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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ZNF706 |
 Gene summary |
| Gene information | Gene symbol | ZNF706 | Gene ID | 51123 |
| Gene name | zinc finger protein 706 | |
| Synonyms | HSPC038|PNAS-106|PNAS-113 | |
| Cytomap | 8q22.3 | |
| Type of gene | protein-coding | |
| Description | zinc finger protein 706 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ZNF706 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000120963
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000517844.5 | ZNF706-202:protein_coding:ZNF706 | 2.968267e+02 | -8.416643e-01 | 1.130672e-11 | 1.081087e-09 |
| CB | UP | ENST00000519744.5 | ZNF706-206:protein_coding:ZNF706 | 1.900127e+00 | 1.090813e+00 | 6.749185e-03 | 2.516725e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ZNF706 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_10712 | chr8 | 101201716:101201743:101202333:101202447:101205435:101205461 | 101202333:101202447 |
| exon_skip_132016 | chr8 | 101201607:101201743:101202333:101202447:101204650:101204701 | 101202333:101202447 |
| exon_skip_132369 | chr8 | 101177997:101178387:101199195:101199239:101199990:101200093 | 101199195:101199239 |
| exon_skip_185369 | chr8 | 101202333:101202447:101204650:101204693:101205435:101205461 | 101204650:101204693 |
| exon_skip_19945 | chr8 | 101202333:101202447:101204650:101204693:101205435:101205682 | 101204650:101204693 |
| exon_skip_210590 | chr8 | 101198726:101199239:101199990:101200123:101201607:101201743 | 101199990:101200123 |
| exon_skip_229168 | chr8 | 101201716:101201743:101202333:101202447:101204650:101204693 | 101202333:101202447 |
| exon_skip_52617 | chr8 | 101198726:101199239:101199990:101200097:101201607:101201743 | 101199990:101200097 |
| exon_skip_63397 | chr8 | 101202333:101202447:101204650:101204779:101205211:101205329 | 101204650:101204779 |
| exon_skip_72477 | chr8 | 101199195:101199239:101199990:101200097:101201607:101201639 | 101199990:101200097 |
| exon_skip_75489 | chr8 | 101177997:101178387:101199990:101200097:101201607:101201657 | 101199990:101200097 |
| exon_skip_76653 | chr8 | 101199195:101199239:101199990:101200097:101201607:101201657 | 101199990:101200097 |
| exon_skip_88650 | chr8 | 101199195:101199239:101199990:101200123:101201607:101201657 | 101199990:101200123 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ZNF706 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000519882 | 101202333 | 101202447 | 3UTR-3UTR |
| ENST00000521272 | 101202333 | 101202447 | 3UTR-3UTR |
| ENST00000521272 | 101204650 | 101204693 | 3UTR-3UTR |
| ENST00000311212 | 101199990 | 101200097 | 5CDS-5UTR |
| ENST00000517844 | 101199990 | 101200097 | 5CDS-5UTR |
| ENST00000518336 | 101199990 | 101200097 | 5CDS-5UTR |
| ENST00000519882 | 101199990 | 101200097 | 5CDS-5UTR |
| ENST00000520347 | 101199990 | 101200097 | 5CDS-5UTR |
| ENST00000520984 | 101199990 | 101200097 | 5CDS-5UTR |
| ENST00000521272 | 101199990 | 101200097 | 5CDS-5UTR |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000519882 | 101202333 | 101202447 | 3UTR-3UTR |
| ENST00000521272 | 101202333 | 101202447 | 3UTR-3UTR |
| ENST00000521272 | 101204650 | 101204693 | 3UTR-3UTR |
| ENST00000311212 | 101199990 | 101200097 | 5CDS-5UTR |
| ENST00000517844 | 101199990 | 101200097 | 5CDS-5UTR |
| ENST00000518336 | 101199990 | 101200097 | 5CDS-5UTR |
| ENST00000519882 | 101199990 | 101200097 | 5CDS-5UTR |
| ENST00000520347 | 101199990 | 101200097 | 5CDS-5UTR |
| ENST00000521272 | 101199990 | 101200097 | 5CDS-5UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000519882 | 101202333 | 101202447 | 3UTR-3UTR |
| ENST00000521272 | 101202333 | 101202447 | 3UTR-3UTR |
| ENST00000521272 | 101204650 | 101204693 | 3UTR-3UTR |
| ENST00000311212 | 101199990 | 101200097 | 5CDS-5UTR |
| ENST00000517844 | 101199990 | 101200097 | 5CDS-5UTR |
| ENST00000518336 | 101199990 | 101200097 | 5CDS-5UTR |
| ENST00000519882 | 101199990 | 101200097 | 5CDS-5UTR |
| ENST00000520347 | 101199990 | 101200097 | 5CDS-5UTR |
| ENST00000520984 | 101199990 | 101200097 | 5CDS-5UTR |
| ENST00000521272 | 101199990 | 101200097 | 5CDS-5UTR |
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Infer the effects of exon skipping event on protein functional features for ZNF706 |
p-ENSG00000120963_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in ZNF706 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000521272 | 101202333 | 101202447 | hsa-miR-3085-5p | chr8:101202410-101202417 | 8mer-1a | chr8:101202402-101202424 | 165.00 | -22.52 |
| Mayo | ENST00000521272 | 101202333 | 101202447 | hsa-miR-1304-3p | chr8:101202438-101202445 | 8mer-1a | chr8:101202424-101202445 | 160.00 | -21.76 |
| Mayo | ENST00000521272 | 101202333 | 101202447 | hsa-miR-6760-3p | chr8:101202436-101202443 | 8mer-1a | chr8:101202424-101202445 | 160.00 | -21.76 |
| Mayo | ENST00000521272 | 101202333 | 101202447 | hsa-miR-6778-3p | chr8:101202382-101202389 | 8mer-1a | chr8:101202378-101202400 | 162.00 | -22.87 |
| MSBB | ENST00000521272 | 101202333 | 101202447 | hsa-miR-3085-5p | chr8:101202410-101202417 | 8mer-1a | chr8:101202402-101202424 | 165.00 | -22.52 |
| MSBB | ENST00000521272 | 101202333 | 101202447 | hsa-miR-1304-3p | chr8:101202438-101202445 | 8mer-1a | chr8:101202424-101202445 | 160.00 | -21.76 |
| MSBB | ENST00000521272 | 101202333 | 101202447 | hsa-miR-6760-3p | chr8:101202436-101202443 | 8mer-1a | chr8:101202424-101202445 | 160.00 | -21.76 |
| MSBB | ENST00000521272 | 101202333 | 101202447 | hsa-miR-6778-3p | chr8:101202382-101202389 | 8mer-1a | chr8:101202378-101202400 | 162.00 | -22.87 |
| ROSMAP | ENST00000521272 | 101202333 | 101202447 | hsa-miR-3085-5p | chr8:101202410-101202417 | 8mer-1a | chr8:101202402-101202424 | 165.00 | -22.52 |
| ROSMAP | ENST00000521272 | 101202333 | 101202447 | hsa-miR-1304-3p | chr8:101202438-101202445 | 8mer-1a | chr8:101202424-101202445 | 160.00 | -21.76 |
| ROSMAP | ENST00000521272 | 101202333 | 101202447 | hsa-miR-6760-3p | chr8:101202436-101202443 | 8mer-1a | chr8:101202424-101202445 | 160.00 | -21.76 |
| ROSMAP | ENST00000521272 | 101202333 | 101202447 | hsa-miR-6778-3p | chr8:101202382-101202389 | 8mer-1a | chr8:101202378-101202400 | 162.00 | -22.87 |
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SNVs in the skipped exons for ZNF706 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ZNF706 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZNF706 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ZNF706 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| DLPFC | SNRNP70 | exon_skip_10712 | 5.596325e-01 | 1.162550e-29 |
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RelatedDrugs for ZNF706 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF706 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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