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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for NTM |
 Gene summary |
| Gene information | Gene symbol | NTM | Gene ID | 50863 |
| Gene name | neurotrimin | |
| Synonyms | CEPU-1|HNT|IGLON2|NTRI | |
| Cytomap | 11q25 | |
| Type of gene | protein-coding | |
| Description | neurotriminIgLON family member 2 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for NTM |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000182667
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PCC | UP | ENST00000436745.5 | NTM-207:protein_coding:NTM | 1.272976e+01 | 1.236604e+00 | 6.742377e-04 | 1.987988e-02 |
| STG | UP | ENST00000425719.6 | NTM-205:protein_coding:NTM | 2.224876e+01 | 3.739783e+00 | 8.001009e-04 | 3.422860e-02 |
| PG | DOWN | ENST00000474900.5 | NTM-212:lncRNA:NTM | 5.878499e+01 | -8.003711e-01 | 4.567240e-06 | 2.808075e-04 |
| CB | DOWN | ENST00000474900.5 | NTM-212:lncRNA:NTM | 2.165389e+02 | -1.710687e+00 | 2.133565e-18 | 4.607998e-15 |
| CB | DOWN | ENST00000436745.5 | NTM-207:protein_coding:NTM | 8.299622e+00 | -1.666787e+00 | 1.066379e-05 | 1.112464e-04 |
| TC | DOWN | ENST00000436745.5 | NTM-207:protein_coding:NTM | 5.099582e+00 | -2.474575e+00 | 4.276624e-06 | 1.315464e-04 |
| TC | DOWN | ENST00000474900.5 | NTM-212:lncRNA:NTM | 2.283137e+02 | -8.521365e-01 | 1.799951e-05 | 4.124504e-04 |
| TC | DOWN | ENST00000539799.5 | NTM-221:protein_coding:NTM | 7.950889e+02 | -8.876488e-01 | 3.555322e-03 | 2.591437e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for NTM |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_118252 | chr11 | 132307689:132307823:132310112:132310232:132314552:132314599 | 132310112:132310232 |
| exon_skip_124482 | chr11 | 132212040:132212147:132306295:132306468:132307689:132307763 | 132306295:132306468 |
| exon_skip_201331 | chr11 | 132310196:132310232:132312665:132312782:132314552:132314599 | 132312665:132312782 |
| exon_skip_206731 | chr11 | 131911564:131911648:132146282:132146514:132212022:132212147 | 132146282:132146514 |
| exon_skip_213252 | chr11 | 132212022:132212147:132306295:132306468:132307689:132307763 | 132306295:132306468 |
| exon_skip_26153 | chr11 | 132317655:132317690:132330153:132330185:132335046:132335051 | 132330153:132330185 |
| exon_skip_57488 | chr11 | 132314552:132314703:132330153:132330185:132335046:132335051 | 132330153:132330185 |
| exon_skip_6473 | chr11 | 132314552:132314703:132317655:132317690:132330153:132330185 | 132317655:132317690 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_57488 | MSBB_PG | 3.712037e-01 | 2.086792e-01 | 1.625245e-01 | 2.111467e-08 |
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Open reading frame (ORF) annotation in the exon skipping event for NTM |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000374786 | 132146282 | 132146514 | Frame-shift |
| ENST00000374786 | 132310112 | 132310232 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000374786 | 132146282 | 132146514 | Frame-shift |
| ENST00000374786 | 132310112 | 132310232 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000374786 | 132146282 | 132146514 | Frame-shift |
| ENST00000374786 | 132310112 | 132310232 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for NTM |
p-ENSG00000182667_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in NTM |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for NTM |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for NTM |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| ADstage | MSBB | IFG | exon_skip_10059 | 4.734135e-01 | 1.094180e-02 | chr11 | + | 132310196 | 132310232 | 132312685 | 132312782 | 132314552 | 132314599 |
| ADstage | MSBB | IFG | exon_skip_57488 | 3.839296e-01 | 4.369657e-02 | chr11 | + | 132314552 | 132314703 | 132330153 | 132330185 | 132335046 | 132335051 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NTM |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| HCC | exon_skip_6473 | rs571365 | chr11:132339189 | 8.068020e-04 | 4.935841e-02 |
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Correlation with RNA binding proteins (RBPs) for NTM |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | TARDBP | exon_skip_118252 | -5.148510e-01 | 3.842212e-12 |
| CB | PABPN1 | exon_skip_118252 | -4.285675e-01 | 1.743162e-08 |
| CB | RBM6 | exon_skip_118252 | -4.023029e-01 | 1.467041e-07 |
| CB | TRA2A | exon_skip_118252 | -5.798459e-01 | 1.157659e-15 |
| CB | HNRNPA2B1 | exon_skip_118252 | -4.835019e-01 | 1.077392e-10 |
| CB | NUP42 | exon_skip_118252 | 4.333286e-01 | 1.161502e-08 |
| DLPFC | EIF4B | exon_skip_57488 | -4.268327e-01 | 2.130845e-16 |
| FL | HNRNPK | exon_skip_57488 | -4.920852e-01 | 3.650511e-13 |
| FL | EIF4B | exon_skip_57488 | -4.083404e-01 | 3.746937e-09 |
| HCC | PCBP1 | exon_skip_57488 | 4.528292e-01 | 3.711047e-15 |
| HCC | TRA2A | exon_skip_57488 | 4.363869e-01 | 4.503270e-14 |
| PG | PCBP1 | exon_skip_57488 | -4.427702e-01 | 4.072329e-09 |
| PG | HNRNPK | exon_skip_57488 | -5.103264e-01 | 4.667367e-12 |
| STG | PCBP1 | exon_skip_57488 | -5.294870e-01 | 1.590196e-07 |
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RelatedDrugs for NTM |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NTM |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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