|
Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for MRPL37 |
Gene summary |
Gene information | Gene symbol | MRPL37 | Gene ID | 51253 |
Gene name | mitochondrial ribosomal protein L37 | |
Synonyms | L2mt|L37mt|MRP-L2|MRP-L37|MRPL2|RPML2 | |
Cytomap | 1p32.3 | |
Type of gene | protein-coding | |
Description | 39S ribosomal protein L37, mitochondrial39S ribosomal protein L2, mitochondrialmitochondrial large ribosomal subunit protein mL37ribosomal protein, mitochondrial, L2 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
Top |
Gene structures and expression levels for MRPL37 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | DOWN | ENST00000336230.10 | MRPL37-201:protein_coding:MRPL37 | 2.513317e+01 | -3.107804e+00 | 1.276857e-07 | 2.615352e-06 |
TC | DOWN | ENST00000336230.10 | MRPL37-201:protein_coding:MRPL37 | 1.606062e+01 | -1.838634e+00 | 5.272936e-04 | 5.997883e-03 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
Top |
Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MRPL37 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_117885 | chr1 | 54205295:54205410:54207360:54207504:54209946:54210131 | 54207360:54207504 |
exon_skip_121148 | chr1 | 54209948:54210131:54212501:54212658:54216141:54216344 | 54212501:54212658 |
exon_skip_140414 | chr1 | 54205295:54205410:54209946:54210131:54212501:54212658 | 54209946:54210131 |
exon_skip_205378 | chr1 | 54209964:54210131:54212501:54212658:54216141:54216344 | 54212501:54212658 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
Top |
Open reading frame (ORF) annotation in the exon skipping event for MRPL37 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000360840 | 54212501 | 54212658 | Frame-shift |
ENST00000360840 | 54209946 | 54210131 | In-frame |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000360840 | 54212501 | 54212658 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000360840 | 54212501 | 54212658 | Frame-shift |
Top |
Infer the effects of exon skipping event on protein functional features for MRPL37 |
p-ENSG00000116221_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000360840 | 1500 | 423 | 54209946 | 54210131 | 725 | 909 | 216 | 277 |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q9BZE1 | 216 | 277 | 218 | 227 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM |
Q9BZE1 | 216 | 277 | 229 | 234 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM |
Q9BZE1 | 216 | 277 | 257 | 259 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM |
Q9BZE1 | 216 | 277 | 265 | 270 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM |
Q9BZE1 | 216 | 277 | 30 | 423 | Chain | ID=PRO_0000045905;Note=39S ribosomal protein L37%2C mitochondrial |
Q9BZE1 | 216 | 277 | 242 | 247 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM |
Q9BZE1 | 216 | 277 | 261 | 264 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Top |
3'-UTR located exon skipping events that lost miRNA binding sites in MRPL37 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Top |
SNVs in the skipped exons for MRPL37 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
AD stage-associated exon skippint events for MRPL37 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MRPL37 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
PCC | exon_skip_121148 | rs3766465 | chr1:54141131 | 2.482296e-04 | 3.548258e-02 |
PCC | exon_skip_121148 | rs671539 | chr1:54141484 | 2.482296e-04 | 3.548258e-02 |
Top |
Correlation with RNA binding proteins (RBPs) for MRPL37 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | RBM6 | exon_skip_121148 | -4.857362e-01 | 8.589765e-11 |
CB | SAMD4A | exon_skip_121148 | -5.329666e-01 | 4.765341e-13 |
CB | CNOT4 | exon_skip_121148 | -5.030498e-01 | 1.402605e-11 |
CB | PCBP4 | exon_skip_121148 | 5.608551e-01 | 1.487183e-14 |
CB | PTBP1 | exon_skip_121148 | -4.932906e-01 | 3.944425e-11 |
Top |
RelatedDrugs for MRPL37 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for MRPL37 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |