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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for PAM |
 Gene summary |
| Gene information | Gene symbol | PAM | Gene ID | 5066 |
| Gene name | peptidylglycine alpha-amidating monooxygenase | |
| Synonyms | PAL|PHM | |
| Cytomap | 5q21.1 | |
| Type of gene | protein-coding | |
| Description | peptidyl-glycine alpha-amidating monooxygenasepancreatic peptidylglycine alpha-amidating monooxygenasepeptidyl alpha-amidating enzymepeptidyl-alpha-hydroxyglycine alpha-amidating lyasepeptidylamidoglycolate lyasepeptidylglycine 2-hydroxylasepeptidyl | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| PAM | GO:0001519 | peptide amidation | 2357221|12699694 |
| PAM | GO:0010043 | response to zinc ion | 12699694 |
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Gene structures and expression levels for PAM |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000145730
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
 |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | DOWN | ENST00000509523.1 | PAM-217:lncRNA:PAM | 4.937422e+00 | -8.401024e-01 | 2.099079e-03 | 2.473305e-02 |
| CB | UP | ENST00000513648.5 | PAM-226:lncRNA:PAM | 2.977800e+00 | 1.110413e+00 | 4.102316e-07 | 7.036996e-06 |
| CB | UP | ENST00000345721.6 | PAM-202:nonsense_mediated_decay:PAM | 1.601267e+02 | 9.234683e-01 | 2.721873e-05 | 2.458004e-04 |
| TC | UP | ENST00000346918.6 | PAM-203:protein_coding:PAM | 1.147924e+01 | 1.096609e+00 | 6.215726e-06 | 1.768743e-04 |
| TC | DOWN | ENST00000509523.1 | PAM-217:lncRNA:PAM | 1.879051e+00 | -1.132984e+00 | 3.168715e-03 | 2.377806e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for PAM |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
 |
| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_103241 | chr5 | 103019790:103019843:103028185:103028238:103028887:103029110 | 103028185:103028238 |
| exon_skip_146331 | chr5 | 103025242:103025334:103028182:103028238:103028887:103029110 | 103028182:103028238 |
| exon_skip_164210 | chr5 | 103025283:103025334:103028182:103028238:103028887:103029110 | 103028182:103028238 |
| exon_skip_18514 | chr5 | 102867281:102867393:102901356:102901413:102913934:102914021 | 102901356:102901413 |
| exon_skip_192560 | chr5 | 103025134:103025334:103028185:103028238:103028887:103029110 | 103028185:103028238 |
| exon_skip_202833 | chr5 | 103019790:103019843:103025134:103025334:103028182:103028222 | 103025134:103025334 |
| exon_skip_203233 | chr5 | 103017334:103017433:103019790:103019843:103025131:103025334 | 103019790:103019843 |
| exon_skip_211110 | chr5 | 103025134:103025334:103028182:103028238:103028887:103029110 | 103028182:103028238 |
| exon_skip_214079 | chr5 | 102867273:102867393:102901356:102901413:102913934:102914021 | 102901356:102901413 |
| exon_skip_217285 | chr5 | 103009751:103009866:103017334:103017433:103019790:103019843 | 103017334:103017433 |
| exon_skip_230631 | chr5 | 103025301:103025334:103028182:103028238:103028887:103029110 | 103028182:103028238 |
| exon_skip_246479 | chr5 | 103025242:103025334:103028185:103028238:103028887:103029110 | 103028185:103028238 |
| exon_skip_259932 | chr5 | 103025283:103025334:103028185:103028238:103028887:103029110 | 103028185:103028238 |
| exon_skip_261949 | chr5 | 103025301:103025334:103028185:103028238:103028887:103029110 | 103028185:103028238 |
