205523483:205523625 | 205523147:205523297 |
| exon_skip_189936 | chr1 | 205529324:205529429:205529521:205530349:205530628:205530705 | 205529521:205530349 |
| exon_skip_222812 | chr1 | 205527828:205527917:205528048:205528168:205528999:205529096 | 205528048:205528168 |
| exon_skip_248822 | chr1 | 205504749:205504796:205523147:205523297:205523483:205523625 | 205523147:205523297 |
| exon_skip_250771 | chr1 | 205526065:205526179:205526367:205526461:205526775:205526835 | 205526367:205526461 |
| exon_skip_252510 | chr1 | 205528131:205528168:205528999:205529096:205529324:205529429 | 205528999:205529096 |
| exon_skip_2791 | chr1 | 205526367:205526461:205526733:205526837:205527794:205527825 | 205526733:205526837 |
| exon_skip_31368 | chr1 | 205504802:205504878:205523147:205523625:205524232:205524329 | 205523147:205523625 |
| exon_skip_3852 | chr1 | 205529324:205529429:205529521:205529563:205530628:205530705 | 205529521:205529563 |
| exon_skip_399 | chr1 | 205504749:205504796:205523483:205523625:205524232:205524329 | 205523483:205523625 |
| exon_skip_4226 | chr1 | 205529521:205529563:205530259:205530349:205530628:205530705 | 205530259:205530349 |
| exon_skip_78261 | chr1 | 205529521:205529563:205530186:205530349:205530628:205530705 | 205530186:205530349 |
| exon_skip_82738 | chr1 | 205504659:205504796:205523147:205523297:205523483:205523501 | 205523147:205523297 |
| exon_skip_91094 | chr1 | 205526367:205526461:205526775:205526837:205527794:205527825 | 205526775:205526837 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for CDK18 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for CDK18 |
p-ENSG00000117266_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in CDK18 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for CDK18 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CDK18 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CDK18 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| PCC | exon_skip_82738 | rs10494871 | chr1:205583736 | 3.812876e-04 | 4.916609e-02 |
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Correlation with RNA binding proteins (RBPs) for CDK18 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| PCC | RBM3 | exon_skip_82738 | 4.093881e-01 | 2.324551e-09 |
| TC | RBM3 | exon_skip_248822 | 4.251122e-01 | 2.103862e-08 |
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RelatedDrugs for CDK18 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDK18 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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