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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for FAM135B |
 Gene summary |
| Gene information | Gene symbol | FAM135B | Gene ID | 51059 |
| Gene name | family with sequence similarity 135 member B | |
| Synonyms | C8ORFK32 | |
| Cytomap | 8q24.23 | |
| Type of gene | protein-coding | |
| Description | protein FAM135B | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for FAM135B |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000147724
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | DOWN | ENST00000517849.1 | FAM135B-207:lncRNA:FAM135B | 1.021805e+00 | -8.602386e-01 | 3.700158e-04 | 7.132041e-03 |
| CB | UP | ENST00000467365.1 | FAM135B-205:nonsense_mediated_decay:FAM135B | 9.035493e+00 | 1.198733e+00 | 1.705007e-07 | 3.331615e-06 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for FAM135B |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_114184 | chr8 | 138151194:138153216:138167895:138168049:138177347:138177420 | 138167895:138168049 |
| exon_skip_125998 | chr8 | 138242942:138243068:138250841:138251014:138256689:138256759 | 138250841:138251014 |
| exon_skip_136386 | chr8 | 138250924:138251014:138256689:138256759:138265703:138265842 | 138256689:138256759 |
| exon_skip_155833 | chr8 | 138250924:138251014:138256689:138256759:138265703:138265835 | 138256689:138256759 |
| exon_skip_202586 | chr8 | 138141208:138141349:138143012:138143109:138145959:138146050 | 138143012:138143109 |
| exon_skip_27062 | chr8 | 138197516:138197669:138242942:138243068:138250841:138251014 | 138242942:138243068 |
| exon_skip_285559 | chr8 | 138265819:138265842:138310841:138310920:138367907:138368002 | 138310841:138310920 |
| exon_skip_59729 | chr8 | 138141198:138141349:138143012:138143109:138145959:138146050 | 138143012:138143109 |
| exon_skip_61490 | chr8 | 138310841:138310920:138367907:138368002:138496671:138496822 | 138367907:138368002 |
| exon_skip_65655 | chr8 | 138310841:138310920:138358338:138358560:138367907:138368002 | 138358338:138358560 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for FAM135B |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000395297 | 138143012 | 138143109 | Frame-shift |
| ENST00000395297 | 138242942 | 138243068 | Frame-shift |
| ENST00000395297 | 138256689 | 138256759 | Frame-shift |
| ENST00000395297 | 138310841 | 138310920 | Frame-shift |
| ENST00000395297 | 138250841 | 138251014 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000395297 | 138143012 | 138143109 | Frame-shift |
| ENST00000395297 | 138256689 | 138256759 | Frame-shift |
| ENST00000395297 | 138310841 | 138310920 | Frame-shift |
| ENST00000395297 | 138250841 | 138251014 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000395297 | 138143012 | 138143109 | Frame-shift |
| ENST00000395297 | 138167895 | 138168049 | Frame-shift |
| ENST00000395297 | 138242942 | 138243068 | Frame-shift |
| ENST00000395297 | 138256689 | 138256759 | Frame-shift |
| ENST00000395297 | 138310841 | 138310920 | Frame-shift |
| ENST00000395297 | 138250841 | 138251014 | In-frame |
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Infer the effects of exon skipping event on protein functional features for FAM135B |
p-ENSG00000147724_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000395297 | 6979 | 1406 | 138250841 | 138251014 | 540 | 712 | 123 | 180 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000395297 | 6979 | 1406 | 138250841 | 138251014 | 540 | 712 | 123 | 180 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000395297 | 6979 | 1406 | 138250841 | 138251014 | 540 | 712 | 123 | 180 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q49AJ0 | 123 | 180 | 1 | 1406 | Chain | ID=PRO_0000314171;Note=Protein FAM135B |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q49AJ0 | 123 | 180 | 1 | 1406 | Chain | ID=PRO_0000314171;Note=Protein FAM135B |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q49AJ0 | 123 | 180 | 1 | 1406 | Chain | ID=PRO_0000314171;Note=Protein FAM135B |
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3'-UTR located exon skipping events that lost miRNA binding sites in FAM135B |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for FAM135B |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for FAM135B |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FAM135B |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for FAM135B |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | TRA2A | exon_skip_202586 | -4.443310e-01 | 5.999061e-08 |
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RelatedDrugs for FAM135B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FAM135B |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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