| exon_skip_265670 | chr5 | 103019790:103019843:103025134:103025334:103028185:103028238 | 103025134:103025334 |
| exon_skip_29111 | chr5 | 102961158:102961229:102974116:102974436:102990272:102990401 | 102974116:102974436 |
| exon_skip_294575 | chr5 | 103019790:103019843:103028182:103028238:103028887:103029110 | 103028182:103028238 |
| exon_skip_34366 | chr5 | 103019790:103019843:103025131:103025334:103028182:103028222 | 103025131:103025334 |
| exon_skip_59144 | chr5 | 103019790:103019843:103025131:103025334:103028887:103029110 | 103025131:103025334 |
| exon_skip_71822 | chr5 | 102866116:102866284:102867273:102867393:102913934:102914021 | 102867273:102867393 |
| exon_skip_77677 | chr5 | 103009766:103009866:103017334:103017433:103019790:103019843 | 103017334:103017433 |
| exon_skip_92062 | chr5 | 102961164:102961229:102974116:102974436:102990272:102990401 | 102974116:102974436 |
| exon_skip_95746 | chr5 | 103019790:103019843:103025131:103025334:103028185:103028238 | 103025131:103025334 |
| exon_skip_99712 | chr5 | 102866116:102866284:102867273:102867393:102901356:102901413 | 102867273:102867393 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_29111 | MSBB_PG | 7.365714e-01 | 8.668519e-01 | -1.302804e-01 | 4.646025e-05 |
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Open reading frame (ORF) annotation in the exon skipping event for PAM |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000438793 | 102901356 | 102901413 | Frame-shift |
| ENST00000438793 | 103017334 | 103017433 | Frame-shift |
| ENST00000438793 | 102974116 | 102974436 | In-frame |
| ENST00000438793 | 103019790 | 103019843 | In-frame |
| ENST00000438793 | 103025131 | 103025334 | In-frame |
| ENST00000438793 | 103028185 | 103028238 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000438793 | 102901356 | 102901413 | Frame-shift |
| ENST00000438793 | 103017334 | 103017433 | Frame-shift |
| ENST00000438793 | 102974116 | 102974436 | In-frame |
| ENST00000438793 | 103025131 | 103025334 | In-frame |
| ENST00000438793 | 103028185 | 103028238 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000438793 | 102867273 | 102867393 | Frame-shift |
| ENST00000438793 | 102901356 | 102901413 | Frame-shift |
| ENST00000438793 | 103017334 | 103017433 | Frame-shift |
| ENST00000438793 | 102974116 | 102974436 | In-frame |
| ENST00000438793 | 103025131 | 103025334 | In-frame |
| ENST00000438793 | 103028185 | 103028238 | In-frame |
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Infer the effects of exon skipping event on protein functional features for PAM |
p-ENSG00000145730_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000438793 | 5449 | 973 | 102974116 | 102974436 | 1634 | 1953 | 388 | 494 |
| ENST00000438793 | 5449 | 973 | 103019790 | 103019843 | 2903 | 2955 | 811 | 828 |
| ENST00000438793 | 5449 | 973 | 103025131 | 103025334 | 2957 | 3159 | 829 | 896 |
| ENST00000438793 | 5449 | 973 | 103028185 | 103028238 | 3161 | 3213 | 897 | 914 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000438793 | 5449 | 973 | 102974116 | 102974436 | 1634 | 1953 | 388 | 494 |
| ENST00000438793 | 5449 | 973 | 103025131 | 103025334 | 2957 | 3159 | 829 | 896 |
| ENST00000438793 | 5449 | 973 | 103028185 | 103028238 | 3161 | 3213 | 897 | 914 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000438793 | 5449 | 973 | 102974116 | 102974436 | 1634 | 1953 | 388 | 494 |
| ENST00000438793 | 5449 | 973 | 103025131 | 103025334 | 2957 | 3159 | 829 | 896 |
| ENST00000438793 | 5449 | 973 | 103028185 | 103028238 | 3161 | 3213 | 897 | 914 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P19021 | 388 | 494 | 388 | 494 | Alternative sequence | ID=VSP_001227;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.5;Dbxref=PMID:15489334 |
| P19021 | 388 | 494 | 31 | 973 | Chain | ID=PRO_0000006362;Note=Peptidyl-glycine alpha-amidating monooxygenase |
| P19021 | 388 | 494 | 1 | 494 | Region | Note=Peptidylglycine alpha-hydroxylating monooxygenase;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P19021 | 388 | 494 | 31 | 863 | Topological domain | Note=Intragranular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P19021 | 811 | 828 | 31 | 973 | Chain | ID=PRO_0000006362;Note=Peptidyl-glycine alpha-amidating monooxygenase |
| P19021 | 811 | 828 | 495 | 817 | Region | Note=Peptidyl-alpha-hydroxyglycine alpha-amidating lyase;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P19021 | 811 | 828 | 31 | 863 | Topological domain | Note=Intragranular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P19021 | 829 | 896 | 829 | 914 | Alternative sequence | ID=VSP_001229;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.9 |
| P19021 | 829 | 896 | 829 | 896 | Alternative sequence | ID=VSP_001228;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7999037;Dbxref=PMID:7999037 |
| P19021 | 829 | 896 | 896 | 896 | Alternative sequence | ID=VSP_038691;Note=In isoform 5. G->GA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2357221;Dbxref=PMID:2357221 |
| P19021 | 829 | 896 | 31 | 973 | Chain | ID=PRO_0000006362;Note=Peptidyl-glycine alpha-amidating monooxygenase |
| P19021 | 829 | 896 | 830 | 831 | Sequence conflict | Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P19021 | 829 | 896 | 31 | 863 | Topological domain | Note=Intragranular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P19021 | 829 | 896 | 888 | 973 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P19021 | 829 | 896 | 864 | 887 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P19021 | 897 | 914 | 829 | 914 | Alternative sequence | ID=VSP_001229;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.9 |
| P19021 | 897 | 914 | 897 | 914 | Alternative sequence | ID=VSP_042209;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9110174;Dbxref=PMID:9110174 |
| P19021 | 897 | 914 | 31 | 973 | Chain | ID=PRO_0000006362;Note=Peptidyl-glycine alpha-amidating monooxygenase |
| P19021 | 897 | 914 | 888 | 973 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P19021 | 388 | 494 | 388 | 494 | Alternative sequence | ID=VSP_001227;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.5;Dbxref=PMID:15489334 |
| P19021 | 388 | 494 | 31 | 973 | Chain | ID=PRO_0000006362;Note=Peptidyl-glycine alpha-amidating monooxygenase |
| P19021 | 388 | 494 | 1 | 494 | Region | Note=Peptidylglycine alpha-hydroxylating monooxygenase;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P19021 | 388 | 494 | 31 | 863 | Topological domain | Note=Intragranular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P19021 | 829 | 896 | 829 | 914 | Alternative sequence | ID=VSP_001229;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.9 |
| P19021 | 829 | 896 | 829 | 896 | Alternative sequence | ID=VSP_001228;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7999037;Dbxref=PMID:7999037 |
| P19021 | 829 | 896 | 896 | 896 | Alternative sequence | ID=VSP_038691;Note=In isoform 5. G->GA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2357221;Dbxref=PMID:2357221 |
| P19021 | 829 | 896 | 31 | 973 | Chain | ID=PRO_0000006362;Note=Peptidyl-glycine alpha-amidating monooxygenase |
| P19021 | 829 | 896 | 830 | 831 | Sequence conflict | Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P19021 | 829 | 896 | 31 | 863 | Topological domain | Note=Intragranular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P19021 | 829 | 896 | 888 | 973 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P19021 | 829 | 896 | 864 | 887 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P19021 | 897 | 914 | 829 | 914 | Alternative sequence | ID=VSP_001229;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.9 |
| P19021 | 897 | 914 | 897 | 914 | Alternative sequence | ID=VSP_042209;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9110174;Dbxref=PMID:9110174 |
| P19021 | 897 | 914 | 31 | 973 | Chain | ID=PRO_0000006362;Note=Peptidyl-glycine alpha-amidating monooxygenase |
| P19021 | 897 | 914 | 888 | 973 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P19021 | 388 | 494 | 388 | 494 | Alternative sequence | ID=VSP_001227;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.5;Dbxref=PMID:15489334 |
| P19021 | 388 | 494 | 31 | 973 | Chain | ID=PRO_0000006362;Note=Peptidyl-glycine alpha-amidating monooxygenase |
| P19021 | 388 | 494 | 1 | 494 | Region | Note=Peptidylglycine alpha-hydroxylating monooxygenase;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P19021 | 388 | 494 | 31 | 863 | Topological domain | Note=Intragranular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P19021 | 829 | 896 | 829 | 914 | Alternative sequence | ID=VSP_001229;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.9 |
| P19021 | 829 | 896 | 829 | 896 | Alternative sequence | ID=VSP_001228;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7999037;Dbxref=PMID:7999037 |
| P19021 | 829 | 896 | 896 | 896 | Alternative sequence | ID=VSP_038691;Note=In isoform 5. G->GA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2357221;Dbxref=PMID:2357221 |
| P19021 | 829 | 896 | 31 | 973 | Chain | ID=PRO_0000006362;Note=Peptidyl-glycine alpha-amidating monooxygenase |
| P19021 | 829 | 896 | 830 | 831 | Sequence conflict | Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P19021 | 829 | 896 | 31 | 863 | Topological domain | Note=Intragranular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P19021 | 829 | 896 | 888 | 973 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P19021 | 829 | 896 | 864 | 887 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P19021 | 897 | 914 | 829 | 914 | Alternative sequence | ID=VSP_001229;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.9 |
| P19021 | 897 | 914 | 897 | 914 | Alternative sequence | ID=VSP_042209;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9110174;Dbxref=PMID:9110174 |
| P19021 | 897 | 914 | 31 | 973 | Chain | ID=PRO_0000006362;Note=Peptidyl-glycine alpha-amidating monooxygenase |
| P19021 | 897 | 914 | 888 | 973 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in PAM |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for PAM |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for PAM |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| ADstage | MSBB | IFG | exon_skip_29111 | -4.098564e-01 | 3.030694e-02 | chr5 | + | 102961158 | 102961229 | 102974116 | 102974436 | 102990272 | 102990401 |
| CDR | MSBB | IFG | exon_skip_29111 | -3.910503e-01 | 3.962304e-02 | chr5 | + | 102961158 | 102961229 | 102974116 | 102974436 | 102990272 | 102990401 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PAM |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for PAM |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | DAZAP1 | exon_skip_214079 | -4.490820e-01 | 1.847668e-08 |
| CB | HNRNPL | exon_skip_214079 | -4.290265e-01 | 8.980027e-08 |
| CB | ELAVL4 | exon_skip_92062 | 4.709764e-01 | 1.184192e-09 |
| CB | HNRNPK | exon_skip_92062 | 4.750567e-01 | 8.129521e-10 |
| CB | PCBP2 | exon_skip_92062 | 4.527685e-01 | 5.981430e-09 |
| CB | HNRNPA0 | exon_skip_92062 | 4.807690e-01 | 4.761387e-10 |
| CB | HNRNPDL | exon_skip_92062 | 4.098746e-01 | 1.902534e-07 |
| CB | HNRNPD | exon_skip_92062 | 4.243426e-01 | 6.246747e-08 |
| CB | NUP42 | exon_skip_92062 | 4.432189e-01 | 1.347582e-08 |
| CB | RALYL | exon_skip_92062 | 5.397676e-01 | 1.021131e-12 |
| CB | PABPC1 | exon_skip_92062 | 4.810466e-01 | 4.638008e-10 |
| CB | SRSF9 | exon_skip_92062 | 4.539641e-01 | 5.393539e-09 |
| CB | HNRNPH2 | exon_skip_92062 | 4.842200e-01 | 3.429927e-10 |
| CB | HNRNPK | exon_skip_202833 | 4.206589e-01 | 3.374966e-08 |
| CB | HNRNPL | exon_skip_265670 | 4.141948e-01 | 5.719729e-08 |
| DLPFC | RBMS2 | exon_skip_29111 | -4.869740e-01 | 7.462531e-19 |
| DLPFC | KHDRBS2 | exon_skip_29111 | 6.902560e-01 | 8.649724e-43 |
| DLPFC | SRSF11 | exon_skip_265670 | -4.345728e-01 | 1.891500e-16 |
| DLPFC | SRSF11 | exon_skip_202833 | -4.516570e-01 | 5.421833e-18 |
| FL | SRSF2 | exon_skip_29111 | 5.391131e-01 | 5.078897e-16 |
| FL | MSI1 | exon_skip_29111 | -5.950454e-01 | 5.733285e-20 |
| FL | ELAVL4 | exon_skip_29111 | 6.301294e-01 | 7.295643e-23 |
| FL | MATR3 | exon_skip_29111 | 6.245140e-01 | 2.244913e-22 |
| FL | ILF2 | exon_skip_29111 | 5.448965e-01 | 2.143757e-16 |
| FL | HNRNPK | exon_skip_29111 | 5.187670e-01 | 9.292675e-15 |
| FL | KHDRBS2 | exon_skip_29111 | 4.180039e-01 | 1.324037e-09 |
| FL | KHDRBS3 | exon_skip_29111 | 5.904743e-01 | 1.288200e-19 |
| FL | HNRNPA0 | exon_skip_29111 | 5.573643e-01 | 3.152588e-17 |
| FL | PUF60 | exon_skip_29111 | 4.316401e-01 | 3.305362e-10 |
| FL | RALYL | exon_skip_29111 | 5.988553e-01 | 2.891142e-20 |
| FL | PTBP1 | exon_skip_29111 | -4.298963e-01 | 3.960887e-10 |
| FL | HNRNPL | exon_skip_29111 | 4.954523e-01 | 2.064777e-13 |
| FL | SRSF9 | exon_skip_29111 | 5.076532e-01 | 4.196580e-14 |
| FL | HNRNPH2 | exon_skip_29111 | 4.718421e-01 | 3.788179e-12 |
| FL | ESRP1 | exon_skip_29111 | 4.963748e-01 | 1.834455e-13 |
| HCC | DAZAP1 | exon_skip_29111 | -6.212830e-01 | 1.965655e-30 |
| HCC | RBMS2 | exon_skip_29111 | -7.475589e-01 | 6.774292e-50 |
| HCC | RBMS3 | exon_skip_29111 | -5.355997e-01 | 1.352542e-21 |
| HCC | MSI1 | exon_skip_29111 | -7.050470e-01 | 3.444118e-42 |
| HCC | RBM25 | exon_skip_29111 | -4.926636e-01 | 4.878456e-18 |
| HCC | ZNF638 | exon_skip_29111 | -5.483601e-01 | 9.393591e-23 |
| HCC | RBM6 | exon_skip_29111 | -6.853746e-01 | 4.511597e-39 |
| HCC | SRSF11 | exon_skip_29111 | -5.823307e-01 | 4.316657e-26 |
| HCC | CNOT4 | exon_skip_29111 | -4.600537e-01 | 1.186888e-15 |
| HCC | RBM5 | exon_skip_29111 | -6.549583e-01 | 1.038629e-34 |
| HCC | IGF2BP2 | exon_skip_29111 | -4.268682e-01 | 1.798245e-13 |
| HCC | TRNAU1AP | exon_skip_29111 | -5.579258e-01 | 1.178909e-23 |
| HCC | PCBP1 | exon_skip_29111 | -4.603507e-01 | 1.131896e-15 |
| HCC | PCBP4 | exon_skip_29111 | -5.032341e-01 | 7.220764e-19 |
| HCC | TRA2A | exon_skip_29111 | -4.013881e-01 | 5.947710e-12 |
| HCC | PCBP2 | exon_skip_29111 | -4.315145e-01 | 9.197856e-14 |
| HCC | KHDRBS2 | exon_skip_29111 | 4.383164e-01 | 3.383215e-14 |
| HCC | SF1 | exon_skip_29111 | -5.276668e-01 | 6.712096e-21 |
| HCC | KHDRBS3 | exon_skip_29111 | -5.832946e-01 | 3.425279e-26 |
| HCC | FUBP3 | exon_skip_29111 | -4.696731e-01 | 2.493368e-16 |
| HCC | ENOX1 | exon_skip_29111 | -4.022258e-01 | 5.326166e-12 |
| HCC | HNRNPA2B1 | exon_skip_29111 | -5.348466e-01 | 1.577557e-21 |
| HCC | PUF60 | exon_skip_29111 | -4.043527e-01 | 4.018837e-12 |
| HCC | PTBP1 | exon_skip_29111 | -7.770390e-01 | 3.268593e-56 |
| HCC | PABPC1 | exon_skip_29111 | -5.060680e-01 | 4.277750e-19 |
| HCC | PABPC4 | exon_skip_29111 | -4.903073e-01 | 7.402123e-18 |
| HCC | SRSF5 | exon_skip_29111 | -4.631001e-01 | 7.279632e-16 |
| HCC | RBM41 | exon_skip_29111 | -5.068662e-01 | 3.688003e-19 |
| HCC | HNRNPF | exon_skip_29111 | -7.078161e-01 | 1.195367e-42 |
| IFG | ELAVL4 | exon_skip_29111 | 4.597037e-01 | 1.384884e-02 |
| IFG | RBM6 | exon_skip_29111 | -4.753848e-01 | 1.056918e-02 |
| IFG | KHDRBS3 | exon_skip_29111 | 4.819873e-01 | 9.397509e-03 |
| IFG | HNRNPH2 | exon_skip_29111 | 5.598426e-01 | 1.949289e-03 |
| IFG | RBM46 | exon_skip_95746 | 4.406756e-01 | 2.141229e-02 |
| IFG | RBM46 | exon_skip_202833 | 7.202657e-01 | 2.272549e-05 |
| IFG | ESRP1 | exon_skip_202833 | -4.158081e-01 | 3.099596e-02 |
| IFG | RBM46 | exon_skip_265670 | 7.224168e-01 | 3.080900e-05 |
| PCC | RBMS2 | exon_skip_29111 | -7.121753e-01 | 4.137794e-34 |
| PCC | MSI1 | exon_skip_29111 | -4.869851e-01 | 5.038240e-14 |
| PCC | ELAVL4 | exon_skip_29111 | 5.874505e-01 | 4.634917e-21 |
| PCC | RBM6 | exon_skip_29111 | -5.174856e-01 | 6.421625e-16 |
| PCC | PCBP4 | exon_skip_29111 | -4.778522e-01 | 1.713638e-13 |
| PCC | RALYL | exon_skip_29111 | 4.691122e-01 | 5.347024e-13 |
| PCC | PTBP1 | exon_skip_29111 | -7.271871e-01 | 3.658620e-36 |
| PCC | PABPC1 | exon_skip_29111 | -5.182490e-01 | 5.724749e-16 |
| PCC | HNRNPF | exon_skip_29111 | -6.116696e-01 | 3.806782e-23 |
| PG | MSI1 | exon_skip_29111 | -5.565706e-01 | 3.570300e-17 |
| PG | ELAVL4 | exon_skip_29111 | 6.416671e-01 | 6.732326e-24 |
| PG | IGF2BP2 | exon_skip_29111 | -4.160506e-01 | 1.607129e-09 |
| PG | MATR3 | exon_skip_29111 | 5.456156e-01 | 1.923507e-16 |
| PG | PCBP1 | exon_skip_29111 | 4.650157e-01 | 8.434963e-12 |
| PG | ILF2 | exon_skip_29111 | 4.625774e-01 | 1.117914e-11 |
| PG | HNRNPK | exon_skip_29111 | 4.629456e-01 | 1.071514e-11 |
| PG | KHDRBS2 | exon_skip_29111 | 5.317182e-01 | 1.494185e-15 |
| PG | KHDRBS3 | exon_skip_29111 | 5.042512e-01 | 6.585939e-14 |
| PG | HNRNPA0 | exon_skip_29111 | 4.840195e-01 | 8.686098e-13 |
| PG | PUF60 | exon_skip_29111 | 5.011404e-01 | 9.901247e-14 |
| PG | RALYL | exon_skip_29111 | 6.267495e-01 | 1.438998e-22 |
| PG | PTBP1 | exon_skip_29111 | -4.188820e-01 | 1.213099e-09 |
| PG | HNRNPL | exon_skip_29111 | 4.663042e-01 | 7.261944e-12 |
| PG | CELF1 | exon_skip_29111 | 4.548348e-01 | 2.694539e-11 |
| PG | HNRNPH2 | exon_skip_29111 | 4.786205e-01 | 1.680819e-12 |
| PG | SART3 | exon_skip_29111 | 4.029349e-01 | 5.718707e-09 |
| STG | SRSF2 | exon_skip_29111 | 4.052002e-01 | 1.088072e-04 |
| STG | ELAVL4 | exon_skip_29111 | 5.476699e-01 | 4.836328e-08 |
| STG | SRSF11 | exon_skip_29111 | 4.035278e-01 | 1.168811e-04 |
| STG | MATR3 | exon_skip_29111 | 5.490390e-01 | 4.409038e-08 |
| STG | PCBP1 | exon_skip_29111 | 4.074771e-01 | 9.864372e-05 |
| STG | ILF2 | exon_skip_29111 | 4.240027e-01 | 4.738372e-05 |
| STG | HNRNPK | exon_skip_29111 | 4.333911e-01 | 3.070451e-05 |
| STG | KHDRBS2 | exon_skip_29111 | 4.147609e-01 | 7.173925e-05 |
| STG | KHDRBS3 | exon_skip_29111 | 6.010275e-01 | 9.450322e-10 |
| STG | HNRNPA0 | exon_skip_29111 | 4.671668e-01 | 5.773892e-06 |
| STG | HNRNPDL | exon_skip_29111 | 4.198149e-01 | 5.726646e-05 |
| STG | RALYL | exon_skip_29111 | 5.494552e-01 | 4.286423e-08 |
| STG | HNRNPL | exon_skip_29111 | 4.484767e-01 | 1.487819e-05 |
| STG | CELF1 | exon_skip_29111 | 4.046327e-01 | 1.114874e-04 |
| STG | HNRNPH2 | exon_skip_29111 | 4.887167e-01 | 1.805079e-06 |
| STG | SART3 | exon_skip_29111 | 4.019964e-01 | 1.247577e-04 |
| STG | FXR2 | exon_skip_192560 | 5.097103e-01 | 1.173449e-06 |
| STG | HNRNPL | exon_skip_192560 | 4.521664e-01 | 2.258782e-05 |
| TC | RBMS2 | exon_skip_92062 | -5.350528e-01 | 1.041859e-12 |
| TC | SRSF2 | exon_skip_92062 | 5.618963e-01 | 4.129755e-14 |
| TC | MSI1 | exon_skip_92062 | -4.663853e-01 | 1.232369e-09 |
| TC | ELAVL4 | exon_skip_92062 | 7.965611e-01 | 8.054267e-35 |
| TC | RBM25 | exon_skip_92062 | 4.637561e-01 | 1.568120e-09 |
| TC | RBM6 | exon_skip_92062 | -4.094215e-01 | 1.480797e-07 |
| TC | MBNL1 | exon_skip_92062 | 4.142372e-01 | 1.021258e-07 |
| TC | MATR3 | exon_skip_92062 | 7.651393e-01 | 1.132386e-30 |
| TC | ILF2 | exon_skip_92062 | 5.660995e-01 | 2.425659e-14 |
| TC | HNRNPK | exon_skip_92062 | 4.629613e-01 | 1.685916e-09 |
| TC | KHDRBS2 | exon_skip_92062 | 8.242561e-01 | 3.933485e-39 |
| TC | KHDRBS3 | exon_skip_92062 | 7.148433e-01 | 3.144830e-25 |
| TC | ENOX1 | exon_skip_92062 | 4.486968e-01 | 5.997190e-09 |
| TC | HNRNPA0 | exon_skip_92062 | 7.331227e-01 | 4.595006e-27 |
| TC | HNRNPDL | exon_skip_92062 | 5.140603e-01 | 1.073799e-11 |
| TC | HNRNPD | exon_skip_92062 | 6.550405e-01 | 4.104923e-20 |
| TC | NUP42 | exon_skip_92062 | 6.945755e-01 | 2.351571e-23 |
| TC | RALYL | exon_skip_92062 | 7.959938e-01 | 9.711337e-35 |
| TC | PTBP1 | exon_skip_92062 | -5.195224e-01 | 5.942458e-12 |
| TC | PTBP3 | exon_skip_92062 | 4.825306e-01 | 2.681478e-10 |
| TC | HNRNPL | exon_skip_92062 | 4.128235e-01 | 1.139637e-07 |
| TC | CELF1 | exon_skip_92062 | 5.696003e-01 | 1.548261e-14 |
| TC | EWSR1 | exon_skip_92062 | 4.123312e-01 | 1.183871e-07 |
| TC | SRSF9 | exon_skip_92062 | 4.162338e-01 | 8.739554e-08 |
| TC | SRSF5 | exon_skip_92062 | 4.555250e-01 | 3.290755e-09 |
| TC | HNRNPH2 | exon_skip_92062 | 7.625943e-01 | 2.298808e-30 |
| TC | ESRP1 | exon_skip_92062 | 6.078871e-01 | 7.907241e-17 |
| TC | FXR2 | exon_skip_294575 | 4.088783e-01 | 1.057536e-07 |
| TC | NUP42 | exon_skip_294575 | 4.231252e-01 | 3.372007e-08 |
| TC | FXR2 | exon_skip_103241 | 4.101340e-01 | 1.053852e-07 |
| TC | NUP42 | exon_skip_146331 | 5.169518e-01 | 4.167869e-12 |
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RelatedDrugs for PAM |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P19021 | approved|nutraceutical | DB00126 | Ascorbic acid | small molecule | P19021 |
Top |
RelatedDiseases for PAM |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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